The interaction of delta9-tetrahydrocannabinol with cholinomimetic drugs in an agonist-antagonist paradigm.

abstract：:Several structural analogs of mazindol were tested as inhibitors of the uptake of [3H] dopamine in rat neostriatum, of [3H] norepinephrine in rat occipital cortex and of [3H] serotonin in whole rat brain. A rather wide range of potencies was observed but a number of the drugs were even more potent than mazindol as upt...

journal_title：European journal of pharmacology

authors： Heikkila RE,Babington RG,Houlihan WJ

更新日期：1981-05-08 00:00:00

abstract：:A microcomputer-based system has been used to apply the technique of excitability testing to the study of the actions of a range of pharmacological agents on the excitability of single primary afferent terminals in the mouse spinal cord in vitro. GABAA analogues all evoked increases in excitability that were bicuculli...

journal_title：European journal of pharmacology

authors： Yu YB,Duchen MR,Biscoe TJ

更新日期：1987-09-23 00:00:00

abstract：:Recently the existence of a neurotensin striatonigral pathway strongly up-regulated by methamphetamine has been demonstrated. The aim of the present study was to investigate, using immunohistochemistry and radioimmunoassay, the modulation of this pathway by dopamine antagonists. Rats were injected either with methamph...

journal_title：European journal of pharmacology

authors： Castel MN,Morino P,Nylander I,Terenius L,Hökfelt T

更新日期：1994-09-01 00:00:00

abstract：:To investigate the structure-activity relationships for potent and selective action of enkephalins at the delta-opioid receptors, two newly synthesized analogues, [Cys(O2NH2)2,Leu5]enkephalin and [Cys(O2NH2)2, Met5] enkephalin and the hexapeptide [D-Ala2,Leu5]enkephalyl-Arg (dalargin) were tested and compared with [Le...

journal_title：European journal of pharmacology

authors： Pencheva N,Bocheva A,Dimitrov E,Ivancheva C,Radomirov R

更新日期：1996-05-23 00:00:00

abstract：:The beta-antagonistic effects of celiprolol were assessed in isolated guinea-pig preparations. The pA2 values obtained were 7.84 +/- 0.07, 7.79 +/- 0.06 and 6.45 +/- 0.11 against the positive chronotropic and inotropic effects in the atria and relaxant effects in the trachea induced by isoproterenol, respectively, ind...

journal_title：European journal of pharmacology

authors： Ochi S,Nakazawa M,Kimura T,Nakagawa Y,Imai S

更新日期：1991-02-26 00:00:00

abstract：:Experiments were designed to determine whether or not ketanserin (R 41 468) antagonizes the augmentation by 5-hydroxytryptamine of contractions evoked in isolated arteries by non-adrenergic vasoconstrictor substances. Rings of rabbit femoral arteries were studied under isometric conditions in organ chambers filled wit...

journal_title：European journal of pharmacology

authors： Van Nueten JM,Janssen PA,De Ridder A,Vanhoutte PM

更新日期：1982-02-05 00:00:00

abstract：:In primary cultured striatal neurons we found that (+-)-trans-1-amino-cyclopentyl-1,3-dicarboxylate (trans-ACPD) could inhibit forskolin-induced cAMP formation in a dose-dependent manner (EC50 156 +/- 38 microM, n = 5, maximal inhibition 37.8 +/- 1.2, n = 37). The trans-ACPD-induced inhibition was totally abolished in...

journal_title：European journal of pharmacology

authors： Manzoni O,Prezeau L,Sladeczek F,Bockaert J

更新日期：1992-04-10 00:00:00

abstract：:The effects of the [Ti IV (C(5)H(5))(2) NCS(2)] metallocene (BCDT), a Titanocene Dichloride derivative, on the growth and differentiation of granulocyte-macrophage progenitor cells [colony-forming unit-granulocyte-macrophage (CFU-GM)] and bone marrow cellularity in normal and Ehrlich ascites tumour-bearing mice were s...

journal_title：European journal of pharmacology

authors： Valadares MC,Queiroz ML

更新日期：2002-03-29 00:00:00

abstract：:Psychostimulant abuse has been a serious social problem worldwide for a long time. Bupropion, which is used as an antidepressant and to aid smoking cessation in the US, is considered to have psychostimulant-like activity. Although activation of the dopaminergic system induces several behavioral effects and bupropion c...

journal_title：European journal of pharmacology

authors： Mori T,Shibasaki M,Ogawa Y,Hokazono M,Wang TC,Rahmadi M,Suzuki T

更新日期：2013-10-15 00:00:00

abstract：:We examined whether danazol has a direct action on ovarian steroid secretion and/or uterine prostaglandin (PG) F2 alpha catabolic activity in immature rats in which the first ovulation was induced and in adult ovariectomized rats. The preovulatory surge of estradiol and progesterone was markedly suppressed together wi...

journal_title：European journal of pharmacology

authors： Kogo H,Takasaki K,Yatabe Y,Nishikawa M,Takeo S,Tamura K

更新日期：1992-01-28 00:00:00

abstract：:This study evaluated the contribution of supraspinal opioid receptors to the production of antinociception, in the rat. I.c.v. administration of a selective mu- (DAMGO) and a selective delta- (DPDPE), but not a selective kappa- (U50,488H) opioid receptor agonist, produced significant dose-dependent increase in mechani...

journal_title：European journal of pharmacology

authors： Miaskowski C,Taiwo YO,Levine JD

更新日期：1991-12-03 00:00:00

abstract：:Oxyntomodulin, a hormone released from jejuno-ileum and composed of the glucagon sequence extended by a C-terminal octapeptide displays original tissue specificity for the gastric mucosa. The aim of this study was to compare the effect of oxyntomodulin on histamine (0.4 mg/kg per h)-stimulated gastric acid secretion i...

journal_title：European journal of pharmacology

authors： Carles-Bonnet C,Jarrousse C,Niel H,Martinez J,Bataille D

更新日期：1991-10-15 00:00:00

abstract：:Inhibition of interleukin-6 (IL-6) holds significant promise as a therapeutic approach for triple negative breast cancer (TNBC). We previously reported that phenylmethimazole (C10) reduces IL-6 expression in several cancer cell lines. We have identified a more potent derivative of C10 termed COB-141. In the present wo...

journal_title：European journal of pharmacology

authors： Noori MS,O'Brien JD,Champa ZJ,Deosarkar SP,Lanier OL,Qi C,Burdick MM,Schwartz FL,Bergmeier SC,McCall KD,Goetz DJ

更新日期：2017-05-15 00:00:00

abstract：:Incubated tissue slices from different regions of the rat brain contained cyclic guanosine 3',5'-monophosphate (cyclic GMP) in the following descending order of content: cerebellum greater than hypothalamus greater than striatum greater than thalamusmidbrain greater than brain stem greater that hippocampus greater tha...

journal_title：European journal of pharmacology

authors： Palmer GC,Duszynski CR

更新日期：1975-06-01 00:00:00

abstract：:Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviors. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral micr...

journal_title：European journal of pharmacology

authors： Kalivas PW,Nemeroff CB,Prange AJ Jr

更新日期：1982-03-26 00:00:00

abstract：:The role of the alpha 1-adrenoceptor subtypes, and their possible change with maturation, in alpha 1-adrenoceptor-induced pressor responses in the rat has not been established. Thus, the effects of the alpha 1D-, alpha 1A/1D- and alpha 1B/1D-adrenoceptor antagonists, BMY 7378 (8-(2-(4-(2-methoxyphenyl)-1-piperazinyl)e...

journal_title：European journal of pharmacology

authors： Ibarra M,Terrón JA,López-Guerrero JJ,Villalobos-Molina R

更新日期：1997-03-19 00:00:00

abstract：:Protective effect of quercetin and alpha-tocopherol on experimental reflux oesophagitis in rats was investigated. Rats received quercetin, (100 mg/kg), alpha-tocopherol (16 mg/kg), omeprazole (30 mg/kg) given at 1 h prior to surgery. Quercetin and alpha-tocopherol significantly inhibited the oesophagitis index to 1.33...

journal_title：European journal of pharmacology

authors： Rao CV,Vijayakumar M

更新日期：2008-07-28 00:00:00

abstract：:This study addressed the possibility that acetylcholine-induced relaxation in the rabbit aorta is mediated by dual mechanisms: one N omega-nitro-L-arginine (NLA)-sensitive, the other glybenclamide-sensitive. Acetylcholine, nitroglycerin and BRL38227 (lemakalim), an activator of glybenclamide-sensitive potassium channe...

journal_title：European journal of pharmacology

authors： Bellan JA,Longenecker LL,Kadowitz PJ,McNamara DB

更新日期：1993-04-06 00:00:00

abstract：:The present study was conducted with an aim to explore the possible role of naringin against ischemia reperfusion induced-neurobehavioral alterations, oxidative damage, cellular and histopathological alterations in cortex, striatum, hippocampus areas of brain. Male Wistar rats (200-220 g) were subjected to bilateral c...

journal_title：European journal of pharmacology

authors： Gaur V,Aggarwal A,Kumar A

更新日期：2009-08-15 00:00:00

abstract：:Sham and electrolytic lesions of the dorsal, median, and dorsal + median raphe nuclei were made in different groups of rats. One week later, daily oral treatment with ethanol (5 g/kg p.o. for 25 days) was started. This treatment produced tolerance to the hypothermic and motor impairing (moving belt test) effects of et...

journal_title：European journal of pharmacology

authors： Lê AD,Kalant H,Khanna JM

更新日期：1982-06-04 00:00:00

abstract：:Pain is a global health challenge. For decades, we have been primarily relying upon opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) for pain management. However, adverse effects related to opioid and NSAID use are severe and often lead to forced drug discontinuation and inadequate pain relief. Despite decade...

journal_title：European journal of pharmacology

authors： Li JX,Zhang Y

更新日期：2012-04-15 00:00:00

abstract：:The disruption of redox state homeostasis, the overexpression of lipogenic transcription factors and enzymes, and the increase in lipogenic precursors induced by sweetened beverages are determinants of the development of nonalcoholic fatty liver disease. This study evaluated the action of nicotinamide (NAM) on the exp...

journal_title：European journal of pharmacology

authors： Mejía SÁ,Gutman LAB,Camarillo CO,Navarro RM,Becerra MCS,Santana LD,Cruz M,Pérez EH,Flores MD

更新日期：2018-01-05 00:00:00

abstract：:To test the hypothesis that the flavonoid compound, fisetin, protects macrophages from lipid accumulation and senescence through regulation of casein kinase 2-interacting protein-1 (CKIP-1)/REGγ (11S regulatory particles, 28 kDa proteasome activator, proteasome activator subunit 3) signaling. RAW264.7 macrophage cells...

journal_title：European journal of pharmacology

authors： Jia Q,Cao H,Shen D,Yan L,Chen C,Xing S

更新日期：2019-12-15 00:00:00

abstract：:Impairment of nitric oxide (NO) - cyclic GMP signaling pathway is likely to contribute to human begnin prostate hyperplasia (BPH). In the present study we have used a model of chronic NO synthesis inhibition to evaluate the functional alterations of prostate smooth muscle (PSM) machinery, and involvement of Rho-kinase...

journal_title：European journal of pharmacology

authors： Calmasini FB,Leiria LO,Alves Junior MJ,Báu FR,Alexandre EC,Silva FH,Mónica FZ,Antunes E

更新日期：2015-07-05 00:00:00

abstract：:A high dose of apomorphine, a stimulator of brain dopamine receptors, caused a reduction in total sleep, intermediate sleep and a delayed appearance of paradoxical sleep. With a lower dose, a small and not significant trend toward an increase of paradoxical sleep was observed. Spiroperidol, considered as a specific bl...

journal_title：European journal of pharmacology

authors： Kafi S,Gaillard JM

更新日期：1976-08-01 00:00:00

abstract：:Opiates depress the potassium-induced efflux of [3H]noradrenaline from the mouse vas deferens in a concentration-dependent (the IC50 for normorphine was 1.5 microM), stereospecific and naloxone-reversible manner. As the concentration of sodium in the extracellular fluid was reduced, the inhibitory action of opiates wa...

journal_title：European journal of pharmacology

authors： Sim JA,Henderson G

更新日期：1981-04-09 00:00:00

abstract：:The characteristics of beta-adrenoceptors on frog and chick erythrocytes have been compared to those present on rat erythrocyte, lung and cerebral cortical membranes. The receptors have been examined using the specific ligand [3H]dihydroalprenolol ([3H]DHA) with conventional filtration techniques. The equilibrium diss...

journal_title：European journal of pharmacology

authors： Dickinson KE,Nahorski SR

更新日期：1981-08-27 00:00:00

abstract：:We report that certain substituted hexahydrobenzo[a]phenanthridines are novel high affinity ligands selective for the dopamine D3 receptor. These data demonstrate that substitutions on the heterocyclic nitrogen and the pendant phenyl ring of this nucleus cause a marked increase in both affinity and selectivity for dop...

journal_title：European journal of pharmacology

authors： Watts VJ,Lawler CP,Knoerzer T,Mayleben MA,Neve KA,Nichols DE,Mailman RB

更新日期：1993-08-03 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is extensively distributed in primary afferent sensory nerves, including those innervating the genitourinary tract. Capsaicin can stimulate the release of CGRP from intracellular stores of these nerves, but this phenomenon has not been investigated in-depth in isolated preparatio...

journal_title：European journal of pharmacology

authors： Sheykhzade M,Gupta S,Sørensen T,Sørensen OA,Koch H,Boonen HC,Back O,Fjalland B

更新日期：2011-09-30 00:00:00

abstract：:The present study concerns previously unreported effects of menthol, a cyclic terpene alcohol produced by the peppermint herb, on anion transporters in polarized human airway Calu-3 epithelia. Application of menthol (0.01-1mM) attenuated transepithelial anion transport, estimated as short-circuit currents (I(SC)), aft...

journal_title：European journal of pharmacology

authors： Morise M,Ito Y,Matsuno T,Hibino Y,Mizutani T,Ito S,Hashimoto N,Kondo M,Imaizumi K,Hasegawa Y

更新日期：2010-06-10 00:00:00