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Baclofen and noradrenergic function in the rat frontal cerebral cortex.

Abstract：

:Possible changes in noradrenergic function were investigated in rat frontal cerebral cortex after acute treatment (1, 2 h) with the GABAB agonist, baclofen. A single i.p. injection of d,l-baclofen 10 mg/kg both reduced noradrenaline (NA) biosynthesis in vivo (31%) and the endogenous concentration of normetanephrine (NMN) (32%) and increased NA levels (28%). Increased [3H]NA uptake (15%) and [3H]dihydroxyphenyl-ethyleneglycol ([3H]DOPEG formation (39%) were observed in cortex slices ex vivo from baclofen-treated animals. The activity of monoamineoxidase (MAO) was unchanged after baclofen treatment. We suggest that baclofen might interfere in vivo with noradrenergic neurotransmission, reducing NA biosynthesis and release in the rat cerebral cortex.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Losada ME

doi

10.1016/0014-2999(91)90369-2

subject

Has Abstract

pub_date

1991-05-02 00:00:00

pages

93-8

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(91)90369-2

journal_volume

197

pub_type

杂志文章

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