Abstract:
:Nomifensine, at a dose of 40 mg/kg, slightly but significantly increased rat striatal acetylcholine 60 min after i.p. administration without affecting choline levels or choline O-acetyltransferase and cholinesterase activities. This drug had no effect on brainstem acetylcholine. In contrast, d-amphetamine and desipramine both produced a small but significant increase in brainstem acetylcholine. It is suggested that nomifensine increased striatal acetylcholine indirectly through blockade of dopamine uptake.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Garattini S,Consolo S,Chittò G,Peri G,Ladinsky Hdoi
10.1016/0014-2999(76)90315-0keywords:
subject
Has Abstractpub_date
1976-01-01 00:00:00pages
199-201issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(76)90315-0journal_volume
35pub_type
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