The aldose reductase inhibitor sorbinil does not prevent the impairment in nitric oxide-mediated neurotransmission in anococcygeus muscle from diabetic rats.

abstract：:In this study, we examined the effects of Salvia miltiorrhiza (Danshen) crude extract, some of its lipid-soluble components (tanshinone I, tanshinone II(A), cryptotanshinone, dihydroisotanshinone I) and the water-soluble compounds (danshensu and salvianolic acid B) on the K(+) channels such as the iberiotoxin-sensitiv...

journal_title：European journal of pharmacology

authors： Lam FF,Seto SW,Kwan YW,Yeung JH,Chan P

更新日期：2006-09-28 00:00:00

abstract：:We have developed an isolated spinal cord-skin preparation of the newborn rat. The spinal cord together with a piece of skin connected to the cord by the saphenous nerve was isolated from 1- to 4-day-old rats and separately superfused with artificial cerebrospinal fluid in two neighbouring chambers. Potentials were re...

journal_title：European journal of pharmacology

authors： Yanagisawa M,Hosoki R,Otsuka M

更新日期：1992-09-22 00:00:00

abstract：:The specific, irreversible binding of [3H]beta-funaltrexamine (beta-FNA) to mu opioid receptors in slices from the corpus striatum and midbrain region containing the ventral tegmentum area (VTA) was accomplished by incubation with [3H]beta-FNA followed by a washing procedure with 1 microM unlabeled naltrexone in the w...

journal_title：European journal of pharmacology

authors： Takahashi M,Portoghese PS,Takemori AE

更新日期：1988-05-10 00:00:00

abstract：:The differentiation-inducing factor-1 (DIF-1) is a signal molecule that induces stalk cell differentiation in the cellular slime mold Dictyostelium discoideum. In addition, DIF-1 is a potent antileukemic agent that induces growth arrest in K562 cells. In this study, we investigated the mechanism of action of DIF-1 in ...

journal_title：European journal of pharmacology

authors： Akaishi E,Narita T,Kawai S,Miwa Y,Sasaguri T,Hosaka K,Kubohara Y

更新日期：2004-02-06 00:00:00

abstract：:Inactivation of gamma-aminobutric acid (GABA) as a neurotransmitter is mediated by diffusion in the synaptic cleft followed by binding to transporter sites and translocation into the intracellular compartment. The GABA transporters of which four subtypes have been cloned (GAT1-4) are distributed at presynaptic nerve e...

journal_title：European journal of pharmacology

authors： Schousboe A,Larsson OM,Sarup A,White HS

更新日期：2004-10-01 00:00:00

abstract：:Nomifensine, at a dose of 40 mg/kg, slightly but significantly increased rat striatal acetylcholine 60 min after i.p. administration without affecting choline levels or choline O-acetyltransferase and cholinesterase activities. This drug had no effect on brainstem acetylcholine. In contrast, d-amphetamine and desipram...

journal_title：European journal of pharmacology

authors： Garattini S,Consolo S,Chittò G,Peri G,Ladinsky H

更新日期：1976-01-01 00:00:00

abstract：:Hypoglycemia developed in fasted rats during forced swimming. This hypoglycemia was mostly abolished by phentolamine, an alpha-adrenolytic agent, or by hexamethonium; was potentiated by propranolol, a beta-adrenolytic agent, of by 5-methoxyindole-2-carboxylic acid, a gluconeogenic inhibitor; and was not affected by an...

journal_title：European journal of pharmacology

authors： Yajima M,Hosokawa T,Ui M

更新日期：1977-03-07 00:00:00

abstract：:Infusion of arachidonic acid through the guinea pig lung or the cat spleen causes a release of thromboxane A2 and prostaglandins, as measured by bioassay. After incubation of human platelets with arachidonate similar metabolites are formed, as demonstrated chromatographically. Infusion of imidazole (50-75 microgram/ml...

journal_title：European journal of pharmacology

authors： Nijkamp FP,Moncada S,White HL,Vane JR

更新日期：1977-07-15 00:00:00

abstract：:NP-252, a new dihydropyridine derivative, and nifedipine non-competitively inhibited contractile responses to KCl and responses to Ca2+ in Ca(2+)-free medium containing KCl in rabbit aorta and renal, mesenteric, coronary and basilar arteries, mesenteric veins and vena cava. The effects of NP-252 in these smaller arter...

journal_title：European journal of pharmacology

authors： Shibata S,Satake N,Kodama I,Hester RK,Wang CG,Jino H,Hojo M,Tatsumi H,Gandhi V,Jones DJ

更新日期：1991-10-22 00:00:00

abstract：:This study aims to investigate the role of zolpidem in lithium-pilocarpine induced status epilepticus (SE) and probable mechanisms involved in seizure threshold alteration. In the present study, lithium chloride (127mg/kg) was administered 20h prior to pilocarpine (60mg/kg) to induce SE in adult male Wistar rats. Diff...

journal_title：European journal of pharmacology

authors： Eslami SM,Ghasemi M,Bahremand T,Momeny M,Gholami M,Sharifzadeh M,Dehpour AR

更新日期：2017-11-15 00:00:00

abstract：:Stimulation of muscarinic M1-receptors in isolated rabbit vas deferens by McN-A-343 inhibited electrically induced twitch contractions susceptible to competitive blockade by (+)-, (+/-), (-)-telenzepine and pirenzepine (pA2 = 9.12, 8.86, 6.98 and 7.79, respectively). The inhibition of twitch contractions by 10(-6) M M...

journal_title：European journal of pharmacology

authors： Eltze M

更新日期：1990-05-03 00:00:00

abstract：:Breast cancer is one of the main diagnosis cancers annually worldwide. It is difficult to thorough cure due to drug resistance and the high possibility of metastasis. SM934 is a novel water-soluble artemisinin analog, and has been reported to have a promising therapeutic effect on multiple autoimmune diseases. In this...

journal_title：European journal of pharmacology

authors： Gu X,Peng Y,Zhao Y,Liang X,Tang Y,Liu J

更新日期：2019-09-05 00:00:00

abstract：:This study examined the mechanism of action of neurotensin on intraluminal pressure in rat proximal colon. The direct and indirect contractile response to neurotensin (100 nM) was abolished in Ca(2+)-free solution, and was antagonized by nifedipine (1-5-10 nM) and potentiated by Bay K 8644 (methyl 1,4-dihydro-2,6-dime...

journal_title：European journal of pharmacology

authors： Mulè F,Serio R

更新日期：1997-01-29 00:00:00

abstract：:Transgenic rabbits expressing loss-of-function pore mutants of the human gene KCNQ1 (K(v)LQT1-Y315S) have a Long QT-Syndrome 1 (LQT1) phenotype. We evaluated for the first time the effect of nicorandil, an opener of ATP-sensitive potassium channels, and of isoproterenol on cardiac action potential duration and heart r...

journal_title：European journal of pharmacology

authors： Biermann J,Wu K,Odening KE,Asbach S,Koren G,Peng X,Zehender M,Bode C,Brunner M

更新日期：2011-01-10 00:00:00

abstract：:A substantial barrier to the treatment of Opioid Use Disorder (OUD) is the elevated relapse rates in affected patients, and a significant contributor to these events of relapse is exposure to cues and contexts that are intensely associated with prior drug abuse. The neurotransmitter dopamine plays a key role in reward...

journal_title：European journal of pharmacology

authors： McKendrick G,Sharma S,Sun D,Randall PA,Graziane NM

更新日期：2020-12-15 00:00:00

abstract：:In addition to S(-)-nicotine, several minor tobacco alkaloids ((+/-)-nornicotine, anabaseine, S(-)-anabasine, and S(-)-N-methylanabasine) are present in tobacco smoke. This study demonstrates that these alkaloids increase fractional 3H release in a concentration-dependent manner from rat striatal slices preloaded with...

journal_title：European journal of pharmacology

authors： Dwoskin LP,Teng L,Buxton ST,Ravard A,Deo N,Crooks PA

更新日期：1995-03-24 00:00:00

abstract：:Estrogen-related receptor alpha (ERRα), one of orphan nuclear receptors, has been recently revealed as an oncogenic regulator in a variety of cancers. However, the linking gain of ERRα expression and cancer progression in cutaneous squamous cell carcinoma (cSCC) is largely unknown. Here, we showed that the mRNA and pr...

journal_title：European journal of pharmacology

authors： Chen H,Pan J,Zhang L,Chen L,Qi H,Zhong M,Shi X,Du J,Li Q

更新日期：2018-04-15 00:00:00

abstract：:The kappa-opioid receptor agonist, U50,488H (trans-(+-)-3,4-dichloro-N-methyl-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide), has recently been reported to induce dystonia after s.c. administration of 5-10 mg/kg in guinea pigs. The dystonic movements observed in response to U50,488H resembled those previously repo...

journal_title：European journal of pharmacology

authors： Richter A,Löscher W

更新日期：1993-05-19 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is characterized by an airways inflammation and by an enhanced generation of reactive oxygen species. The aim of our study was to assess the inflammation and the oxidative stress in airways of COPD patients with acute exacerbation of disease and in stability. Furthermore, w...

journal_title：European journal of pharmacology

authors： Carpagnano GE,Resta O,Foschino-Barbaro MP,Spanevello A,Stefano A,Di Gioia G,Serviddio G,Gramiccioni E

更新日期：2004-11-28 00:00:00

abstract：:Glucose is the primary energy fuel of life. A glucose transporter, the sodium-glucose transporter (SGLT), is receiving attention as a novel therapeutic target in disease. This review summarizes the physiological role of SGLT in cerebral ischemia, cancer, cardiac disease, and intestinal ischemia, which has encouraged a...

journal_title：European journal of pharmacology

authors： Yamazaki Y,Harada S,Tokuyama S

更新日期：2018-03-05 00:00:00

abstract：:The treatment of alcohol dependence mainly consists of psychological, social, and pharmacotherapeutic interventions aiming to reduce physical withdrawal, craving, and alcohol relapse. During the last years, it has become increasingly clear that adjuvant pharmacotherapy is efficacious especially in rehabilitation progr...

journal_title：European journal of pharmacology

authors： Kiefer F,Mann K

更新日期：2005-12-05 00:00:00

abstract：:Diabetic nephropathy (DN) is a major cause of end-stage renal disease and one of the most severe diabetic complications. However, there is lack of effective treatments for DN and the underlying mechanisms of the renal injury remain unclear. In current study, we evaluated the effects of silibinin on DN and further expl...

journal_title：European journal of pharmacology

authors： Liu Y,Ye J,Cao Y,Zhang R,Wang Y,Zhang S,Dai W,Ye S

更新日期：2019-02-15 00:00:00

abstract：:Intrastriatal injection of kainic acid (5 nmoles) to rats led to severe destruction of nerve cell bodies throughout the caudate-putamen complex and an extensive proliferation of glial cells. Lesioned striata displayed a significant 23% loss of beta-adrenoceptor binding sites 21--24 days after injection of kainic acid....

journal_title：European journal of pharmacology

authors： Nahorski SR,Howlett DR,Redgrave P

更新日期：1979-12-07 00:00:00

abstract：:Discovery in the early 1990s of caveolin-1, the structural protein responsible for maintaining the ohm shape of caveolae, greatly enhanced investigations to elucidate the role of these little caves in the plasma membrane. Perhaps one of the most important realizations concerning caveolae and caveolin is that these ele...

journal_title：European journal of pharmacology

authors： Xu Y,Buikema H,van Gilst WH,Henning RH

更新日期：2008-05-13 00:00:00

abstract：:Oxymetazoline was recognized with nanomolar affinity by 5-HT1A, 5-HT1B and 5-HT1D binding sites and mimicked the effects of 5-hydroxytryptamine with about the same potency and intrinsic activity as the endogenous amine in the corresponding functional tests. At 5-HT1C receptors, oxymetazoline behaved as a mixed agonist...

journal_title：European journal of pharmacology

authors： Schoeffter P,Hoyer D

更新日期：1991-04-17 00:00:00

abstract：:Barbiturates and the related depressant drugs, etazolate and etomidate, inhibited both the binding of [3H]bicuculline methochloride (BMC) to gamma-aminobutyric acid (GABA) receptor sites and the binding of [3H] beta-carboline-3-carboxylic acid methyl ester (beta CCM) to benzodiazepine receptor sites in mammalian brain...

journal_title：European journal of pharmacology

authors： Wong EH,Snowman AM,Leeb-Lundberg LM,Olsen RW

更新日期：1984-07-13 00:00:00

abstract：:Experiments were designed to examine some characteristics of an orally active antihypertensive agent, SGB-1534 on alpha-adrenoceptors in spinally anesthetized dogs. In the saphenous arterial bed perfused by a constant pump volume, saphenous nerve stimulation and bolus applications of norepinephrine and phenylephrine i...

journal_title：European journal of pharmacology

authors： Imagawa J,Sakai K

更新日期：1986-11-19 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide, is found in the central nervous system as well as in the heart. CGRP shows high sequence homology with amylin, salmon calcitonin, and adrenomedullin. This study aimed to investigate the effect of CGRP on atrial hemodynamics and atrial natriuretic pe...

journal_title：European journal of pharmacology

authors： Piao FL,Cao C,Han JH,Kim SZ,Kim SH

更新日期：2004-01-12 00:00:00

abstract：:In the present study, we investigated the vasculoprotective effect of sigma-1 receptor stimulation with fluvoxamine on pressure overload hypertrophy-induced vascular injury in the thoracic aorta and defined mechanisms underlying that activity. Wistar rats underwent bilateral ovariectomy, and two weeks later were furth...

journal_title：European journal of pharmacology

authors： Bhuiyan MS,Tagashira H,Fukunaga K

更新日期：2011-01-15 00:00:00

abstract：:Immunocytochemical and Co(2+) uptake studies revealed that in primary cultures of rat cortical neurones, the majority of neurones are gamma-aminobutyric acid (GABA) immunopositive and can express Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors. By fura-2 microfluorimetry, it...

journal_title：European journal of pharmacology

authors： Fischer W,Franke H,Scheibler P,Allgaier C,Illes P

更新日期：2002-03-01 00:00:00