Indirubin-3'-oxime suppresses human cholangiocarcinoma through cell-cycle arrest and apoptosis.

abstract：:High glucose is one of the possible causes for osteoporosis and fracture in diabetes mellitus. Our previous study showed that silibinin can increase osteogenic effect by stimulating osteogenic genes expression in human bone marrow stem cells (hBMSCs). However, no study has yet investigated the effect of silibinin on o...

journal_title：European journal of pharmacology

authors： Ying X,Chen X,Liu H,Nie P,Shui X,Shen Y,Yu K,Cheng S

更新日期：2015-10-15 00:00:00

abstract：:This study assessed the effect of an uncontrollable stressor on the preference for a palatable solution (sucrose 1%), and on the preference for a context associated with a single administration of D-amphetamine (3 mg/kg i.p.) by means of the conditioning place preference test. We also evaluated the effect of prior nal...

journal_title：European journal of pharmacology

authors： Zurita A,Murúa S,Molina V

更新日期：1996-03-28 00:00:00

abstract：:Tolterodine is a new muscarinic receptor antagonist intended for the treatment of urinary urge incontinence and other symptoms related to an overactive bladder. The aim of the present study was to compare the antimuscarinic properties of tolterodine with those of oxybutynin, in vitro and in vivo. Tolterodine effective...

journal_title：European journal of pharmacology

authors： Nilvebrant L,Andersson KE,Gillberg PG,Stahl M,Sparf B

更新日期：1997-05-30 00:00:00

abstract：:The aim of this study was to investigate role of the N-Methyl-D-Aspartate (NMDA) receptors in the decrease of morphine analgesia in mice after nociceptive sensitization. We used a hot plate test to assess effects of morphine on pain behavior in male NMRI mice. All drugs were administered through an intraperitoneal rou...

journal_title：European journal of pharmacology

authors： Ahmadi S,Golbaghi H,Azizbeigi R,Esmailzadeh N

更新日期：2014-08-15 00:00:00

abstract：:We synthesized the o-, m- and p-bromo derivatives of dl-threo-methylphenidate from the corresponding bromophenylacetonitriles by modification of the literature synthesis of methylphenidate (Panizzon, Helv. Chim. Acta 1944, 27, 1748). In in vitro binding assays all three dl-threo bromo compounds had higher affinities t...

journal_title：European journal of pharmacology

authors： Pan D,Gatley SJ,Dewey SL,Chen R,Alexoff DA,Ding YS,Fowler JS

更新日期：1994-10-24 00:00:00

abstract：:The therapeutic potential of cannabidiol, the major non-psychotropic Cannabis constituent, was investigated in rats exposed to ischemia/reperfusion liver injury. Ischemia was induced by clamping the pedicle of the left hepatic lobe for 30 min, and cannabidiol (5mg/kg, i.v.) was given 1h following the procedure and eve...

journal_title：European journal of pharmacology

authors： Fouad AA,Jresat I

更新日期：2011-11-16 00:00:00

abstract：:Unlike classical antipsychotic drugs, clozapine activates the hypothalamo-pituitary-adrenal axis and induces a specific regional pattern of Fos-protein expression in the rat forebrain. Whether corticosterone plays a role in the clozapine-induced Fos response is the subject of this study. Some rats were adrenalectomize...

journal_title：European journal of pharmacology

authors： Sebens JB,Middelveld RJ,Koch T,Ter Horst GJ,Korf J

更新日期：2001-04-06 00:00:00

abstract：:Co-dergocrine (Hydergine), an ergot preparation composed of four dihydrogenated peptide ergot alkaloids (dihydroergocornine, dihydroergocristine, dihydro-alpha-ergokryptine, dihydro-beta-ergokryptine, 3:3:2:1), has been reported to exert in vivo effects suggesting an interaction with dopaminergic systems. The present ...

journal_title：European journal of pharmacology

authors： Markstein R

更新日期：1982-12-24 00:00:00

abstract：:Diabetes mellitus is associated with an increased risk of cardiovascular disease. Endothelial dysfunction (i.e. decreased endothelium-dependent vasorelaxation) plays a key role in the pathogenesis of diabetic vascular disease. The present study was undertaken to determine whether diabetes induced by streptozotocin alt...

journal_title：European journal of pharmacology

authors： Fatehi-Hassanabad Z,Imen-Shahidi M,Fatehi M,Farrokhfall K,Parsaeei H

更新日期：2006-03-27 00:00:00

abstract：:The effects of MCI-154, a cardiotonic agent which has direct effects on cardiac myofilaments, on postischemic contractile dysfunction were studied in dog heart subjected to a 30-min occlusion of the left anterior descending coronary artery followed by reperfusion, and compared with the effects of milrinone and dobutam...

journal_title：European journal of pharmacology

authors： Abe Y,Kitada Y,Narimatsu A,Tobe A

更新日期：1991-01-10 00:00:00

abstract：:Maternal hyperglycemia can result in defects in glucose metabolism and pancreatic β-cell function in offspring. The purpose of this study was to evaluate the impact of maternal diabetes mellitus on pancreatic islets, muscle and adipose tissue of the offspring, with or without oral l-Arginine supplementation. The induc...

journal_title：European journal of pharmacology

authors： Carvalho DS,Diniz MM,Haidar AA,Cavanal MF,da Silva Alves E,Carpinelli AR,Gil FZ,Hirata AE

更新日期：2016-11-15 00:00:00

abstract：:The pruritogenic potency of tryptase and its involvement in anti-pruritic effect of intravenous nafamostat mesilate (NFM) were studied in mice. An intradermal injection of tryptase (0.05-1 ng/site) elicited scratching in ICR mice, while chymase was without effects at doses of 0.05-50 ng/site. The dose-response curve o...

journal_title：European journal of pharmacology

authors： Ui H,Andoh T,Lee JB,Nojima H,Kuraishi Y

更新日期：2006-01-13 00:00:00

abstract：:Adrenomedullin administered peripherally in the rabbit (at doses of 1.25, 2.5 and 5 microg/kg ) caused a dose-dependent conjunctival hyperemia accompanied by an increase of inflammatory cell number and prostaglandin E(2) concentration in the aqueous humor, and of uveal vascular response and myeloperoxidase activity. T...

journal_title：European journal of pharmacology

authors： Clementi G,Floriddia ML,Prato A,Marino A,Drago F

更新日期：2000-07-21 00:00:00

abstract：:Several major antiepileptic drugs, including carbamazepine, phenytoin and phenobarbital, induce xenobiotic metabolizing enzymes via activation of nuclear receptors, including pregnane X receptor (NR1I2) and constitutive androstane receptor (NR1I3). Via activation of these xenobiotic sensors, antiepileptic drugs may al...

journal_title：European journal of pharmacology

authors： Ambroziak K,Kuteykin-Teplyakov K,Luna-Tórtos C,Al-Falah M,Fedrowitz M,Löscher W

更新日期：2010-02-25 00:00:00

abstract：:In isolated, perfused rabbit ear artery bradykinin, like [Met5]enkephalin and angiotensin II, inhibited neurogenic constrictions in concentrations lower than 10(-8) M without affecting the responses to exogenous norepinephrine. The IC50 value of bradykinin was 1.95 x 10(-10) M. The inhibitory action of bradykinin and ...

journal_title：European journal of pharmacology

authors： Rónai AZ

更新日期：1991-05-30 00:00:00

abstract：:Helicobacter pylori (H. pylori) and nonsteroidal anti-inflammatory drugs (NSAID) are the most common pathogens in the gastroduodenal mucosa in animals and humans, but their relationship in ulcerogenesis has been little studied. According to some authors, H. pylori infection in humans does not act synergistically with ...

journal_title：European journal of pharmacology

authors： Pawlik T,Konturek PC,Konturek JW,Konturek SJ,Brzozowski T,Cześnikiewicz M,Plonka M,Bielanski W,Areny H

更新日期：2002-08-02 00:00:00

abstract：:MK-886, an inhibitor of the 5-lipoxygenase-activating protein (FLAP), potently suppresses leukotriene biosynthesis in intact cells and is frequently used to define a role of the 5-lipoxygenase (EC 1.13.11.34) pathway in cellular or animal models of inflammation, allergy, cancer, and cardiovascular disease. Here we sho...

journal_title：European journal of pharmacology

authors： Koeberle A,Siemoneit U,Northoff H,Hofmann B,Schneider G,Werz O

更新日期：2009-04-17 00:00:00

abstract：:We investigated protein kinase C participation in the contractile response to 5-hydroxytryptamine (5-HT), and in the interaction between 5-HT and endothelin-1, in aortas from control and diabetic rats. Diabetic rats display attenuated reactivity to 5-HT (i.e., approximately 47% of control maximum). The protein kinase ...

journal_title：European journal of pharmacology

authors： James GM,Hodgson WC

更新日期：1997-03-12 00:00:00

abstract：:The effects of acute treatment with (S)-2-[[(7-fluoroindan-4-yl)oxy]methyl]morpholine monohydrochloride (YM992), venlafaxine, fluoxetine and citalopram on extracellular norepinephrine levels were examined in the rat frontal cortex by in vivo microdialysis. YM992 (3, 10, 30 mg/kg, i.p.) dose-dependently increased extra...

journal_title：European journal of pharmacology

authors： Hatanaka K,Yatsugi S,Yamaguchi T

更新日期：2000-04-21 00:00:00

abstract：:To investigate whether argatroban ((2R,4R)-4-methyl-1-[N(2)-((RS)-3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid hydrate, a selective thrombin inhibitor, exerts a direct action on phenotype conversion of vascular smooth muscle cells, cultured rabbit aortic vascular smooth muscl...

journal_title：European journal of pharmacology

authors： Yoshinaga M,Sunagawa M,Shimada S,Nakamura M,Murayama S,Kosugi T

更新日期：2003-02-07 00:00:00

abstract：:Physiological experiments suggest that the angiotensin AT1 receptor type predominates in rat vas deferens. Membrane binding experiments, using 125I-[Sarl,Ile8]angiotensin II, confirm the presence of angiotensin AT1 receptors and the absence of angiotensin AT2 receptors in this tissue. Angiotensin II and the angiotensi...

journal_title：European journal of pharmacology

authors： Maletínská L,Slaninová J,Kunes J,Zelezná B

更新日期：1998-06-26 00:00:00

abstract：:The specific binding of [3H]threo-(+/-)-methylphenidate to membranes prepared from rat striatum was significantly reduced following either surgical lesions of the medial forebrain bundle or intracerebroventricular administration of 6-hydroxydopamine. The decrease in the density of [3H]threo-(+/-)-methylphenidate bindi...

journal_title：European journal of pharmacology

authors： Janowsky A,Schweri MM,Berger P,Long R,Skolnick P,Paul SM

更新日期：1985-01-22 00:00:00

abstract：:Schizophrenia is a serious psychiatric disorder that is most frequently treated with the administration of antipsychotics. Although onset of schizophrenia typically occurs in late adolescence, the majority of preclinical research on the behavioral effects of antipsychotics and their mechanism(s) of action has been con...

journal_title：European journal of pharmacology

authors： Wiley JL

更新日期：2008-01-14 00:00:00

abstract：:Tryptase, a serine protease synthesized by and stored in mast cells, is implicated as an important mediator in the pathogenesis of airway inflammation. In this study, tryptase was evaluated for its ability to induce microvascular leakage into the airways of guinea pigs. Dose- and time-dependent increases in airway mic...

journal_title：European journal of pharmacology

authors： Greenfeder S,Sehring S,McHugh N,Corboz M,Rivelli M,Anthes JC,Billah M,Egan RW,Chapman RW

更新日期：2001-05-11 00:00:00

abstract：:Lung fibrosis is a common side effect of the chemotherapeutic agent, bleomycin. Current evidence suggests that reactive oxygen species may play a key role in the development of lung fibrosis. The present study examined the effect of mesna on bleomycin-induced lung fibrosis in rats. Animals were divided into three grou...

journal_title：European journal of pharmacology

authors： El-Medany A,Hagar HH,Moursi M,At Muhammed R,El-Rakhawy FI,El-Medany G

更新日期：2005-02-10 00:00:00

abstract：:The pharmacology of cannabidiol, the non-psychoactive major component of Cannabis sativa, is of growing interest as it becomes more widely prescribed. This study aimed to examine the effects of cannabidiol on a wide range of contractile agents in rat small resistance arteries, in comparison with large arteries, and to...

journal_title：European journal of pharmacology

authors： Mazeh AC,Angus JA,Wright CE

更新日期：2021-01-15 00:00:00

abstract：:The vasoactive properties of the neurokinins (substance P (SP), neurokinin A (NKA), neurokinin B (NKB)) and some selective analogues were assessed in the arterial and venous mesenteric beds of the rat. Although both sides of the mesenteric vasculature displayed endothelium-dependent relaxation in response to acetylcho...

journal_title：European journal of pharmacology

authors： D'Orléans-Juste P,Claing A,Télémaque S,Warner TD,Regoli D

更新日期：1991-11-12 00:00:00

abstract：:Endothelial dysfunction ensuing inhibition of nitric oxide synthase (NOS) was investigated in male Sprague-Dawley rats given N(omega)-nitro-L-arginine methyl ester (L-NAME) in drinking water for 8 weeks. Age-matched rats served as controls. L-NAME-treated rats, as compared to control animals, showed: (1) a clear-cut i...

journal_title：European journal of pharmacology

authors： De Gennaro Colonna V,Rossoni G,Rigamonti A,Bonomo S,Manfredi B,Berti F,Muller E

更新日期：2002-08-16 00:00:00

abstract：:Emodin, 1,3,8-trihydroxy-6-methyl-anthraquinone, is an anthraquinone derivative from the roots of Rheum officinale Baill that has been used to treat many diseases in digestive system for thousands of years. This study is to disclose the mechanism of Emodin to treat cholestatic hepatitis via anti-inflammatory pathway. ...

journal_title：European journal of pharmacology

authors： Ding Y,Zhao L,Mei H,Zhang SL,Huang ZH,Duan YY,Ye P

更新日期：2008-08-20 00:00:00

abstract：:The activity of a selective tachykinin NK1 receptor antagonist, PD 154075 ([(2-benzofuran)-CH2OCO]-(R)-alpha-MeTrp-(S)-NHCH(CH3) Ph), was examined in radioligand binding studies, in a [Sar9,Met(O2)11]substance P-induced foot-tapping model in the gerbil, and in cisplatin-induced acute and delayed emesis in the ferret. ...

journal_title：European journal of pharmacology

authors： Singh L,Field MJ,Hughes J,Kuo BS,Suman-Chauhan N,Tuladhar BR,Wright DS,Naylor RJ

更新日期：1997-02-26 00:00:00