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Intracardiac phenylbiguanide causes excitation of spinal neurons by activation of cardiac sympathetic afferents.

Abstract：

:The responses of spinothalamic, spinoreticular, and unidentified spinal neurons to intracardiac administration of phenylbiguanide, a 5-HT3 receptor agonist, were examined in anesthetized cats and monkeys. Eighteen neurons were excited, 5 were inhibited, and 12 were unresponsive to this stimulus. Results suggest that cardiac sympathetic afferents mediate the excitatory responses produced by phenylbiguanide, because bilateral cervical vagotomy failed to block these responses, and aortic injections of phenylbiguanide had little effect on cell activity.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Blair RW,Chandler MJ,Bolser DC,Foreman RD

doi

10.1016/0014-2999(92)90218-s

keywords:

subject

Has Abstract

pub_date

1992-05-27 00:00:00

pages

119-22

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(92)90218-S

journal_volume

216

pub_type

杂志文章

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