Epinephrine as a potent releaser of immunoreactive beta-endorphin in rats.

abstract：:Adenosine has been reported to have beneficial effects against ischemic brain damage, although the mechanisms are not fully clarified. To examine the role of adenosine on the ischemia-evoked release of neurotransmitters, we applied a highly selective agonist for adenosine A1 receptor, 2-chloro-N6-cyclopentyladenosine ...

journal_title：European journal of pharmacology

authors： Goda H,Ooboshi H,Nakane H,Ibayashi S,Sadoshima S,Fujishima M

更新日期：1998-09-18 00:00:00

abstract：:Protective effect of quercetin and alpha-tocopherol on experimental reflux oesophagitis in rats was investigated. Rats received quercetin, (100 mg/kg), alpha-tocopherol (16 mg/kg), omeprazole (30 mg/kg) given at 1 h prior to surgery. Quercetin and alpha-tocopherol significantly inhibited the oesophagitis index to 1.33...

journal_title：European journal of pharmacology

authors： Rao CV,Vijayakumar M

更新日期：2008-07-28 00:00:00

abstract：:The effect of systemic administration of the nonselective dopamine receptor agonist apomorphine on efflux of serotonin (5-hydroxytryptamine, 5-HT) in striatum and hippocampus of freely moving rats was examined using in vivo microdialysis. 5-HT efflux was increased by a moderate dose of apomorphine sufficient for a pos...

journal_title：European journal of pharmacology

authors： Mendlin A,Martín FJ,Jacobs BL

更新日期：1998-06-26 00:00:00

abstract：:In the present study we investigated whether muscarinic receptors in human airway smooth muscle are coupled to phosphoinositide metabolism as a possible transduction mechanism of contraction. Using isolated bronchial smooth muscle preparations, we found that the muscarinic agonist methacholine caused a time- and conce...

journal_title：European journal of pharmacology

authors： Meurs H,Timmermans A,Van Amsterdam RG,Brouwer F,Kauffman HF,Zaagsma J

更新日期：1989-05-19 00:00:00

abstract：:The effects of intracerebral microinjections of neurotensin and xenopsin on self-stimulation of the medial prefrontal cortex of the rat were studied. Unilateral microinjections into the medial prefrontal cortex of neurotensin at doses of 0.625, 1.25, 2.5, 5 and 10 nmol produced a dose-related decrease of self-stimulat...

journal_title：European journal of pharmacology

authors： Ferrer JM,Sabater R,Saez JA

更新日期：1993-01-26 00:00:00

abstract：:[3H]Neuropeptide Y labelled neuropeptide Y receptors in rat forebrain membranes as a homogenous class of high-affinity sites. Between 80 and 85% of these receptors showed high affinity for Y1-selective antagonists such as (R)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-D-arginine amide (BIBP3226). While competitiv...

journal_title：European journal of pharmacology

authors： Vanderheyden PM,Van Liefde I,De Backer JP,Vauquelin G

更新日期：1997-07-23 00:00:00

abstract：:The mechanisms underlying the capsaicin-induced relaxation of the acetylcholine- as well as KCl-contraction were studied by measuring isometric force and phosphorylation of 20-kDa regulatory light chain subunit of myosin (MLC(20)) in ileal longitudinal smooth muscles of rats. Capsaicin relaxed acetylcholine- and KCl-s...

journal_title：European journal of pharmacology

authors： Fujimoto S,Mori M

更新日期：2004-03-08 00:00:00

abstract：:In urethane-anesthetized rats, the effects of intravenous injections of morphine, levorphanol, dextrorphan, pentazocine and naloxone were studied studied on the activity in nerve fibres of the cervical sympathetic trunk, and on mean arterial blood pressure and heart rate. Impulse frequency in sympathetic nerve fibres ...

journal_title：European journal of pharmacology

authors： Jurna I,Rummel W

更新日期：1984-05-18 00:00:00

abstract：:It is widely believed that metabotropic glutamate (mGlu) receptors play a potential role in memory formation. However, the particular function of different classes of mGluRs, or even subtypes, remains elusive. We show here that intraperitoneal injection of the class I selective antagonist 1-aminoindan-1,5-dicarboxylic...

journal_title：European journal of pharmacology

authors： Nielsen KS,Macphail EM,Riedel G

更新日期：1997-05-20 00:00:00

abstract：:Beat-to-beat alternations of the cardiac monophasic action potential, known as electrical alternans, were studied at drug concentrations that have known arrhythmogenic outcomes. Electrical alternans were elicited from the heart of anesthetized guinea pigs, both in the absence and presence of drugs that inhibit the del...

journal_title：European journal of pharmacology

authors： Fossa AA,Wisialowski T,Wolfgang E,Wang E,Avery M,Raunig DL,Fermini B

更新日期：2004-02-20 00:00:00

abstract：:Rats were injected with 15 mg/kg (i.p.) mianserin or vehicle (saline) for 4, 10 or 21 days and 5-HT2 receptor binding and mRNA levels measured. Treatment with mianserin induced a substantial decrease in 5-HT2 radioligand binding (44-59% decrease; P less than 0.05 vs. control). No changes in the amount of 5-HT2 or, as ...

journal_title：European journal of pharmacology

authors： Roth BL,Ciaranello RD

更新日期：1991-06-19 00:00:00

abstract：:The effect of the pro-inflammatory cytokine, interleukin-1beta on an NMDA receptor-independent form of synaptic plasticity brought about by the application of the K+ channel blocker tetraethylammonium, was examined in the rat dentate gyrus in vitro. Field excitatory postsynaptic potentials (EPSPs) were recorded from t...

journal_title：European journal of pharmacology

authors： Coogan AN,O'Connor JJ

更新日期：1999-06-18 00:00:00

abstract：:We recently observed that the 5-hydroxytryptamine (5-HT)(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)-cycloh exanecarboxamide (WAY 100635) enhanced antipsychotic-induced catalepsy, which we hypothesized to be due to a blockade of tonic 5-HT(1A) receptor activation. Here, we ex...

journal_title：European journal of pharmacology

authors： Prinssen EP,Koek W,Kleven MS

更新日期：2000-04-28 00:00:00

abstract：:The effects of serotonin (5-HT) on a beta-adrenergic response were studied, using the voltage clamp technique, in Xenopus laevis oocytes surrounded by their follicular cells. noradrenaline induced marked hyperpolarization, with a specific increase in the permeability of the membrane toward K+. Application of 10 microM...

journal_title：European journal of pharmacology

authors： Fujita R,Tamazawa Y,Barnard EA,Matsumoto M

更新日期：1993-08-24 00:00:00

abstract：:The effect of several pyrolysate mutagens on the benzodiazepine and GABA receptors was investigated. Of amino-gamma-carbolines, Trp-P-1 antagonized the suppressive effect of diazepam on the pentylenetetrazol-induced convulsions and death, whereas Trp-P-2 by itself precipitated seizures and death in male mice. Both Trp...

journal_title：European journal of pharmacology

authors： Muraki T,Yamazoe Y,Kato R

更新日期：1984-02-10 00:00:00

abstract：:The effect of NZ-107 (4-bromo-5-(3-ethoxy-4-methoxybenzylamino)-3(2H)-pyridazinone) on late-phase airway responses and airway hyperreactivity was investigated in the guinea pig. Challenge with inhaled ovalbumin in conscious guinea pigs actively sensitized with inhaled ovalbumin caused triphasic bronchial obstruction, ...

journal_title：European journal of pharmacology

authors： Iwama T,Shikada K,Yamamoto A,Sakashita M,Hibi M,Tanaka S

更新日期：1991-07-09 00:00:00

abstract：:In epithelial tumors, the epidermal growth factor receptor (EGFR) controls key signaling pathways responsible for growth, proliferation, migration, and survival of tumor cells. The epidermal growth factor receptor variant III (EGFRvIII) is the most common EGFR mutation that occurs in up to 30% of high-grade gliomas es...

journal_title：European journal of pharmacology

authors： Chistiakov DA,Chekhonin IV,Chekhonin VP

更新日期：2017-09-05 00:00:00

abstract：:Effects of the alpha2-adrenoceptor antagonist yohimbine on the antinociception produced by a low dose of naloxone were examined in a rat model of carrageenan-induced inflammation. In rats receiving saline prior to naloxone injection, the low dose of naloxone (5 microg/kg, i.p.) significantly prolonged paw withdrawal l...

journal_title：European journal of pharmacology

authors： Tsuruoka M,Hiruma Y,Matsutani K,Matsui Y

更新日期：1998-05-08 00:00:00

abstract：:The novel anti-ischemic compound, BMS-204352 ((3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indol-2-one)), strongly activates the voltage-gated K+ channel KCNQ5 in a concentration-dependent manner with an EC50 of 2.4 microM. At 10 microM, BMS-204352 increased the steady state current ...

journal_title：European journal of pharmacology

authors： Dupuis DS,Schrøder RL,Jespersen T,Christensen JK,Christophersen P,Jensen BS,Olesen SP

更新日期：2002-02-22 00:00:00

abstract：:In the presence of 3 x 10(-6) M captopril, 5 x 10(-7) M des-Asp-Angiotensin I was found to inhibit the electrically (1 and 2 Hz) induced contraction of the rabbit pulmonary artery but had no significant effect on the noradrenaline-stimulated contraction. 2.8 x 10(-6) M indomethacin and 10(-6) M losartan but not 10(-6)...

journal_title：European journal of pharmacology

authors： Sim MK,Soh KS

更新日期：1995-09-15 00:00:00

abstract：:Diazepam (10(-5)-3 X 10(-4) M) selectively enhanced the negative inotropic responses of guinea-pig atria and the relaxation of guinea-pig taenia coli caused by adenosine and ATP. In the atria, the effect of 2-chloroadenosine, a stable analog of adenosine, was not affected by diazepam. Segments of guinea-pig atria or t...

journal_title：European journal of pharmacology

authors： Moritoki H,Fukuda H,Kotani M,Ueyama T,Ishida Y,Takei M

更新日期：1985-07-11 00:00:00

abstract：:Statins are well-known inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which block the mevalonate pathway. The activity of statins not only decreases cholesterol levels but also ameliorates inflammation and modulates the immune system. In this study, we investigated the effects of simvastatin ...

journal_title：European journal of pharmacology

authors： Sahid MNA,Liu S,Kiyoi T,Maeyama K

更新日期：2017-11-05 00:00:00

abstract：:Dysfunction of the innate immune system has been reported to cause intestinal inflammation. Vitamin D3 is known to be an important immune system regulator and exerts anti-inflammatory effects. We investigated in vitro effects of vitamin D3 and its derivatives on the innate immune system in HT-29 cells, a line of human...

journal_title：European journal of pharmacology

authors： Hidaka M,Wakabayashi I,Takeda Y,Fukuzawa K

更新日期：2013-12-05 00:00:00

abstract：:Herein, we examined the direct coupling of human dopamine D1 receptors to G(s) proteins using an antibody capture assay together with a detection technique employing scintillation proximity assay beads. Using a specific antibody, dopamine (DA) and the selective dopamine D1 receptor agonists, 6-chloro-7,8-dihydroxy-1-p...

journal_title：European journal of pharmacology

authors： Cussac D,Pasteau V,Millan MJ

更新日期：2004-02-06 00:00:00

abstract：:Some behavioural effects of flunitrazepam were investigated in two sets of experiments in C57BL/6 mice. In the first set, flunitrazepam administration (0.025 or 0.05 mg/kg) enhanced the locomotor activity of mice. In the second set, memory impairments were observed following posttraining (immediately or 30 min, but no...

journal_title：European journal of pharmacology

authors： Castellano C,Filibeck U,Pavone F

更新日期：1984-09-03 00:00:00

abstract：:Cocaine and several sigma receptor ligands inhibit dopamine uptake via a common site. This is evidenced by a concentration-dependent inhibition of dopamine uptake and displacement of the binding of [3H]WIN 35,428 (also called CFT), a cocaine analog with high affinity for the dopamine transporter. Since several sigma r...

journal_title：European journal of pharmacology

authors： Izenwasser S,Newman AH,Katz JL

更新日期：1993-10-19 00:00:00

abstract：:There are several inconsistencies in the literature as regards the characteristics of benzamide and butyrophenone binding to dopamine D2-like receptors. The variations observed in Bmax, Kd and Ki values have led to hypotheses, such as the existence of a specific "benzamide binding site' and that dopamine D2 receptors ...

journal_title：European journal of pharmacology

authors： Malmberg A,Jerning E,Mohell N

更新日期：1996-05-06 00:00:00

abstract：:Calcium entry blockers can effectively preserve high-energy phosphates in ischemic heart. However, little is known about the optimal timing of drug therapy. The moment of nisoldipine administration in relation to its protective efficacy during ischemia and reperfusion was studied in rat hearts. Nisoldipine (50 nM), gi...

journal_title：European journal of pharmacology

authors： De Jong JW

更新日期：1985-11-26 00:00:00

abstract：:We have previously reported that 15-hydroxyeicosatetraenoic acid (15-HETE), a metabolite of arachidonic acid by 15-lipoxygenase, causes pulmonary vasoconstriction via increasing the intracellular Ca(2+) concentration ([Ca(2+)]i). However, the multiple sources of Ca(2+) that contribute to Ca(2+) elevation during and af...

journal_title：European journal of pharmacology

authors： Zheng X,Li Q,Tang X,Liang S,Chen L,Zhang S,Wang Z,Guo L,Zhang R,Zhu D

更新日期：2008-12-28 00:00:00

abstract：:The present study has examined the antidiabetic effects of 21 days co-administration of xenin-8-Gln with the dual-acting fusion peptide, exendin-4/gastrin, as well as persistence of beneficial metabolic benefits, in high fat fed (HFF) mice. Xenin-8-Gln, exendin-4 and gastrin represent compounds that activate receptors...

journal_title：European journal of pharmacology

authors： Hasib A,Khan D,Craig SL,Gault VA,Flatt PR,Irwin N

更新日期：2019-12-15 00:00:00