Zebrafish models of cardiovascular diseases and their applications in herbal medicine research.


:The zebrafish (Danio rerio) has recently become a powerful animal model for cardiovascular research and drug discovery due to its ease of maintenance, genetic manipulability and ability for high-throughput screening. Recent advances in imaging techniques and generation of transgenic zebrafish have greatly facilitated in vivo analysis of cellular events of cardiovascular development and pathogenesis. More importantly, recent studies have demonstrated the functional similarity of drug metabolism systems between zebrafish and humans, highlighting the clinical relevance of employing zebrafish in identifying lead compounds in Chinese herbal medicine with potential beneficial cardiovascular effects. This paper seeks to summarise the scope of zebrafish models employed in cardiovascular studies and the application of these research models in Chinese herbal medicine to date.


Eur J Pharmacol


Seto SW,Kiat H,Lee SM,Bensoussan A,Sun YT,Hoi MP,Chang D




Has Abstract


2015-12-05 00:00:00












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    abstract::The humanized anti-CD52 antibody alemtuzumab is successfully used in the treatment of multiple sclerosis (MS) and is thought to exert most of its therapeutic action by depletion and repopulation of mainly B and T lymphocytes. Although neuroprotective effects of alemtuzumab have been suggested, direct effects of anti-C...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Ellwardt E,Vogelaar CF,Maldet C,Schmaul S,Bittner S,Luchtman D

    更新日期:2020-03-15 00:00:00

  • Vasopressin-induced contraction in the rat basilar artery in vitro.

    abstract::Vasopressin ([Arg(8)]vasopressin)-induced contraction was characterized using receptor agonists and antagonists for vasopressin and channel blockers in the rat basilar artery ring preparations. Vasopressin induced rhythmic contractions superimposed on a contraction in endothelium-intact preparations but not in denuded...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Katori E,Ohta T,Nakazato Y,Ito S

    更新日期:2001-03-23 00:00:00

  • Epigenetic regulation of lipoprotein lipase gene via BRD4, which is potentially associated with adipocyte differentiation and insulin resistance.

    abstract::Lipoprotein lipase (LPL) is the rate-controlling enzyme for the accumulation of triacylglycerol into adipocytes, which acts by digesting it into glycerol and fatty acids. In this study, we found that treatment with (+)-JQ1, an inhibitor of the bromodomain and extra-terminal (BET) family proteins, for 4 days from the e...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Inoue T,Hariya N,Imamochi Y,Dey A,Ozato K,Goda T,Kubota T,Mochizuki K

    更新日期:2019-09-05 00:00:00

  • Anxiolytic homophthalazines increase Fos-like immunoreactivity in selected brain areas of the rat.

    abstract::Nerisopam, an anxiolytic and antipsychotic homophthalazine induces rapid, intense expression of Fos-like immunoreactivity in the rostral, dorsomedial and lateral parts of the striatum in the rat. Fos-positive cells also occurred in the globus pallidus, the olfactory tubercle and in the accumbens nucleus (in the cone a...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Palkovits M,Baffi JS,Berzsenyi P,Horváth EJ

    更新日期:1997-07-16 00:00:00

  • Altered binding properties of beta-adrenergic receptors and lack of coupling to adenylate cyclase in P815 mastocytoma cells.

    abstract::P815, a murine mastocytoma cell line, possesses beta-adrenergic binding sites as assessed by using [3H]dihydroalprenolol (antagonist) and [3H]hydroxybenzylisoproterenol (agonist). The number of binding sites per cell was 29 000 for the agonist and 75 000 for the antagonist, as determined by direct binding assays and i...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Durieu-Trautmann O,Delavier-Klutchko C,Hoebeke J,Strosberg AD

    更新日期:1985-01-22 00:00:00

  • Role of nonselective cation channels as Ca2+ entry pathway in endothelin-1-induced contraction and their suppression by nitric oxide.

    abstract::The present study was carried out to clarify the role of nonselective cation channels as a Ca2+ entry pathway in the contraction and the increase in [Ca2+]i induced by endothelin- in endothelium-denuded rat thoracic aorta rings, and their suppression by nitric oxide (NO). In Ca2+-free medium, the endothelin-1-induced ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Zhang XF,Komuro T,Miwa S,Minowa T,Iwamuro Y,Okamoto Y,Ninomiya H,Sawamura T,Masaki T

    更新日期:1998-07-10 00:00:00

  • Long-term antidepressant treatments alter 5-HT2A and 5-HT2C receptor-mediated hyperthermia in Fawn-Hooded rats.

    abstract::We have recently demonstrated that hyperthermia induced by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and m-chlorophenylpiperazine (m-CPP) are separately mediated by selective stimulation of 5-HT2A and 5-HT2C receptors, respectively in Wistar rats. Furthermore, hyperthermia induced by either DOI or m-CPP was ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Aulakh CS,Mazzola-Pomietto P,Murphy DL

    更新日期:1995-08-25 00:00:00

  • Behavioral evidence for the involvement of gamma-aminobutyric acid in the actions of ethanol.

    abstract::Behavioral interactions between ethanol and GABA-mimetic and GABA antagonist drugs were evaluated by duration of narcosis and motor incoordination (inhibition of bar holding) in mice. Aminooxyacetic acid (AOAA), baclofen, and tetrahydroisoxazolopyridineol (THIP) (GABA mimetics) lengthened ethanol narcosis, while picro...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Martz A,Deitrich RA,Harris RA

    更新日期:1983-04-22 00:00:00

  • Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug.

    abstract::The new antisecretory drug, telenzepine (4,9-dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno-[3,4 - b][1,5]benzodiazepin-10-one), was investigated for its inhibition of functionally intact muscarinic receptors involved in gastric acid secretion in rabbit fundic glands, perfused mouse stomach in vitro, p...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Eltze M,Gönne S,Riedel R,Schlotke B,Schudt C,Simon WA

    更新日期:1985-06-07 00:00:00

  • Neurotoxicity of the meperidine analogue N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on brain catecholamine neurons in the mouse.

    abstract::The effect of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) on central monoamine neurons in mice was investigated using histo- and biochemical techniques. NMPTP (2 X 10 mg/kg i.v.) produced a rapid and long-lasting reduction (-30%) of striatal dopamine, while the dopamine levels were only transiently reduced in...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Hallman H,Olson L,Jonsson G

    更新日期:1984-01-13 00:00:00

  • Ouabain-induced contraction of vascular smooth muscle in spontaneously hypertensive rats and the effect of hydralazine.

    abstract::The effect of ouabain (10(-3) M) on contractile responses of SHR (spontaneously hypertensive rat) and WKY (Wistar-Kyoto rat) aortas and mesenteric arteries was studied. Ouabain addition caused a rapid contraction of aortic strips with a steeper rate of rise and a larger maximal force development in strips from SHR tha...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Morita S,Iwasaki T,Nagai K,Miyata S,Kawai Y

    更新日期:1988-07-14 00:00:00

  • Endogenous acetylcholine modulates impulsive action via alpha4beta2 nicotinic acetylcholine receptors in rats.

    abstract::Nicotine has been well established as an impulsive action-inducing agent, but it remains unknown whether endogenous acetylcholine affects impulsive action via nicotinic acetylcholine receptors. In the present study, the 3-choice serial reaction time task (3-CSRTT), a simple and valid assessment of impulsive action, wa...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Tsutsui-Kimura I,Ohmura Y,Izumi T,Yamaguchi T,Yoshida T,Yoshioka M

    更新日期:2010-09-01 00:00:00

  • Effects of phentolamine, phenoxybenzamine and desipramine on clonidine-induced blockade of cardiac acceleration in the dog.

    abstract::Clonidine reduced cardiac acceleration induced by low frequency electrical stimulation of cardiac sympathetic nerve fibers in anesthetized and vagotomized dogs. This effect of clonidine was abolished by short periods of high frequency electrical stimulation. The inhibitory effect of clonidine was observed with 10- as ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Scriabine A,Stavorski JM

    更新日期:1977-03-07 00:00:00

  • NMDA receptor antagonists increase the release of dopamine in the substantia nigra of reserpine-treated rats.

    abstract::Microdialysis of the substantia nigra pars reticulata in freely moving rats disclosed a steady release of dopamine and its metabolites which was greatly reduced after reserpine (4 mg/kg s.c.) and alpha-methyl-p-tyrosine (200 mg/kg i.p.) pretreatments. Local infusion of high K+ (100 mM) or L-3,4-dihydroxyphenylalanine ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Biggs CS,Fowler LJ,Whitton PS,Starr MS

    更新日期:1996-03-28 00:00:00

  • Resveratrol provides late-phase cardioprotection by means of a nitric oxide- and adenosine-mediated mechanism.

    abstract::We used two experimental models to prove that resveratrol (trans-3,4',5-trihydroxystilbene) reduces cardiac ischemic-reperfusion injury by means of a nitric oxide- and adenosine-dependent mechanism. (1). ACUTE EX VIVO: resveratrol (10 microM, 10 min) infusion in Langendorff-perfused normoxic rat hearts significantly i...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Bradamante S,Barenghi L,Piccinini F,Bertelli AA,De Jonge R,Beemster P,De Jong JW

    更新日期:2003-03-28 00:00:00

  • Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats.

    abstract::Rutin exhibits antidiabetic, antioxidant and anti-inflammatory properties, which makes rutin an attractive candidate for diabetic complications. The present study was designed to investigate the potential effect of rutin on diabetic neuropathy. After induction of diabetic neuropathy, rutin (5mg/kg, 25mg/kg and 50mg/kg...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Tian R,Yang W,Xue Q,Gao L,Huo J,Ren D,Chen X

    更新日期:2016-01-15 00:00:00

  • Valproic acid promotes the epithelial-to-mesenchymal transition of breast cancer cells through stabilization of Snail and transcriptional upregulation of Zeb1.

    abstract::Histone deacetylases (HDACs) can regulate cancer progression and its inhibitors (HDACIs) have been widely used for cancer therapy. Valproic acid (VPA, 2-propylpentanoic acid) can inhibit the class I HDAC and suppress the malignancy of solid cancers. Our present study revealed that 1 mM VPA, which has no effect on cell...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Zhang S,Tang Z,Qing B,Tang R,Duan Q,Ding S,Deng D

    更新日期:2019-12-15 00:00:00

  • Chelation of dietary iron prevents iron accumulation and macrophage infiltration in the type I diabetic kidney.

    abstract::We previously reported that the functional deletion of p21, a cyclin-dependent kinase inhibitor, in mice attenuated renal cell senescence in streptozotocin (STZ)-induced type 1 diabetic mice. In the present study, we investigated the effect of iron chelation on renal cell senescence and inflammation in the type 1 diab...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Morita T,Nakano D,Kitada K,Morimoto S,Ichihara A,Hitomi H,Kobori H,Shiojima I,Nishiyama A

    更新日期:2015-06-05 00:00:00

  • Different targets for i.v. vs. i.c.v. administered morphine for its effect on colonic motility in dogs.

    abstract::The effects of intracerebroventricular (i.c.v.) or intravenous (i.v.) administration of morphine on colonic motility were investigated in conscious dogs chronically fitted with a strain gauge transducer sutured to the serosa of the proximal colon. Morphine administered i.v. (100 micrograms/kg) or i.c.v. (10 micrograms...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Fioramonti J,Fargeas MJ,Bueno L

    更新日期:1985-10-29 00:00:00

  • Telenzepine enantiomers block muscarinic M1-receptors with opposite kinetics.

    abstract::Stimulation of muscarinic M1-receptors in isolated rabbit vas deferens by McN-A-343 inhibited electrically induced twitch contractions susceptible to competitive blockade by (+)-, (+/-), (-)-telenzepine and pirenzepine (pA2 = 9.12, 8.86, 6.98 and 7.79, respectively). The inhibition of twitch contractions by 10(-6) M M...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Eltze M

    更新日期:1990-05-03 00:00:00

  • Rotigotine protects against glutamate toxicity in primary dopaminergic cell culture.

    abstract::In Parkinson disease the degeneration of dopaminergic neurones is believed to lead to a disinhibition of the subthalamic nucleus thus increasing the firing rate of the glutamatergic excitatory projections to the substantia nigra. In consequence, excessive glutamatergic activity will cause excitotoxicity and oxidative ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Oster S,Radad K,Scheller D,Hesse M,Balanzew W,Reichmann H,Gille G

    更新日期:2014-02-05 00:00:00

  • Effects of selective adenosine A1 and A2 receptor agonists and antagonists on local rates of energy metabolism in the rat brain.

    abstract::The quantitative [14C]2-deoxyglucose autoradiographic technique was applied to the measurement of the cerebral metabolic effects of adenosine A1 and A2 receptor agonists and antagonists in adult rats. The adenosine A1 receptor agonist and antagonist, 2-chloro-N6-cyclopentyladenosine (CCPA) and 8-cyclopentyl-1,3-diprop...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Nehlig A,Daval JL,Boyet S

    更新日期:1994-06-02 00:00:00

  • Propyl gallate sensitizes human lung cancer cells to cisplatin-induced apoptosis by targeting heme oxygenase-1 for TRC8-mediated degradation.

    abstract::Heme oxygenase-1 (HO-1) significantly contributes to survival of cancer cells and is being considered as one of therapeutic targets for cancer treatment. Propyl gallate (PG) is a synthetic phenolic compound that possess a potent anti-oxidant and anti-inflammatory activities. In the present study, we investigated wheth...

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    authors: Jo EJ,Park SJ,Kim BC

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  • Allosteric interactions of three muscarine antagonists at bovine tracheal smooth muscle and cardiac M2 receptors.

    abstract::The kinetics of [3H]dexetimide dissociation from muscarine receptors in bovine cardiac left ventricular and tracheal smooth muscle membranes were studied in the absence and presence of three muscarine antagonists. It was found that [3H]dexetimide dissociation from cardiac muscarine receptors was monophasic and very fa...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Roffel AF,Elzinga CR,Meurs H,Zaagsma J

    更新日期:1989-03-07 00:00:00

  • Using behaviour to predict stroke severity in conscious rats: post-stroke treatment with 3', 4'-dihydroxyflavonol improves recovery.

    abstract::Prognostic models are used to predict outcome in stroke patients and to stratify treatment groups in clinical trials. No one has previously attempted to use such models in stroke recovery studies in animals. We have now shown the predictive value of assigning stroke severity ratings, based on behaviours displayed in c...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Roulston CL,Callaway JK,Jarrott B,Woodman OL,Dusting GJ

    更新日期:2008-04-14 00:00:00

  • Suppression of TRIF-dependent signaling pathway of toll-like receptors by (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine.

    abstract::Toll-like receptors (TLRs) play an important role in the recognition of microbial pathogens and induce innate immune responses. The recognition of microbial components by TLRs triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interfero...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Gu GJ,Eom SH,Suh CW,Koh KO,Kim DY,Youn HS

    更新日期:2013-12-05 00:00:00

  • Subthreshold pharmacological and genetic approaches to analyzing CaV2.1-mediated NMDA receptor signaling in short-term memory.

    abstract::Ca(V)2.1 is highly expressed in the nervous system and plays an essential role in the presynaptic modulation of neurotransmitter release machinery. Recently, the antiepileptic drug levetiracetam was reported to inhibit presynaptic Ca(V)2.1 functions, reducing glutamate release in the hippocampus, although the precise ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Takahashi E,Niimi K,Itakura C

    更新日期:2010-10-25 00:00:00

  • Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.

    abstract::One of the best known bioactive triterpenoids is oleanolic acid, a widespread 3-hydroxy-17-carboxy oleanane-type compound. In order to determine whether further oxidation of carbon 3 affects anti-inflammatory activity in mice, different tests were carried out on oleanolic acid and its 3-oxo-analogue oleanonic acid, wh...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Giner-Larza EM,Máñez S,Recio MC,Giner RM,Prieto JM,Cerdá-Nicolás M,Ríos JL

    更新日期:2001-09-28 00:00:00

  • The nicotinic acetylcholine receptor of the bovine chromaffin cell, a new target for dihydropyridines.

    abstract::The effects of 1,4-dihydropyridine derivatives on divalent cation transients and catecholamine release stimulated by either high K+ or the nicotinic receptor agonist dimethyl-phenyl-piperazinium (DMPP) have been compared in bovine adrenal chromaffin cells. The activation of Ca2+ entry pathways was followed by measurin...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: López MG,Fonteríz RI,Gandía L,de la Fuente M,Villarroya M,García-Sancho J,García AG

    更新日期:1993-10-15 00:00:00

  • Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic.

    abstract::The antinociceptive profile of selected histamine H(2) and histamine H(3) receptor antagonists led to the discovery of improgan, a non-brain-penetrating analgesic agent which does not act on known histamine receptors. Because no chemical congener of improgan has yet been discovered which has both antinociceptive and b...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Hough LB,Nalwalk JW,Lu Q,Shan Z,Svokos K,Wentland MP,Montero MJ

    更新日期:2005-10-17 00:00:00