Effect of diethyldithiocarbamate on the activity of nitric oxide-releasing vasodilators.

abstract：:Increased O-Linked β-N-acetylglucosamine (O-GlcNAc) is observed in several pathologies, and unbalanced O-GlcNAcylation levels favor endothelial dysfunction. Whether augmented O-GlcNAc impacts the uterine artery (UA) function and how it affects the UA during pregnancy remains to be elucidated. We hypothesized that gluc...

journal_title：European journal of pharmacology

authors： Dela Justina V,Priviero F,Dos Passos RR Jr,Webb RC,Lima VV,Giachini FR

更新日期：2020-08-05 00:00:00

abstract：:Dopamine (DA) is thought to have a neurotransmitter role in the spinal cord of the rat. Intrathecal administration of the DA receptor agonist apomorphine has previously been shown to reduce nocifensive responses. The present experiments investigated the site of action of apomorphine, and the mechanisms by which DA ago...

journal_title：European journal of pharmacology

authors： Barasi S,Duggal KN

更新日期：1985-11-19 00:00:00

abstract：:Studies were done to assess the effects of 4-aminopyridine (4AP) and streptomycin (SM) on transmitter release parameters and extracellularly recorded presynaptic action potential. The application of 5 micrometer 4AP resulted in a marked increase in the mean quantal content (m1) associated with an increase in the total...

journal_title：European journal of pharmacology

authors： Enomoto K,Maeno T

更新日期：1981-11-19 00:00:00

abstract：:With some latency, ouabain (10(-6)--10(-5) M) induced a long-lasting contractile response of the isolated vas deferens of the guinea-pig. The ouabain-induced contraction was potentiated by pretreatment with tropolone, whereas it was prevented by pretreatment with cocaine, bretylium, reserpine or phentolamine. The resp...

journal_title：European journal of pharmacology

authors： Katsuragi T,Fukushi Y,Suzuki T

更新日期：1978-02-15 00:00:00

abstract：:In mice with acute dextran sulfate sodium colitis, we examined the effect of inducible nitric oxide synthase inhibition by (1S,5S,6R,7R)-7chloro-3-amino-5methyl-2-azabicyclo[4.1.0]heptane hydrochloride (ONO-1714) on colonic biochemistry, injury, and inflammation. Colonic luminal nitrate and nitrite were measured by th...

journal_title：European journal of pharmacology

authors： Naito Y,Takagi T,Ishikawa T,Handa O,Matsumoto N,Yagi N,Matsuyama K,Yoshida N,Yoshikawa T

更新日期：2001-01-19 00:00:00

abstract：:Pancreatic adenocarcinoma is a leading cause of cancer death in the United States and represents a challenging chemotherapeutic problem. The pharmacological control of angiogenesis might represent a novel approach to the management of pancreas cancer, since the pathological development of vascular supply is a critical...

journal_title：European journal of pharmacology

authors： Bocci G,Danesi R,Marangoni G,Fioravanti A,Boggi U,Esposito I,Fasciani A,Boschi E,Campani D,Bevilacqua G,Mosca F,Del Tacca M

更新日期：2004-09-13 00:00:00

abstract：:Local administration of amitriptyline into the rat hindpaw produces peripheral antinociception; this is reduced by adenosine receptor antagonists and appears to involve endogenous adenosine. The present study used peripheral microdialysis: (a) to determine whether amitriptyline could enhance extracellular tissue level...

journal_title：European journal of pharmacology

authors： Sawynok J,Reid AR,Liu XJ,Parkinson FE

更新日期：2005-08-22 00:00:00

abstract：:The aim of the present study was to correlate the impairment of cognitive function induced by scopolamine with the activity of dopaminergic synapses in brain areas which are innervated by the mesocortical limbic system (e.g. hippocampus and frontal cortex) or by the mesostriatal system (e.g. striatum and nucleus accum...

journal_title：European journal of pharmacology

authors： Memo M,Missale C,Trivelli L,Spano PF

更新日期：1988-05-10 00:00:00

abstract：:We sought to examine the involvement of central cannabinoid CB2 receptor activation in modulating mechanical allodynia in a mouse model of neuropathic pain. JWH133 was demonstrated to be a selective cannabinoid CB2 receptor agonist in mice, reducing forskolin-stimulated cAMP production in CHO cells expressing mouse ca...

journal_title：European journal of pharmacology

authors： Yamamoto W,Mikami T,Iwamura H

更新日期：2008-03-31 00:00:00

abstract：:Tricyclic antidepressants not only inhibit monoamine reuptake but also modulate Cys-loop receptors. However, it is not understood how this modulation is involved in their therapeutic effects. We analyzed the mechanisms of inhibition of homomeric 5-HT(3A) and alpha7-5HT(3A) receptors by tricyclic antidepressants at the...

journal_title：European journal of pharmacology

authors： Gumilar F,Bouzat C

更新日期：2008-04-14 00:00:00

abstract：:Oxyntomodulin is a hormone and a growth factor. It activates two receptors, the Glucagon-like peptide 1 (GLP-1) and the glucagon receptor. GLP-1 mimetics are on the market as treatments for type 2 diabetes and are well tolerated. These drugs have shown neuroprotective properties in animal models of neurodegenerative d...

journal_title：European journal of pharmacology

authors： Liu W,Li Y,Jalewa J,Saunders-Wood T,Li L,Hölscher C

更新日期：2015-10-15 00:00:00

abstract：:We investigated the effects of L-arginine and NG-nitro-L-arginine methyl ester (L-NAME) on macromolecule extravasation in the microcirculation of awake hamsters by computer-assisted image analysis of the distribution of FITC (fluorescein isothiocyanate)-dextran fluorescence in dorsal fold skin preparations. This analy...

journal_title：European journal of pharmacology

authors： Gimeno G,Carpentier PH,Desquand-Billiald S,Hanf R,Finet M

更新日期：1998-04-10 00:00:00

abstract：:The present study examined patterns of analgesia by intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of the serotonin 5-HT3 receptor agonist, 2-methylserotonin (1-100 micrograms) against acute thermal, mechanical or formalin-induced chemo-inflammatory pain in male rats. Neither i.c.v. or i.t. 2-me...

journal_title：European journal of pharmacology

authors： Giordano J

更新日期：1991-06-25 00:00:00

abstract：:The overactivation of glutamate receptors is a major cause of Ca(2+) overload in cells, potentially leading to cell damage and death. There is an abundance of agents and mechanisms by which glutamate receptor activation can be prevented or modulated in order to control these effects. They include the well-established,...

journal_title：European journal of pharmacology

authors： Stone TW,Addae JI

更新日期：2002-07-05 00:00:00

abstract：:Quantitative characterization of the kappa opioid receptor in the rabbit ear artery was carried out using three kappa-selective agonist compounds, dynorphin-(1-13), U-69593 and ethylketocyclazocine. Kinetic analysis was performed using the antagonist, MR 2266. Two other in vitro preparations were studied for compariso...

journal_title：European journal of pharmacology

authors： Berzetei IP,Fong A,Yamamura HI,Duckles SP

更新日期：1988-07-14 00:00:00

abstract：:The present study was aimed to evaluate the antihypertensive effect of diosmin in deoxycorticosterone acetate (DOCA)-salt induced hypertension in male Wistar rats. Hypertension was induced in uninephrectomized rats by weekly twice subcutaneous injection of DOCA (25 mg/kg body weight) and 1% NaCl in the drinking water ...

journal_title：European journal of pharmacology

authors： Silambarasan T,Raja B

更新日期：2012-03-15 00:00:00

abstract：:The purpose of the present study was to test whether kava extract and its constituents kawain, dihydrokawain, methysticin, dihydromethysticin and yangonin provide protection against ischemic brain damage. To this end, we used a model of focal cerebral ischemia in mice and rats. Ischemia was induced by microbipolar coa...

journal_title：European journal of pharmacology

authors： Backhauss C,Krieglstein J

更新日期：1992-05-14 00:00:00

abstract：:The present paper describes a theoretical study on the mechanism underlying the reaction of cellular glutathione (GSH) with polyunsaturated fatty acid ozonides. The reaction can be catalyzed by glutathione S-transferases and leads to detoxication of the ozonides. Semi-empirical molecular orbital computer calculations ...

journal_title：European journal of pharmacology

authors： Hempenius RA,de Vries J,Rietjens IM

更新日期：1992-12-01 00:00:00

abstract：:Inhibitors of phosphodiesterases 3 and 4, the main cyclic AMP (cAMP) degrading enzymes in arteries, may have therapeutic potential in cerebrovascular disorders. We analysed the effects of such phosphodiesterases in guinea pig cerebral arteries with organ bath technique and cyclic nucleotide assays. Guinea pig and huma...

journal_title：European journal of pharmacology

authors： Birk S,Edvinsson L,Olesen J,Kruuse C

更新日期：2004-04-05 00:00:00

abstract：:Previous studies of myocardium have shown that ischemic preconditioning could be mimicked by nitroglycerin through stimulating the release of calcitonin gene-related peptide (CGRP). The present study examined whether nitroglycerin could also provide a preconditioning stimulus in the peripheral vascular bed (the anse i...

journal_title：European journal of pharmacology

authors： Dun Y,Hao YB,Wu YX,Zhang Y,Zhao RR

更新日期：2001-11-02 00:00:00

abstract：:The effects of clozapine on dopamine neurons projecting to the medial-prefrontal cortex, nuclei accumbens and caudatus were compared. Clozapine (1.25 mg/kg i.v.) maximally stimulated the firing rate and burst activity of dopamine neurons projecting to the medialprefrontal cortex. Much higher doses (5 and 10 mg/kg i.v....

journal_title：European journal of pharmacology

authors： Melis M,Diana M,Gessa GL

更新日期：1999-02-05 00:00:00

abstract：:To test the hypothesis that the flavonoid compound, fisetin, protects macrophages from lipid accumulation and senescence through regulation of casein kinase 2-interacting protein-1 (CKIP-1)/REGγ (11S regulatory particles, 28 kDa proteasome activator, proteasome activator subunit 3) signaling. RAW264.7 macrophage cells...

journal_title：European journal of pharmacology

authors： Jia Q,Cao H,Shen D,Yan L,Chen C,Xing S

更新日期：2019-12-15 00:00:00

abstract：:The effects of acute or repeated treatment of male albino BKW mice with caerulein, a cholecystokinin octapeptide (CCK-8) agonist, and with devazepide (MK-329) and L-365,260, antagonists at CCKA ('peripheral') and CCKB ('central') receptors respectively, on motor activity and [propionyl-3H]propionylated-CCK-8 ([3H]pCCK...

journal_title：European journal of pharmacology

authors： Vasar E,Stephenson JD,Meldrum BS

更新日期：1991-09-24 00:00:00

abstract：:Animal models of arthritis are widely used to de-convolute disease pathways and to identify novel drug targets and therapeutic approaches. However, the high attrition rates of drugs in Phase II/III rates means that a relatively small number of drugs reach the market, despite showing efficacy in pre-clinical models. Th...

journal_title：European journal of pharmacology

authors： McNamee K,Williams R,Seed M

更新日期：2015-07-15 00:00:00

abstract：:The goals of the present study were: (1) to investigate the binding properties of (R)- and (S)-procyclidine and two achiral derivatives of muscarinic M1, M2 and M4 receptor subtypes and (2) to identify the interactions which allow these receptors to discriminate between the two stereoisomers. (R)-Procyclidine showed a...

journal_title：European journal of pharmacology

authors： Waelbroeck M,Camus J,Tastenoy M,Lambrecht G,Mutschler E,Tacke R,Christophe J

更新日期：1990-09-18 00:00:00

abstract：:The present investigation was designed to study the cardioprotective effects of nicorandil and pioglitazone preconditioning in myocardial ischemia/reperfusion-induced hemodynamic, biochemical and histological changes in rats. Oral doses of nicorandil (3 or 6 mg/kg) and pioglitazone (10 or 20mg/kg) were administered on...

journal_title：European journal of pharmacology

authors： Ahmed LA,Salem HA,Attia AS,Agha AM

更新日期：2011-08-01 00:00:00

abstract：:Agmatine, an endogenous ligand for imidazoline I(1) receptor, has previously been shown to prevent opioid tolerance in rats and mice, but the cellular mechanisms remain unknown. In the present study, the effects of agmatine activation on imidazoline I(1) receptor on the desensitization, down-regulation and internaliza...

journal_title：European journal of pharmacology

authors： Gao Y,Li F,Wu N,Su RB,Liu Y,Lu XQ,Liu Y,Li J

更新日期：2008-12-03 00:00:00

abstract：:1-Phenyl-3-(2-thiazolyl)-2-thiourea (200 mg/kg, 1 h) protected the adrenergic nerve plexus in the mouse atrium against the destructive action of i.v. 5,7-dihydroxytryptamine. Protection was also observed with ethanol (4 g/kg, 1 h) and with nialamide (50 mg/kg, 2 h). ...

journal_title：European journal of pharmacology

authors： Allis B,Cohen G

更新日期：1977-06-01 00:00:00

abstract：:The bronchial smooth muscle of the rat was examined for contractile responses to excitatory amino acids. The nerve-mediated contraction induced by electrical field stimulation was enhanced by exogenous L-glutamate (L-Glu). The apparent affinity (ED50) of L-Glu was 3.5 +/- 0.1 mM. Both tetrodotoxin and hemicholinium-3 ...

journal_title：European journal of pharmacology

authors： Aas P,Tansø R,Fonnum F

更新日期：1989-05-02 00:00:00

abstract：:Therapeutic angiogenesis is a promising strategy for treating ischemia. The lysophospholipid mediator sphingosine-1-phosphate (S1P) acts on vascular endothelial cells to stimulate migration and tube formation, and plays the critical role in developmental angiogenesis. We developed poly(lactic-co-glycolic-acid) (PLGA)-...

journal_title：European journal of pharmacology

authors： Qi X,Okamoto Y,Murakawa T,Wang F,Oyama O,Ohkawa R,Yoshioka K,Du W,Sugimoto N,Yatomi Y,Takuwa N,Takuwa Y

更新日期：2010-05-25 00:00:00