Abstract:
:The function of multidrug resistance-associated protein 2 (Mrp2) in the intestine and liver, as well as intestinal Mrp2 expression, was analyzed in CCl(4)-induced acute hepatic failure rats with hyperbilirubinemia. The plasma level of bilirubin glucuronides, endogenous Mrp2-substrates, was 26 microM at 24 h after CCl(4) treatment. Mrp2 protein levels in jejunum decreased to 41% of control level. Mrp2-mediated efflux of 2,4-dinitrophenyl-S-glutathione (DNP-GSH), an Mrp2-substrate, in jejunum decreased to 31% of control in vitro, and was almost completely suppressed in vivo to the same level as that in the presence of probenecid, an Mrp2-inhibitor. Biliary excretion of DNP-GSH was suppressed to the same level as that inhibited by intravenous probenecid. The suppression of Mrp2 and the increased plasma bilirubin glucuronides recovered within 24 h thereafter. These results suggest that hyperbilirubinemia in disease states may be related to the systemic suppression of Mrp2 function.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Yokooji T,Murakami T,Yumoto R,Nagai J,Takano Mdoi
10.1016/j.ejphar.2006.06.079subject
Has Abstractpub_date
2006-09-28 00:00:00pages
152-60issue
1-3eissn
0014-2999issn
1879-0712pii
S0014-2999(06)00684-4journal_volume
546pub_type
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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