Thermoregulatory effects of intraventricularly injected dopamine in the goat.


:Dopamine (DA) was injected in the third brain ventricle of goats and the thermoregulatory effects were studied under different ambient conditions. The effects depended on dose, ambient conditions and cannula used. In the cold, there was a drop in body temperature, sometimes accompanied by suppression of shivering and by vasodilatation. Both temperature decrease and suppression of shivering were dose-dependent but there was no relation between magnitude of temperature drop and occurrence of shivering suppression. In a thermoneutral environment, there was either a slight vasoconstriction or hypothermia, occasionally accompanied by induction of panting. In the heat, either hypothermia or hyperthermia was observed. Hypothermia was accompanied by an increase in panting. Hyperthermia only occurred when the animals became excited as a result of the injection of DA. It is concluded that DA acts by stimulating the thermoregulatory pathway from heat sensors to heat loss effectors at a locus similar to that for 5-hydroxytryptamine in the thermoregulation model of Bligh et al. (1971).


Eur J Pharmacol


De Roij TA,Frens J,Bakker J,Németh F




Has Abstract


1977-05-01 00:00:00














  • Rapid effects of MPTP in the mouse colon.

    abstract::Mechanical responses of the mouse colon to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were measured in vitro. MPTP caused muscle relaxation with an onset time of about 10 s. This relaxation was inhibited by propranolol. Pretreatment of the animals with reserpine significantly reduced the MPTP-induced relaxati...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Hanani M

    更新日期:1990-01-17 00:00:00

  • Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold.

    abstract::This study examined whether the antinociceptive activity of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol), a GABA agonist, is mediated through an action exerted at the level of the spinal cord. Intrathecal injection of doses of THIP devoid of motor effects (1-2 micrograms) did not increase tail flick or hot pl...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Hammond DL,Drower EJ

    更新日期:1984-08-03 00:00:00

  • Effects of aging and hypertension on the participation of endothelium-derived constricting factor (EDCF) in norepinephrine-induced contraction of rat femoral artery.

    abstract::Endothelium-dependent contraction elicited by high concentrations of acetylcholine was described in hypertensive as well as in aged normotensive rats. The contribution of endothelium-derived constricting factor (EDCF) to norepinephrine-induced contraction is still unknown. We aimed to compare EDCF participation to nor...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Líšková S,Petrová M,Karen P,Kuneš J,Zicha J

    更新日期:2011-09-30 00:00:00

  • Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes.

    abstract::Bimoclomol is a new compound that improves cell survival under experimental stress conditions partly by increasing intracellular heat shock proteins (HSPs). HSPs, especially HSP70, play a cytoprotective role in the rat heart. Rat neonatal cardiomyocytes were used to determine the ability of bimoclomol to induce HSP70 ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Polakowski JS,Wegner CD,Cox BF

    更新日期:2002-01-18 00:00:00

  • A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic systems.

    abstract::Dopamine injected directly into the caudate--putamen, nucleus accumbens or tuberculum olfactorium of rat brain, following a nialamide pretreatment, caused dose-dependent hyperactivity. The hyperactivity was more intense after injections into the nucleus accumbens, but was limited by the development of stereotyped biti...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Costall B,Naylor RJ

    更新日期:1976-11-01 00:00:00

  • Nitric oxide inhalation attenuates pulmonary hypertension and improves gas exchange in endotoxin shock.

    abstract::Nitric oxide (10 ppm) inhaled by pigs before or during endotoxin shock induced by an infusion of E. coli lipopolysaccharide. Nitric oxide inhalation selectively attenuated pulmonary hypertension during endotoxin infusion without influencing mean arterial blood pressure and cardiac output. Upon cessation of nitric oxid...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Weitzberg E,Rudehill A,Lundberg JM

    更新日期:1993-03-16 00:00:00

  • Indomethacin reverses interleukin-1-induced hyperinsulinemia in conscious and freely moving rats.

    abstract::With the aim of studying the mechanism by which peripherally injected interleukin-1 increases the serum levels of insulin in conscious rats, the effects of indomethacin, a cyclooxygenase inhibitor, on interleukin-1-induced hyperinsulinemia were examined using male Wistar rats implanted with intra-atrial cannulas. The ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Uehara A,Okumura T,Kumei Y,Takasugi Y,Namiki M

    更新日期:1991-01-03 00:00:00

  • Alpha 2-adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat.

    abstract::In chloralose-anaesthesized cats, clonidine, an alpha 2-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole alpha 2-adrenoceptor agonist, and was reversed by SK & F 864...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Downie JW,Espey MJ,Gajewski JB

    更新日期:1991-03-26 00:00:00

  • Functional characterization of α7 nicotinic acetylcholine and NMDA receptor signaling in SH-SY5Y neuroblastoma cells in an ERK phosphorylation assay.

    abstract::In the present study, the functional properties of α7 nicotinic acetylcholine receptors (α7 nAChRs) and N-methyl-D-aspartate receptors (NMDARs) endogenously expressed in SH-SY5Y human neuroblastoma cells were characterized in an extracellular-signal regulated kinase (ERK) phosphorylation assay. Both choline and N-meth...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Elnagar MR,Walls AB,Helal GK,Hamada FM,Thomsen MS,Jensen AA

    更新日期:2018-05-05 00:00:00

  • Suppression of isoproterenol-induced cardiotoxicity in rats by raspberry ketone via activation of peroxisome proliferator activated receptor-α.

    abstract::The peroxisome proliferator-activated receptor-α (PPAR-α) controls the lipid and glucose metabolism and also affects inflammation, cell proliferation and apoptosis during cardiovascular disease. Raspberry ketone (RK) is a red raspberry (Rubusidaeus, Family-Rosaceae) plant constituent, which activates PPAR-α. This stud...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Khan V,Sharma S,Bhandari U,Sharma N,Rishi V,Haque SE

    更新日期:2019-01-05 00:00:00

  • Chromodacryorrhea and repetitive hind paw tapping: models of peripheral and central tachykinin NK1 receptor activation in gerbils.

    abstract::The in vivo pharmacological profiles of the selective tachykinin NK1 receptor agonists, [Sar9,Met(O2)11]substance P and GR 73632, were examined in gerbils. Both agonists induced a pronounced chromodacryorrhea following intravenous injection which was stereoselectively antagonised by the tachykinin NK1 receptor antagon...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Bristow LJ,Young L

    更新日期:1994-03-03 00:00:00

  • Amnesia induced by beta-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade.

    abstract::Administration of drugs activating cannabinoid CB(1) receptors in the brain induces memory deficit in rodents, and blockade of these receptors may restore memory capacity in these animals. Central administration of beta-amyloid or beta-amyloid fragments may also lead to memory disturbances. This study was undertaken t...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Mazzola C,Micale V,Drago F

    更新日期:2003-09-23 00:00:00

  • Glucocorticoids for the treatment of post-traumatic stress disorder and phobias: a novel therapeutic approach.

    abstract::Post-traumatic stress disorder (PTSD) and phobias belong to the most common anxiety disorders and to the most common psychiatric illnesses in general. In both disorders, aversive memories are thought to play an important role in the pathogenesis and symptomatology. Previously, we have reported that elevated glucocorti...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章,评审


    authors: de Quervain DJ,Margraf J

    更新日期:2008-04-07 00:00:00

  • Characterisation of [3H]gabapentin binding to a novel site in rat brain: homogenate binding studies.

    abstract::The binding characteristics of [3H]gabapentin, the radiolabelled analogue of the novel anticonvulsant gabapentin (1-(aminomethyl)cyclohexaneacetic acid) were studied using purified synaptic plasma membranes prepared from rat cerebral cortex. In 10 mM HEPES buffer [3H]gabapentin bound to a single population of sites wi...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Suman-Chauhan N,Webdale L,Hill DR,Woodruff GN

    更新日期:1993-02-15 00:00:00

  • (+/-)-tamsulosin, an alpha 1A-adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart.

    abstract::The influence of (+/-)-tamsulosin, a selective alpha 1A-adrenoceptor antagonist, on the positive inotropic effect and the accumulation of inositol phosphates that are induced via alpha 1-adrenoceptors was studied in comparison with that of another alpha 1A-adrenoceptor ligand oxymetazoline in the rabbit ventricular my...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Yang HT,Endoh M

    更新日期:1996-10-03 00:00:00

  • Activation of P2Y receptors by ATP and by its analogue, ADPbetaS, triggers two calcium signal pathways in the longitudinal muscle of mouse distal colon.

    abstract::Our previous research showed that ATP and adenosine 5'-O-2-thiodiphosphate (ADPbetaS) induce contractile effects in the longitudinal muscle of mouse distal colon via activation of P2Y receptors which are not P2Y(1) or P2Y(12) subtypes. This study investigated the nature of the P2Y receptor subtype(s) and the mechanism...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Zizzo MG,Mulè F,Serio R

    更新日期:2008-10-24 00:00:00

  • Inhibitory effects of hesperetin on Kv1.5 potassium channels stably expressed in HEK 293 cells and ultra-rapid delayed rectifier K(+) current in human atrial myocytes.

    abstract::In the present study, the inhibitory effects of hesperetin (HSP) on human cardiac Kv1.5 channels expressed in HEK 293 cells and the ultra-rapid delayed rectifier K(+) current (Ikur) in human atrial myocytes were examined by using the whole-cell configuration of the patch-clamp techniques. We found that hesperetin rapi...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Wang H,Wang HF,Wang C,Chen YF,Ma R,Xiang JZ,Du XL,Tang Q

    更新日期:2016-10-15 00:00:00

  • Carvedilol treatment ameliorates acute coxsackievirus B3-induced myocarditis associated with oxidative stress reduction.

    abstract::Oxidative stress has been implicated in the pathogenesis of acute myocarditis. The imbalance between the occurrence of reactive oxygen species and the cellular antioxidant defense mechanism plays a key role in myocardial injury of viral myocarditis. Carvedilol, a nonselective beta-adrenoceptor antagonist with addition...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Li YC,Ge LS,Yang PL,Tang JF,Lin JF,Chen P,Guan XQ

    更新日期:2010-08-25 00:00:00

  • Atorvastatin protects myocardium against ischemia-reperfusion arrhythmia by increasing Connexin 43 expression: A rat model.

    abstract::Atorvastatin has protective effects against myocardial ischemia-reperfusion injuries and ischemia-reperfusion arrhythmia. This study was designed to investigate whether atorvastatin is able to protect against myocardial ischemia-reperfusion injury by enhancing the expression of Connexin 43 (Cx43) via the activation of...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Bian B,Yu X,Wang Q,Teng T,Nie J

    更新日期:2015-12-05 00:00:00

  • Diabetes-induced DNA damage and apoptosis are associated with poly (ADP ribose) polymerase 1 inhibition in the rat testis.

    abstract::Molecular mechanisms responsible for diabetes-induced testicular dysfunction are not well understood. This study investigated oxidative stress, stage-dependent DNA base modification and expression of poly (ADP ribose) polymerase 1 (PARP1) in the testes of streptozotocin-induced diabetic rats. Hyperglycemia led to test...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Kilarkaje N,Al-Hussaini H,Al-Bader MM

    更新日期:2014-08-15 00:00:00

  • Suppressive efficacy of roxithromycin against human peripheral-blood mononuclear cells stimulated with hemolytic streptococci superantigen.

    abstract::Bacterial colonization might influence the clinical response of psoriasis patients to the therapeutic efficacy of immunosuppressive drugs. Macroride antibiotics are used for the treatment of psoriasis patients; however, few studies have investigated the immunoregulatory efficacy of macrorides in bacterial superantigen...

    journal_title:European journal of pharmacology

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    authors: Kamogawa S,Kagami K,Maeda M,Arai K,Okubo Y,Tsuboi R,Hirano T

    更新日期:2009-01-14 00:00:00

  • DNA vaccination efficiently induces antibodies to Nogo-A and does not exacerbate experimental autoimmune encephalomyelitis.

    abstract::Antibodies against the neurite outgrowth inhibitor Nogo-A enhance axonal regeneration following spinal cord injury. However, antibodies directed against myelin components can also enhance CNS inflammation. The present study was designed to assess the efficacy of DNA vaccination for generating antibodies against Nogo-A...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Bourquin C,van der Haar ME,Anz D,Sandholzer N,Neumaier I,Endres S,Skerra A,Schwab ME,Linington C

    更新日期:2008-06-24 00:00:00

  • Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein.

    abstract::A specific binding site for the antiepileptic drug levetiracetam (2S-(oxo-1-pyrrolidinyl)butanamide, Keppra) in rat brain, referred to as the levetiracetam binding site, was discovered several years ago. More recently, this binding site has been identified as the synaptic vesicle protein 2A (SV2A), a protein present i...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Gillard M,Chatelain P,Fuks B

    更新日期:2006-04-24 00:00:00

  • Carvedilol abrogates hypoxia-induced oxidative stress and neuroinflammation in microglial BV2 cells.

    abstract::Microglia initially undergo rapid activation in response to injury and stressful stimuli, such as hypoxia. Oxidative stress and the inflammatory response play critical roles in hypoxic-ischemic brain injury. Carvedilol is a β-blocker used to treat high blood pressure and heart failure. In this study, we investigated w...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Gao X,Wu B,Fu Z,Zhang Z,Xu G

    更新日期:2017-11-05 00:00:00

  • Notoginsenoside R1, a unique constituent of Panax notoginseng, blinds proinflammatory monocytes to protect against cardiac hypertrophy in ApoE-/- mice.

    abstract::Notoginsenoside R1, a unique constituent from the root of Panax notoginseng, exerts anti-inflammatory, anti-oxidative and anti-apoptotic properties. The purpose of this study was to assess the contribution of the anti-inflammatory effects of R1 to the amelioration of isoproterenol (ISO)-induced hypertrophied hearts of...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Xiao J,Zhu T,Yin YZ,Sun B

    更新日期:2018-08-15 00:00:00

  • Inotropic effects and Na+,K+-ATPase inhibition of ouabain in isolated guinea-pig atria and diaphragm.

    abstract::Effects of ouabain on force of contraction were compared in electrically driven isolated tissue preparations of guinea-pig left atria and diaphragm. A distinct and steady positive inotropic effect of ouabain was observed in atrial preparations, whereas in diaphragm preparations, ouabain produced only a slight and tran...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Yamamoto S,Fox AA,Greeff K

    更新日期:1981-05-22 00:00:00

  • Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction.

    abstract::The human ether-a-go-go-related gene (hERG) cardiac K(+) channels are one of the representative pharmacological targets for development of drugs against cardiovascular diseases such as arrhythmia. Panax ginseng has been known to have cardio-protective effects. However, little is known about the molecular mechanisms of...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Choi SH,Shin TJ,Hwang SH,Lee BH,Kang J,Kim HJ,Jo SH,Choe H,Nah SY

    更新日期:2011-08-01 00:00:00

  • Tacrine and physostigmine block nicotinic receptors in Xenopus oocytes injected with Torpedo electroplaque membranes.

    abstract::Tacrine and physostigmine were tested for direct nicotinic actions on Xenopus oocytes microinjected with Torpedo electroplaque membranes. In this preparation, responses to acetylcholine arise 6-8 h after microinjection, due to the incorporation of nicotinic receptors into the plasma membrane by a process not involving...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Cantí C,Bodas E,Marsal J,Solsona C

    更新日期:1998-12-18 00:00:00

  • Modification of hepatic cytochrome P450 profile by cocaine-induced hepatotoxicity in DBA/2 mouse.

    abstract::Previous studies in our laboratory have shown that a hepatotoxic dose of cocaine increases coumarin 7-hydroxylase activity in male DBA/2 mouse liver. In the present study, the dose- and time-dependent responses of the hepatic CYP2A4/5 complex to cocaine-induced liver damage were studied. Cocaine increased CYP2A4/5 lev...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Pellinen P,Stenbäck F,Raunio H,Pelkonen O,Pasanen M

    更新日期:1994-11-01 00:00:00

  • Effects of methylnaltrexone on morphine-induced inhibition of contraction in isolated guinea-pig ileum and human intestine.

    abstract::We investigated the effects of methylnaltrexone on morphine-induced inhibition of smooth muscle-strip contraction in isolated guinea-pig ileum and human small intestine. The longitudinal muscle-strip was immersed in a temperature-controlled (37 degrees C) bath containing a physiological solution of 95% O2 and 5% CO2 w...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Yuan CS,Foss JF,Moss J

    更新日期:1995-03-24 00:00:00