Abstract：
:NP-252, a new dihydropyridine derivative, and nifedipine non-competitively inhibited contractile responses to KCl and responses to Ca2+ in Ca(2+)-free medium containing KCl in rabbit aorta and renal, mesenteric, coronary and basilar arteries, mesenteric veins and vena cava. The effects of NP-252 in these smaller arteries and veins were much greater than those in aorta. However, a similar differential selectivity was not seen with nifedipine. In aorta, only NP-252 reduced total La3+ resistant 45Ca binding. However, the increases in bound 45Ca at La3+ resistant sites and 45Ca unidirectional influx due to KCl were inhibited by both NP-252 and nifedipine. The displacement of [3H]nitrendipine binding to rabbit aorta was monophasic for both NP-252 and nifedipine. In guinea-pig papillary muscles, NP-252 (greater than 10(-7) M) slightly decreased action potential duration, developed tension and slow action potentials. The cardiac effects of NP-252 were much less prominent than those of nifedipine. These results indicate that NP-252 inhibits voltage-operated Ca2+ channels in small arteries and veins much more effectively than those in aorta, and this tissue selectivity is more apparent for NP-252 than nifedipine.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Shibata S,Satake N,Kodama I,Hester RK,Wang CG,Jino H,Hojo M,Tatsumi H,Gandhi V,Jones DJdoi
10.1016/0014-2999(91)90888-wsubject
Has Abstractpub_date
1991-10-22 00:00:00pages
337-44issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(91)90888-Wjournal_volume
203pub_type
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