Effect of nomifensine on acetylcholine and choline in the rat striatum and brainstem.

Abstract:

:Nomifensine, at a dose of 40 mg/kg, slightly but significantly increased rat striatal acetylcholine 60 min after i.p. administration without affecting choline levels or choline O-acetyltransferase and cholinesterase activities. This drug had no effect on brainstem acetylcholine. In contrast, d-amphetamine and desipramine both produced a small but significant increase in brainstem acetylcholine. It is suggested that nomifensine increased striatal acetylcholine indirectly through blockade of dopamine uptake.

journal_name

Eur J Pharmacol

authors

Garattini S,Consolo S,Chittò G,Peri G,Ladinsky H

doi

10.1016/0014-2999(76)90315-0

keywords:

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

199-201

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(76)90315-0

journal_volume

35

pub_type

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