Abstract：
:As there are significant amounts of functional endothelin receptors in the mammalian urinary tract, we examined the effect of experimental diabetes on the expression of endothelin receptors and their mRNAs in the rat bladder dome. The density of endothelin receptors in the rat bladder dome was higher (8 and 16 weeks following the onset of diabetes) than in age-matched controls. Insulin treatment, started 8 weeks after the induction of diabetes, partially reversed the endothelin receptor alterations. The pharmacological profile of the endothelin receptors in the bladder dome was similar in all groups and was consistent with the predominance of the endothelin ET(A) receptor subtype (ET(A):ET(B)=approximately 4:1). Autoradiographic studies demonstrated that the endothelin receptors were located in all tissue components of the bladder, including epithelial and muscular layers. Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) data indicated that diabetes increased the expression level of gene transcripts for both endothelin receptor subtypes and that insulin treatment reversed the mRNA upregulation.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Saito M,Wada Y,Ikeda K,Wang Z,Smith SD,Foster HE,Nishi K,Weiss RM,Latifpour Jdoi
10.1016/s0014-2999(99)00753-0keywords:
subject
Has Abstractpub_date
2000-01-17 00:00:00pages
253-63issue
3eissn
0014-2999issn
1879-0712pii
S0014299999007530journal_volume
387pub_type
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journal_title：European journal of pharmacology
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abstract：:Posttraumatic nerve recovery remains a challenge in regenerative medicine. As such, there is a need for agents that limit nerve damage and enhance nerve regeneration. Here we investigate rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase inhibitor, with anti-inflammatory and antioxidant properties...
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journal_title：European journal of pharmacology
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