Effects of alpha-adrenoceptor agents on norepinephrine release from vas deferens of several species including man.

Abstract:

:Unlike the situation with the vas deferens of rats, guinea-pigs, rabbits and dogs, neither phentolamine nor yohimbine enhanced electrically-evoked release of [3H]norepinephrine from the in vitro human vas deferens. However, clonidine produced, by a phentolamine-sensitive mechanism, a concentration-related inhibition of release in the human vas deferens. The results indicate that, even though presynaptic alpha-adrenoceptors exist, a negative feedback regulation of release by norepinephrine, which occurs in the vas deferens of the other species, may not be functionally important in the vas deferens of the human.

journal_name

Eur J Pharmacol

authors

Belis JA,Colby JE,Westfall DP

doi

10.1016/0014-2999(82)90495-2

subject

Has Abstract

pub_date

1982-03-26 00:00:00

pages

487-90

issue

4

eissn

0014-2999

issn

1879-0712

pii

0014-2999(82)90495-2

journal_volume

78

pub_type

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