BHT-920 and LY-171555 (quinpirole) have similar affinities for striatal D-2 dopamine receptors, and similar affinities for striatal D-1 dopamine receptors.

abstract：:Some conopeptides derived from cone snails act on specific subunits of the NMDA receptor and thus, exert an influence on the dopamine system. In this study, one such conopeptide, conantokin G, was administered i.c.v. in conjunction with methamphetamine, a potent central nervous system stimulant known to cause dopamine...

journal_title：European journal of pharmacology

authors： Bush L,McCabe T,Hanson GR

更新日期：2000-01-03 00:00:00

abstract：:MK-801 (a potent non-competitive antagonist of N-methyl-D-aspartic acid-mediated events) in subcutaneous doses of 0.1 and 0.2 mg/kg increased the threshold for electroconvulsions and in doses of 0.0031 and 0.0125 mg/kg enhanced the protective activity of valproate against maximal electroshock-induced convulsions in mi...

journal_title：European journal of pharmacology

authors： Urbańska E,Dziki M,Kleinrok Z,Czuczwar SJ,Turski WA

更新日期：1991-08-06 00:00:00

abstract：:The antinociceptive profile of selected histamine H(2) and histamine H(3) receptor antagonists led to the discovery of improgan, a non-brain-penetrating analgesic agent which does not act on known histamine receptors. Because no chemical congener of improgan has yet been discovered which has both antinociceptive and b...

journal_title：European journal of pharmacology

authors： Hough LB,Nalwalk JW,Lu Q,Shan Z,Svokos K,Wentland MP,Montero MJ

更新日期：2005-10-17 00:00:00

abstract：:Calsequestrin (CASQ) is a major Ca(2+) storage protein within the sarcoplasmic reticulum (SR) of both cardiac and skeletal muscles. CASQ reportedly acts as a Ca(2+) buffer and Ca(2+)-channel regulator through its unique Ca(2+)-dependent oligomerization, maintaining the free Ca(2+) concentration at a low level (0.5-1mM...

journal_title：European journal of pharmacology

authors： Kang C,Nissen MS,Sanchez EJ,Lam KS,Milting H

更新日期：2010-11-10 00:00:00

abstract：:The present study has examined the functional activity of the 5-HT1D receptor agonist, sumatriptan, and antagonists, GR127935 (2'-methyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-carboxyl ic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide), GR55562 (3-[3-(dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridiny...

journal_title：European journal of pharmacology

authors： Walsh DM,Beattie DT,Connor HE

更新日期：1995-12-04 00:00:00

abstract：:The displacement of [3H]flunitrazepam by unlabelled flunitrazepam or zolpidem was used to assess the affinity and density of sub-types of GABA(A) receptors in the superior frontal and primary motor cortices of ten alcoholic, seven alcoholic-cirrhotic and ten matched control cases. The binding was best fitted by a mode...

journal_title：European journal of pharmacology

authors： Lewohl JM,Crane DI,Dodd PR

更新日期：1997-05-20 00:00:00

abstract：:The ability of isoproterenol to relax guinea-pig trachea was examined in tissues precontracted with three concentrations of methacholine or three corresponding equieffective concentrations of leukotriene D4. Although increasing the concentration of either contractile agent progressively shifted isoproterenol concentra...

journal_title：European journal of pharmacology

authors： Torphy TJ

更新日期：1984-07-20 00:00:00

abstract：:The effects of alpha 2-adrenoceptor and GABA receptor agonists on citric acid-induced cough and increased tidal volume were investigated in conscious guinea pigs. Inhalation of low doses of B-HT 920 (5-allyl-2-amino 5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine dihydrochloride), and xylazine significantly inhibited cit...

journal_title：European journal of pharmacology

authors： Callaway JK,King RG

更新日期：1992-09-22 00:00:00

abstract：:It has been shown that α(2)-adrenoceptors mediate vasopressor responses in pithed rats. However, the corresponding α(2)-adrenoceptor subtypes have not been pharmacologically identified. Thus, this study set out to identify the specific subtypes (α(2A), α(2B) and α(2C)) mediating the vasopressor responses to the α(2)-a...

journal_title：European journal of pharmacology

authors： Villamil-Hernández MT,Alcántara-Vázquez O,Sánchez-López A,Manrique-Maldonado G,Villalón CM,Centurión D

更新日期：2012-09-15 00:00:00

abstract：:Fat tissue plays an important role in the regulation of inflammatory processes. Increased visceral fat has been associated with a higher production of cytokines that triggers a low-grade inflammatory response, which eventually may contribute to the development of insulin resistance. In the present study, we investigat...

journal_title：European journal of pharmacology

authors： Alarcon-Aguilar FJ,Almanza-Perez J,Blancas G,Angeles S,Garcia-Macedo R,Roman R,Cruz M

更新日期：2008-12-03 00:00:00

abstract：:Two experiments were designed to elucidate the involvement of the hypothalamic-pituitary-adrenal axis and the 5-hydroxytryptamine (5-HT) system in the acquisition of lithium chloride-conditioned taste aversion. In Experiment 1, rats were administered either vehicle or 50 mg/kg nefazodone daily for 4 weeks. Rats were t...

journal_title：European journal of pharmacology

authors： Gorzalka B,Hanson L,Harrington J,Killam S,Campbell-Meiklejohn D

更新日期：2003-06-20 00:00:00

abstract：:The effects of MP 518, an acylated 2-chlorobenzylidene hydrazidone derivative with antihypertensive properties were investigated on the Ca current, ICa, recorded under whole-cell patch-clamp in single frog ventricular cells. MP 518 (1-100 microM) had no effect on ICa under control conditions. However, at 10 microM it ...

journal_title：European journal of pharmacology

authors： Scamps F,Tran G,Rinjard P,Binet P,Miocque M,Vassort G

更新日期：1993-01-15 00:00:00

abstract：:Alterations in iron homeostasis are well described in obese patients. The effects of iron chelators on adipose tissue and other organs affected by obesity have been the interest of experimental studies, both in vivo and in vitro. The aim of this review was to update the available information indicating the potential o...

journal_title：European journal of pharmacology

authors： Rodrigues de Morais T,Gambero A

更新日期：2019-10-15 00:00:00

abstract：:Changes in autonomic receptor systems (alpha- and beta-adrenoceptors and muscarinic receptors) were compared in the aging and failing human heart. In both settings responsiveness of beta-adrenoceptors and all other receptor systems that evoke their effects via cyclic AMP accumulation was diminished. Muscarinic recepto...

journal_title：European journal of pharmacology

authors： Brodde OE,Leineweber K

更新日期：2004-10-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a multifactorial autoimmune disease that develops as a consequence of macrophage- and T cell-dependent pancreatic β-cell death. Multiple approaches for induction of anti-inflammatory/regulatory mechanisms that would attenuate T1D have been utilized, with little or no beneficial effects. To ach...

journal_title：European journal of pharmacology

authors： Koprivica I,Gajic D,Saksida T,Cavalli E,Auci D,Despotovic S,Pejnovic N,Stosic-Grujicic S,Nicoletti F,Stojanovic I

更新日期：2019-12-01 00:00:00

abstract：:Extracellular fluid levels of excitatory amino acids (glutamate, Glu; and aspartate, Asp) in the locus coeruleus and the behavioral signs during naloxone-precipitated withdrawal from kappa-opioid receptor agonists, butorphanol and (5 alpha, 7 alpha, 8 beta) -(+)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4,5]dec-8-yl]-...

journal_title：European journal of pharmacology

authors： Hoshi K,Ma T,Ho IK

更新日期：1996-10-31 00:00:00

abstract：:In the attempt to find a pharmacological treatment for the spasm of the internal anal sphincter, usually associated with anal fissures, the activity of caerulein on human internal and sphincter was investigated in vitro and in vivo. In the isolated distal part of the internal and sphincter, caerulein (0.61 microM) dep...

journal_title：European journal of pharmacology

authors： Carpenedo F,Infantino A,Floreani M,Dodi G

更新日期：1983-02-18 00:00:00

abstract：:Phenoxybenzamine greatly attenuated phenylephrine-induced contractions of dog saphenous vein in vitro, but had less effect on contractions induced by clonidine. The phenoxybenzamine-resistant responses to clonidine were not affected by prazosin or by corynanthine but were competitively antagonized by yohimbine (pA2 8....

journal_title：European journal of pharmacology

authors： Constantine JW,Lebel W,Archer R

更新日期：1982-12-03 00:00:00

abstract：:Previously, we demonstrated the enhanced affinity of opioid receptors for naloxone in striatal slices from morphine-dependent mice. In our present study, binding characteristics of the mu opioid receptor agonists, [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAMGO) and dihydromorphine, the delta opioid receptor agonist, [D-Ala2...

journal_title：European journal of pharmacology

authors： Abdelhamid EE,Takemori AE

更新日期：1991-06-06 00:00:00

abstract：:Topiramate [2,3:4, 5-bis-O-(1-methyl-ethylidene-)-beta-D-fructopyranose sulfamate], administered intraperitoneally (i.p.) up to 5 mg/kg, did not influence the threshold for electroconvulsions. In doses of 10-30 mg/kg, topiramate significantly raised the threshold. This novel antiepileptic drug, in subprotective doses,...

journal_title：European journal of pharmacology

authors： Swiader M,Kotowski J,Gasior M,Kleinrok Z,Czuczwar SJ

更新日期：2000-06-30 00:00:00

abstract：:Baicalein was a major bioactive flavonoid derived from Radix Scutellariae in Xiao-Chai-Hu-Tang which was commonly used to treat chronic hepatitis and liver fibrosis in China. The aim of this study was to assess whether chronic baicalein administration could prevent liver fibrosis induced by carbon tetrachloride (CCl(4...

journal_title：European journal of pharmacology

authors： Sun H,Che QM,Zhao X,Pu XP

更新日期：2010-04-10 00:00:00

abstract：:It has been reported that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) can modulate opioid tolerance via its action on learning and memory. In this study, we examine if CaMKII can directly affect opioid tolerance. We found that spinal CaMKII activity was increased in rats tolerant to morphine. In these rats,...

journal_title：European journal of pharmacology

authors： Wang ZJ,Tang L,Xin L

更新日期：2003-03-28 00:00:00

abstract：:Protamine is the only agent approved to reverse heparin-induced anticoagulation. Due to the significant adverse effects of protamine there is an important need for an alternative agent with an improved safety profile. The pharmacodynamics of PM102, a novel peptide-based heparin antagonist, was evaluated and compared t...

journal_title：European journal of pharmacology

authors： Cushing DJ,Cooper WD,Cohen ML,McVoy JR,Sobel M,Harris RB

更新日期：2010-06-10 00:00:00

abstract：:Vasopressin ([Arg(8)]vasopressin)-induced contraction was characterized using receptor agonists and antagonists for vasopressin and channel blockers in the rat basilar artery ring preparations. Vasopressin induced rhythmic contractions superimposed on a contraction in endothelium-intact preparations but not in denuded...

journal_title：European journal of pharmacology

authors： Katori E,Ohta T,Nakazato Y,Ito S

更新日期：2001-03-23 00:00:00

abstract：:Little research has been conducted investigating the long-term impact of opioid exposure during adolescence. These experiments were conducted to determine the behavioral effects of morphine exposure during periadolescence (postnatal days 30-32) versus young adulthood (postnatal days 65-67) on subsequent sensitivity to...

journal_title：European journal of pharmacology

authors： White DA,Holtzman SG

更新日期：2005-12-28 00:00:00

abstract：:Cats were treated for 35 days with flurazepam, 5 mg/kg per day. The drug was administered through a gastric fistula. Ro15-1788, a benzodiazepine antagonist, caused an abstinence syndrome when administered through the gastric fistula 24 h after the last dose of chronic treatment. Abstinence signs included increased mus...

journal_title：European journal of pharmacology

authors： Rosenberg HC,Chiu TH

更新日期：1982-06-16 00:00:00

abstract：:A specific binding site for the antiepileptic drug levetiracetam (2S-(oxo-1-pyrrolidinyl)butanamide, Keppra) in rat brain, referred to as the levetiracetam binding site, was discovered several years ago. More recently, this binding site has been identified as the synaptic vesicle protein 2A (SV2A), a protein present i...

journal_title：European journal of pharmacology

authors： Gillard M,Chatelain P,Fuks B

更新日期：2006-04-24 00:00:00

abstract：:We investigated the role of interleukin-1 in the induction of a Ca(2+)-independent nitric oxide (NO) synthase by bacterial endotoxin in vivo. In anaesthetized rats, pretreatment with interleukin-1 receptor antagonist (interleukin-1ra; 16 mg kg-1 i.v., followed by an infusion of 2.4 mg kg-1 h-1) ameliorated the delayed...

journal_title：European journal of pharmacology

authors： Szabó C,Wu CC,Gross SS,Thiemermann C,Vane JR

更新日期：1993-11-30 00:00:00

abstract：:Restraint for 1 h induced significant antinociceptive activity, as assessed by the hot plate test, in female mice. The antinociceptive activity was significant throughout the 1 h period of observation starting immediately after restraint. Prior administration of the histamine H2 receptor agonist dimaprit (1.5-6.0 mg/k...

journal_title：European journal of pharmacology

authors： Wong CL

更新日期：1995-06-12 00:00:00

abstract：:Heparin is a natural polymer widely used in medicine especially during the treatment of cardiovascular diseases since it is a potent blood anticoagulant. In case of emergency, e.g., massive hemorrhage, the anticoagulant activity of heparin has to be quickly stopped by the administration of a heparin reversing agent. C...

journal_title：European journal of pharmacology

authors： Kalaska B,Sokolowska E,Kaminski K,Szczubialka K,Kramkowski K,Mogielnicki A,Nowakowska M,Buczko W

更新日期：2012-07-05 00:00:00