Thermoregulatory effects of intraventricularly injected dopamine in the goat.


:Dopamine (DA) was injected in the third brain ventricle of goats and the thermoregulatory effects were studied under different ambient conditions. The effects depended on dose, ambient conditions and cannula used. In the cold, there was a drop in body temperature, sometimes accompanied by suppression of shivering and by vasodilatation. Both temperature decrease and suppression of shivering were dose-dependent but there was no relation between magnitude of temperature drop and occurrence of shivering suppression. In a thermoneutral environment, there was either a slight vasoconstriction or hypothermia, occasionally accompanied by induction of panting. In the heat, either hypothermia or hyperthermia was observed. Hypothermia was accompanied by an increase in panting. Hyperthermia only occurred when the animals became excited as a result of the injection of DA. It is concluded that DA acts by stimulating the thermoregulatory pathway from heat sensors to heat loss effectors at a locus similar to that for 5-hydroxytryptamine in the thermoregulation model of Bligh et al. (1971).


Eur J Pharmacol


De Roij TA,Frens J,Bakker J,Németh F




Has Abstract


1977-05-01 00:00:00














  • Effects of cenobamate (YKP3089), a newly developed anti-epileptic drug, on voltage-gated sodium channels in rat hippocampal CA3 neurons.

    abstract::New, more effective pharmacologic treatments for epilepsy are needed, as a substantial portion of patients (>30%) are refractory to currently available anti-epileptic drugs. Cenobamate (YKP3089) is an investigational anti-epileptic drug in clinical development. Two completed adequate and well-controlled studies demons...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Nakamura M,Cho JH,Shin H,Jang IS

    更新日期:2019-07-15 00:00:00

  • Ginkgolide B, a constituent of Ginkgo biloba, facilitates glutamate exocytosis from rat hippocampal nerve terminals.

    abstract::Although previous studies have demonstrated that Ginkgo biloba extract has modest effects in the improvement of memory and cognitive function of the Alzheimer's disease patients, the mechanism(s) underlying its beneficial effects remain(s) unclear. In this study, the effect of ginkgolide B, one of the major constituen...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Wang SJ,Chen HH

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  • Further studies on ocular responses to DP receptor stimulation.

    abstract::Prostaglandin D2 (PGD2) and the selective DP receptor agonist BW 245C have been previously shown to lower intraocular pressure in rabbits, while PGD2, but not BW 245C, caused plasma extravasation, eosinophil infiltration, and goblet cell depletion. In these present studies definition of the ocular pharmacology of pros...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Woodward DF,Spada CS,Hawley SB,Williams LS,Protzman CE,Nieves AL

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  • Infliximab reduces CD147, MMP-3, and MMP-9 expression in peripheral blood monocytes in patients with active rheumatoid arthritis.

    abstract::Recent studies have reported elevated expression levels in active rheumatoid arthritis patients of the cluster of differentiation (CD) 147 on CD14(+) peripheral blood monocytes and as a result, CD147 may be a target for the development of a novel rheumatoid arthritis therapy. This report describes the inhibitory effec...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章,随机对照试验


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  • Clopidogrel delays gastric ulcer healing in rats.

    abstract::Clopidogrel is not safe enough for the gastric mucosa in patients with high risk of peptic ulcer. This study aimed to explore if clopidogrel delays gastric ulcer healing and elucidate the involved mechanisms. Gastric ulcer was induced in rats and the ulcer size, mucosal epithelial cell proliferation of the ulcer margi...

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  • Obeticholic acid protects against diabetic cardiomyopathy by activation of FXR/Nrf2 signaling in db/db mice.

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    journal_title:European journal of pharmacology

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    authors: Wu H,Liu G,He Y,Da J,Xie B

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  • Pharmacological characterization of the ghrelin receptor antagonist, GSK1614343 in rat RC-4B/C cells natively expressing GHS type 1a receptors.

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    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Perdonà E,Faggioni F,Buson A,Sabbatini FM,Corti C,Corsi M

    更新日期:2011-01-10 00:00:00

  • Autoradiographic comparison of in vitro binding characteristics of various tritiated adenosine A2A receptor ligands in rat, mouse and pig brain and first ex vivo results.

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    authors: Sihver W,Schulze A,Wutz W,Stüsgen S,Olsson RA,Bier D,Holschbach MH

    更新日期:2009-08-15 00:00:00

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    journal_title:European journal of pharmacology

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    authors: Deckers IA,Rampart M,Bult H,Herman AG

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  • Amino acid residue 200 on the alpha1 subunit of GABA(A) receptors affects the interaction with selected benzodiazepine binding site ligands.

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    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Schaerer MT,Buhr A,Baur R,Sigel E

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  • Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain.

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    authors: D'Agostino G,Erbelding D,Kilbinger H

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  • Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model.

    abstract::Inflammatory bowel disease (IBD) is characterized by chronic, recurring inflammation of the digestive tract. Current therapeutic approaches are limited and include biologics and steroids such as anti-TNFα monoclonal antibodies and corticosteroids, respectively. Significant adverse drug effects can occur for chronic us...

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    authors: Sanderlin EJ,Marie M,Velcicky J,Loetscher P,Yang LV

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  • Effect of tolcapone, a catechol-O-methyltransferase inhibitor, on striatal dopaminergic transmission during blockade of dopamine uptake.

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  • Effects of THA on ionic currents in myelinated axons of Xenopus laevis.

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    journal_title:European journal of pharmacology

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    authors: Elinder F,Mohammed AK,Winblad B,Arhem P

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  • Mitomycin C induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-200b and its targeting of RhoE.

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    journal_title:European journal of pharmacology

    pub_type: 杂志文章


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    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Cappendijk SL,Hurd YL,Nylander I,van Ree JM,Terenius L

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    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Nagahara Y,Suzuki E,Sekine Y,Uchiro H,Yoshimi Y,Shinomiya T,Ikekita M

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    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Rulan D,Zhenbang Y,Yipu Z,Yuan G,Galaj E,Xiaorui S,Wenshuya L,Jiaqi L,Yan Z,Chang Y,Xi Y,Li S,Yixiao L,Haishui S

    更新日期:2021-01-24 00:00:00