Abstract：
:Dopamine (DA) was injected in the third brain ventricle of goats and the thermoregulatory effects were studied under different ambient conditions. The effects depended on dose, ambient conditions and cannula used. In the cold, there was a drop in body temperature, sometimes accompanied by suppression of shivering and by vasodilatation. Both temperature decrease and suppression of shivering were dose-dependent but there was no relation between magnitude of temperature drop and occurrence of shivering suppression. In a thermoneutral environment, there was either a slight vasoconstriction or hypothermia, occasionally accompanied by induction of panting. In the heat, either hypothermia or hyperthermia was observed. Hypothermia was accompanied by an increase in panting. Hyperthermia only occurred when the animals became excited as a result of the injection of DA. It is concluded that DA acts by stimulating the thermoregulatory pathway from heat sensors to heat loss effectors at a locus similar to that for 5-hydroxytryptamine in the thermoregulation model of Bligh et al. (1971).
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
De Roij TA,Frens J,Bakker J,Németh Fdoi
10.1016/0014-2999(77)90153-4subject
Has Abstractpub_date
1977-05-01 00:00:00pages
1-7issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(77)90153-4journal_volume
43pub_type
杂志文章abstract：:The pharmacology of neurogenic trigeminovascular vasodilator responses in the dura mater is of interest for understanding the pathophysiology of migraine and to develop new therapies for this disabling common condition. Aminergic mechanisms have been implicated in migraine through direct study of amines in patients, a...
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pub_type： 杂志文章,评审
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journal_title：European journal of pharmacology
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pub_type： 杂志文章,评审
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journal_title：European journal of pharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2012-09-15 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(89)90235-5
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