Differential relaxant effects of isoproterenol on methacholine- versus leukotriene D4-induced contraction in the guinea-pig trachea.

abstract：:The effects of histamine H(1) receptor antagonists (promethazine, diphenhydramine, chlorphenilamine and triprolidine) on hippocampal theta rhythm during eight-arm radial maze performance were investigated using rats. Promethazine showed a significant increase in the number of total errors and working memory errors at ...

journal_title：European journal of pharmacology

authors： Masuoka T,Mikami A,Yasuda M,Shinomiya K,Kamei C

更新日期：2007-12-08 00:00:00

abstract：:In the isolated perfused guinea-pig heart low-pH buffer (pH 5), lactic acid (5 mM), capsaicin (10(-7) M) and nicotine (10(-4) M) all evoked a clear-cut release of calcitonin gene-related peptide (CGRP) from sensory nerves. Incubation with the proposed capsaicin receptor antagonist, capsazepine (10(-5) M), significantl...

journal_title：European journal of pharmacology

authors： Franco-Cereceda A,Lundberg JM

更新日期：1992-10-06 00:00:00

abstract：:Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization o...

journal_title：European journal of pharmacology

authors： Potter PE,White TD

更新日期：1982-05-07 00:00:00

abstract：:Adjuvant-induced arthritis is associated with body weight loss and decreased pituitary growth hormone (GH) and hepatic insulin-like growth factor-I (IGF-I) synthesis. Cytokines as tumor necrosis factor (TNF) mediate wasting associated with chronic inflammation. The aim of this study was to analyse whether the inhibiti...

journal_title：European journal of pharmacology

authors： Granado M,Priego T,Martín AI,Vara E,López-Calderón A,Angeles Villanúa M

更新日期：2006-04-24 00:00:00

abstract：:Binding sites for the sigma ligand [3H]di-o-tollylguanidine ([3H]DTG) have been reported to be altered in the brains of genetically dystonic rats. In the present study, selective sigma 1 and sigma 2 assay conditions were utilized in an effort to define which subpopulation of [3H]DTG binding sites is altered in the dys...

journal_title：European journal of pharmacology

authors： Weissman AD,McCann DJ,Lorden JF,Su TP

更新日期：1993-12-07 00:00:00

abstract：:In the present study we examined the effect of the cannabinoid receptor agonist, [[1 a,2-(R)-5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyc lohexyl]-phenol; CP 55,940] on [14C]acetylcholine and [3H]norepinephrine release from hippocampal slices and on [14C]acetylcholine release from striatal slices. CP 55,...

journal_title：European journal of pharmacology

authors： Gifford AN,Samiian L,Gatley SJ,Ashby CR Jr

更新日期：1997-04-18 00:00:00

abstract：:We examined the effects of taurine on levels of low-density lipoprotein (LDL) cholesterol and glucose, and an endothelium-dependent relaxation in response to acetylcholine in cholesterol-fed or streptozotocin-induced diabetic mice. The acetylcholine-induced concentration-dependent relaxation was significantly attenuat...

journal_title：European journal of pharmacology

authors： Kamata K,Sugiura M,Kojima S,Kasuya Y

更新日期：1996-05-06 00:00:00

abstract：:Pulmonary arterial remodeling is a crucial cause of increased pulmonary artery pressure during pulmonary hypertension (PH). Recently, growing evidence has upheld the contribution of endothelial-mesenchymal transition (EndMT) to pulmonary arterial remodeling, but the underlying mechanisms remain largely unaddressed. mi...

journal_title：European journal of pharmacology

authors： Liu T,Zou XZ,Huang N,Ge XY,Yao MZ,Liu H,Zhang Z,Hu CP

更新日期：2019-11-15 00:00:00

abstract：:Electrically stimulated release of [3H]dopamine [( 3H]DA) in slices of rat striatum was dose dependently inhibited by apomorphine (67% maximal inhibition) with an EC50 of 17 nM. DA receptor inactivation with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ; 0.5 and 2 mg/kg) dose dependently shifted the ED50 for ap...

journal_title：European journal of pharmacology

authors： Yokoo H,Goldstein M,Meller E

更新日期：1988-10-18 00:00:00

abstract：:This study investigated whether increased polyol pathway activity could contribute to alterations in nitrergic neurotransmission in anococcygeus muscles from 8-week diabetic rats. In the presence of guanethidine (10-30 microM) and clonidine (0.01-0.05 microM), relaxations obtained to nitrergic nerve stimulation (0.5-5...

journal_title：European journal of pharmacology

authors： Way KJ,Reid JJ

更新日期：1996-12-27 00:00:00

abstract：:Topoisomerase I (Top1) is the specific target of the anticancer drug camptothecin (CPT) that interferes with enzyme activity promoting Top1-mediated DNA breaks and inhibition of DNA and RNA synthesis. To define the specific transcriptional response to CPT, we have determined the CPT-altered transcription profiles in y...

journal_title：European journal of pharmacology

authors： Lotito L,Russo A,Bueno S,Chillemi G,Fogli MV,Capranico G

更新日期：2009-01-28 00:00:00

abstract：:The actions of carbachol were studied on the firing response of neostriatal neurons recorded intracellularly from in vitro slice preparations of the rat brain. Carbachol (1-10 microM) reversibly reduced the afterhyperpolarization in neostriatal neurons. This effect was accompanied by an increase in both firing frequen...

journal_title：European journal of pharmacology

authors： Pineda JC,Bargas J,Flores-Hernández J,Galarraga E

更新日期：1995-08-15 00:00:00

abstract：:Hydrogen sulfide (H2S) is a gaseous molecule and is endogenously produced in the brain by cystathionine beta-synthase, 3-mercaptopyruvate-sulfurtransferase, cysteine aminotransferase and cystathionine γ-lyase. Physiologically, H2S acts as a neuromodulator and regulates synaptic activity of neurons and glia to promote ...

journal_title：European journal of pharmacology

authors： He JT,Li H,Yang L,Mao CY

更新日期：2019-04-15 00:00:00

abstract：:Adrenomedullin is a peptide recently isolated from pheochromocytoma that has vasorelaxant and long-lasting hypotensive activities. Plasma levels of adrenomedullin are elevated in patients with congestive heart failure, but the effects of adrenomedullin on the cardiac function are unclear. We, thus, investigated the ef...

journal_title：European journal of pharmacology

authors： Ihara T,Ikeda U,Tate Y,Ishibashi S,Shimada K

更新日期：2000-02-25 00:00:00

abstract：:The object of the present paper was to investigate the in vivo pharmacological profile of the dihydropyridine neuropeptide Y Y(1) receptor antagonist 1,4-Dihydro-4-[3-[[[[3-[spiro(indene-4,1'-piperidin-1-yl)]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridine dicarboxylic acid, dimethylester (H 394/84). The ...

journal_title：European journal of pharmacology

authors： Malmström RE,Balmér KC,Weilitz J,Nordlander M,Sjölander M

更新日期：2001-04-20 00:00:00

abstract：:Quantitative characterization of the kappa opioid receptor in the rabbit ear artery was carried out using three kappa-selective agonist compounds, dynorphin-(1-13), U-69593 and ethylketocyclazocine. Kinetic analysis was performed using the antagonist, MR 2266. Two other in vitro preparations were studied for compariso...

journal_title：European journal of pharmacology

authors： Berzetei IP,Fong A,Yamamura HI,Duckles SP

更新日期：1988-07-14 00:00:00

abstract：:Many studies have demonstrated that cyclophosphamide (CPA) can affect hepatic cytochrome p450 (CYP) isoenzyme activity in animals. We have investigated the effect of CPA on gene expression of various CYP enzymes as well as beta-actin in the human acute promyelocytic leukemia cell line (HL-60S) and its multidrug-resist...

journal_title：European journal of pharmacology

authors： Xie HJ,Lundgren S,Broberg U,Finnström N,Rane A,Hassan M

更新日期：2002-08-09 00:00:00

abstract：:The neurotransmitter serotonin is an evolutionary ancient molecule that has remarkable modulatory effects in almost all central nervous system integrative functions, such as mood, anxiety, stress, aggression, feeding, cognition and sexual behavior. After giving a short outline of the serotonergic system (anatomy, rece...

journal_title：European journal of pharmacology

authors： Olivier B

更新日期：2015-04-15 00:00:00

abstract：:The purpose of this study was to delineate the distribution of beta-adrenoceptor density in the cat heart, with an emphasis on areas within the left ventricle. beta-Adrenoceptor densities, determined for hearts obtained from five cats, were not significantly different in the left and rights atria, i.e. 47.6 +/- 7.2 an...

journal_title：European journal of pharmacology

authors： Lathers CM,Levin RM,Spivey WH

更新日期：1986-10-14 00:00:00

abstract：:We have examined the motor responses to the dopamine D(3) receptor-preferring agonist, S(+)-(4aR,10bR)-3,4,4a, 10b-tetrahydro-4-propyl-2H,5H-1-benzopyranol[4,3-b]-1,4-oxazin+ ++-9-ol ((+)-PD128,907), by non-habituated male rats during postnatal development. (+)-PD128,907 (0.025 and 0.1 mg/kg) increased motor activity ...

journal_title：European journal of pharmacology

authors： Heijtz RD,Ogren SO,Fuxe K

更新日期：2000-03-24 00:00:00

abstract：:The effect of depletion of catecholamines by tyramine or reserpine on the bradykinin-induced relaxation of the rat duodenum aan rabbit ileum was the object of this study. The relaxation was not affected by catecholamine depletion due to repeated addition of tyramine to the isolated organs from either normal or reserpi...

journal_title：European journal of pharmacology

authors： Ufkes JG,Van der Meer C

更新日期：1975-08-01 00:00:00

abstract：:Recently, it has been shown that release of cytochrome c from the mitochondria to the cytosol is required for activation of the caspase-3-dependent cascade in apoptosis, and also for alpha-synuclein aggregation. In the present study, we examined the effects of talipexole and pramipexole on the release of cytochrome c ...

journal_title：European journal of pharmacology

authors： Kakimura J,Kitamura Y,Takata K,Kohno Y,Nomura Y,Taniguchi T

更新日期：2001-04-06 00:00:00

abstract：:Detailed antagonist competition curves for [3H]prazosin-labelled binding sites in rat cerebral cortex membranes reveal anomalous binding characteristics. Dihydroergocryptine and indoramine compete in a steep, monophasic manner while WB4101 and phentolamine exhibit shallow competition curves. Computer-assisted analysis...

journal_title：European journal of pharmacology

authors： Morrow AL,Battaglia G,Norman AB,Creese I

更新日期：1985-02-26 00:00:00

abstract：:The antiarrhythmic activity of amitriptyline, a tricyclic antidepressant, was evaluated in anesthetized dogs 24 h after coronary occlusion, during the period of spontaneous ventricular arrhythmias. In all experiments amitriptyline was administered i.v. in incremental doses of 0.3 mg/kg at 1 min intervals until a conve...

journal_title：European journal of pharmacology

authors： Wilkerson RD,Sanders PW

更新日期：1978-10-01 00:00:00

abstract：:The direct positive inotropic effect of histamine was studied on paced left atrial preparation from guinea pigs. Histamine (10(-8) to 10(-4) M) increased the maximum tension developed in left atria incubated at 35degreesC and driven at 2 Hz. The maximum increase in tension was 60% of that observed with norepinephrine....

journal_title：European journal of pharmacology

authors： Steinburg MI,Holland DR

更新日期：1975-11-01 00:00:00

abstract：:[(3)H]Granisetron binding to 5-HT(3) type serotonin receptors was examined in homogenates of rat forebrain and NG 108-15 cells. We have applied an allosteric model to 5-HT(3) receptor binding for the first time. Slope factors of displacement improved the modelling. Serotonin displaced [(3)H]granisetron binding with mi...

journal_title：European journal of pharmacology

authors： Maksay G,Bíró T,Bugovics G

更新日期：2005-05-02 00:00:00

abstract：:The experiments concerned the effect of ethacrynic acid (0.5 mM) on the adenosine triphosphate (ATP) content of rat mast cells and the effect on histamine release induced by the ionophore A23187 (10 microM). Ethacrynic acid decreased the ATP level of the cells in presence of antimycin A and glucose as well as in prese...

journal_title：European journal of pharmacology

authors： Johansen T

更新日期：1983-09-02 00:00:00

abstract：:In the present study, we investigated whether copper ions are involved in the decomposition of endogenous S-nitrosothiols by ultraviolet (UV) light irradiation in the mouse gastric fundus. The effects of copper ions and chelators of copper(I) and copper(II), neocuproine and cuprozine, respectively, were studied on rel...

journal_title：European journal of pharmacology

authors： Ogülener N,Ergün Y

更新日期：2004-02-06 00:00:00

abstract：:This study assessed the effect of an uncontrollable stressor on the preference for a palatable solution (sucrose 1%), and on the preference for a context associated with a single administration of D-amphetamine (3 mg/kg i.p.) by means of the conditioning place preference test. We also evaluated the effect of prior nal...

journal_title：European journal of pharmacology

authors： Zurita A,Murúa S,Molina V

更新日期：1996-03-28 00:00:00

abstract：:The involvement of a central mechanism in the antiemetic effect of AS-8112 ((R)-5-bromo-N-(1-ethyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridinecarboxamide x 2 fumarate), a novel and potent dopamine D2, D3, and 5-HT(3) receptor antagonist, was investigated in ferrets. Intracerebroventricul...

journal_title：European journal of pharmacology

authors： Yoshikawa T,Yoshida N,Oka M

更新日期：2001-11-23 00:00:00