Abstract:
:The aim of this study was to investigate the contribution of the Na(+)/H(+) exchanger to cerebral ischemia using SM-20220 (N-(aminoiminomethyl)-1-methyl-1H-indole-2-carboxamide methanesulfonate), a newly synthesized compound. In in vitro experiments, we evaluated the inhibitory effect of SM-20220 on the Na(+)/H(+) exchanger in cultured neurons and glial cells. The IC(50) of SM-20220 in neurons and glial cells was 5 nM and 20 nM, respectively. To examine the in vivo effects of SM-20220 on brain injury, we used a transient middle cerebral artery occlusion model in rats. SM-20220 given intravenously 1 h after occlusion significantly reduced the extent of cerebral edema, Na(+) content and infarcted area in a dose-dependent manner. The results of the present study suggest that the Na(+)/H(+) exchanger is involved in the aggravation of brain edema and infarction, and its inhibitor may exert protective effects on post-ischemic brain damage.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Kuribayashi Y,Itoh N,Kitano M,Ohashi Ndoi
10.1016/s0014-2999(99)00645-7keywords:
subject
Has Abstractpub_date
1999-10-27 00:00:00pages
163-8issue
2eissn
0014-2999issn
1879-0712pii
S0014-2999(99)00645-7journal_volume
383pub_type
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