Ketanserin blocks alpha 1-adrenoceptors of porcine vascular smooth muscle cells.

abstract：:Although cyclosporine A (CsA) is a potent immunomodulating agent and is commonly used as a systemic agent for the management of psoriasis patients, current clinical treatments are not always effective due to the clinical inefficacy of low-doses and numerous harmful effects of higher doses. Currently, the combined use ...

journal_title：European journal of pharmacology

authors： Kim CH,Kim JY,Lee AY

更新日期：2015-06-05 00:00:00

abstract：:We tested if discontinuation of cocaine self-administration can lead to the development of depressive-like symptoms in the forced swim test expressed as changes in immobility, swimming and climbing behaviors in rats. A "yoked" procedure in which rats were run simultaneously in groups of three, with two rats received t...

journal_title：European journal of pharmacology

authors： Frankowska M,Gołda A,Wydra K,Gruca P,Papp M,Filip M

更新日期：2010-02-10 00:00:00

abstract：:This study addressed the possibility that acetylcholine-induced relaxation in the rabbit aorta is mediated by dual mechanisms: one N omega-nitro-L-arginine (NLA)-sensitive, the other glybenclamide-sensitive. Acetylcholine, nitroglycerin and BRL38227 (lemakalim), an activator of glybenclamide-sensitive potassium channe...

journal_title：European journal of pharmacology

authors： Bellan JA,Longenecker LL,Kadowitz PJ,McNamara DB

更新日期：1993-04-06 00:00:00

abstract：:Nerve growth factor (NGF) is known to regulate the development and survival of select populations of neurons via its binding/activation of the TrkA and p75(NTR) receptors. However, in some physiological circumstances NGF dysregulation can result in debilitating pathologies, including diabetic neuropathies, interstitia...

journal_title：European journal of pharmacology

authors： Eibl JK,Strasser BC,Ross GM

更新日期：2013-05-15 00:00:00

abstract：:Benzodiazepines (BDZs) and non-BDZ sedative-hypnotics are effective for the management of chronic insomnia; however, they are associated with adverse effects such as headache, dizziness, and palpitations. Furthermore, long-term use of these medications is associated with decreased blood pressure (BP) or depressed baro...

journal_title：European journal of pharmacology

authors： Kagota S,Morikawa K,Ishida H,Chimoto J,Maruyama-Fumoto K,Yamada S,Shinozuka K

更新日期：2021-02-05 00:00:00

abstract：:While the angiogenic effects of Neuropeptide Y (NPY) in myocardial ischemia and hypercholesterolemia have been studied, its effects on altering oxidative stress, fibrosis and cell death are not known. We hypothesized that local infiltration of NPY in a swine model of chronic myocardial ischemia and hypercholesterolemi...

journal_title：European journal of pharmacology

authors： Matyal R,Sakamuri S,Wang A,Mahmood E,Robich MP,Khabbaz K,Hess PE,Sellke FW,Mahmood F

更新日期：2013-10-15 00:00:00

abstract：:The role of flexibility of the alkyl side chain in the tetrahydrocannabinols to cannabinoid activity has been delineated in previous studies with side chain analogs of Delta(8)-tetrahydrocannabinol with double or triple bonds. This study investigated the site of antinociceptive action for these analogs through analysi...

journal_title：European journal of pharmacology

authors： Wiley JL,Patrick GS,Crocker PC,Saha B,Razdan RK,Martin BR

更新日期：2000-06-02 00:00:00

abstract：:The effect of omeprazole, a proton pump inhibitor, on the forward passage of the crop contents of chicks receiving 20% medium chain or long chain triacylglycerol was studied. Medium chain triacylglycerol significantly delayed the crop emptying of chicks compared with long chain triacylglycerol. Omeprazole also signifi...

journal_title：European journal of pharmacology

authors： Mabayo RT,Furuse M,Okumura J

更新日期：1995-01-24 00:00:00

abstract：:We investigated whether or not insulin and cAMP-elevating agents induce the proliferation of adult rat hepatocytes during the early and late phases of primary culture. Adult rat hepatocytes synthesized a significant amount of DNA when cultured in the presence of 10(-7) M insulin for 3 h. Under these conditions, the nu...

journal_title：European journal of pharmacology

authors： Kimura M,Ogihara M

更新日期：1997-05-26 00:00:00

abstract：:Stimulation of the right trigeminal ganglion in pentobarbital anaesthetised rats increased mean arterial blood pressure and decreased right carotid vascular resistance but had no effect on left carotid vascular resistance. Sumatriptan (0.3 mg/kg i.v.) pretreatment did not significantly affect basal levels or stimulati...

journal_title：European journal of pharmacology

authors： Spokes RA,Middlefell VC

更新日期：1995-07-25 00:00:00

abstract：:This study investigated the characteristics of atrial natriuretic peptide (ANP) release from superfused sliced atria and ventricles of rats. Right atria spontaneously released more immunoreactive ANP (Ir-ANP: pg/min per mg tissue) (32 +/- 3) than did left atria (11 +/- 2) or right ventricles (1.5 +/- 0.5). Addition of...

journal_title：European journal of pharmacology

authors： Zongazo MA,Carayon A,Masson F,Maistre G,Noé E,Eurin J,Barthelemy C,Komajda M,Legrand JC

更新日期：1991-12-10 00:00:00

abstract：:The main aim of the study was to examine analgesic effects of the topical opioids and non-steroidal anti-inflammatory drugs (NSAIDs) in a radiant heat tail-flick nociception model. Also, we have tested whether the addition of lauric acid to propylene glycol improves skin permeation for the opioids and NSAIDs. We found...

journal_title：European journal of pharmacology

authors： Kolesnikov Y,Sõritsa D

更新日期：2008-01-28 00:00:00

abstract：:Two experiments were designed to elucidate the involvement of the hypothalamic-pituitary-adrenal axis and the 5-hydroxytryptamine (5-HT) system in the acquisition of lithium chloride-conditioned taste aversion. In Experiment 1, rats were administered either vehicle or 50 mg/kg nefazodone daily for 4 weeks. Rats were t...

journal_title：European journal of pharmacology

authors： Gorzalka B,Hanson L,Harrington J,Killam S,Campbell-Meiklejohn D

更新日期：2003-06-20 00:00:00

abstract：:[3H]Zolpidem, a novel hypnotic drug possessing a chemical structure unrelated to that of benzodiazepine (BZD) was employed as a new ligand to determine its binding characteristics to membrane preparations of rat cerebral cortex and cerebellum. In both structures, the imidazopyridine [3H]zolpidem bound with high affini...

journal_title：European journal of pharmacology

authors： Arbilla S,Allen J,Wick A,Langer SZ

更新日期：1986-11-04 00:00:00

abstract：:Melanocortin peptides have been shown to produce neuroprotection in experimental ischemic stroke. The aim of the present investigation was to identify the therapeutic treatment window of melanocortins, and to determine whether these neuropeptides chronically protect against damage consequent to brain ischemia. A 10-mi...

journal_title：European journal of pharmacology

authors： Giuliani D,Leone S,Mioni C,Bazzani C,Zaffe D,Botticelli AR,Altavilla D,Galantucci M,Minutoli L,Bitto A,Squadrito F,Guarini S

更新日期：2006-05-24 00:00:00

abstract：:Effects of chelerythrine and bisindolylmaleimide I on action potential duration and on voltage-activated K(+) and Ca(2+) currents in rat ventricular myocytes were studied using perforated patch-clamp technique. The action potentials were markedly prolonged after application of 20 microM chelerythrine or 100 nM bisindo...

journal_title：European journal of pharmacology

authors： Voutilainen-Myllylä S,Tavi P,Weckström M

更新日期：2003-04-11 00:00:00

abstract：:Dopamine injected directly into the caudate--putamen, nucleus accumbens or tuberculum olfactorium of rat brain, following a nialamide pretreatment, caused dose-dependent hyperactivity. The hyperactivity was more intense after injections into the nucleus accumbens, but was limited by the development of stereotyped biti...

journal_title：European journal of pharmacology

authors： Costall B,Naylor RJ

更新日期：1976-11-01 00:00:00

abstract：:Recombinant P2X2 receptor was observed by atomic force microscope in the aqueous phase. The P2X2 receptor was expressed in an insect cell line, and recombinant proteins were prepared under native conditions. The membrane fractions were extracted, and histidine-tagged receptor protein was purified from the fractions by...

journal_title：European journal of pharmacology

authors： Nakazawa K,Yamakoshi Y,Tsuchiya T,Ohno Y

更新日期：2005-08-22 00:00:00

abstract：:The extracts of Phellodendron amurense (P. amurense) have been shown to contain many active ingredients e.g. flavone glycosides and to exert a wide range of physiological activities including anti-tumor activity. However, the effects of phellamurin (Phe), a plant flavonone glycoside from the leaves of P. amurense, on ...

journal_title：European journal of pharmacology

authors： Zhang H,Jiang H,Zhang H,Liu J,Hu X,Chen L

更新日期：2019-09-05 00:00:00

abstract：:Intestinal subepithelial myofibroblasts (IMFs) exist just under the epithelial membrane directly facing the mucosal microvascular capillary surface distributed in the lamina propria. In the gastrointestinal tract, ATP is released from epithelial and endothelial cells in response to mechanical stimuli. Although it has ...

journal_title：European journal of pharmacology

authors： Nakamura T,Iwanaga K,Murata T,Hori M,Ozaki H

更新日期：2011-04-25 00:00:00

abstract：:The kinetics of [3H]dexetimide dissociation from muscarine receptors in bovine cardiac left ventricular and tracheal smooth muscle membranes were studied in the absence and presence of three muscarine antagonists. It was found that [3H]dexetimide dissociation from cardiac muscarine receptors was monophasic and very fa...

journal_title：European journal of pharmacology

authors： Roffel AF,Elzinga CR,Meurs H,Zaagsma J

更新日期：1989-03-07 00:00:00

abstract：:The non N-methyl-D-aspartate (NMDA) receptor antagonists dinitroquinoxaline-2,3-dione (DNQX) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), both inhibit the visually driven response of sustained ganglion cells in the cat retina in vivo. In contrast to these findings, the potent NMDA receptor antagonist 3-[+/- )-2-ca...

journal_title：European journal of pharmacology

authors： Kay CD,Ikeda H

更新日期：1989-05-19 00:00:00

abstract：:Pain is a global health challenge. For decades, we have been primarily relying upon opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) for pain management. However, adverse effects related to opioid and NSAID use are severe and often lead to forced drug discontinuation and inadequate pain relief. Despite decade...

journal_title：European journal of pharmacology

authors： Li JX,Zhang Y

更新日期：2012-04-15 00:00:00

abstract：:There is controversy concerning the inhibitory effect of arginine-vasopressin (AVP) on human platelet adenylate cyclase activity, which putatively involves Gi as the G-protein. To clarify this point, the effects of AVP on human platelet membranes were studied by measuring the activities of the high-affinity GTPase, as...

journal_title：European journal of pharmacology

authors： Vittet D,Mathieu MN,Cantau B,Chevillard C

更新日期：1988-06-10 00:00:00

abstract：:We characterized the acute effects of oxidized low-density lipoproteins (oxidized-LDL) on vascular reactivity in isolated aorta from wild-type C57BL/6J mice, and compared these with the chronic alterations in vascular function observed in apolipoprotein-E gene knockout [ApoE(-/-)] mice fed a high-fat diet, which resul...

journal_title：European journal of pharmacology

authors： Jiang F,Gibson AP,Dusting GJ

更新日期：2001-07-20 00:00:00

abstract：:Treatment of rat reticulocytes with tetradecanoyl phorbol acetate (TPA), a tumor-promoting phorbol ester which activates protein kinase C, resulted in an about 50% decrease in the stimulation of adenylate cyclase activity by a subsequent challenge with a beta-adrenoceptor agonist. This phenomenon mimics agonist-induce...

journal_title：European journal of pharmacology

authors： Yamashita A,Kurokawa T,Une Y,Ishibashi S

更新日期：1988-07-07 00:00:00

abstract：:Although a number of muscarinic agonists have been used in clinical trials for Alzheimer's Disease, many of these compounds are low in potency and have only limited intrinsic efficacy. The present study describes four non-quaternary oxadiazole based muscarinic agonists from a quinuclidine and a 1-azanorbornane series....

journal_title：European journal of pharmacology

authors： Freedman SB,Harley EA,Marwood RS,Patel S

更新日期：1990-10-09 00:00:00

abstract：:Several selective phosphodiesterase 4 inhibitors were found to be potent inhibitors of the N-formyl-Met-Leu-Phe (fMLP)-induced leukotriene B4 biosynthesis by human polymorphonuclear leukocytes with IC50s in the nanomolar range (0.09-26 nM). The rank order of potency was 6-(4-pyridylmethyl)-8-(3-nitrophenyl)quinoline (...

journal_title：European journal of pharmacology

authors： Denis D,Riendeau D

更新日期：1999-02-19 00:00:00

abstract：:The coronavirus disease-19 (COVID-19) outbreak that is caused by a highly contagious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a zoonotic pandemic, with approximately 24.5 million positive cases and 8.3 lakhs deaths globally. The lack of effective drugs or vaccine provoked the research fo...

journal_title：European journal of pharmacology

authors： M P,Reddy GJ,Hema K,Dodoala S,Koganti B

更新日期：2021-01-05 00:00:00

abstract：:The zero-trans influx of uridine in human erythrocytes is inhibited by lidoflazine and analogs thereof. The concentrations required for inhibition of nucleoside transport were higher when the compounds were simultaneously added with uridine than upon preincubation of the inhibitors with the erythrocytes. R70380 proved...

journal_title：European journal of pharmacology

authors： Pirovano IM,Van Belle H,Ijzerman AP

更新日期：1990-12-15 00:00:00