Trans-ACPD inhibits cAMP formation via a pertussis toxin-sensitive G-protein.

abstract：:In the guinea-pig ileum, both sarafotoxin S6c and IRL1620 (Suc-[Glu9,Ala11,15]endothelin-1-(8-21) induced a concentration-dependent biphasic effect (relaxation and contraction), but distinct tachyphylaxis of the tissue. Cross-tachyphylaxis and additivity experiments evidenced distinct receptors for these agonists. BQ-...

journal_title：European journal of pharmacology

authors： Miasiro N,Karaki H,Matsuda Y,Paiva AC,Rae GA

更新日期：1999-03-19 00:00:00

abstract：:Stimulation of [35S]GTPgammaS binding by serotonin (5-hydroxytryptamine, 5-HT) receptor ligands was characterized in rat hippocampal membranes. The optimized assay contained 30-50 microg protein, 300 microM GDP and 0.1 nM [35S]GTPgammaS, incubated at 37 degrees C for 20 min. At 10 microM, the 5-HT1A receptor agonist R...

journal_title：European journal of pharmacology

authors： Alper RH,Nelson DL

更新日期：1998-02-19 00:00:00

abstract：:Osthole is a coumarin extracted from Cnidium monnieri (L.) Cusson. The medicinal plant is widely used in Vietnamese as well as Chinese traditional medicine as a vasodilating and antihypertensive agent. Here we have tested the proposition that the block of Ca(v)1.2 channels is mainly responsible for its vascular activi...

journal_title：European journal of pharmacology

authors： Fusi F,Sgaragli G,Ha le M,Cuong NM,Saponara S

更新日期：2012-04-05 00:00:00

abstract：:Recently published studies have suggested that behavioral and neurochemical changes induced by selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors are potentiated by coadministration of a 5-HT1A receptor antagonist. The potentiating effect is hypothesized to be due to antagonism of somatodendritic 5-HT...

journal_title：European journal of pharmacology

authors： Sànchez C

更新日期：1997-09-10 00:00:00

abstract：:Acetylshikonin, a naphthoquinone isolated from the Chinese herb medicine, tzu ts'ao, was demonstrated to inhibit the polymyxin B-induced hind-paw edema in normal as well as in adrenalectomized mice. Liver glycogen content was increased in adrenalectomized mice pretreated with dexamethasone, but not with acetylshikonin...

journal_title：European journal of pharmacology

authors： Wang JP,Raung SL,Chang LC,Kuo SC

更新日期：1995-01-05 00:00:00

abstract：:The influence of degradation by peptidases on concentration-response relationships for peptide agonists of the tachykinin and bombesin-like families was investigated. The combined presence of three peptidase inhibitors, phosphoramidon (1 microM), captopril (1 microM) and bestatin (100 microM), had no significant effec...

journal_title：European journal of pharmacology

authors： Hall JM,Fox AJ,Morton IK

更新日期：1990-02-06 00:00:00

abstract：:A single electroconvulsive shock produced analgesia (expressed as prolongation of hot-plate latency) in Wistar rats 45 min after the shock. The analgesic action was prevented by administration of nifedipine, 5 mg/kg i.p., 15 min before the electroconvulsive shock, while nifedipine injection after electroconvulsive sho...

journal_title：European journal of pharmacology

authors： Antkiewicz-Michaluk L,Michaluk J,Vetulani J

更新日期：1994-03-11 00:00:00

abstract：:The possibility of a role of hypothalamic growth hormone (GH)-releasing factor (GRF) in GH secretion induced by centrally administered galanin was investigated in freely moving male rats. Intracerebroventricular (i.c.v.) injection of synthetic galanin (0.4 or 2 micrograms/rat) elicited a dose-related increase in plasm...

journal_title：European journal of pharmacology

authors： Murakami Y,Kato Y,Koshiyama H,Inoue T,Yanaihara N,Imura H

更新日期：1987-04-29 00:00:00

abstract：:The cerebellum receives indolaminergic fibers influencing Purkinje cell discharges. Data from our laboratories have demonstrated an endogenous release of serotonin (5-HT) and a Na(+)-dependent uptake and Ca(2+)-dependent release of [3H]5-HT from slices, homogenates and synaptosomal fractions of the rat cerebellar mole...

journal_title：European journal of pharmacology

authors： Beas-Zárate C,Morales-Villagran A,Tapia-Arizmendi G,Feria-Velasco A

更新日期：1991-05-30 00:00:00

abstract：:Attempts were made to find whether [3H]batrachotoxinin A 20-alpha-benzoate provides a specific probe for measuring interactions of local anesthetics with the sodium channel complex. [3H]Batrachotoxinin A 20-alpha-benzoate binding, [14C]guanidine and 22Na uptake were investigated in rat brain crude synaptosomal prepara...

journal_title：European journal of pharmacology

authors： Pauwels PJ,Leysen JE,Laduron PM

更新日期：1986-05-27 00:00:00

abstract：:Endogenous hydrogen sulfide is produced by cystathionine-γ-lyase and cystathionine-β-synthase in a variety of tissues and has recently been implicated in the regulation of cardiac functions. Acceleration of the heart rate in response to catecholamines is impaired in patients with cirrhosis. The present study was aimed...

journal_title：European journal of pharmacology

authors： Babaei-Karamshahlou M,Hooshmand B,Hajizadeh S,Mani AR

更新日期：2012-12-05 00:00:00

abstract：:The novel antiepileptic and neuroprotective drug felbamate (1 mM) caused a marked inhibition of voltage-dependent Na+ currents expressed in Xenopus oocytes upon injection of the cRNA encoding alpha-subunits from rat and human brain. This inhibition was present only if felbamate was perfused on the intracellular side o...

journal_title：European journal of pharmacology

authors： Taglialatela M,Ongini E,Brown AM,Di Renzo G,Annunziato L

更新日期：1996-12-05 00:00:00

abstract：:As there are significant amounts of functional endothelin receptors in the mammalian urinary tract, we examined the effect of experimental diabetes on the expression of endothelin receptors and their mRNAs in the rat bladder dome. The density of endothelin receptors in the rat bladder dome was higher (8 and 16 weeks f...

journal_title：European journal of pharmacology

authors： Saito M,Wada Y,Ikeda K,Wang Z,Smith SD,Foster HE,Nishi K,Weiss RM,Latifpour J

更新日期：2000-01-17 00:00:00

abstract：:Membrane preparations of guinea-pig lung (containing multiple muscarinic receptor subtypes) and heart (containing M2 receptors only) were incubated with either neuraminidase, parainfluenza virus (which contains neuraminidase), or virus plus 2,3-dehydro-2-deoxy-N-acetylneuraminic acid, a neuraminidase inhibitor. None o...

journal_title：European journal of pharmacology

authors： Fryer AD,el-Fakahany EE,Jacoby DB

更新日期：1990-05-31 00:00:00

abstract：:Large doses of dexamphetamine, methylamphetamine and MPTP failed to induce the formation of 6-hydroxydopamine (6-OHDA) in rat striatum. The potent dopamine (DA) releasing actions of these drugs and of the MPTP metabolite MPP+ were shown by intracerebral dialysis of DA in conscious rats but 6-OHDA was not detectable in...

journal_title：European journal of pharmacology

authors： Rollema H,De Vries JB,Westerink BH,Van Putten FM,Horn AS

更新日期：1986-12-02 00:00:00

abstract：:The increase in blood clotting factor VIII (antihaemophilic factor, F-VIII) and fibrinolytic activity induced by the administration of neurohypophyseal hormone analogues, was assayed in sheep. Peptides with high selectivity for vasopressin V1, V2 or myometrial oxytocin receptors in the dose range of 0.1-10 micrograms/...

journal_title：European journal of pharmacology

authors： Neuenschwander S,Pliska V

更新日期：1997-04-04 00:00:00

abstract：:Cytotrienin A, a member of the triene-ansamycin family, was initially identified to be an inducer of apoptosis and recently shown to be an inhibitor of translation that interferes with eukaryotic elongation factor 1A function. In human lung carcinoma A549 cells, cytotrienin A was found to inhibit more strongly the cel...

journal_title：European journal of pharmacology

authors： Yamada Y,Taketani S,Osada H,Kataoka T

更新日期：2011-09-30 00:00:00

abstract：:Diphenylhydantoin (DPH) is known to be a potent anticonvulsant agent, useful in treating and preventing grand mal seizures. More recently, DPH was reported also to be a potent antiarrhythmic agent acting by means of a depressant action on the heart. The present experiments demonstrated that DPH has also a potent antia...

journal_title：European journal of pharmacology

authors： Lisander B,Jaju B,Wang SC

更新日期：1975-03-01 00:00:00

abstract：:In the present study, the role of reactive oxygen species and the contribution of antioxidant defence in the time course of changes in acetylcholine-stimulated endothelium-dependent and sodium nitroprusside-stimulated endothelium-independent relaxation were investigated in aortic rings isolated from 6-month streptozot...

journal_title：European journal of pharmacology

authors： Karasu C

更新日期：2000-03-31 00:00:00

abstract：:Icariin is a major active component of the traditional herb Epimedium, also known as Horny Goat Weed. It has been extensively studied throughout the past several years and is known to exert anti-oxidative, anti-neuroinflammatory, and anti-apoptotic effects. It is now being considered as a potential therapeutic agent f...

journal_title：European journal of pharmacology

authors： Jin J,Wang H,Hua X,Chen D,Huang C,Chen Z

更新日期：2019-01-05 00:00:00

abstract：:Endogenous cannabinoid ligands and cannabinoid CB(1) receptor agonists have been shown to exert potent anticonvulsant effects in various experimental models of epilepsy. The purpose of this study was to determine the effects of arachidonyl-2'-chloroethylamide (ACEA; N-(2-chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide, ...

journal_title：European journal of pharmacology

authors： Luszczki JJ,Czuczwar P,Cioczek-Czuczwar A,Czuczwar SJ

更新日期：2006-10-10 00:00:00

abstract：:Binding sites for the sigma ligand [3H]di-o-tollylguanidine ([3H]DTG) have been reported to be altered in the brains of genetically dystonic rats. In the present study, selective sigma 1 and sigma 2 assay conditions were utilized in an effort to define which subpopulation of [3H]DTG binding sites is altered in the dys...

journal_title：European journal of pharmacology

authors： Weissman AD,McCann DJ,Lorden JF,Su TP

更新日期：1993-12-07 00:00:00

abstract：:Conscious guinea-pigs received platelet activating factor (PAF, 0.03-0.25 microgram/kg, i.v.) and colloidal carbon (C, tracer for microvascular leakage). Fifteen min later the animal was killed and C-labelled microvessels (leakage) were detected in the mucosal/submucosal region of tracheal and bronchial sections. PAF ...

journal_title：European journal of pharmacology

authors： O'Donnell SR,Barnett CJ

更新日期：1987-06-26 00:00:00

abstract：:[123I]Iodobenzofuran ([123I]IBF) is a new single photon emission computed tomography (SPECT) tracer for visualization of the dopamine D2 receptors. A tracer constant infusion paradigm was developed to measure the binding potential, density (Bmax) and affinity (KD) of the dopamine D2 receptor in baboons. Three baboons ...

journal_title：European journal of pharmacology

authors： Laruelle M,al-Tikriti MS,Zea-Ponce Y,Zoghbi SS,Baldwin RM,Charney DS,Hoffer PB,Kung HF,Innis RB

更新日期：1994-09-22 00:00:00

abstract：:Thiazolidinedione and isoxazolidinedione insulin sensitizers activate peroxisome proliferator-activated receptor gamma (PPAR gamma). Some thiazolidinediones modify ion channels in smooth muscles; however, the mechanism by which their actions occur has not been clarified. We, thus, examined the effects of three thiazol...

journal_title：European journal of pharmacology

authors： Eto K,Ohya Y,Nakamura Y,Abe I,Fujishima M

更新日期：2001-06-29 00:00:00

abstract：:Morphine and aspartic acid were administered separately and in combination to 80 rats divided into 8 groups. Ten and 20 min following the injections, brain, liver and kidney L-asparaginase activity was determined. Morphine decreased brain and liver L-asparaginase activity and increased that of kidney. Aspartic acid co...

journal_title：European journal of pharmacology

authors： Koyuncuoğlu H,Keyer-Uysal M,Berkman K,Güngör M,Genç EM

更新日期：1979-12-20 00:00:00

abstract：:Observations of sigma (sigma) receptor heterogeneity have prompted interest in identifying ligands for sigma receptor subtypes. Selective ligands for the sigma-2 are unavailable, but [3H]ifenprodil labels sigma-2 sites. Therefore, isomers and analogues of ifenprodil were compared as potential sigma-2 ligands. Threo-if...

journal_title：European journal of pharmacology

authors： Hashimoto K,London ED

更新日期：1995-02-06 00:00:00

abstract：:The aim of this study was to investigate the contribution of the Na(+)/H(+) exchanger to cerebral ischemia using SM-20220 (N-(aminoiminomethyl)-1-methyl-1H-indole-2-carboxamide methanesulfonate), a newly synthesized compound. In in vitro experiments, we evaluated the inhibitory effect of SM-20220 on the Na(+)/H(+) exc...

journal_title：European journal of pharmacology

authors： Kuribayashi Y,Itoh N,Kitano M,Ohashi N

更新日期：1999-10-27 00:00:00

abstract：:In bovine aortic endothelial cells (BAEC), pertussis toxin (PTx) ADP-ribosylated two major substrates with apparent molecular masses of 40 and 41 kDa, whereas cholera toxin (CTx) ADP-ribosylated two other substrates of 44 and 50 kDa. [alpha-32P]GTP bound to three bands in the 22-27 kDa range. Immunoblot analysis revea...

journal_title：European journal of pharmacology

authors： Gil-Longo J,Dufour MN,Guillon G,Lugnier C

更新日期：1993-10-15 00:00:00

abstract：:Platycodi Radix is the root of Platycodon grandiflorum and it is widely used in the traditional Oriental medicine as an expectorant for pulmonary diseases and a remedy for respiratory disorders. Platycodin D is the major constituent of triterpene saponins in the root. This study investigates apoptosis by platycodin D ...

journal_title：European journal of pharmacology

authors： Ahn KS,Hahn BS,Kwack K,Lee EB,Kim YS

更新日期：2006-05-10 00:00:00