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Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test.

Abstract：

:The effects of intra-amygdalar neuropeptide Y infusions were assessed in rats using the social interaction test. Neuropeptide Y administered into the central nucleus of the amygdala did not alter behavior, while injections into the basolateral nucleus of the amygdala produced an increased social interaction time. Furthermore, the anxiolytic-like effect was antagonized by co-administration of the potent neuropeptide Y Y1 receptor antagonist ((R)-N-[[4-(aminocarbonylaminomethyl)-phenyl]methyl]-N2-(diphen ylacetyl)-argininamide trifluoroacetate) 3304, but not with the inactive enantiomer ((R)-N-[[4-(aminocarbonylaminomethyl)-phenyl]methyl]-N2-(diphen ylacetyl)-argininamide trifluoroacetate) 3457. Therefore, neuropeptide Y produces an anxiolytic-like effect in the social interaction test through neuropetide Y Y1 receptors located in the basolateral amygdala.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Sajdyk TJ,Vandergriff MG,Gehlert DR

doi

10.1016/s0014-2999(99)00018-7

keywords:

subject

Has Abstract

pub_date

1999-03-05 00:00:00

pages

143-7

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(99)00018-7

journal_volume

368

pub_type

杂志文章

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