The effect of Bay K 8644 on angiotensin II-induced contractions of rabbit aortic strips.

abstract：:While muscarinic receptor antagonists are used to reduce motor side effects associated with the use of antipsychotic drugs, their site of action remains unclear. The study investigated the site of action of the non-selective muscarinic receptor antagonist atropine on catalepsy induced by the selective dopamine D2 rece...

journal_title：European journal of pharmacology

authors： Alcock SJ,Hemsley KM,Crocker AD

更新日期：2001-07-27 00:00:00

abstract：:The effect of diethyldithiocarbamate (DETC, 10(-3) M) on the vasorelaxant activity of acetylcholine, nitric oxide (NO), nitrite, glyceryl trinitrate or dinitrosyl iron cysteine complexes was studied in isolated rat aortic rings contracted with norepinephrine. Pretreatment of these segments with DETC attenuated the vas...

journal_title：European journal of pharmacology

authors： Vedernikov YP,Mordvintcev PI,Malenkova IV,Vanin AF

更新日期：1992-02-25 00:00:00

abstract：:A series of oximes and related compounds were assessed for their ability to restore soman-induced neuromuscular block in the isolated diaphragm preparation of the rat, guinea-pig and marmoset. In the rat the bispyridinium oximes HS6, HI6 and HS14 were superior to P2S and all other compounds tested. Conversely, in the ...

journal_title：European journal of pharmacology

authors： French MC,Wetherell JR,White PD

更新日期：1983-08-05 00:00:00

abstract：:We investigated the influence of inhibition of nitric oxide (NO) synthase, using NG-nitro-L-arginine (L-NNA) or NG-mono-methyl-L-arginine (L-NMMA), and the effects of exogenous donor of NO, such as glyceryl trinitrate (GTN), on the healing of chronic gastric ulcers induced by acetic acid, on gastric blood flow around ...

journal_title：European journal of pharmacology

authors： Konturek SJ,Brzozowski T,Majka J,Pytko-Polonczyk J,Stachura J

更新日期：1993-08-03 00:00:00

abstract：:The aim of this study was to characterise the 5-HT receptor(s) mediating secretory responses of isolated human colonic mucosa to 5-HT. Sheets of muscle-stripped mucosa from proximal (ascending) and distal (sigmoid) human colon were set up in Ussing chambers for measurement of short-circuit current (Isc). Serosal appli...

journal_title：European journal of pharmacology

authors： Borman RA,Burleigh DE

更新日期：1996-08-15 00:00:00

abstract：:The roles of α2-adrenergic receptors located in the spinal cord in the regulation of blood glucose levels were studied in imprinting control region (ICR) mice. Mice were treated intrathecally (i.t.) with clonidine or yohimbine, and the blood glucose levels were measured at 0, 30, 60 and 120min after i.t. administratio...

journal_title：European journal of pharmacology

authors： Sim YB,Park SH,Kim SS,Lim SM,Jung JS,Suh HW

更新日期：2014-10-15 00:00:00

abstract：:Delta9-tetrahydrocannabinol induces [Ca2+]i increases in DDT1MF-2 smooth muscle cells. Both Ca2+ entry and release from intracellular Ca2+ stores were concentration dependently activated. The Ca2+ entry component contributed most to the increases in [Ca2+]i. Stimulation with delta9-tetrahydrocannabinol after functiona...

journal_title：European journal of pharmacology

authors： Filipeanu CM,de Zeeuw D,Nelemans SA

更新日期：1997-10-01 00:00:00

abstract：:There has been a flurry of activity to develop agonists and antagonists for the member of the opioid receptor family, NOP receptor (also known as ORL1), in part to understand its role in pain. Modifications of a hexapeptide originally identified from a combinatorial library have led to the discovery of a high affinity...

journal_title：European journal of pharmacology

authors： Khroyan TV,Polgar WE,Orduna J,Zaveri NT,Judd AK,Tuttle DJ,Sanchez A,Toll L

更新日期：2007-03-29 00:00:00

abstract：:We have previously proposed that pro-inflammatory cytokines and nitric oxide (NO) contributed to reversible myocardial depression in patients with sepsis and congestive heart failure. Sepsis and heart failure are also associated with refractoriness to beta-adrenoceptor agonists. Therefore, the chronotropic effects of ...

journal_title：European journal of pharmacology

authors： Oddis CV,Finkel MS

更新日期：1997-02-12 00:00:00

abstract：:The effects of GABA on depolarization-induced (26 mM K+) release of radiolabeled dopamine (DA) and acetylcholine (ACh) from slices of rat caudate nucleus were examined with a superfusion method. GABA, in concentrations of 10(-5)--10(-3) M, dose-dependently enhanced the release of DA, either accumulated by high-affinit...

journal_title：European journal of pharmacology

authors： Stoof JC,Den Breejen EJ,Mulder AH

更新日期：1979-07-15 00:00:00

abstract：:In this study, we determined the protective potential of trans resveratrol against oxygen-glucose deprivation (OGD) induced reactive oxygen species mediated apoptotic damages in PC12 cells. In vitro model of ischemic cerebral stroke was created by keeping cells in an OGD condition for 6h followed by 24h reoxygenation....

journal_title：European journal of pharmacology

authors： Agrawal M,Kumar V,Kashyap MP,Khanna VK,Randhawa GS,Pant AB

更新日期：2011-09-01 00:00:00

abstract：:The inhibitory effect of cytochalasin B on contraction of smooth muscle cells isolated from guinea-pig taenia coli was investigated. Cytochalasin B (10-70 microM) inhibited the high K+ (70 mM)-induced contraction in a dose-dependent manner, and the maximum and the half-maximum effects were obtained at 50 and 15 microM...

journal_title：European journal of pharmacology

authors： Obara K,Yabu H

更新日期：1994-04-01 00:00:00

abstract：:The action of calcitonin gene-related peptide (CGRP) on the vasodepressor response to adenosine was investigated in anesthetized rats. I.v. bolus injections of adenosine (1-100 microg/kg), acetylcholine (0.05-0.4 microg/kg), isoproterenol (1-30 ng/kg), nitroglycerin (0.3-10 microg/kg) and diltiazem (10-300 microg/kg) ...

journal_title：European journal of pharmacology

authors： Sakai K,Saito K,Akima M

更新日期：1998-03-05 00:00:00

abstract：:In this study we have investigated the functional activity of GR127935 (2-methyl-1,2,4 oxadiazol-3-yl)-biphenyl-[4-carboxylic acid 4-methoxy-3-(4-methyl-piperazine-1-yl]-amide) at human 5-HT1D alpha and 5-HT1D beta receptors which have been expressed in a Chinese Hamster Ovary (CHO) cell line. Using [35S] GTP gamma S ...

journal_title：European journal of pharmacology

authors： Watson JM,Burton MJ,Price GW,Jones BJ,Middlemiss DN

更新日期：1996-10-31 00:00:00

abstract：:MK-801, phenobarbital and clonazepam blocked convulsions elicited in mice by bicuculline. Treatment with Ro 15-1788 antagonized the anticonvulsant action of clonazepam, but not MK-801 or phenobarbital. The anticonflict effect in the rat of chlordiazepoxide, but not MK-801, was antagonized by Ro 15-1788. Despite having...

journal_title：European journal of pharmacology

authors： Clineschmidt BV

更新日期：1982-10-15 00:00:00

abstract：:Results demonstrate for the first time that ethanol exerts two different effects on the lipid order of chick-liver mitochondria and microsomes: a fluidizing effect both in the core and at the surface of the membrane, which depends on its physical presence, and a rigidization of the surface of these membranes which occ...

journal_title：European journal of pharmacology

authors： Sanchez-Amate MC,Carrasco MP,Zurera JM,Segovia JL,Marco C

更新日期：1995-03-16 00:00:00

abstract：:3H-Mepyramine (3H-MEP) binds to slide-mounted tissue sections with characteristics indicating the labelling of a H1-histamine receptor. It is saturable (Bmax 12 pg/g tissue), of a high affinity (KD 0.5 mM) and possesses a drug specificity similar to that observed for H1 receptors in a variety of systems. In agreement ...

journal_title：European journal of pharmacology

authors： Palacios JM,Young WS 3rd,Kuhar MJ

更新日期：1979-10-01 00:00:00

abstract：:Skeletal myogenesis comprises myoblast replication and differentiation into striated multinucleated myotubes. Agents that interfere with myoblast replication are important tools for the understanding of myogenesis. Recently, we showed that cholesterol depletion by methyl-β-cyclodextrin (MCD) enhances the differentiati...

journal_title：European journal of pharmacology

authors： Portilho DM,Soares CP,Morrot A,Thiago LS,Butler-Browne G,Savino W,Costa ML,Mermelstein C

更新日期：2012-11-05 00:00:00

abstract：:Although convulsions due to local anesthetic systemic toxicity are thought to be due to inhibition of GABA(A) receptor-linked currents in the central nervous system, the mechanism of action remains unclear. We therefore examined the effects of local anesthetics on gamma-aminobutyric acid (GABA)-induced currents using ...

journal_title：European journal of pharmacology

authors： Sugimoto M,Uchida I,Fukami S,Takenoshita M,Mashimo T,Yoshiya I

更新日期：2000-08-11 00:00:00

abstract：:Using the curve-shift method, we studied the effects of four doses (0.003, 0.03, 0.3 and 3 mg/kg, s.c.) of granisetron (endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3- carboxamide hydrochloride), a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist, on the potentiation of brain stimulatio...

journal_title：European journal of pharmacology

authors： Rompré PP,Injoyan R,Hagan JJ

更新日期：1995-12-20 00:00:00

abstract：:The ability of the kappa-opioid receptor agonist U69593 to attenuate the sensitization and cross-sensitization which develops to the conditioned rewarding effects of morphine and cocaine was examined using an unbiased place-preference conditioning procedure. The influence of U69593 treatment upon sensitization and cro...

journal_title：European journal of pharmacology

authors： Shippenberg TS,LeFevour A,Thompson AC

更新日期：1998-03-12 00:00:00

abstract：:The vasodepressor actions of the cyclic endoperoxides PGG2 and PGH2 were compared with those of their products PGD2 and PGE2 using anaesthetised normotensive and genetically hypertensive rats. Given into the aortic arch of normotensives PGE2 was approximately 6 times more potent than PGH2 and 11 times more potent tha...

journal_title：European journal of pharmacology

authors： Armstrong JM,Boura AL,Hamberg M,Samuelsson B

更新日期：1976-10-01 00:00:00

abstract：:High temperature requirement A2 (HtrA2)/Omi is a mitochondrial serine protease that is released into the cytosol from mitochondria and in turn promotes caspase activation by proteolyzing inhibitor of apoptosis proteins. Here we asked whether treatment with an HtrA2/Omi inhibitor, 5-[5-(2-nitrophenyl)furfuryliodine]-1,...

journal_title：European journal of pharmacology

authors： Bhuiyan MS,Fukunaga K

更新日期：2007-02-28 00:00:00

abstract：:The inhibition of alpha2A-adrenoceptor-mediated Ca2+ elevation by alpha2-adrenoceptor antagonists was measured in HEL human erythroleukemia cells. The antagonists could be divided in two classes: those that displayed surmountable inhibition (right-shift of the agonist dose-response curve), and those that displayed dif...

journal_title：European journal of pharmacology

authors： Kukkonen JP,Huifang G,Jansson CC,Wurster S,Cockcroft V,Savola JM,Akerman KE

更新日期：1997-09-17 00:00:00

abstract：:Increased phasic activity in the bladder smooth muscle of animal models and patients with detrusor overactivity has been suggested to underlie the pathophysiology of overactive bladder. Potassium (K+) channels are key regulators of bladder smooth muscle tone and thus may play a role in this altered phasic activity. In...

journal_title：European journal of pharmacology

authors： Vahabi B,Lawson K,McKay NG,Sellers DJ

更新日期：2011-06-25 00:00:00

abstract：:Galectins are carbohydrate-binding proteins and these have very high affinity for β-galactoside containing glycoproteins and glycolipids. Amongst sixteen types of galectin, the role of galectin 1, 3, 9 and 12 is defined in the development and progression of different types of leukemia including acute myeloid leukemia,...

journal_title：European journal of pharmacology

authors： Zheng Y,Feng W,Wang YJ,Sun Y,Shi G,Yu Q

更新日期：2019-02-05 00:00:00

abstract：:The effect of NZ-107 (4-bromo-5-(3-ethoxy-4-methoxybenzylamino)-3(2H)-pyridazinone) on late-phase airway responses and airway hyperreactivity was investigated in the guinea pig. Challenge with inhaled ovalbumin in conscious guinea pigs actively sensitized with inhaled ovalbumin caused triphasic bronchial obstruction, ...

journal_title：European journal of pharmacology

authors： Iwama T,Shikada K,Yamamoto A,Sakashita M,Hibi M,Tanaka S

更新日期：1991-07-09 00:00:00

abstract：:Previously, we demonstrated the enhanced affinity of opioid receptors for naloxone in striatal slices from morphine-dependent mice. In our present study, binding characteristics of the mu opioid receptor agonists, [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAMGO) and dihydromorphine, the delta opioid receptor agonist, [D-Ala2...

journal_title：European journal of pharmacology

authors： Abdelhamid EE,Takemori AE

更新日期：1991-06-06 00:00:00

abstract：:Inhibition of glutamate carboxypeptidase (GCP) II (EC 3.4.17.21), also termed N-acetylated alpha-linked acidic dipeptidase (NAALADase), has been shown to protect against ischemic injury presumably via decreasing glutamate and increasing N-acetyl-aspartyl-glutamate (NAAG). NAAG is a potent and selective mGlu3 receptor ...

journal_title：European journal of pharmacology

authors： Thomas AG,Liu W,Olkowski JL,Tang Z,Lin Q,Lu XC,Slusher BS

更新日期：2001-10-26 00:00:00

abstract：:To shed light on the discrepancy between reported binding and functional affinity and selectivity at alpha(1b/B)-adrenoceptors, the antagonist (+)-cyclazosin was reinvestigated in rat and rabbit tissues. It displayed a competitive antagonism at alpha(1A) and alpha(1D)-adrenoceptors of rat prostatic vas deferens and ao...

journal_title：European journal of pharmacology

authors： Marucci G,Angeli P,Buccioni M,Gulini U,Melchiorre C,Sagratini G,Testa R,Giardinà D

更新日期：2005-10-17 00:00:00