Abstract:
:The present study was undertaken to investigate whether gap junctional communication could be involved in morphine-induced antinociceptive response using blockers of the gap junctional channel, carbenoxolone and Gap27. Intrathecal pretreatment with either carbenoxolone or Gap27 caused a dose-dependent attenuation of morphine-induced antinociception. Furthermore, the dose-response line for morphine-induced antinociception was shifted to the right by 2.53-fold following intrathecal treatment with carbenoxolone. These findings suggest that gap-junctional-dependent communication in the mouse spinal cord may play, at least in part, a role in the expression of morphine-induced antinociception.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Suzuki M,Narita M,Nakamura A,Suzuki Tdoi
10.1016/j.ejphar.2006.01.038keywords:
subject
Has Abstractpub_date
2006-03-27 00:00:00pages
169-71issue
1-3eissn
0014-2999issn
1879-0712pii
S0014-2999(06)00067-7journal_volume
535pub_type
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