The N-terminal 1-16, but not C-terminal 17-29, galanin fragment affects the flexor reflex in rats.

abstract：:We found that pergolide, a dopamine D1/D2 receptor agonist used in the clinical therapy of Parkinson's disease, protects SH-SY5Y neuroblastoma cells from cell death induced by a brief pulse (15 min) of 1 mM H(2)O(2). Neuroprotection was found when pergolide was added to the culture medium either simultaneously with (E...

journal_title：European journal of pharmacology

authors： Uberti D,Piccioni L,Colzi A,Bravi D,Canonico PL,Memo M

更新日期：2002-01-02 00:00:00

abstract：:Rats trained to discriminate 1.0 mg/kg of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from saline in a two-lever operant choice task were administered doses of mescaline, LSD, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), quipazine, TFMPP and RU-24969. The DOM-stimulus generalized to the three hallucinogenic...

journal_title：European journal of pharmacology

authors： Glennon RA,Young R,Rosecrans JA

更新日期：1983-07-22 00:00:00

abstract：:Radioligand receptor binding techniques were used to characterize the effects of different structural types of antidepressant drugs on neurotransmitter receptors. The tricyclic antidepressants more or less potently inhibited the binding to rat brain preparations of several different radiolabelled ligands [3H]WB4101, [...

journal_title：European journal of pharmacology

authors： Hall H,Ogren SO

更新日期：1981-03-26 00:00:00

abstract：:We used in vitro autoradiography to identify the endothelin-1 receptor subtype(s) in the superficial gray layer of the superior colliculus of rats. These studies showed dense binding of (3-[125I]iodotyrosyl13)-[Ala11,15]Ac-endothelin-1-(6-2 1) (BQ3020) (for endothelin ETB receptors), while tissues incubated with [125I...

journal_title：European journal of pharmacology

authors： D'Amico M,Di Filippo C,Rossi F

更新日期：1998-04-17 00:00:00

abstract：:The effects of RX 781094, a new and potent alpha 2-adrenoceptor antagonist, on locus coeruleus (LC) unit activity were examined. Low doses of RX 781094 produced suppression of spontaneous LC unit activity which could be reversed with yohimbine. The increase in LC firing produced by WB 4101 could also be reversed with ...

journal_title：European journal of pharmacology

authors： Goldstein JM,Knobloch LC,Malick JB

更新日期：1983-07-15 00:00:00

abstract：:The present study was undertaken to investigate whether gap junctional communication could be involved in morphine-induced antinociceptive response using blockers of the gap junctional channel, carbenoxolone and Gap27. Intrathecal pretreatment with either carbenoxolone or Gap27 caused a dose-dependent attenuation of m...

journal_title：European journal of pharmacology

authors： Suzuki M,Narita M,Nakamura A,Suzuki T

更新日期：2006-03-27 00:00:00

abstract：:The purpose of this study was to examine the influence of ageing on the alterations in binding characteristics of adrenoceptors and membrane phospholipid fatty acids in rat heart following repeated administration of epinephrine. The maximal number of binding sites (Bmax) and dissociation constant (Kd) of [3H]prazosin ...

journal_title：European journal of pharmacology

authors： Benediktsdóttir VE,Skúladóttir GV,Gudbjarnason S

更新日期：1995-05-26 00:00:00

abstract：:After prolonged stimulation, the delta-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S363 in the C-terminus of the human delta-opioid receptor. Morphine...

journal_title：European journal of pharmacology

authors： Navratilova E,Eaton MC,Stropova D,Varga EV,Vanderah TW,Roeske WR,Yamamura HI

更新日期：2005-09-20 00:00:00

abstract：:We investigated the effects of antithrombin, a plasma inhibitor of coagulation factors, in rats with puromycin aminonucleoside-induced nephrosis, which is an experimental model of human nephrotic syndrome. Antithrombin (50 or 500 IU/kg/i.v.) was administered to rats once a day for 10 days immediately after the injecti...

journal_title：European journal of pharmacology

authors： Yamashita J,Nakajima K,Ohno Y,Kaneshiro Y,Matsuo T,Tanaka H,Kaneko K

更新日期：2008-07-28 00:00:00

abstract：:We compared hypolocomotion and catalepsy mediated by striatal dopamine D2 and adenosine A2A receptors using microinfusions of the adenosine A2A receptor agonist 2-p-(2-carboxyethyl) phenethylamino-5'-N-ethylcarboxamidoadenosine hydrochloride (CGS21680) and the dopamine D2 receptor antagonist raclopride into the nucleu...

journal_title：European journal of pharmacology

authors： Hauber W,Münkle M

更新日期：1997-04-04 00:00:00

abstract：:Slices of rat kidney cortex were incubated in [3H]noradrenaline, then placed in a flow cell and subjected to electrical field stimulation. At a stimulation frequency of 5 Hz, both the alpha 2-adrenoceptor antagonist idazoxan (0.1 microM) and the alpha 1-adrenoceptor antagonist prazosin (0.1 microM) significantly enhan...

journal_title：European journal of pharmacology

authors： Murphy TV,Majewski H

更新日期：1989-10-10 00:00:00

abstract：:Parkinson's disease (PD) is a complex and widespread neurodegenerative disease characterized by depletion of midbrain dopaminergic (DA) neurons. Key issues are the development of therapies that can stop or reverse the disease progression, identification of dependable biomarkers, and better understanding of the pathoph...

journal_title：European journal of pharmacology

authors： Iyer M,Subramaniam MD,Venkatesan D,Cho SG,Ryding M,Meyer M,Vellingiri B

更新日期：2020-12-17 00:00:00

abstract：:The role beta-adrenoceptors in the control of venous tone is not clear. This study examines the dose-response effects of isoprenaline, a non-selective beta-adrenoceptor agonist, on mean circulatory filling pressure (MCFP), an index of body venous tone, in conscious and unrestrained rats. Dose-response curves of isopre...

journal_title：European journal of pharmacology

authors： Abdelrahman A,Pang CC

更新日期：1990-11-13 00:00:00

abstract：:In Ca-free solution norepinephrine (NE) produced only a phasic contraction in the media-intima layer of rabbit aorta. The second application of NE was almost ineffective. Incubation of the muscle with Ca for a short period (Ca loading) restored the ability to produce a phasic contraction in Ca-free solution. Various i...

journal_title：European journal of pharmacology

authors： Karaki H,Kubota H,Urakawa N

更新日期：1979-06-15 00:00:00

abstract：:The involvement of essential sulfhydryl groups in alpha 2-adrenoceptor function was investigated in the cerebral cortex of 7 and 70 day old rats. N-Ethylmaleimide (NEM) inhibited specific [3H]clonidine binding to cerebral cortical membranes in a concentration-dependent and biphasic manner in both infant and adult rats...

journal_title：European journal of pharmacology

authors： Kawai M,Nomura Y

更新日期：1983-08-05 00:00:00

abstract：:Hyperglycemia is a common defining feature in the development of endothelial dysfunction which plays a key role in the pathogenesis of both type 1 and type 2 diabetes. Caveolin-1 is the main structural component of caveolae which might be involved in the pathophysiology of macrovascular complications of diabetes. In t...

journal_title：European journal of pharmacology

authors： Elçioğlu KH,Kabasakal L,Cetinel S,Conturk G,Sezen SF,Ayanoğlu-Dülger G

更新日期：2010-09-10 00:00:00

abstract：:Increasing stimulation frequency and monensin were utilized in attempts to enhance Na+ influx and thereby elicit the maximum rate of ouabain-sensitive 86Rb+ uptake in rat atrial muscle. Increasing stimulation frequency between 0 and 9 Hz enhanced the rate of ouabain-sensitive 86Rb+ uptake, whereas the uptake rate appe...

journal_title：European journal of pharmacology

authors： Kennedy RH,Seifen E,Kafiluddi R

更新日期：1986-09-23 00:00:00

abstract：:Hydrogen sulfide (H2S) is a gaseous molecule and is endogenously produced in the brain by cystathionine beta-synthase, 3-mercaptopyruvate-sulfurtransferase, cysteine aminotransferase and cystathionine γ-lyase. Physiologically, H2S acts as a neuromodulator and regulates synaptic activity of neurons and glia to promote ...

journal_title：European journal of pharmacology

authors： He JT,Li H,Yang L,Mao CY

更新日期：2019-04-15 00:00:00

abstract：:The effects of L-nitroarginine (L-NNA), an inhibitor of nitric oxide (NO) synthesis, on non-adrenergic, non-cholinergic inhibitory transmission in the circular smooth muscle of the rat gastric fundus were studied. The relaxation in response to nerve stimulation in the presence of guanethidine and atropine was depresse...

journal_title：European journal of pharmacology

authors： Shimamura K,Fujisawa A,Toda N,Sunano S

更新日期：1993-01-26 00:00:00

abstract：:Excessive proliferation of epidermal keratinocytes is a typical aspect of chronic skin diseases such as psoriasis. In the present study, the effect of phosphodiesterase 7A (PDE7A) inhibitor ASB16165 on proliferation of keratinocytes was investigated to examine the role of PDE7A in keratinocyte proliferation and the po...

journal_title：European journal of pharmacology

authors： Goto M,Kadoshima-Yamaoka K,Murakawa M,Yoshioka R,Tanaka Y,Inoue H,Murafuji H,Kanki S,Hayashi Y,Nagahira K,Ogata A,Nakatsuka T,Fukuda Y

更新日期：2010-05-10 00:00:00

abstract：:The effects of i.v. injected delta9-tetrahydrocannabinol (delta9-THC) on behaviour, body temperature and levels of brain monoamines, measured spectrophotofluorimetrically, of the rat were determined. Doses of delta9-THC in the range of 0.05--5.0 mg/kg produced biphasic changes in behaviour, body temperature and levels...

journal_title：European journal of pharmacology

authors： Taylor DA,Fennessy MR

更新日期：1977-11-15 00:00:00

abstract：:In rat brain cortex slices, ethanol was three times more potent in inhibiting [3H]noradrenaline ([3H]NA) release evoked by N-methyl-D-aspartate (NMDA) than in inhibiting the release evoked by kainic acid. Methanol, 1-propanol, 1-butanol, 1-pentanol and 1-hexanol shared the inhibitory property of ethanol on NMDA-evoked...

journal_title：European journal of pharmacology

authors： Fink K,Göthert M

更新日期：1990-11-27 00:00:00

abstract：:Thapsigargin (TG), an inhibitor of Ca(2+) ATPase pumps in the endoplasmic reticulum (ER), inhibits replication of human vascular smooth muscle cell (hVSMC) at low nM concentrations. TG blocks replication of other cell types through promotion of ER stress (ERS). In order to determine whether ERS may mediate the cytosta...

journal_title：European journal of pharmacology

authors： Shukla N,Wan S,Angelini GD,Jeremy JY

更新日期：2013-08-15 00:00:00

abstract：:Goniothalamin, a natural occurring styryl-lactone, is a novel compound with putative anticancer activities. In the present study, the mechanism of action of goniothalamin was further investigated in human breast cancer MDA-MB-231 cells. Goniothalamin treatment of cells significantly induced cell cycle arrest at G(2)/M...

journal_title：European journal of pharmacology

authors： Chen WY,Wu CC,Lan YH,Chang FR,Teng CM,Wu YC

更新日期：2005-10-17 00:00:00

abstract：:MK-801 (a potent non-competitive antagonist of N-methyl-D-aspartic acid-mediated events) in subcutaneous doses of 0.1 and 0.2 mg/kg increased the threshold for electroconvulsions and in doses of 0.0031 and 0.0125 mg/kg enhanced the protective activity of valproate against maximal electroshock-induced convulsions in mi...

journal_title：European journal of pharmacology

authors： Urbańska E,Dziki M,Kleinrok Z,Czuczwar SJ,Turski WA

更新日期：1991-08-06 00:00:00

abstract：:Previous studies of myocardium have shown that ischemic preconditioning could be mimicked by nitroglycerin through stimulating the release of calcitonin gene-related peptide (CGRP). The present study examined whether nitroglycerin could also provide a preconditioning stimulus in the peripheral vascular bed (the anse i...

journal_title：European journal of pharmacology

authors： Dun Y,Hao YB,Wu YX,Zhang Y,Zhao RR

更新日期：2001-11-02 00:00:00

abstract：:The effect of idebenone on the changes in adenosine and nucleotide metabolism occurring in hippocampal slices after ischemia-like conditions (superfusion with glucose-free Krebs solution gassed with 95% N2-5% CO2) and during reperfusion with normal Krebs solution was investigated by measuring adenosine and inosine out...

journal_title：European journal of pharmacology

authors： Latini S,Pedata F,Pepeu G

更新日期：1993-11-02 00:00:00

abstract：:Recently the existence of a neurotensin striatonigral pathway strongly up-regulated by methamphetamine has been demonstrated. The aim of the present study was to investigate, using immunohistochemistry and radioimmunoassay, the modulation of this pathway by dopamine antagonists. Rats were injected either with methamph...

journal_title：European journal of pharmacology

authors： Castel MN,Morino P,Nylander I,Terenius L,Hökfelt T

更新日期：1994-09-01 00:00:00

abstract：:In our previous study, it was found that linoleoyl ethanolamide (LE) is present in sake lees, which are produced as a byproduct during the making of Japanese sake. LE is a fatty acid ethanolamide, which have been demonstrated to exert a variety of biological functions, and in this study, the anti-inflammatory effects ...

journal_title：European journal of pharmacology

authors： Ishida T,Nishiumi S,Tanahashi T,Yamasaki A,Yamazaki A,Akashi T,Miki I,Kondo Y,Inoue J,Kawauchi S,Azuma T,Yoshida M,Mizuno S

更新日期：2013-01-15 00:00:00

abstract：:Several reports suggest that enteric cholinergic neurons are subject to a tonic inhibitory modulation, whereas few studies are available concerning the role of facilitatory pathways. Glutamate, the main excitatory neurotransmitter in the central nervous system (CNS), has recently been described as an excitatory neurot...

journal_title：European journal of pharmacology

authors： Giaroni C,Zanetti E,Chiaravalli AM,Albarello L,Dominioni L,Capella C,Lecchini S,Frigo G

更新日期：2003-08-22 00:00:00