L-arginine-induced dilatation of goat coronary artery involves activation of K(ATP) channels.

abstract：:Endothelin-1-(1-31) is a new bioactive 31-amino-acid-length peptide generated from big endothelin-1 by chymase or other chymotrypsin-type proteases with various pathophysiologic functions. In this study, we have detected the specific and monophasic binding of [125I]endothelin-1-(1-31) in porcine lung membranes. Compet...

journal_title：European journal of pharmacology

authors： Kitamura H,Cui P,Sharmin S,Yano M,Kido H

更新日期：2003-03-28 00:00:00

abstract：:A number of neurosteroids exert antiseizure and/or neuroprotective properties. The aim of this study was to evaluate the effect of the neurosteroid alphaxalone on the protective action of conventional antiepileptics in four seizure tests. Alphaxalone (up to 5 mg/kg) did not exert a significant action against amygdala-...

journal_title：European journal of pharmacology

authors： Borowicz KK,Zadrozniak M,Swiader M,Kowalska A,Kleinrok Z,Czuczwar SJ

更新日期：2002-08-02 00:00:00

abstract：:The effects of intracerebroventricular (i.c.v.) or intravenous (i.v.) administration of morphine on colonic motility were investigated in conscious dogs chronically fitted with a strain gauge transducer sutured to the serosa of the proximal colon. Morphine administered i.v. (100 micrograms/kg) or i.c.v. (10 micrograms...

journal_title：European journal of pharmacology

authors： Fioramonti J,Fargeas MJ,Bueno L

更新日期：1985-10-29 00:00:00

abstract：:The effect of diethyldithiocarbamate (DETC, 10(-3) M) on the vasorelaxant activity of acetylcholine, nitric oxide (NO), nitrite, glyceryl trinitrate or dinitrosyl iron cysteine complexes was studied in isolated rat aortic rings contracted with norepinephrine. Pretreatment of these segments with DETC attenuated the vas...

journal_title：European journal of pharmacology

authors： Vedernikov YP,Mordvintcev PI,Malenkova IV,Vanin AF

更新日期：1992-02-25 00:00:00

abstract：:The study compared the efficacy of acute versus chronic metrifonate treatment to improve initial and reversal learning of the water maze spatial navigation task in medial septal-lesioned rats. Acute oral administration of 30 mg/kg metrifonate at 30 min, but not at 150 or 360 min, before training improved the initial a...

journal_title：European journal of pharmacology

authors： Riekkinen M,Schmidt BH,Riekkinen P Jr

更新日期：1997-11-05 00:00:00

abstract：:We investigated the effect of probucol, a lipid-lowering agent with antioxidant properties, on HCl plus ethanol-induced gastric mucosal injury and on the healing of acetic acid-induced gastric ulcers in rats. When the free radical-scavenging activity of probucol was measured by an electron spin resonance technique, th...

journal_title：European journal of pharmacology

authors： Ito M,Suzuki Y,Ishihara M,Suzuki Y

更新日期：1998-08-07 00:00:00

abstract：:Quantitative receptor autoradiography has been employed to determine the binding distribution of [3H]SR 95531 (2'-(3'-carboxy-2',3'-propyl)-3-amino-6-p-methoxyphenylpyrazinium bromide), a GABAA receptor antagonist, in the rat brain. The location showed good correspondence, in most areas, with the binding of [3H]GABA t...

journal_title：European journal of pharmacology

authors： Bristow DR,Martin IL

更新日期：1988-03-29 00:00:00

abstract：:The novel CCK antagonist L364,718 was tested on caerulein- and morphine-induced antinociception in rat using the paw pressure test. Caerulein-induced antinociception (ED50 = 30 micrograms/kg) was significantly inhibited by L354,718 (200 micrograms/kg i.p.) which on its own did not affect paw pressure threshold. In con...

journal_title：European journal of pharmacology

authors： Rattray M,Jordan CC,De Belleroche J

更新日期：1988-07-26 00:00:00

abstract：:While the angiogenic effects of Neuropeptide Y (NPY) in myocardial ischemia and hypercholesterolemia have been studied, its effects on altering oxidative stress, fibrosis and cell death are not known. We hypothesized that local infiltration of NPY in a swine model of chronic myocardial ischemia and hypercholesterolemi...

journal_title：European journal of pharmacology

authors： Matyal R,Sakamuri S,Wang A,Mahmood E,Robich MP,Khabbaz K,Hess PE,Sellke FW,Mahmood F

更新日期：2013-10-15 00:00:00

abstract：:We investigated the effects of acute p.o. pretraining treatment with an indirect acetylcholinesterase inhibitor, metrifonate, on water maze spatial navigation and passive avoidance behavior. Metrifonate (10-100 mg/kg, orally, p.o.) did not improve the water maze or passive avoidance performance of young intact rats. H...

journal_title：European journal of pharmacology

authors： Riekkinen P Jr,Schmidt B,Stefanski R,Kuitunen J,Riekkinen M

更新日期：1996-08-08 00:00:00

abstract：:Emodin is a natural anthraquinone in rhubarb. It has been identified as a prokinetic drug for gastrointestinal motility in Chinese traditional medicine. Emodin contracts smooth muscle by increasing the concentration of intracellular Ca(2+). In many smooth muscles, increasing intracellular Ca(2+) activates Ca(2+)-activ...

journal_title：European journal of pharmacology

authors： Xu L,Ting-Lou,Lv N,Zhu X,Chen Y,Yang J

更新日期：2009-08-01 00:00:00

abstract：:It is known that low-dose aspirin is effective in coronary artery therapy, although it has not yet been clarified how it exerts its action. Here, we report that treatment of coronary artery patients with 100 mg/day of aspirin does not attenuate thrombin generation, but reduces free thrombin by favouring the formation ...

journal_title：European journal of pharmacology

authors： Di Micco B,Colonna G,Di Micco P,Di Micco G,Russo BM,Macalello MA,Ragone R

更新日期：2003-01-26 00:00:00

abstract：:Isoflavones are compounds structurally similar to the mammalian estrogens and have received considerable attention for their preventive actions on bone loss. Here, we synthesized the novel isoflavone derivatives and examined their activities in bone cells. We found that the novel isoflavone derivatives markedly inhibi...

journal_title：European journal of pharmacology

authors： Tang CH,Chang CS,Tan TW,Liu SC,Liu JF

更新日期：2010-12-01 00:00:00

abstract：:Although the vasorelaxant effects of taurine have been studied in rabbit ear artery, rat isolated aorta and mesenteric artery, its pharmacological properties in other vascular beds and underlying mechanism(s) are still not well clarified. The present study was designed to observe the effects of taurine on the contract...

journal_title：European journal of pharmacology

authors： Niu LG,Zhang MS,Liu Y,Xue WX,Liu DB,Zhang J,Liang YQ

更新日期：2008-02-02 00:00:00

abstract：:We now describe the preparation and characterization of a novel radioligand, 2-[125I]iodo-5-methoxy-carbonylamino-N-acetyltryptamine (2-[125I]MCA-NAT), with high affinity and pharmacological selectivity for melatonin ML2 receptor sites. 2-[125I]MCA-NAT was prepared by introducing an [125I]iodine molecule on carbon 2 o...

journal_title：European journal of pharmacology

authors： Molinari EJ,North PC,Dubocovich ML

更新日期：1996-04-22 00:00:00

abstract：:The present study was undertaken to compare the properties of the [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) binding site in the dorsal raphe nucleus with the hippocampal 5-HT1A receptor. In both tissues inclusion of 1 mM Mg2+ enhanced specific [3H]8-OH-DPAT binding, while 1 mM GTP decreased radioligand bi...

journal_title：European journal of pharmacology

authors： Johnson RG,Fiorella D,Winter JC,Rabin RA

更新日期：1997-06-18 00:00:00

abstract：:Dextromethorphan which is an active ingredient in many cough medicines has been previously shown to potentiate amnesic effect of morphine in rats. However, the effect of dextromethorphan, that is also a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, in combination with morphine on hippocampus-based lo...

journal_title：European journal of pharmacology

authors： Ghasemzadeh Z,Rezayof A

更新日期：2017-01-05 00:00:00

abstract：:This study compares the antimitogenic effects of iloprost and prostaglandin E1 on platelet-derived growth factor-BB stimulated DNA synthesis ([3H]thymidine incorporation) in bovine coronary artery smooth muscle cells. When added 20-24 h after stimulation with platelet-derived growth factor-BB (20 ng/ml), both iloprost...

journal_title：European journal of pharmacology

authors： Zucker TP,Bönisch D,Hasse A,Grosser T,Weber AA,Schrör K

更新日期：1998-03-19 00:00:00

abstract：:As methamphetamine-induced neurotoxicity has been proposed to involve oxidative stress, reduced and oxidized glutathione (GSH and GSSG, respectively), vitamin E and ascorbate were measured in the striata of rats killed 2 or 24 h after a neurotoxic regimen of methamphetamine. At 2 h, methamphetamine increased GSH and G...

journal_title：European journal of pharmacology

authors： Harold C,Wallace T,Friedman R,Gudelsky G,Yamamoto B

更新日期：2000-07-14 00:00:00

abstract：:The opioid properties of endomorphin derivatives containing a C-terminal alcoholic(-ol) function were compared to the parent amidated compounds in isolated organs (longitudinal muscle strip of guinea-pig ileum and mouse vas deferens). Similar data were also generated for the mu-opioid receptor selective agonist synthe...

journal_title：European journal of pharmacology

authors： Al-Khrasani M,Orosz G,Kocsis L,Farkas V,Magyar A,Lengyel I,Benyhe S,Borsodi A,Rónai AZ

更新日期：2001-06-01 00:00:00

abstract：:It has been reported that icariin protects neurons against ischemia/reperfusion injury. In this study, we found that icariin could enhance neuronal viability and suppress neuronal death after oxygen and glucose deprivation (OGD). Further study showed that neuroprotection by icariin was through the induction of Sirtuin...

journal_title：European journal of pharmacology

authors： Wang L,Zhang L,Chen ZB,Wu JY,Zhang X,Xu Y

更新日期：2009-05-01 00:00:00

abstract：:Normal human blood platelets in plasma were incubated at 2 degrees C with tritiated 5-hydroxytryptamine ([3H]5HT), and the specific receptor binding was displaced by the addition of unlabelled 5HT. The kinetic parameters of this binding were established and a two-site model for the platelet 5HT receptor demonstrated. ...

journal_title：European journal of pharmacology

authors： Peters JR,Grahame-Smith DG

更新日期：1980-12-05 00:00:00

abstract：:In rabbits, i.v. delta9-tetrahydrocannabinol (delta9-THC) at 0.5 mg/kg was challenged with i.v. arecoline (0.025 mg/kg), nicotine (0.02 mg/kg) or physostigmine (PHYSO, 0.05 mg/kg), and observations were made on quantified EEG and behavior. The cholinomimetics effectively reversed the cortical and hippocampal EEG alter...

journal_title：European journal of pharmacology

authors： Jones BC,Consroe PF,Laird HE 2nd

更新日期：1976-08-01 00:00:00

abstract：:Metabotropic glutamate mGlu(1) receptors play a modulatory role in the nervous system. They enhance cell excitability, modulate synaptic neurotransmission and are involved in synaptic plasticity. During the last 10 years, several selective metabotropic glutamate mGlu(1) receptor competitive antagonists and potentiator...

journal_title：European journal of pharmacology

authors： Lesage A,Steckler T

更新日期：2010-08-10 00:00:00

abstract：:The effects of acute and chronic administration of tianeptine, a novel antidepressant agent, on the hypothalamo-pituitary-adrenal axis were studied in the adult male rat. A single injection of tianeptine did not alter the activity of the hypothalamo-pituitary-adrenal axis. In contrast, chronic administration of tianep...

journal_title：European journal of pharmacology

authors： Delbende C,Tranchand Bunel D,Tarozzo G,Grino M,Oliver C,Mocaër E,Vaudry H

更新日期：1994-01-14 00:00:00

abstract：:The pharmacological activity of N-methyl-actinodaphnine, isolated from Illigera luzonensis, was determined by functional and binding experiments with peripheral tissues. In a functional study, N-methyl-actinodaphnine was a simple competitive antagonist of contractions elicited by phenylephrine (pA2 = 7.11) in rat thor...

journal_title：European journal of pharmacology

authors： Guh JH,Ko FN,Yu SM,Wu YC,Teng CM

更新日期：1995-06-06 00:00:00

abstract：:Identification of natural products that have antitumor activity is invaluable to the chemoprevention and therapy of cancer. The embryos of lotus (Nelumbo nucifera) seeds are consumed in beverage in some parts of the world for their presumed health-benefiting effects. In this report we studied the effects of neferine, ...

journal_title：European journal of pharmacology

authors： Zhang X,Liu Z,Xu B,Sun Z,Gong Y,Shao C

更新日期：2012-02-29 00:00:00

abstract：:It has been shown that inflammation of rat paws elicits accumulation of opioid peptide beta-endorphin-containing immune cells in the inflamed subcutaneous tissue, contributing to immunocyte-produced pain suppression. However, the possible mechanisms involved in the pharmacological application of beta-endorphin in rat ...

journal_title：European journal of pharmacology

authors： Stanojević S,Mitić K,Vujić V,Kovacević-Jovanović V,Dimitrijević M

更新日期：2006-11-07 00:00:00

abstract：:Molecules regulating cell death constitute prominent therapeutic targets. The pro-apoptotic role of serine protease inhibitors prompted us to search for novel modulators of this process. We have tested some recently synthesized antithrombotic compounds for their potential to induce apoptotic cell death. Cell based ana...

journal_title：European journal of pharmacology

authors： Celhar T,Batista Napotnik T,Obreza A,Zega A,Anderluh PS,Kikelj D,Mlinaric-Rascan I

更新日期：2009-01-05 00:00:00

abstract：:The antinociceptive profile of selected histamine H(2) and histamine H(3) receptor antagonists led to the discovery of improgan, a non-brain-penetrating analgesic agent which does not act on known histamine receptors. Because no chemical congener of improgan has yet been discovered which has both antinociceptive and b...

journal_title：European journal of pharmacology

authors： Hough LB,Nalwalk JW,Lu Q,Shan Z,Svokos K,Wentland MP,Montero MJ

更新日期：2005-10-17 00:00:00