Abstract：
:Forskolin inhibited the response to electrical field stimulation (0.1 Hz) and antagonised contractile responses to noradrenaline in the isolated rat vas deferens. The inhibition of the response to electrical stimulation (IC50 0.1 microM) was not affected by either propranolol or yohimbine. Both isoprenaline and forskolin enhanced the total tritium efflux during transmural stimulation of vas deferens which had been prelabelled with [3H]noradrenaline. These data provide evidence that beta-adrenoceptor stimulation enhances noradrenaline release in the vas deferens, although the postsynaptic relaxant effect on smooth muscle predominates in determining the net response. The data are consistent with a stimulation of adenylate cyclase in mediation of both presynaptic and postsynaptic effects of beta-adrenoceptor agonists in the vas deferens.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Hovevei-Sion D,Finberg JP,Bomzon A,Youdim MBdoi
10.1016/0014-2999(83)90650-7subject
Has Abstractpub_date
1983-11-25 00:00:00pages
295-9issue
3-4eissn
0014-2999issn
1879-0712pii
0014-2999(83)90650-7journal_volume
95pub_type
杂志文章abstract：:The integrity of endothelial cell monolayers, a critical requirement for barrier maintenance, is needed for the prevention of edema formation. To investigate the mechanisms by which 2-phenyl-4-quinolone (YT-1) provided protection against serotonin-induced exudation, rat heart endothelial cell cultures were used. In th...
journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1997-09-24 00:00:00
abstract：:CysLT1 receptors are known to be involved in the pathogenesis of asthma. However, the functional roles of CysLT2 receptors in this condition have not been determined. The purpose of this study is to develop an experimental model of CysLT2 receptor-mediated LTC4-induced lung air-trapping in guinea pigs and use this mod...
journal_title：European journal of pharmacology
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更新日期：2017-01-05 00:00:00
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journal_title：European journal of pharmacology
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更新日期：2012-05-05 00:00:00
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journal_title：European journal of pharmacology
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更新日期：2019-12-15 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1981-06-10 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/s0014-2999(97)01338-1
更新日期：1997-11-19 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章,评审
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更新日期：2020-11-15 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(96)00420-7
更新日期：1996-09-12 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/s0014-2999(97)00104-0
更新日期：1997-03-19 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2008.12.013
更新日期：2009-02-14 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2010.11.028
更新日期：2011-02-25 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/s0014-2999(01)01199-2
更新日期：2001-08-24 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(85)90779-4
更新日期：1985-06-19 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.ejphar.2008.02.096
更新日期：2008-05-13 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2011.10.008
更新日期：2011-12-30 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(95)00069-w
更新日期：1995-04-24 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(86)90715-6
更新日期：1986-04-29 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2005-11-21 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(90)90105-f
更新日期：1990-03-27 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1991-07-23 00:00:00
abstract：:High pressure liquid chromatography (HPLC) combined with radiochemical detection was used to show that [3H]noradrenaline (NA) and [14C]ATP were released concomitantly during field stimulation of the rat vas deferens. The release of radioactivity (3H and 14C) in response to three consecutive field stimulations was cons...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(88)90254-3
更新日期：1988-12-06 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(95)00215-7
更新日期：1995-07-14 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2012.10.041
更新日期：2013-01-05 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2020-08-05 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2013.08.011
更新日期：2013-10-15 00:00:00
abstract：:Dopamine (DA) was injected in the third brain ventricle of goats and the thermoregulatory effects were studied under different ambient conditions. The effects depended on dose, ambient conditions and cannula used. In the cold, there was a drop in body temperature, sometimes accompanied by suppression of shivering and ...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(77)90153-4
更新日期：1977-05-01 00:00:00
abstract：:Pretreatment with the non-competitive NMDA (N-methyl-D-aspartate) antagonist MK801 (0.5, 1.0 mg/kg, s.c.) suppressed the behavioral signs of withdrawal in morphine-dependent rats. However, the same doses of MK801 that suppressed morphine withdrawal also simultaneously produced phencyclidine (PCP)-like behaviors. Pretr...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(91)90358-w
更新日期：1991-05-02 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2017.09.037
更新日期：2017-11-15 00:00:00
abstract：:Berend Olivier has had a long-standing interest in the utility of animal models for a wide variety of therapeutic indications. His work has spanned multiple types of models, blending ethological, or species typical and naturalistic behaviors, along with methodologies based on learned behavior. He has consistently done...
journal_title：European journal of pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.ejphar.2014.11.046
更新日期：2015-04-15 00:00:00
abstract：:Cats, sedated and paralyzed, showed a significant increase in body temperature after intravenous injection of morphine while animals with additional spinal blockade (C3) from injection of 2% lidocaine solution, did not. The results suggest that motor activity is not necessary for morphine-induced hyperthermia in the c...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(78)90113-9
更新日期：1978-06-01 00:00:00
