当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect.

Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect.

Abstract：

:Prolactin blood level and apomorphine-induced yawning were studied in rats treated with the substituted benzamide amisulpride in association with bromocriptine or carmoxirole; two dopamine D(2) receptor agonists with high or low propensity to cross the brain-blood barrier, respectively. Administration of amisulpride produced a maximum increase in rat serum prolactin level (315+/-18%) vs. vehicle-treated animals (ED(50)=0.25+/-0.017 mg/kg, s.c.). The concurrent administration of carmoxirole or bromocriptine completely reversed the hyperprolactinemia induced by amisulpride (0.5 mg/kg, s.c.) (ID(50)=14.9+/-0.8 mg/kg and 0.81+/-0.03 mg/kg, respectively). Carmoxirole (15 mg/kg, i.p.) did not affect yawning induced by apomorphine (0.08 mg/kg, s.c.) nor amisulpride (0.5 mg/kg, s.c.) blockade of apomorphine-induced yawning. Conversely, a significant increase in the number of yawns was observed when bromocriptine (0.8 mg/kg, i.p.) was associated with apomorphine in the absence or presence of amisulpride. These results suggested that a peripheral dopamine D(2) receptor agonists could be a useful tool in alleviating amisulpride-induced hyperprolactinemia without possibly affecting its central effect.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Marchese G,Ruiu S,Casti P,Bartholini F,Saba P,Gessa GL,Pani L

doi

10.1016/s0014-2999(02)01896-4

keywords:

subject

Has Abstract

pub_date

2002-06-28 00:00:00

pages

109-14

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014299902018964

journal_volume

447

pub_type

杂志文章

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