Abstract:
:The pharmacological features of dopamine receptors in identifiable giant neurone types of a snail (Achatina fulica Férussac) were studied. Under voltage clamp, two neurone types, LVMN (left ventral multiple spike neurone) and d-RPeAN (dorsal-right pedal anterior neurone), produced an inward current (Iin) in response to dopamine, (-)-noradrenaline and epinine, whereas v-LCDN (ventral-left cerebral distinct neurone) produced an outward current (Iout) in response to dopamine and epinine. Mammalian dopamine receptor agonists, fenoldopam (dopamine D1-like receptor agonist), (+/-)-SKF 38393 (1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8- diol) (D1-like), apomorphine (D2-like), (-)-quinpirole (D3 and D4) and methylergometrine showed slight or no effect. (+/-)-SKF 83566 ((+/-)-7-bromo-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benza zepine) (dopamine D1-like receptor antagonist) and (+)-UH 232 (cis-(+)-5-methoxy-1-methyl-2-(di-n-propylamino)tetralin) (D3 and D2) non-competitively inhibited the Iin of LVMN and d-RPeAN, but (+/-)-sulpiride (D2-like) was without effect. In contrast, (+/-)-sulpiride competitively inhibited Iout of v-LCDN, (+)-UH 232 non-competitively inhibited Iout of v-LCDN but (+/-)-SKF 83566 was without effect. H-7 (1-(5-isoquinolinesulfonyl)-2-methylpiperazine) (non-selective protein kinase inhibitor) inhibited Iin of LVMN and d-RPeAN, but did not affect Iout of v-LCDN. Dopamine-induced Iin was Na(+)-dependent; Iout was K(+)-dependent. Ouabain did not affect these currents. We propose that the pharmacological features of Achatina neuronal dopamine receptors are not fully comparable to those of mammals, although intracellular signal transduction systems linked with dopamine receptors may similarly exist in different animal species.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Emaduddin M,Liu GJ,Takeuchi Hdoi
10.1016/0014-2999(95)00301-zsubject
Has Abstractpub_date
1995-09-05 00:00:00pages
113-24issue
1-3eissn
0014-2999issn
1879-0712pii
0014-2999(95)00301-Zjournal_volume
283pub_type
杂志文章abstract::The aim of the present study was to correlate the impairment of cognitive function induced by scopolamine with the activity of dopaminergic synapses in brain areas which are innervated by the mesocortical limbic system (e.g. hippocampus and frontal cortex) or by the mesostriatal system (e.g. striatum and nucleus accum...
journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/0014-2999(88)90670-x
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/s0014-2999(96)00575-4
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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doi:10.1016/j.ejphar.2006.06.079
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/0014-2999(84)90252-8
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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更新日期:1981-04-09 00:00:00
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journal_title:European journal of pharmacology
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doi:10.1016/j.ejphar.2013.02.035
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/j.ejphar.2013.05.006
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/j.ejphar.2005.01.042
更新日期:2005-04-04 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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更新日期:1990-01-17 00:00:00
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/0014-2999(85)90417-0
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/j.ejphar.2004.08.016
更新日期:2004-10-06 00:00:00
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journal_title:European journal of pharmacology
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更新日期:1975-06-01 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/0014-2999(87)90311-6
更新日期:1987-04-29 00:00:00
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journal_title:European journal of pharmacology
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doi:10.1016/j.ejphar.2005.12.019
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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更新日期:1996-06-13 00:00:00
abstract::Mouse peritoneal inflammatory macrophages have a saturable binding site for [3H]flunitrazepam with a KD of 43 +/- 7 nM and Bmax of 391 +/- 58 fmol per 10(6) cells, which corresponds to 250 000 sites per cell. The IC50 values for PK 11195, Ro 5-4864, diazepam, flunitrazepam, clonazepam, ethyl-beta carboline 3-carboxyla...
journal_title:European journal of pharmacology
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