Abstract:
:In the present study, the mechanism of relaxant response of nitric oxide precursor, L-arginine, was investigated in goat isolated coronary artery. L-arginine (1 mM) reversed the U-46619 (1 microM)-induced contraction both in endothelium-intact and endothelium-denuded arterial ring preparations. L-arginine analogues, L-NAME, L-NNA and L-NMMA and the guanylyl cyclase inhibitor, methylene blue failed to attenuate the relaxant response of L-arginine. These observations negate the involvement of nitric oxide in mediating the relaxation by L-arginine. K(ATP) channel blocker, glibenclamide (3 microM), abolished the vasorelaxant responses of L-arginine in endothelium-denuded preparations, thereby suggesting the involvement of KATP channels. Further, L-arginine also failed to induce relaxation of the coronary arterial rings constricted with K+ (80 mM)-PSS. Taken together, the results of the present study suggest that L- arginine relaxes goat isolated coronary artery through activation of K(ATP) channels.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Deka DK,Mishra SK,Raviprakash Vdoi
10.1016/j.ejphar.2009.03.031subject
Has Abstractpub_date
2009-05-01 00:00:00pages
113-7issue
1-3eissn
0014-2999issn
1879-0712pii
S0014-2999(09)00238-6journal_volume
609pub_type
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