Abstract:
:A microcomputer-based system has been used to apply the technique of excitability testing to the study of the actions of a range of pharmacological agents on the excitability of single primary afferent terminals in the mouse spinal cord in vitro. GABAA analogues all evoked increases in excitability that were bicuculline sensitive. GABA itself also evoked biphasic changes in excitability, or occasionally only suppressed terminal excitability. This latter effect was often enhanced in the presence of bicuculline, and resembled the action of the GABAB agonist, baclofen. The GABAA action could be enhanced by concurrent application of either benzodiazepine, midazolam or flurazepam. Bicuculline alone frequently decreased excitability. This action could be abolished by blocking synaptic activity with a low Ca2+ high Mg2+ superfusate, and was therefore considered to be due to reduction of the tonic action of GABA released at synaptic connections. Comparison of the action of these agents on terminals in the spastic mutant mouse showed an increased sensitivity of the GABA response to the benzodiazepines in mutant animals.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Yu YB,Duchen MR,Biscoe TJdoi
10.1016/0014-2999(87)90554-1subject
Has Abstractpub_date
1987-09-23 00:00:00pages
371-82issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(87)90554-1journal_volume
141pub_type
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