Human colonic mucosa possesses a mixed population of 5-HT receptors.

abstract：:Early philosophers and psychologists defined and began to describe attention. Beginning in the 1950's, numerous models of attention were developed. This corresponded with an increased understanding of pharmacological approaches to manipulate neurotransmitter systems. The present review focuses on the knowledge that ha...

journal_title：European journal of pharmacology

authors： Burk JA,Blumenthal SA,Maness EB

更新日期：2018-09-15 00:00:00

abstract：:7-Nitroindazole (a selective neuronal nitric oxide (NO) synthase inhibitor) at 25 and 50 mg/kg, 30 min before the test, did not influence the electroconvulsive threshold. However, at 50 mg/kg, it enhanced the anticonvulsive activity of phenobarbital against maximal electroshock and did not affect that of carbamazepine...

journal_title：European journal of pharmacology

authors： Borowicz KK,Kleinrok Z,Czuczwar SJ

更新日期：1997-07-23 00:00:00

abstract：:Nitric oxide synthases (NOS) and cyclooxygenase-2 (COX-2) are important enzymes involved in ulcer healing but interactions between them have not been clearly defined. The aim of this study was to investigate the effects of selective or non-selective inhibition of NOS on the expression and activity of COX-2 during heal...

journal_title：European journal of pharmacology

authors： Guo JS,Cho CH,Wang JY,Koo MW

更新日期：2006-05-01 00:00:00

abstract：:Dihydralazine (0.1 mg/kg), injected intravenously into male Sprague-Dawley rats, caused a decrease in mean arterial blood pressure and an increase in renal plasma flow, while urine volume remained unchanged. Dihydralazine had no effect on kallikrein excretion in the urine and on kallikrein activity in the renal cortex...

journal_title：European journal of pharmacology

authors： Bönner G,Beck D,Deeg M,Marin-Grez M,Gross F

更新日期：1982-02-26 00:00:00

abstract：:The endocannabinoid system appears to have an important role in specific aspects of learning and memory, yet there has been no systematic study of the role of cannabinoid receptors in contextual fear conditioning. The present study examined the effects of cannabinoid CB(1) receptor blockade on the acquisition, consoli...

journal_title：European journal of pharmacology

authors： Arenos JD,Musty RE,Bucci DJ

更新日期：2006-06-13 00:00:00

abstract：:Overexpression of Cav3.2 T-type Ca2+ channels in L4 dorsal root ganglion (DRG) participates in neuropathic pain after L5 spinal nerve cutting (L5SNC) in rats. The L5SNC-induced neuropathic pain also involves high mobility group box 1 (HMGB1), a damage-associated molecular pattern protein, and its target, the receptor ...

journal_title：European journal of pharmacology

authors： Tomita S,Sekiguchi F,Kasanami Y,Naoe K,Tsubota M,Wake H,Nishibori M,Kawabata A

更新日期：2020-12-05 00:00:00

abstract：:Inhibition of glutamate carboxypeptidase (GCP) II (EC 3.4.17.21), also termed N-acetylated alpha-linked acidic dipeptidase (NAALADase), has been shown to protect against ischemic injury presumably via decreasing glutamate and increasing N-acetyl-aspartyl-glutamate (NAAG). NAAG is a potent and selective mGlu3 receptor ...

journal_title：European journal of pharmacology

authors： Thomas AG,Liu W,Olkowski JL,Tang Z,Lin Q,Lu XC,Slusher BS

更新日期：2001-10-26 00:00:00

abstract：:High affinity binding sites for [3H]leukotriene C4 ([3H]LTC4) have been identified and characterised in guinea-pig lung membranes. [3H]LTC4 bound to these membranes with a pharmacological specificity totally distinct to that previously observed for [3H]LTD4 binding in guinea-pig lung. Scatchard analysis of saturation ...

journal_title：European journal of pharmacology

authors： Norman P,Abram TS,Kluender HC,Gardiner PJ,Cuthbert NJ

更新日期：1987-11-17 00:00:00

abstract：:Synaptic transmission in intact pieces of the Torpedo electric organ treated with vesamicol (2-(4-phenylpiperidino)cyclohexanol, formerly AH5183) was elicited by trains of repetitive electrical stimulation at different frequencies. When the frequency of stimulation was increased from 10 to 50 or 100 Hz, micromolar con...

journal_title：European journal of pharmacology

authors： Girod R,Loctin F,Dunant Y

更新日期：1991-03-19 00:00:00

abstract：:We have described here the changes of the biophysical and pharmacological properties of the sarcolemmal ATP-sensitive K+ channels (KATP) of rat skeletal muscle fibres, occurring from an early postnatal period (5 days) to adulthood (210 days). The age-dependent changes of the mean current of the KATP channel (channel a...

journal_title：European journal of pharmacology

authors： Tricarico D,Petruzzi R,Conte Camerino DC

更新日期：1997-03-05 00:00:00

abstract：:Cd2+ competitively antagonizes Ca2+ in the evoked release of acetylcholine from nerve terminals in the frog sciatic-sartorius neuromuscular junction. The dissociation constant between Cd2+ and its receptor sites was calculated to be 1.7 microM. In agreement with previous work we found that brief exposures to 100-500 m...

journal_title：European journal of pharmacology

authors： Cooper GP,Manalis RS

更新日期：1984-04-06 00:00:00

abstract：:Indomethacin and ibuprofen inhibited adrenaline- and calcium ionophore A23187-stimulated 45Ca2+ uptake by isolated human platelets in a concentration-dependent manner. Mediation of these effects by thromboxane A2 (TXA2) inhibition was discounted since under the same experimental conditions, adrenaline did not stimulat...

journal_title：European journal of pharmacology

authors： Gill J,Dandona P,Jeremy JY

更新日期：1990-10-02 00:00:00

abstract：:This study investigates the anti-inflammatory effects of 1-(2-chlorophenyl)-N-methyl-N(1-methylpropyl)-3-isoquinoline carboxamide and 7-chloro-5-(4-chlorophenyl)-1, 3-dihydro-1-methyl-2-H-1,4-benzodiazepin-2-one in paw oedema induced by carrageenan in mice. Pretreatment (24 h) with both ligands inhibited oedema format...

journal_title：European journal of pharmacology

authors： Torres SR,Nardi GM,Ferrara P,Ribeiro-do-Valle RM,Farges RC

更新日期：1999-12-03 00:00:00

abstract：:The release of endogenous aspartic acid (Asp), glutamic acid (Glu) and gamma-aminobutyric acid (GABA) was investigated in synaptosomes prepared from various regions of the rat brain. The basal release of Asp, Glu and GABA from various regions was 12-35, 24-107 and 15-43 pmol/min per mg protein, respectively. Exposure ...

journal_title：European journal of pharmacology

authors： Kamisaki Y,Hamahashi T,Hamada T,Maeda K,Itoh T

更新日期：1992-06-24 00:00:00

abstract：:The calmodulin inhibitor 1,3-dihydro-1-[1-((4-methyl-4H,6H-pyrrolo[1,2-a]-[4,1]benzoxazepin - 4-yl)methyl)-4-piperidinyl]-2H-benzimidazol-2-one maleate (CGS 9343B) caused a reversible block of voltage-activated Ca2+, Na+, and K+ currents in differentiated rat pheochromocytoma (PC12) cells. The drug also inhibited nico...

journal_title：European journal of pharmacology

authors： Neuhaus R,Reber BF

更新日期：1992-06-05 00:00:00

abstract：:The role of pertussis toxin-sensitive G proteins on the alpha 2-adrenoceptor and mu-opioid receptor-mediated inhibition of the efferent function of capsaicin-sensitive neurones was investigated in guinea-pig atria pretreated with guanethidine. In the presence of atropine, CGP 20712A (2-hydroxy-5-(2-[hydroxy-3-(4-[(1-m...

journal_title：European journal of pharmacology

authors： Amerini S,Rubino A,Mantelli L,Filippi S,Ledda F

更新日期：1992-06-17 00:00:00

abstract：:Atherosclerosis is regarded as chronic inflammatory disease. The IL-6/STAT3 pathway plays an important role in inflammation. We previously described a small-molecule compound, Bazedoxifene, which target IL-6/STAT3 pathway and has been approved for clinical use for osteoporosis in postmenopausal women. The aim of this ...

journal_title：European journal of pharmacology

authors： Luo P,Wang Y,Zhao C,Guo J,Shi W,Ma H,Liu T,Yan D,Huo S,Wang M,Li C,Lin J,Li S,Lv J,Zhang C,Lin L

更新日期：2021-02-15 00:00:00

abstract：:To characterise the safety, tolerability, pharmacodynamics (bronchodilatory effect) and pharmacokinetics of inhaled umeclidinium in patients with chronic obstructive pulmonary disease (COPD). The first investigation was a single dose, randomised, double-blind, placebo-controlled study (clinicaltrials.gov: NCT00515502)...

journal_title：European journal of pharmacology

authors： Tal-Singer R,Cahn A,Mehta R,Preece A,Crater G,Kelleher D,Pouliquen IJ

更新日期：2013-02-15 00:00:00

abstract：:18-Methoxycoronaridine, a novel iboga alkaloid congener, reduces drug self-administration in animal models of addiction. Previously, we proposed that these effects are mediated by the ability of 18-methoxycoronaridine to inhibit nicotinic alpha3beta4 acetylcholine receptors. In an attempt to identify more potent 18-me...

journal_title：European journal of pharmacology

authors： Pace CJ,Glick SD,Maisonneuve IM,He LW,Jokiel PA,Kuehne ME,Fleck MW

更新日期：2004-05-25 00:00:00

abstract：:The study concerned the effect of arachidonic acid metabolites on the inflammatory reaction in granulation tissue of open wounds in rats. Metabolites or inhibitors were applied in a wound chamber attached to circular, open, full-thickness skin wounds 5 days post-wounding. The adjacent wound served as control. Blood fl...

journal_title：European journal of pharmacology

authors： Lundberg C,Gerdin B

更新日期：1984-01-27 00:00:00

abstract：:The study investigated the effects of dopamine D1-like receptor stimulation on the autonomic nervous system. Fenoldopam (20 microg/kg) was injected i.v. in conscious sinoaortic denervated dogs, that is, surgically deprived of baroreflex pathways. In barodenervated dogs, fenoldopam (20 microg/kg) induced arterial hypot...

journal_title：European journal of pharmacology

authors： Vernejoul F,Damase-Michel C,Montastruc JL,Tran MA

更新日期：2002-05-31 00:00:00

abstract：:Adenosine relaxes the coronary arteries of various species through A2 receptors. The mechanism(s) by which adenosine causes relaxation of the coronary smooth muscle through changes in intracellular Ca levels is not understood. Therefore, the aim of this study was to evaluate the vasodilatory action of adenosine in nor...

journal_title：European journal of pharmacology

authors： Ramagopal MV,Nakazawa M,Mustafa SJ

更新日期：1989-01-02 00:00:00

abstract：:Alopecia is resulted from various factors that can decrease the regeneration capability of hair follicles and affect hair cycles. This process can be devastating physically and psychologically. Nevertheless, the available treatment strategies are limited, and the therapeutic outcomes are not satisfactory. According to...

journal_title：European journal of pharmacology

authors： Yuan AR,Bian Q,Gao JQ

更新日期：2020-08-15 00:00:00

abstract：:The beta 1- and beta 2-adrenoceptor agonist and thromboxane A2 (TXA2) antagonist properties of trimetoquinol (TMQ, I) and 1-benzyl substituted TMQ analogues [3'-iodo-4',5'-dimethoxy TMQ, II; 3',5'-diiodo-4'-dimethoxy TMQ, III; 3',4'-dimethoxy-5'-nitro TMQ, IV; 3',4'-dimethoxy-5'-amino TMQ; V; and 3',4'-dimethoxy TMQ, ...

journal_title：European journal of pharmacology

authors： Shams G,Romstedt KJ,Gerhardt MA,Harrold MW,Miller DD,Feller DR

更新日期：1990-08-02 00:00:00

abstract：:In rabbits, i.v. delta9-tetrahydrocannabinol (delta9-THC) at 0.5 mg/kg was challenged with i.v. arecoline (0.025 mg/kg), nicotine (0.02 mg/kg) or physostigmine (PHYSO, 0.05 mg/kg), and observations were made on quantified EEG and behavior. The cholinomimetics effectively reversed the cortical and hippocampal EEG alter...

journal_title：European journal of pharmacology

authors： Jones BC,Consroe PF,Laird HE 2nd

更新日期：1976-08-01 00:00:00

abstract：:Acute treatment of rats with morphine (10 mg/kg) resulted in a marked reduction of motor response to inescapable electric footshock (EFS). Nalorphine (2mg/kg) antagonized this action of morphine. Pretreatment with synthetic ACTH 1-24 (10 IU) 60 min prior to testing also inhibited this morphine-induced reduction, where...

journal_title：European journal of pharmacology

authors： Gispen WH,Van Wimersma Greidanus TB,Waters-Ezrin C,Zimmermann E,Krivoy WA,De Wied D

更新日期：1975-08-01 00:00:00

abstract：:Heparin is a natural polymer widely used in medicine especially during the treatment of cardiovascular diseases since it is a potent blood anticoagulant. In case of emergency, e.g., massive hemorrhage, the anticoagulant activity of heparin has to be quickly stopped by the administration of a heparin reversing agent. C...

journal_title：European journal of pharmacology

authors： Kalaska B,Sokolowska E,Kaminski K,Szczubialka K,Kramkowski K,Mogielnicki A,Nowakowska M,Buczko W

更新日期：2012-07-05 00:00:00

abstract：:Because of their importance in pathophysiology, the dopamine receptors have been the subjects of intense pharmacological and physiological research. Their structures have remained mostly unknown until recently with the application of molecular biological approaches. The cloning of the first dopamine receptor, the D2 r...

journal_title：European journal of pharmacology

authors： Civelli O,Bunzow JR,Grandy DK,Zhou QY,Van Tol HH

更新日期：1991-08-14 00:00:00

abstract：:The anticonvulsant compound oxcarbazepine and its principal 10-monohydroxy metabolite protected potently against electroshock-induced tonic hindlimb extension. Maximal plasma concentrations depended on dose and were reached < or = 1 h after an oral dose of oxcarbazepine and < 2 h after monohydroxy derivative. In mice,...

journal_title：European journal of pharmacology

authors： Wamil AW,Schmutz M,Portet C,Feldmann KF,McLean MJ

更新日期：1994-12-27 00:00:00

abstract：:We have recently proposed that retinoic acid receptor (NR1B) is a promising target of neuroprotective therapy for intracerebral hemorrhage, since pretreatment of mice with an NR1B1/NR1B2 agonist Am80 attenuated various pathological and neurological abnormalities associated with the disease. In the present study we fur...

journal_title：European journal of pharmacology

authors： Matsushita H,Hijioka M,Hisatsune A,Isohama Y,Shudo K,Katsuki H

更新日期：2012-05-15 00:00:00