Abstract:
:The aim of the present study was to correlate the impairment of cognitive function induced by scopolamine with the activity of dopaminergic synapses in brain areas which are innervated by the mesocortical limbic system (e.g. hippocampus and frontal cortex) or by the mesostriatal system (e.g. striatum and nucleus accumbens). The results indicate that acetylcholine receptor blockade induced by the intraperitoneal injection of 0.5 mg/kg scopolamine resulted in a selective decrease in the content of the dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). This effect appeared to be specific for the hippocampus and frontal cortex. Indeed, dopamine turnover in striatum and nucleus accumbens was not affected by scopolamine treatment. The scopolamine-induced decrease of dopamine turnover in both hippocampus and frontal cortex paralleled in terms of both time- and dose-dependence the drug-induced amnesic effects, as measured by a passive avoidance behavioral test.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Memo M,Missale C,Trivelli L,Spano PFdoi
10.1016/0014-2999(88)90670-xsubject
Has Abstractpub_date
1988-05-10 00:00:00pages
367-70issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(88)90670-Xjournal_volume
149pub_type
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