Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A(2) receptor antagonist.

abstract：:Inhibitory effects of the saponin fraction and its principal constituents, escins Ia, Ib, IIa, and IIb, from horse chestnuts on gastric emptying were investigated in mice loaded with a non-nutrient or nutrient meal. The saponin fraction and escins Ia-IIb inhibited gastric emptying of a 1.5% carboxymethyl cellulose sod...

journal_title：European journal of pharmacology

authors： Matsuda H,Li Y,Murakami T,Yamahara J,Yoshikawa M

更新日期：1999-03-05 00:00:00

abstract：:Inflammation has been reported to be closely related to exaggeration of cerebral ischemia and neurodegenerative diseases. Microglia, resident immune cells in the central nervous system, can be activated in response to neuronal injury and produce proinflammatory cytokines, resulting in further aggravation of neuronal i...

journal_title：European journal of pharmacology

authors： Hara H,Kimoto D,Kajita M,Takada C,Kamiya T,Adachi T

更新日期：2017-01-15 00:00:00

abstract：:GABAA receptors are pentameric chloride ion channels that are opened by GABA. We have screened a cell line derived from human glioblastoma, U3047MG, for expression of GABAA receptor subunit isoforms and formation of functional ion channels. We identified GABAA receptors subunit α2, α3, α5, β1, β2, β3, δ, γ3, π, and θ ...

journal_title：European journal of pharmacology

authors： Babateen O,Jin Z,Bhandage A,Korol SV,Westermark B,Forsberg Nilsson K,Uhrbom L,Smits A,Birnir B

更新日期：2015-02-05 00:00:00

abstract：:Morphine produces a state dependent learning. The hippocampus is involved in this kind of learning. Gap junctions (GJs) are involved in some of the effects of morphine and exist in different areas of the hippocampus. We investigated the effects of blocking GJ channels of the hippocampal CA1 area, by means of pre-test ...

journal_title：European journal of pharmacology

authors： Beheshti S,Hosseini SA,Noorbakhshnia M,Eivani M

更新日期：2014-12-15 00:00:00

abstract：:Effects of N-ethylmaleimide or forskolin on electrically evoked dopamine release were investigated in striatal slices of rats pretreated with methamphetamine. N-Ethylmaleimide and forskolin both enhanced the evoked dopamine release in a concentration-dependent manner. The enhancement by N-ethylmaleimide of spontaneous...

journal_title：European journal of pharmacology

authors： Yamada S,Yokoo H,Nishi S

更新日期：1994-05-23 00:00:00

abstract：:A major challenge in translational research is to reduce the currently high proportion of new candidate treatment agents for neuroinflammatory disease, which fail to reproduce promising effects observed in animal models when tested in patients. This disturbing situation has raised criticism against the currently used ...

journal_title：European journal of pharmacology

authors： 't Hart BA

更新日期：2015-07-15 00:00:00

abstract：:The humanized anti-CD52 antibody alemtuzumab is successfully used in the treatment of multiple sclerosis (MS) and is thought to exert most of its therapeutic action by depletion and repopulation of mainly B and T lymphocytes. Although neuroprotective effects of alemtuzumab have been suggested, direct effects of anti-C...

journal_title：European journal of pharmacology

authors： Ellwardt E,Vogelaar CF,Maldet C,Schmaul S,Bittner S,Luchtman D

更新日期：2020-03-15 00:00:00

abstract：:We report that certain substituted hexahydrobenzo[a]phenanthridines are novel high affinity ligands selective for the dopamine D3 receptor. These data demonstrate that substitutions on the heterocyclic nitrogen and the pendant phenyl ring of this nucleus cause a marked increase in both affinity and selectivity for dop...

journal_title：European journal of pharmacology

authors： Watts VJ,Lawler CP,Knoerzer T,Mayleben MA,Neve KA,Nichols DE,Mailman RB

更新日期：1993-08-03 00:00:00

abstract：:The rat vas deferens has been considered to be the tissue of choice to study alpha-adrenergic drugs. However, some of these agonists have elicited complex responses in this organ. Therefore, detailed characterization of alpha-adrenoceptor-mediated responses of the rat vas deferens was the aim of this work. Experiments...

journal_title：European journal of pharmacology

authors： Díaz-Toledo A,Martí MC

更新日期：1988-11-08 00:00:00

abstract：:We have investigated the effects of substituting extracellular Na+ by choline or K+ on responses of quin2- and fura-2-loaded human platelets to thrombin and platelet-activating factor (PAF). Na+ substitution by choline did not affect the extent of the rise in [Ca2+]i evoked by either agonist. The response to thrombin,...

journal_title：European journal of pharmacology

authors： Sage SO,Rink TJ

更新日期：1986-08-22 00:00:00

abstract：:In cardiac muscle cells both T-and L-type Ca(2+) channels (TTCCs and LTCCs, respectively) are expressed, and the latter are relevant to a process known as excitation-contraction coupling (ECC). Evidence obtained from docking studies suggests that isoindolines derived from α-amino acids bind to the LTCC CaV1.2. In the ...

journal_title：European journal of pharmacology

authors： Santamaria-Herrera MA,Ríos-Pérez EB,de la Rosa JA,García-Castañeda M,Osornio-Garduño DS,Ramos-Mondragón R,Mancilla-Percino T,Avila G

更新日期：2016-06-15 00:00:00

abstract：:In order to investigate the possible role of the N-methyl-D-aspartate (NMDA) receptor in the development of the behavioural recovery which occurs following unilateral labyrinthectomy (vestibular compensation) in the guinea pig, we administered systemically the specific NMDA receptor/channel antagonists MK801 and CPP (...

journal_title：European journal of pharmacology

authors： Darlington CL,Smith PF

更新日期：1989-12-19 00:00:00

abstract：:N(G)-(Nitro-L-arginine (L-NOARG), an inhibitor of nitric oxide synthase, induces catalepsy in mice. The objective of the present work was to investigate if serotonergic drugs are able to modulate this effect. Results showed that the cataleptogenic effect of L-NOARG (40 mg/kg) in male albino-Swiss mice was enhanced by ...

journal_title：European journal of pharmacology

authors： Nucci-da-Silva LP,Guimarães FS,Del Bel EA

更新日期：1999-08-20 00:00:00

abstract：:In the isolated perfused guinea-pig heart low-pH buffer (pH 5), lactic acid (5 mM), capsaicin (10(-7) M) and nicotine (10(-4) M) all evoked a clear-cut release of calcitonin gene-related peptide (CGRP) from sensory nerves. Incubation with the proposed capsaicin receptor antagonist, capsazepine (10(-5) M), significantl...

journal_title：European journal of pharmacology

authors： Franco-Cereceda A,Lundberg JM

更新日期：1992-10-06 00:00:00

abstract：:In cultured rat heart muscle cells, reversible long-term ATP depletion induces a decrease in beta-adrenoceptor density and a fall in isoproterenol- as well as forskolin-stimulated cAMP formation. However, isoproterenol-stimulated adenylyl cyclase activity in membrane preparations is not reduced after ATP depletion. Th...

journal_title：European journal of pharmacology

authors： Wagenknecht B,Beuttler C

更新日期：1991-11-13 00:00:00

abstract：:We have investigated, by using the whole-cell patch-clamp technique, the Ca2+ channel antagonist properties of eliprodil in cultured cerebellar granule cells which are known to express L-, N-, P- as well as Q- and R-type Ca2+ channels. Eliprodil maximally antagonized 50% of the voltage-dependent Ba2+ current with an I...

journal_title：European journal of pharmacology

authors： Biton B,Godet D,Granger P,Avenet P

更新日期：1997-04-04 00:00:00

abstract：:Anandamide is an endogenous ligand at both the inhibitory cannabinoid CB(1) receptor and the excitatory vanilloid receptor 1 (VR1). The CB(1) receptor and vanilloid VR1 receptor are expressed in about 50% and 40% of dorsal root ganglion neurons, respectively. While all vanilloid VR1 receptor-expressing cells belong to...

journal_title：European journal of pharmacology

authors： Morisset V,Ahluwalia J,Nagy I,Urban L

更新日期：2001-10-19 00:00:00

abstract：:Imatinib (IMA) is the standard treatment for CML; however, stopping IMA sometimes results in disease relapse, which suggests that leukemic stem cells (LSCs) remain in such patients, even after complete molecular remission has been achieved. Therefore, new strategies will be required to eradicate LSCs. The Janus kinase...

journal_title：European journal of pharmacology

authors： Yagi K,Shimada A,Sendo T

更新日期：2018-04-15 00:00:00

abstract：:Epristeride, a 5alpha-reductase inhibitor, decreases prostate size and improves symptoms in men with benign prostatic hyperplasia. However, little is known about the histopathology of the prostate after treatment with epristeride. To study the relationship between apoptosis and the mechanism of epristeride in the trea...

journal_title：European journal of pharmacology

authors： Sun ZY,Wu HY,Wang MY,Tu ZH

更新日期：1999-04-29 00:00:00

abstract：:The effect of Ca2+ on the oxytocin-induced, sustained contraction of rat uterine muscle in Ca-free medium after prolonged incubation with 3 mM EGTA (Ca-free contraction) was investigated. A micromolar concentration of Ca2+ caused phasic contraction followed by relaxation while a submicromolar concentration caused rela...

journal_title：European journal of pharmacology

authors： Matsuo K,Uchida MK

更新日期：1987-08-21 00:00:00

abstract：:The binding of the bisquaternary muscarine receptor antagonist heptane-1,7-bis(dimethyl-3'-phthalimidopropyl)-ammonium bromide (C7/3-phth) was investigated at a number of cholinergic binding sites using (-)-[3H]nicotine, [3H]pirenzepine and (-)-[3H]quinuclidinyl benzilate ([3H]QNB) in both central and peripheral tissu...

journal_title：European journal of pharmacology

authors： Christopoulos A,Loiacono R,Mitchelson F

更新日期：1993-06-15 00:00:00

abstract：:It has been previously demonstrated that selegiline, an irreversible monoamine oxidase B (MAO-B) inhibitor, potentiates glial reaction to injury and possesses some 'trophic-like' activities which do not depend on the inhibition of MAO-B and which are probably associated with the induction of astrocyte-derived neurotro...

journal_title：European journal of pharmacology

authors： Semkova I,Wolz P,Schilling M,Krieglstein J

更新日期：1996-11-07 00:00:00

abstract：:Eribis peptide 94 (EP 94) is a novel enkephalin analog, thought to interact with the μ- and δ-opioid receptors. The purpose of the present study was to examine the cardioprotective potential of EP 94 in two clinically relevant porcine models of myocardial ischaemia and reperfusion, and to investigate if such an effect...

journal_title：European journal of pharmacology

authors： Karlsson LO,Grip L,Bissessar E,Bobrova I,Gustafsson T,Kavianipour M,Odenstedt J,Wikström G,Gonon AT

更新日期：2011-01-25 00:00:00

abstract：:The pharmacological actions of sotalol, (-)-propranolol and prazosin on norepinephrine (NE) concentration and creatine kinase (CK) activity in the coronary sinus blood of the ischemic heart were studied in open-chest dogs. A 60 min occlusion of the left anterior descending coronary artery was followed by a reperfusion...

journal_title：European journal of pharmacology

authors： Lamontagne D,Yamaguchi N,Nadeau R,De Champlain J,Godin D,Campeau N

更新日期：1986-04-09 00:00:00

abstract：:Effects of histamine receptor ligands on the glibenclamide-sensitive K+ currents induced by K+ channel openers, cromakalim and Y-26763, were examined in follicle-enclosed Xenopus oocytes. Histamine H1 receptor antagonists, promethazine, dimethindene and chlorpheniramine all decreased cromakalim-induced K+ currents wit...

journal_title：European journal of pharmacology

authors： Sakuta H

更新日期：1994-01-01 00:00:00

abstract：:Prolactin blood level and apomorphine-induced yawning were studied in rats treated with the substituted benzamide amisulpride in association with bromocriptine or carmoxirole; two dopamine D(2) receptor agonists with high or low propensity to cross the brain-blood barrier, respectively. Administration of amisulpride p...

journal_title：European journal of pharmacology

authors： Marchese G,Ruiu S,Casti P,Bartholini F,Saba P,Gessa GL,Pani L

更新日期：2002-06-28 00:00:00

abstract：:The effect of two serotonin precursors, 5-hydroxytryptophan (5-OH-TRP) and indolepyruvic acid (IPA), a tryptophan ketoanalogue, on rat pineal indole metabolism during the light-dark cycle was investigated. 5-OH-TRP drastically increased the production of 5-hydroxyindoleacetic acid at a dose of only 10 mg/kg, whereas 5...

journal_title：European journal of pharmacology

authors： Ferretti C,Blengio M,Ghi P,Genazzani E

更新日期：1990-10-23 00:00:00

abstract：:Macrophage-stimulating protein (MSP) and its receptor, recepteur d'origine nantais (RON), play an important role in cell proliferation and migration. We have investigated the role of MSP in hydrogen peroxide (H2O2)-induced renal tubular apoptosis. Human renal proximal tubular (HK-2) cells were incubated with H2O2 for ...

journal_title：European journal of pharmacology

authors： Lee KE,Kim EY,Kim CS,Choi JS,Bae EH,Ma SK,Park JS,Jung YD,Kim SH,Lee JU,Kim SW

更新日期：2013-09-05 00:00:00

abstract：:[3H]Rauwolscine binds with high affinity to alpha 2-adrenoceptors (Kd = 4.8 +/- 1.3 nM, Bmax = 79 +/- 26 fmol/mg protein, micromolar affinity for 5-HT) as well as to 5-HT1-like receptors (Kd = 13 +/- 2.7 nM, Bmax = 147 +/- 11.4 fmol/mg protein, nanomolar affinity for 5-HT) in human brain cortex membranes. The Ki value...

journal_title：European journal of pharmacology

authors： Convents A,De Keyser J,De Backer JP,Vauquelin G

更新日期：1989-01-17 00:00:00

abstract：:The nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a novel member of the opioid receptor family with little affinity for traditional opioids. This receptor and its endogenous ligand, N/OFQ, are widely distributed in the brain and are implicated in many physiological functions including pain regulation. [(pF)...

journal_title：European journal of pharmacology

authors： Kuo CJ,Liao YY,Guerrini R,Calo' G,Chiou LC

更新日期：2008-01-28 00:00:00