Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin.

abstract：:New, more effective pharmacologic treatments for epilepsy are needed, as a substantial portion of patients (>30%) are refractory to currently available anti-epileptic drugs. Cenobamate (YKP3089) is an investigational anti-epileptic drug in clinical development. Two completed adequate and well-controlled studies demons...

journal_title：European journal of pharmacology

authors： Nakamura M,Cho JH,Shin H,Jang IS

更新日期：2019-07-15 00:00:00

abstract：:The mucociliary activity of the rabbit maxillary sinus is increased after exposure to airway irritants such as cigarette smoke and capsaicin. This effect is partly due to a cholinergic reflex but involves an atropine-resistant response probably mediated by the release of tachykinins such as substance P or neurokinin A...

journal_title：European journal of pharmacology

authors： Lindberg S,Dolata J

更新日期：1993-02-16 00:00:00

abstract：:H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) is a compound characterized in vitro as a potent and selective inhibitor of protein kinase A (PKA). In this study, we found that H89 reduced the phosphorylation of the myosin regulatory light chain (MRLC) at Thr-18/Ser-19 and induced disassembly of stre...

journal_title：European journal of pharmacology

authors： Umeda D,Yamada K,Tachibana H

更新日期：2008-08-20 00:00:00

abstract：:The effects of a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) on serum leptin levels were investigated in mice. 5-HTP dose dependently increased serum leptin levels in mice. Pretreatment of the peripheral aromatic amino acid decarboxylase inhibitor carbidopa suppressed 5-HTP-induced hyperleptinemia. These re...

journal_title：European journal of pharmacology

authors： Yamada J,Sugimoto Y,Ujikawa M

更新日期：1999-10-21 00:00:00

abstract：:The novel dopaminergic agents (+)- and (-)-3-PPP were evaluated for their effects upon thermoregulation in rats maintained at room temperature (approximately 22 degrees C). Although approximately 30 times less potent than apomorphine, (+)-3-PPP induced a clearcut, dose-dependent and haloperidol/pimozide-reversible hyp...

journal_title：European journal of pharmacology

authors： Hjorth S,Carlsson A,Clark D,Svensson K,Sanchez D

更新日期：1985-01-08 00:00:00

abstract：:Our laboratory recently reported that a group of novel indole quinuclidine analogs bind with nanomolar affinity to cannabinoid type-1 and type-2 receptors. This study characterized the intrinsic activity of these compounds by determining whether they exhibit agonist, antagonist, or inverse agonist activity at cannabin...

journal_title：European journal of pharmacology

authors： Franks LN,Ford BM,Madadi NR,Penthala NR,Crooks PA,Prather PL

更新日期：2014-08-15 00:00:00

abstract：:The efficacy of cetirizine in comparison with meclizine, another piperazine H1 receptor antagonist, in rat pleurisy caused by allergen or autacoid was investigated. Sensitization was achieved by subcutaneous injection of a mixture of ovalbumin and aluminium hydroxide. Fourteen days later, the animals were challenged w...

journal_title：European journal of pharmacology

authors： Pasquale CP,e Silva PM,Lima MC,Diaz BL,Rihoux JP,Vargaftig BB,Cordeiro RS,Martins MA

更新日期：1992-11-13 00:00:00

abstract：:Berberine, which is a major constituent of the rhizome of Coptidis japonica (CJ), inhibits IL-8 production in colonic epithelial cells and improves 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. In our preliminary studies, berberine inhibited lipid peroxidation in liposomes prepared from l-α-phosp...

journal_title：European journal of pharmacology

authors： Lee IA,Hyun YJ,Kim DH

更新日期：2010-12-01 00:00:00

abstract：:K(+)-channel blocker properties have been reported for mast cell-degranulating peptide (MCD) in the central nervous system, but its action mechanism in mast cells remains unknown. We studied the effect of MCD on the membrane potential of rat peritoneal mast cells using the fluorescent probe bis-oxonol. Unexpectedly, M...

journal_title：European journal of pharmacology

authors： Mousli M,Bronner C,Bueb JL,Landry Y

更新日期：1991-07-12 00:00:00

abstract：:By using acutely dissociated dorsal raphe nucleus neurons (DRN) from young mice, direct and anti-opioid effects of Neuropeptide FF (NPFF) receptors were measured. The NPFF analog 1 DMe (10 µM) had no effect on resting Ca2+ channels but reduced the magnitude of Ca2+ transients induced by depolarization in 83.3% neurons...

journal_title：European journal of pharmacology

authors： Ding Z,Zajac JM

更新日期：2014-10-05 00:00:00

abstract：:In isolated rat aorta, endothelin-1 induced contractions at lower concentrations than endothelin-3. The contractile effects were augmented by removing the endothelium. In contrast, endothelium-1 and endothelin-3 at similar concentrations induced endothelium-dependent relaxation in norepinephrine-stimulated aorta. IRL ...

journal_title：European journal of pharmacology

authors： Karaki H,Sudjarwo SA,Hori M,Sakata K,Urade Y,Takai M,Okada T

更新日期：1993-02-16 00:00:00

abstract：:In this study we aimed to test central administration of CDP-choline on serum ghrelin, leptin, glucose and corticosterone levels in rats. Intracerebroventricular (i.c.v.) 0.5, 1.0 and 2.0 µmol CDP-choline and saline were administered to male Wistar-Albino rats. For the measurement of serum leptin and ghrelin levels, b...

journal_title：European journal of pharmacology

authors： Kiyici S,Basaran NF,Cavun S,Savci V

更新日期：2015-10-05 00:00:00

abstract：:To determine if an Ag(+)-induced contracture is associated with the Ca(2+)-induced Ca2+ release mechanism in the sarcoplasmic reticulum, effects of Ca(2+)-induced Ca2+ release modulators on the Ag(+)-induced contracture were studied with single fibers of frog toe skeletal muscle. The fiber treated with 1 mM caffeine c...

journal_title：European journal of pharmacology

authors： Oba T,Nihonyanagi K,Yamaguchi M

更新日期：1995-03-16 00:00:00

abstract：:Plasma adrenaline mainly originates from adrenaline-containing cells in the adrenal medulla, whereas plasma noradrenaline reflects not only the release from sympathetic nerves but also the secretion from noradrenaline-containing cells in the adrenal medulla. The present study was undertaken to examine the mechanisms i...

journal_title：European journal of pharmacology

authors： Shimizu T,Yokotani K

更新日期：2009-03-15 00:00:00

abstract：:In rats, a selective inhibition for 3 weeks of monoamineoxydase (MAO) type B elicited by daily doses of pargyline (2.5 mumol/kg) or (-)-deprenyl (1 mumol/kg) attenuated the NE dependent stimulation of cortical adenylate cyclase and reduced the number of brain recognition sites for beta-adrenergic receptor ligands. Sim...

journal_title：European journal of pharmacology

authors： Zsilla G,Barbaccia ML,Gandolfi O,Knoll J,Costa E

更新日期：1983-04-22 00:00:00

abstract：:Dextromethorphan which is an active ingredient in many cough medicines has been previously shown to potentiate amnesic effect of morphine in rats. However, the effect of dextromethorphan, that is also a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, in combination with morphine on hippocampus-based lo...

journal_title：European journal of pharmacology

authors： Ghasemzadeh Z,Rezayof A

更新日期：2017-01-05 00:00:00

abstract：:Dihydralazine (0.1 mg/kg), injected intravenously into male Sprague-Dawley rats, caused a decrease in mean arterial blood pressure and an increase in renal plasma flow, while urine volume remained unchanged. Dihydralazine had no effect on kallikrein excretion in the urine and on kallikrein activity in the renal cortex...

journal_title：European journal of pharmacology

authors： Bönner G,Beck D,Deeg M,Marin-Grez M,Gross F

更新日期：1982-02-26 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) may have a pivotal role in the genesis of mechanical inflammatory hyperalgesia in rats and in the nociceptive writhing response in mice. Thalidomide has been shown to selectively inhibit TNF-alpha production. We therefore investigated the effect of thalidomide on these responses...

journal_title：European journal of pharmacology

authors： Ribeiro RA,Vale ML,Ferreira SH,Cunha FQ

更新日期：2000-03-10 00:00:00

abstract：:Metastasis in breast cancer is a leading cause of mortality among women in many countries. This study investigated the anti-cancer role of benzoimidazoquinazoline and benzimidazotriazin; two novel compounds that were designed, synthesized, structurally elucidated, and biologically evaluated as potent anti-angiogenic a...

journal_title：European journal of pharmacology

authors： Hazem RM,Mohamed AA,Ghareb N,Mehanna ET,Mesbah NM,Abo-Elmatty DM,Elgawish MS

更新日期：2021-02-05 00:00:00

abstract：:Beat-to-beat alternations of the cardiac monophasic action potential, known as electrical alternans, were studied at drug concentrations that have known arrhythmogenic outcomes. Electrical alternans were elicited from the heart of anesthetized guinea pigs, both in the absence and presence of drugs that inhibit the del...

journal_title：European journal of pharmacology

authors： Fossa AA,Wisialowski T,Wolfgang E,Wang E,Avery M,Raunig DL,Fermini B

更新日期：2004-02-20 00:00:00

abstract：:Osteoporosis is a reduction in skeletal mass due to an imbalance between bone resorption and bone formation. Bone morphogenetic protein (BMP) plays important roles in osteoblastic differentiation and bone formation. Therefore, components involved in BMP activation are good targets for the development of anti-osteoporo...

journal_title：European journal of pharmacology

authors： Tang CH,Yang RS,Chien MY,Chen CC,Fu WM

更新日期：2008-01-28 00:00:00

abstract：:In this study we have characterized the pharmacological profile of the non-peptide tachykinin NK(2) receptor antagonist ibodutant (MEN15596) in guinea pig isolated main bronchi contractility. The antagonist potency of ibodutant was evaluated using the selective NK(2) receptor agonist [βAla8]NKA(4-10)-mediated contract...

journal_title：European journal of pharmacology

authors： Santicioli P,Meini S,Giuliani S,Lecci A,Maggi CA

更新日期：2013-11-15 00:00:00

abstract：:Swallowing is a patterned motor activity generated by neurons located within the nucleus tractus solitarii (NTS). Previous experiments have shown that administration of excitatory amino acids within the NTS induces swallowing. The present study was undertaken to identify the receptor subtypes involved in this effect. ...

journal_title：European journal of pharmacology

authors： Kessler JP,Jean A

更新日期：1991-08-16 00:00:00

abstract：:Intravenous (i.v.) administration of cytidine-5'-diphosphate choline (CDP-choline) (100, 250 and 500 mg/kg) increased blood pressure in normal rats and reversed hypotension in haemorrhagic shock. Choline (54 mg/kg; i.v.), at the dose equimolar to 250 mg/kg CDP-choline decreased blood pressure of rats in both condition...

journal_title：European journal of pharmacology

authors： Savci V,Goktalay G,Cansev M,Cavun S,Yilmaz MS,Ulus IH

更新日期：2003-05-09 00:00:00

abstract：:Brefelamide is an aromatic amide isolated from Dictyostelium cellular slime molds. We found that brefelamide has a potent inhibitory growth effect measured by MTT assay in 1321N1 human astrocytoma cells. The inhibition was associated with reduced phosphorylation of extracellular signal-regulated kinase (ERK). Brefelam...

journal_title：European journal of pharmacology

authors： Honma S,Saito M,Kikuchi H,Saito Y,Oshima Y,Nakahata N,Yoshida M

更新日期：2009-08-15 00:00:00

abstract：:We have used in situ hybridization to study the localization of mRNA encoding the beta 2-adrenoceptor in tissue sections of the human and rat lung and compared this with the distribution of beta 2-receptor binding sites using receptor autoradiography. To localize beta 2-receptor mRNA, a [32P]labeled antisense RNA prob...

journal_title：European journal of pharmacology

authors： Hamid QA,Mak JC,Sheppard MN,Corrin B,Venter JC,Barnes PJ

更新日期：1991-02-25 00:00:00

abstract：:Terfenadine, a histamine H(1) receptor antagonist, has been associated with clinical ventricular arrhythmias and in vitro excitation-conduction blocks, whereas anti-ischemic and antiarrhythmic effects have been shown with cicletanine, a prostacyclin generation stimulator. We aimed at determining in vitro if cicletanin...

journal_title：European journal of pharmacology

authors： Criniti A,Picard S,Monti F,Dawodu AA,Ruvolo G,Puddu PE,Campa PP

更新日期：1999-10-15 00:00:00

abstract：:The effects of some alpha 1-adrenoceptor antagonists (prazosin, nonselective for the alpha 1A- and alpha 1B-adrenoceptor subtypes; 5-methyl-urapidil, selective for the alpha 1A-adrenoceptor subtype; chloroethylclonidine, selective for the alpha 1B-adrenoceptor subtype) and nifedipine were compared on contractile respo...

journal_title：European journal of pharmacology

authors： Teng CM,Guh JH,Ko FN

更新日期：1994-11-14 00:00:00

abstract：:Chemotherapy-induced neuropathies are widespread disorders evoked by characteristic damage of the nervous system. Sensory alterations, as paresthesia and dysesthesia, and severe pain are disabling side effects that altered quality of life, leading to therapy discontinuation. These kind of neuropathies are extremely di...

journal_title：European journal of pharmacology

authors： Di Cesare Mannelli L,Zanardelli M,Ghelardini C

更新日期：2013-07-05 00:00:00

abstract：:Thoracic preganglionic sympathetic nerve activity, blood pressure, heart rate and femoral arterial conductance were recorded in anaesthetised, paralysed cats. Cumulative dose-response curves were constructed for 8-OH-DPAT, ipsapirone and clonidine. All three drugs caused dose-related falls in blood pressure which were...

journal_title：European journal of pharmacology

authors： Ramage AG,Fozard JR

更新日期：1987-06-19 00:00:00