Cannabinoid modulation of intestinal propulsion in mice.

Abstract:

:The effect of cannabinoid receptor activation and blockade on the propulsive activity in the mouse small intestine was assessed in the present study by measuring the transit of an orally administered, non-absorbable marker. The cannabinoid receptor agonist WIN 55,212-2 (R(+)-[2,3-dihydro-5-methyl-3[(morpholinyl)methyl]pyrrolo[1,2,3-de-1, 4benzoxazin-yl]-(1-naphthalenyl)methanone mesylate) inhibited, while the selective cannabinoid CB1 receptor antagonist SR 141716A (N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyraz ole-carboxamide) stimulated the marker transit. Furthermore, a per se non-effective dose of SR 141716A reversed WIN 55,212-2-induced reduction of the transit. The results of the present study suggest a role for cannabinoid CB1 receptors in the control of propulsive activity in the mouse small intestine.

journal_name

Eur J Pharmacol

authors

Colombo G,Agabio R,Lobina C,Reali R,Gessa GL

doi

10.1016/s0014-2999(97)01555-0

subject

Has Abstract

pub_date

1998-02-26 00:00:00

pages

67-9

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(97)01555-0

journal_volume

344

pub_type

杂志文章
  • Behavioural genetics in mood and anxiety: a next step in finding novel pharmacological targets.

    abstract::The pharmacological treatment of mood and anxiety disorders has for long relied on the serendipitous findings of monoaminergic and benzodiazepine drugs more than 50 years ago. These treatments, however, are therapeutically insufficient and even though more recently developed drugs are particularly improving side effec...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejphar.2008.01.057

    authors: de Mooij-van Malsen AJ,Olivier B,Kas MJ

    更新日期:2008-05-13 00:00:00

  • Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells.

    abstract::Rosmarinic acid (RA) is a polyphenolic compound with various pharmacological properties, including, anti-inflammatory, immunomodulatory, and neuroprotective, as well as having antioxidant and anticancer activities. This study evaluated the effects and mechanisms of RA in two racially different triple-negative breast c...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2020.173419

    authors: Messeha SS,Zarmouh NO,Asiri A,Soliman KFA

    更新日期:2020-10-15 00:00:00

  • BIIE0246: a selective and high affinity neuropeptide Y Y(2) receptor antagonist.

    abstract::The in vitro biological characterisation of the first potent and selective non-peptide neuropeptide Y Y(2) receptor antagonist, (S)-N(2)-[[1-[2-[4-[(R,S)-5,11-dihydro-6(6h)-oxodibenz[b, e]azepin-11-yl]-1-piperazinyl]-2-oxoethyl] cylopentyl] acetyl]-N-[2-[1,2-dihydro-3,5(4H)-dioxo-1,2-diphenyl-3H-1,2, 4-triazol-4-yl]et...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(99)00650-0

    authors: Doods H,Gaida W,Wieland HA,Dollinger H,Schnorrenberg G,Esser F,Engel W,Eberlein W,Rudolf K

    更新日期:1999-11-19 00:00:00

  • Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts.

    abstract::Osteoporosis is a reduction in skeletal mass due to an imbalance between bone resorption and bone formation. Bone morphogenetic protein (BMP) plays important roles in osteoblastic differentiation and bone formation. Therefore, components involved in BMP activation are good targets for the development of anti-osteoporo...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2007.10.013

    authors: Tang CH,Yang RS,Chien MY,Chen CC,Fu WM

    更新日期:2008-01-28 00:00:00

  • A novel Pseudolaric acid B derivative, Hexahydropseudolaric acid B, exterts an immunomodulatory effect in vitro/in vivo evaluation.

    abstract::Identification of immunosuppressants from natural sources has a proven track record in immune mediated disorders. Pseudolaric acid B is a diterpenoid isolated from the roots of Pseudolarix amabilis, possessing potent immunomodulatory effect. However, the cytotoxicity limits its future clinical application. The purpose...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2014.10.009

    authors: Li T,Chen H,Yang Z,Wang W,Wang YT,Zhang LM,Zhao JH,Zhou X,Li YM

    更新日期:2014-12-15 00:00:00

  • Tissue selectivity of substance P alkyl esters: suggesting multiple receptors.

    abstract::Previous studies from this laboratory suggested that two subtypes of substance P receptor may exist, based on the observations that substance P and related peptides did not exhibit complete cross-desensitisation on guinea-pig ileum, and that two distinct rank orders of potency of tachykinins were observed in various t...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(83)90052-3

    authors: Watson SP,Sandberg BE,Hanley MR,Iversen LL

    更新日期:1983-01-28 00:00:00

  • A kinetic analysis of a catechol-specific binding site in the microsomal fraction from the rabbit aorta.

    abstract::(-)-3/-Norepinephrine (3H-NE) binding to the microsomal fraction of the rabbit aorta has been studied. Binding appears to increase linearly with time up to at least 30 min, shows no evidence of stereoselectivity and may be inhibited only by compounds possessing the catechol or 3-methoxy-4hydroxyphenyl moieties, with t...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(76)90324-1

    authors: Ruffolo RR,Mccreery RL,Patil PN

    更新日期:1976-08-01 00:00:00

  • A novel carbazole derivative, MHY407, sensitizes cancer cells to doxorubicin-, etoposide-, and radiation treatment via DNA damage.

    abstract::In this study, we synthesized a novel carbazole derivative, MHY407, as a sensitizer of cancer cells to increase DNA damage. We then evaluated the anticancer effects of MHY407 and identified the molecular mechanism for the sensitization of breast cancer cell lines. MHY407 significantly increased DNA damage as determine...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2012.10.001

    authors: Yoon S,Kim JH,Lee YJ,Ahn MY,Choi G,Kim WK,Yang Z,Lee HJ,Moon HR,Kim HS

    更新日期:2012-12-15 00:00:00

  • Chronic gastric ulcer healing in rats subjected to selective and non-selective cyclooxygenase-2 inhibitors.

    abstract:UNLABELLED:The influence of different nonsteroidal anti-inflammatory drugs (NSAIDs) and of a proton pump inhibitor on the healing parameters of a chronic gastric ulcer was evaluated. Wistar rats were used after the induction of a chronic acetic acid ulcer. The animals were treated orally for 8 and 15 days, twice daily,...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(02)01494-2

    authors: Berenguer B,Alarcón de la Lastra C,Moreno FJ,Martín MJ

    更新日期:2002-05-03 00:00:00

  • Involvement of sulfhydryl groups in cerebral cortical [3H]clonidine binding in developing rats.

    abstract::The involvement of essential sulfhydryl groups in alpha 2-adrenoceptor function was investigated in the cerebral cortex of 7 and 70 day old rats. N-Ethylmaleimide (NEM) inhibited specific [3H]clonidine binding to cerebral cortical membranes in a concentration-dependent and biphasic manner in both infant and adult rats...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(83)90169-3

    authors: Kawai M,Nomura Y

    更新日期:1983-08-05 00:00:00

  • Pharmacological identification of the α₂-adrenoceptor subtypes mediating the vasopressor responses to B-HT 933 in pithed rats.

    abstract::It has been shown that α(2)-adrenoceptors mediate vasopressor responses in pithed rats. However, the corresponding α(2)-adrenoceptor subtypes have not been pharmacologically identified. Thus, this study set out to identify the specific subtypes (α(2A), α(2B) and α(2C)) mediating the vasopressor responses to the α(2)-a...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2012.06.011

    authors: Villamil-Hernández MT,Alcántara-Vázquez O,Sánchez-López A,Manrique-Maldonado G,Villalón CM,Centurión D

    更新日期:2012-09-15 00:00:00

  • Effects of fluoroquinolones on HERG currents.

    abstract::We have investigated the effects of four fluoroquinolones on the human ether-à-go-go-related gene (HERG) mediated K(+) currents to evaluate their potential to induce QT-prolongation. HERG currents were measured from stably transfected Chinese hamster ovary (CHO) cells by means of the patch-clamp technique. Bath applic...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(00)00693-2

    authors: Bischoff U,Schmidt C,Netzer R,Pongs O

    更新日期:2000-10-20 00:00:00

  • Comparison of clenbuterol enantiomers using four psychopharmacological tests sensitive to beta-agonists.

    abstract::The effects of the enantiomers of clenbuterol were compared in four psychopharmacological tests in which beta-adrenergic agonists are known to be active. In mice (+/-)-clenbuterol 0.06 mg/kg decreased motor activity and antagonized the hypothermia induced by 16 mg/kg of apomorphine; at 0.5 mg/kg it increased head-twit...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(85)90481-9

    authors: Martin P,Puech AJ,Brochet D,Soubrié P,Simon P

    更新日期:1985-10-29 00:00:00

  • Affinity of cyamemazine metabolites for serotonin, histamine and dopamine receptor subtypes.

    abstract::Animal and human pharmacological studies indicate that the antipsychotic action of cyamemazine results from blockade of dopamine D(2) receptors, its anxiolytic properties from serotonin 5-HT(2C) receptor antagonism and the low incidence of extrapyramidal side effects from a potent 5-HT(2A) receptor antagonistic action...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2007.09.025

    authors: Benyamina A,Arbus C,Nuss P,Garay RP,Neliat G,Hameg A

    更新日期:2008-01-14 00:00:00

  • Differential expression of cannabinoid CB(2) receptor mRNA in mouse immune cell subpopulations and following B cell stimulation.

    abstract::Cannabinoid CB(2) receptor is reported to be expressed in varying amounts in different human immune subpopulations. To examine the expression pattern of CB(2) in the mouse, immune cell subpopulations were purified and studied by semiquantitative Reverse Transcription-Polymerase Chain Reaction (RT-PCR). CB(2) mRNA was ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(01)01122-0

    authors: Lee SF,Newton C,Widen R,Friedman H,Klein TW

    更新日期:2001-07-06 00:00:00

  • Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats.

    abstract::Rutin exhibits antidiabetic, antioxidant and anti-inflammatory properties, which makes rutin an attractive candidate for diabetic complications. The present study was designed to investigate the potential effect of rutin on diabetic neuropathy. After induction of diabetic neuropathy, rutin (5mg/kg, 25mg/kg and 50mg/kg...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2015.12.021

    authors: Tian R,Yang W,Xue Q,Gao L,Huo J,Ren D,Chen X

    更新日期:2016-01-15 00:00:00

  • An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity.

    abstract::Cathepsin S is a major histocompatibility complex (MHC) class II associated invariant chain (Ii) degrading enzyme expressed in antigen presenting cells such as B cells and dendritic cells. This enzyme is essential for MHC class II associated antigen processing and presentation to CD4(+) T cells. Compound I, a selectiv...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2006.03.051

    authors: Desai SN,White DM,O'shea KM,Brown ML,Cywin CL,Spero DM,Panzenbeck MJ

    更新日期:2006-05-24 00:00:00

  • Effect of cardamonin on hepatic ischemia reperfusion induced in rats: Role of nitric oxide.

    abstract::Ischemia reperfusion (I/R) injury is a cellular damage in a hypoxic organ following the restoration of oxygen delivery. It may occur during organ transplantation, trauma and hepatectomies. Nitric oxide (NO) effects during hepatic I/R are complicated. The iNOS-derived NO has a deleterious effect, whereas eNOS-derived N...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2017.09.037

    authors: Atef Y,El-Fayoumi HM,Abdel-Mottaleb Y,Mahmoud MF

    更新日期:2017-11-15 00:00:00

  • Endothelin-1 induces potent constriction of lymphatic vessels in situ.

    abstract::The response of lymph vessels, arterioles and venules in the exteriorized rat mesentery to endothelin-1, vasopressin and norepinephrine was examined with the aid of high-resolution television microscopy. On a molar basis, endothelin-1 was more potent than vasopressin to contract the three types of vessels. Norepinephr...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(89)90135-0

    authors: Fortes ZB,Scivoletto R,Garcia-Leme J

    更新日期:1989-10-24 00:00:00

  • The effects of N-methyl-D-aspartate antagonists on the development of vestibular compensation in the guinea pig.

    abstract::In order to investigate the possible role of the N-methyl-D-aspartate (NMDA) receptor in the development of the behavioural recovery which occurs following unilateral labyrinthectomy (vestibular compensation) in the guinea pig, we administered systemically the specific NMDA receptor/channel antagonists MK801 and CPP (...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(89)90320-8

    authors: Darlington CL,Smith PF

    更新日期:1989-12-19 00:00:00

  • Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia.

    abstract::Global forebrain ischemia results in damage to the pyramids in the CA1 hippocampal subfield, which is particularly vulnerable to excitotoxic processes. Morphological and functional disintegration of this area leads to a cognitive dysfunction and neuropsychiatric disorders. Treatment with N-methyl-d-aspartate receptor ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2011.05.069

    authors: Gellért L,Fuzik J,Göblös A,Sárközi K,Marosi M,Kis Z,Farkas T,Szatmári I,Fülöp F,Vécsei L,Toldi J

    更新日期:2011-09-30 00:00:00

  • Effect of uncouplers of oxidative phosphorylation on transmitter release in dystrophic mice.

    abstract::Intracellular recording was used to study the effect of uncouplers of oxidative phosphorylation on miniature endplate potentials (m.e.p.p.s) in skeletal muscles from dystrophic mice and their clinically normal littermates. Control m.e.p.p. frequency in muscles from dystrophic mice was not significantly different from ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(88)90637-1

    authors: Kelly S,Morgan G,Smith J

    更新日期:1988-02-16 00:00:00

  • Role of histamine H1 and H2 receptor antagonists in the prevention of intimal thickening.

    abstract::Vascular smooth muscle cell migration to the intima from the media and proliferation in the intima play key roles in atherosclerosis and restenosis after coronary angioplasty. Histamine released from adherent platelets at the injured artery and from mast cells in atheromas has stimulant actions on both smooth muscle c...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(98)00716-x

    authors: Miyazawa N,Watanabe S,Matsuda A,Kondo K,Hashimoto H,Umemura K,Nakashima M

    更新日期:1998-11-27 00:00:00

  • Studies on the H2-receptor antagonism of MK-208 in isolated rabbit gastric glands.

    abstract::Using isolated rabbit gastric glands, the H2-receptor antagonist MK-208 was investigated with respect to its effects on [14C]aminopyrine uptake as an index of gastric acid secretion. In addition to shifting the histamine concentration-response curve to the right in a parallel fashion, the antagonism produced by MK-208...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(84)90733-7

    authors: Shepherd-Rose AJ,Pendleton RG

    更新日期:1984-11-13 00:00:00

  • 1-Methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-CH3-MPTP) is a more potent dopaminergic neurotoxin than MPTP in mice.

    abstract::The administration to mice of 1-methyl-4-(2'-methylphenyl)-1,2,3, 6-tetrahydropyridine (2'-CH3-MPTP), a substituted analog of the dopaminergic neurotoxin MPTP caused even more dopaminergic toxicity than MPTP itself. Under conditions in which MPTP was relatively ineffective (i.e. two injections per day of 0.113 mmol/kg...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(86)90115-9

    authors: Youngster SK,Duvoisin RC,Hess A,Sonsalla PK,Kindt MV,Heikkila RE

    更新日期:1986-03-18 00:00:00

  • Terfenadine induces thymocyte apoptosis via mitochondrial pathway.

    abstract::The treatment of rat thymocytes with 10 microM terfenadine resulted in a significant increase in DNA fragmentation. The DNA fragmentation induced by terfenadine was dependent on its concentration and incubation time. In terfenadine-treated cells, the translocation of phosphatidylserine from the inside of plasma membra...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2004.05.048

    authors: Enomoto R,Komai T,Yoshida Y,Sugahara C,Kawaguchi E,Okazaki K,Kinoshita H,Komatsu H,Konishi Y,Lee E

    更新日期:2004-08-02 00:00:00

  • Palmitoylethanolamide treatment reduces retinal inflammation in streptozotocin-induced diabetic rats.

    abstract::Although the pathogenesis of diabetic retinopathy (DR) is still insufficiently understood, new evidences indicate 'retinal inflammation' as an important player in the pathogenesis of the complication. Accordingly, common sets of upregulated inflammatory cytokines are found in serum, vitreous and aqueous samples obtain...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2015.11.035

    authors: Paterniti I,Di Paola R,Campolo M,Siracusa R,Cordaro M,Bruschetta G,Tremolada G,Maestroni A,Bandello F,Esposito E,Zerbini G,Cuzzocrea S

    更新日期:2015-12-15 00:00:00

  • Biphasic elevation of plasma histamine induced by water immersion stress, and their sources in rats.

    abstract::The effect of water immersion stress on the plasma concentration of histamine, in Wistar and mast cell-deficient (Ws/Ws) rats, was investigated. The histamine content of the plasma, skin and gastric mucosa, as well as the level of activity of histidine decarboxylase in the gastric mucosa, were determined by high perfo...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(98)00670-0

    authors: Huang ZL,Mochizuki T,Watanabe H,Kagoshima M,Maeyama K

    更新日期:1998-11-06 00:00:00

  • Felbamate inhibits cloned voltage-dependent Na+ channels from human and rat brain.

    abstract::The novel antiepileptic and neuroprotective drug felbamate (1 mM) caused a marked inhibition of voltage-dependent Na+ currents expressed in Xenopus oocytes upon injection of the cRNA encoding alpha-subunits from rat and human brain. This inhibition was present only if felbamate was perfused on the intracellular side o...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(96)00802-3

    authors: Taglialatela M,Ongini E,Brown AM,Di Renzo G,Annunziato L

    更新日期:1996-12-05 00:00:00

  • Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19).

    abstract::Since estrogen and selective estrogen receptor modulators can inhibit inflammatory responses, we studied the regulatory role of several selective estrogen receptor modulators on interleukin-6 (IL-6) expression in human retinal pigment epithelial cells (ARPE-19). ARPE-19 cells were exposed to lipopolysaccharide with si...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2010.05.006

    authors: Paimela T,Hyttinen JM,Viiri J,Ryhänen T,Karvonen MK,Unkila M,Uusitalo H,Salminen A,Kaarniranta K

    更新日期:2010-08-25 00:00:00