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Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.

Abstract：

:Beat-to-beat alternations of the cardiac monophasic action potential, known as electrical alternans, were studied at drug concentrations that have known arrhythmogenic outcomes. Electrical alternans were elicited from the heart of anesthetized guinea pigs, both in the absence and presence of drugs that inhibit the delayed rectifier K(+) channel encoded by the human ether a-go-go related-gene (HERG), and are associated with the fatal arrhythmia, Torsade de Pointes. Two other HERG inhibiting drugs not associated with Torsade de Pointes were also studied. At concentrations known to be proarrhythmic, E-4031 and bepridil increased mean alternans 10 and 40 ms at pacing frequencies

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Fossa AA,Wisialowski T,Wolfgang E,Wang E,Avery M,Raunig DL,Fermini B

doi

10.1016/j.ejphar.2003.12.028

keywords:

subject

Has Abstract

pub_date

2004-02-20 00:00:00

pages

209-21

issue

2

eissn

0014-2999

issn

1879-0712

pii

S0014299903028310

journal_volume

486

pub_type

杂志文章

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