Capsazepine inhibits low pH- and lactic acid-evoked release of calcitonin gene-related peptide from sensory nerves in guinea-pig heart.

abstract：:The present study was undertaken to investigate the effects of intracavernosal injections of adrenomedullin, a novel hypotensive peptide, on penile erection in anesthetized cats. Responses to adrenomedullin were compared to those elicited by intracavernosal injection of the control triple-drug combination (1.65 mg pap...

journal_title：European journal of pharmacology

authors： Champion HC,Wang R,Shenassa BB,Murphy WA,Coy DH,Hellstrom WJ,Kadowitz PJ

更新日期：1997-01-14 00:00:00

abstract：:We investigated the effects of histamine on the motility of isolated segments from canine ureters and characterized pharmacologically the histamine receptors involved. We also evaluated the effects of various autacoids (5-HT, carbachol, noradrenaline, thromboxane, prostaglandin F2alpha) on the motility of canine urete...

journal_title：European journal of pharmacology

authors： Dodel RC,Hafner D,Borchard U

更新日期：1996-12-30 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) released from vasodilator nerves is implicated in the gastroprotective action of capsaicin. This experimental paradigm was used to prove the effectiveness of a monoclonal anti-CGRP antibody. The experiments were performed in anaesthetized rats in which intragastric capsaicin (0.5...

journal_title：European journal of pharmacology

authors： Peskar BM,Wong HC,Walsh JH,Holzer P

更新日期：1993-11-30 00:00:00

abstract：:The efficacy of SR 47436 (BMS-186295), 2-n-butyl-3-[(2'-(1H-tetrazol-5-yl)- biphenyl-4-yl)methyl]-1,3-diaza-spiro[4,4]non-1-en-4-one, a non-peptide angiotensin AT1 receptor antagonist, was characterized in various conscious hypertensive rat models. In spontaneously hypertensive rats, single intravenous or oral doses o...

journal_title：European journal of pharmacology

authors： Lacour C,Canals F,Galindo G,Cazaubon C,Segondy D,Nisato D

更新日期：1994-11-03 00:00:00

abstract：:This paper describes the pharmacological activity of D,L-(tetrazol-5-yl)glycine, a structurally novel and highly potent agonist at the N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor. D,L-(Tetrazol-5-yl)glycine potently displaced NMDA receptor binding to rat brain membranes as measured using [3H]...

journal_title：European journal of pharmacology

authors： Schoepp DD,Smith CL,Lodge D,Millar JD,Leander JD,Sacaan AI,Lunn WH

更新日期：1991-10-15 00:00:00

abstract：:Newly developed acyclic nucleoside phosphonates, derivatives of adenine and 2,6-diaminopurine bearing the 2-hydroxy-3-(phosphonomethoxy)propyl (HPMP) moiety at the N9-side chain (i.e., HPMPA and HPMPDAP, respectively) were screened for in vitro immunobiological activity, using mouse resident peritoneal macrophages and...

journal_title：European journal of pharmacology

authors： Potmesil P,Krecmerová M,Kmonícková E,Holý A,Zídek Z

更新日期：2006-07-01 00:00:00

abstract：:It has been reported that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) can modulate opioid tolerance via its action on learning and memory. In this study, we examine if CaMKII can directly affect opioid tolerance. We found that spinal CaMKII activity was increased in rats tolerant to morphine. In these rats,...

journal_title：European journal of pharmacology

authors： Wang ZJ,Tang L,Xin L

更新日期：2003-03-28 00:00:00

abstract：:Clinical use of gentamicin over prolonged periods is limited because of dose- and time-dependent nephrotoxicity. Primarily, lysosomal phospholipidosis, intracellular oxidative stress and heightened inflammation have been implicated. Hydrogen sulphide is an endogenously produced signal transduction molecule with strong...

journal_title：European journal of pharmacology

authors： Dam VP,Scott JL,Ross A,Kinobe RT

更新日期：2012-06-15 00:00:00

abstract：:Breast cancer is one of the main diagnosis cancers annually worldwide. It is difficult to thorough cure due to drug resistance and the high possibility of metastasis. SM934 is a novel water-soluble artemisinin analog, and has been reported to have a promising therapeutic effect on multiple autoimmune diseases. In this...

journal_title：European journal of pharmacology

authors： Gu X,Peng Y,Zhao Y,Liang X,Tang Y,Liu J

更新日期：2019-09-05 00:00:00

abstract：:Although accumulated data suggest that calcitonin gene-related peptide (CGRP) produces anabolic effects in skeletal tissue by directly acting on osteogenic cells, neither the distribution of CGRP receptor subtypes nor the associated cellular signaling pathways are well understood. In this study, we have pharmacologica...

journal_title：European journal of pharmacology

authors： Kawase T,Okuda K,Burns DM

更新日期：2003-06-06 00:00:00

abstract：:Corticotropin releasing factor (CRF) is a hypothalamic hormone that also displays autocrine/paracrine roles at peripheral sites. High concentrations of CRF have been identified in endothelial cells and other inflammatory tissues. We investigated the effects of CRF and antagonists in the regulation of prostaglandin syn...

journal_title：European journal of pharmacology

authors： Fleisher-Berkovich S,Rimon G,Danon A

更新日期：1998-07-24 00:00:00

abstract：:The effects of ICS 205-930 [3 alpha-tropanyl)-1H-indole-3-carboxylic acid ester), an antagonist of 5-HT at neuronal M receptors, were examined in anaesthetised greyhounds subject to acute coronary artery occlusion and reperfusion. Intravenous administration of 0.3 or 2.0 mg kg-1 of ICS 205-930 did not significantly al...

journal_title：European journal of pharmacology

authors： Coker SJ,Dean HG,Kane KA,Parratt JR

更新日期：1986-08-15 00:00:00

abstract：:Bitter taste receptors (Tas2rs) initiate a bitter taste signaling involving the activation of taste-specific G protein gustducin and phosphodiesterases (PDEs); it leads to the decrease of cytosolic level of cyclic adenosine monophosphate (cAMP) in taste cells. Recent studies have identified the expression of Tas2rs in...

journal_title：European journal of pharmacology

authors： Liu M,Qian W,Subramaniyam S,Liu S,Xin W

更新日期：2020-04-05 00:00:00

abstract：:RES-701-1 (cyclic (Gly1-Asp9)(Gly-Asn-Trp-His-Gly-Thr-Ala-Pro-Asp-Trp-Phe- Phe-Asn-Tyr-Tyr-Trp)), a peptide isolated from Streptomyces sp., has been reported to inhibit the endothelin ETB receptor. We examined the effects of this peptide on the blood vessels and the small intestine. In isolated rat aorta without endot...

journal_title：European journal of pharmacology

authors： Karaki H,Sudjarwo SA,Hori M,Tanaka T,Matsuda Y

更新日期：1994-09-12 00:00:00

abstract：:The effects of serotonin (5-HT) on a beta-adrenergic response were studied, using the voltage clamp technique, in Xenopus laevis oocytes surrounded by their follicular cells. noradrenaline induced marked hyperpolarization, with a specific increase in the permeability of the membrane toward K+. Application of 10 microM...

journal_title：European journal of pharmacology

authors： Fujita R,Tamazawa Y,Barnard EA,Matsumoto M

更新日期：1993-08-24 00:00:00

abstract：:We have investigated whether the histamine H3-receptors influence nonadrenergic noncholinergic (NANC) bronchoconstriction in guinea-pig in vivo. Atropine, propranolol, mepyramine and cimetidine were administered to block the effects of beta-adrenoceptor-, acetylcholine, H1- and H2-receptor-mediated responses, respecti...

journal_title：European journal of pharmacology

authors： Ichinose M,Barnes PJ

更新日期：1989-12-12 00:00:00

abstract：:We investigated the effects of 7-nitroindazole, a specific inhibitor of neuronal nitric oxide (NO) synthase, on NO concentration and on blood flow in rat hippocampus after transient forebrain ischemia which was induced by 4-vessel occlusion for 10 min. NO concentration was measured directly by an NO-selective electrod...

journal_title：European journal of pharmacology

authors： Jiang MH,Kaku T,Hada J,Hayashi Y

更新日期：1999-09-10 00:00:00

abstract：:3H-Mepyramine (3H-MEP) binds to slide-mounted tissue sections with characteristics indicating the labelling of a H1-histamine receptor. It is saturable (Bmax 12 pg/g tissue), of a high affinity (KD 0.5 mM) and possesses a drug specificity similar to that observed for H1 receptors in a variety of systems. In agreement ...

journal_title：European journal of pharmacology

authors： Palacios JM,Young WS 3rd,Kuhar MJ

更新日期：1979-10-01 00:00:00

abstract：:The effects of procaine, mepivacaine and phenylbutazone on pain perception in the equine were studied using two behavioral assays of nociception; the thermal evoked hoof withdrawal reflex and skin twitch reflex. Pain perception threshold was measured as the latency from onset of thermal stimuli to reflex withdrawal of...

journal_title：European journal of pharmacology

authors： Kamerling SG,Dequick DJ,Weckman TJ,Sprinkle FP,Tobin T

更新日期：1984-12-15 00:00:00

abstract：:The preparation and the biological activities of the four stereoisomers of 3-[5-(3-amino-1,2,4-oxadiazol)yl]-1-azabicyclo[2.2.1]heptane are described. The most potent stereoisomer, 3a, has the 3R,4R configuration, and in vitro activities in (pD2(% efficacy): ileum 8.8 (87%), hippocampus 9.8 (116%) and ganglion 10.2 (3...

journal_title：European journal of pharmacology

authors： Pombo-Villar E,Wiederhold KH,Mengod G,Palacios JM,Supavilai P,Boddeke HW

更新日期：1992-08-03 00:00:00

abstract：:The biological activity of two galanin (GAL) fragments, GAL-(1-16) and GAL-(17-29), was tested in vivo by using a spinal nociceptive flexor reflex model in the rat. Intrathecal (i.t.) GAL-(1-16) had a similar biphasic effect on the flexor reflex, with facilitation at lower doses and facilitation followed by depression...

journal_title：European journal of pharmacology

authors： Xu XJ,Wiesenfeld-Hallin Z,Fisone G,Bartfai T,Hökfelt T

更新日期：1990-06-21 00:00:00

abstract：:Aripiprazole is the first dopamine D(2)/D(3) receptor partial agonist approved for use in the treatment of psychiatric disorders including schizophrenia, bipolar disorder, and unipolar depression in the US. Aripiprazole has demonstrated a relatively favorable side effect profile compared to other commonly prescribed a...

journal_title：European journal of pharmacology

authors： Tadori Y,Forbes RA,McQuade RD,Kikuchi T

更新日期：2009-04-01 00:00:00

abstract：:The aim of this work was to investigate the effect of P-glycoprotein modulators on human extraneuronal monoamine transporter (EMT)-mediated transport. The experiments were performed using a cell line from human embryonic kidney (HEK293 cells) stably transfected with pcDNA3hEMT (293(hEMT)), or with pcDNA3 alone (293(co...

journal_title：European journal of pharmacology

authors： Martel F,Keating E,Azevedo I

更新日期：2001-06-22 00:00:00

abstract：:Using the ex vivo chick embryo retina to study the efficacy of antagonists in blocking the excitotoxic effects of excitatory amino acid agonists, we previously identified phencyclidine as the most powerful known anti-excitotoxin. Here we show that MK-801 is 5 times more powerful than phencyclidine as an anti-excitotox...

journal_title：European journal of pharmacology

authors： Olney J,Price M,Salles KS,Labruyere J,Frierdich G

更新日期：1987-09-23 00:00:00

abstract：:The formation of epidural fibrosis adjacent to the dura mater is a complex multi-step process that is associated with a marked reduction in tissue cellularity and the excessive deposition of extracellular matrix components. Extensive epidural fibrosis is a major cause of post-laminectomy syndrome. Decorin strongly inh...

journal_title：European journal of pharmacology

authors： Turkoglu E,Dinc C,Tuncer C,Oktay M,Serbes G,Sekerci Z

更新日期：2014-02-05 00:00:00

abstract：:The release of newly synthesised [3H]acetylcholine was evoked by electrical field stimulation (5 Hz, 600 pulses) of epithelium-deprived guinea-pig trachea strips after sensory neuropeptides depletion with 3 microM capsaicin. The selective tachykinin NK(2) receptor agonist [betaAla(8)]neurokinin A-(4-10) increased in a...

journal_title：European journal of pharmacology

authors： D'Agostino G,Erbelding D,Kilbinger H

更新日期：2000-05-12 00:00:00

abstract：:Adrenomedullin administered peripherally in the rabbit (at doses of 1.25, 2.5 and 5 microg/kg ) caused a dose-dependent conjunctival hyperemia accompanied by an increase of inflammatory cell number and prostaglandin E(2) concentration in the aqueous humor, and of uveal vascular response and myeloperoxidase activity. T...

journal_title：European journal of pharmacology

authors： Clementi G,Floriddia ML,Prato A,Marino A,Drago F

更新日期：2000-07-21 00:00:00

abstract：:Endogenous opioid peptides have been demonstrated to regulate luteinizing hormone (LH) secretion in a variety of species. Studies in rodents suggest a role of opioid peptide systems in controlling the timing of the LH surge, which is entrained to the circadian rhythm. The current studies utilize clocinnamox, a novel l...

journal_title：European journal of pharmacology

authors： Lieberman PB,Woods JH,Young EA

更新日期：1998-07-03 00:00:00

abstract：:The muscarinic agonists, xanomeline and carbachol, displayed similar intrinsic activities in stimulating neuronal nitric oxide synthase at muscarinic M1 receptors in Chinese hamster ovary (CHO) cells, with xanomeline being more potent. Pre-incubation (1 h) with 1 microM xanomeline, followed by extensive washing, resul...

journal_title：European journal of pharmacology

authors： Christopoulos A,El-Fakahany EE

更新日期：1997-09-03 00:00:00

abstract：:The effect of cannabinoid receptor activation and blockade on the propulsive activity in the mouse small intestine was assessed in the present study by measuring the transit of an orally administered, non-absorbable marker. The cannabinoid receptor agonist WIN 55,212-2 (R(+)-[2,3-dihydro-5-methyl-3[(morpholinyl)methyl...

journal_title：European journal of pharmacology

authors： Colombo G,Agabio R,Lobina C,Reali R,Gessa GL

更新日期：1998-02-26 00:00:00