Endothelial dysfunction induced by oxidized low-density lipoproteins in isolated mouse aorta: a comparison with apolipoprotein-E deficient mice.

abstract：:The effects of menatetrenone, a vitamin K2 homologue, on osteoclast-like cell formation in mouse bone marrow culture were investigated. After 7 days of incubation, menatetrenone at 10(-6) M, 3 x 10(-6) M and 10(-5) M dose dependently inhibited the tartrate-resistant acid phosphatase-positive multinucleated cell format...

journal_title：European journal of pharmacology

authors： Akiyama Y,Hara K,Tajima T,Murota S,Morita I

更新日期：1994-09-22 00:00:00

abstract：:Several studies have recently suggested a principal role of adenosine in the pathogenesis of radiocontrast media-induced nephropathy. In the present experiments, we therefore investigated the renal protective effects of 8-(noradamantan-3-yl)-1,3-dipropylxanthine (KW-3902), a potent and selective adenosine A1 receptor ...

journal_title：European journal of pharmacology

authors： Yao K,Heyne N,Erley CM,Risler T,Osswald H

更新日期：2001-02-23 00:00:00

abstract：:Perfusion of the 1S,3R isomer of trans-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD, 50 microM), or arachidonic acid (10 microM), for 5 min produced only depression of the field excitatory postsynaptic potential recorded in the CA1 region of rat hippocampal slices from which the CA3 region had been removed. However...

journal_title：European journal of pharmacology

authors： Collins DR,Davies SN

更新日期：1993-08-24 00:00:00

abstract：:Two reserpine dosage schedules were applied to Wistar rats (a) 5 mg/kg i.p. 6 hr before sacrifice and (b) 5 mg/kg i.p. at 36, 24 and 12 hr prior to sacrifice. Control animals were correspondingly sham-injected. The coeliac-mesenteric ganglion complex was removed and processed either for the Falck-Hillarp fluorescence ...

journal_title：European journal of pharmacology

authors： Lever JD,Presley R,Santer RM,Lu KS

更新日期：1975-12-01 00:00:00

abstract：:To determine the role of protein kinase C in the regulation of intestinal fluid transport, experiments were performed with the rat jejunum in vivo, using the active phorbol ester, 4-beta-phorbol 12-myristate 13-acetate (PMA), as stimulator of protein kinase C. Intraluminally administered PMA dose dependently reversed ...

journal_title：European journal of pharmacology

authors： Beubler E,Hinterleitner T,Horina G

更新日期：1990-07-17 00:00:00

abstract：:We report that cloricromene (5-30 microM) inhibited thrombin-induced platelet aggregation and synergized with other antiplatelet compounds. The antiaggregatory effect of subthreshold concentrations of the prostaglandin (PG)I2 analogue, iloprost (0.2 nM), or of sodium nitroprusside (1 micron), acting through a nitric o...

journal_title：European journal of pharmacology

authors： Mollace V,Prosdocimi M,Nisticó G

更新日期：1992-11-10 00:00:00

abstract：:Cats were treated for 35 days with flurazepam, 5 mg/kg per day. The drug was administered through a gastric fistula. Ro15-1788, a benzodiazepine antagonist, caused an abstinence syndrome when administered through the gastric fistula 24 h after the last dose of chronic treatment. Abstinence signs included increased mus...

journal_title：European journal of pharmacology

authors： Rosenberg HC,Chiu TH

更新日期：1982-06-16 00:00:00

abstract：:It has been previously found that the systemic administration of low doses of N-methyl-D-aspartate (NMDA) in mice induces motor depression. The effects of the systemic administration of different doses of NMDA (10, 30 and 60 mg/kg s.c.) on the motor activity and on the in vivo extracellular levels of adenosine in the ...

journal_title：European journal of pharmacology

authors： Melani A,Corsi C,Giménez-Llort L,Martínez E,Ogren SO,Pedata F,Ferré S

更新日期：1999-11-26 00:00:00

abstract：:The alpha1-adrenoceptor subtypes of rat prostate were characterized in binding and functional experiments. In binding experiments, [3H]tamsulosin bound to a single class of binding sites with an affinity (pKD) of 10.79+/-0.04 and Bmax of 87+/-2 fmol mg(-1) protein. This binding was inhibited by prazosin, 2-(2,6-dimeth...

journal_title：European journal of pharmacology

authors： Hiraoka Y,Ohmura T,Oshita M,Watanabe Y,Morikawa K,Nagata O,Kato H,Taniguchi T,Muramatsu I

更新日期：1999-01-29 00:00:00

abstract：:Using microdialysis in rat prefrontal cortex, we found that 1 mg/kg of the stimulant methylphenidate and the non-stimulant atomoxetine, two widely used treatments for Attention Deficit/Hyperactivity Disorder (ADHD), produce robust increases in the extracellular levels of histamine, which plays a key role in attention,...

journal_title：European journal of pharmacology

authors： Horner WE,Johnson DE,Schmidt AW,Rollema H

更新日期：2007-03-08 00:00:00

abstract：:Kynuramine increased heart rate and blood pressure in pithed rats. Heart rate responses were blocked by beta-adrenoceptor antagonists and reserpine pretreatment. Both of these treatments reduced the pressor responses to kynuramine. Remaining pressor activity was inhibited by phentolamine. The pressor responses to kynu...

journal_title：European journal of pharmacology

authors： Johnson TD,Clarke DE

更新日期：1983-02-18 00:00:00

abstract：:Soluble amyloid β-protein (Aβ) oligomers are primary mediators of synaptic dysfunction associated with the progression of Alzheimer's disease. Such Aβ oligomers exist dependent on their rates of aggregation and metabolism. Use of selective somatostatin receptor-subtype agonists have been identified as a potential mean...

journal_title：European journal of pharmacology

authors： Sandoval KE,Farr SA,Banks WA,Crider AM,Morley JE,Witt KA

更新日期：2012-05-15 00:00:00

abstract：:The cardiovascular effects of atriopeptins (AP) I, II and III were compared in spontaneously beating or electrically stimulated guinea pig atria and in rabbit aortic strips precontracted by various agonists. Atriopeptins did not significantly affect sinus nodal rate or atrial contractility. AP II and III, although mor...

journal_title：European journal of pharmacology

authors： Bergey JL,Kotler D

更新日期：1985-04-02 00:00:00

abstract：:Emodin, an anthraquinone derivative isolated from root and rhizome of Rheum palmatum, has been reported to have promising anti-diabetic activity. The present study was to explore the possible mechanism of emodin to ameliorate insulin resistance. Insulin resistance was induced by feeding a high fat diet to Sprague-Dawl...

journal_title：European journal of pharmacology

authors： Cao Y,Chang S,Dong J,Zhu S,Zheng X,Li J,Long R,Zhou Y,Cui J,Zhang Y

更新日期：2016-06-05 00:00:00

abstract：:This study investigated a potential interaction between MK-801 and morphine tolerance using electroencephalography (EEG), EEG spectral parameters and behavior in the rat. Rats were treated for 7 days with morphine alone or with morphine and MK-801. Control groups received chronic MK-801 alone or saline. On day 8 all r...

journal_title：European journal of pharmacology

authors： Haberny KA,Young GA

更新日期：1994-08-11 00:00:00

abstract：:The effect of Ca2+ on the oxytocin-induced, sustained contraction of rat uterine muscle in Ca-free medium after prolonged incubation with 3 mM EGTA (Ca-free contraction) was investigated. A micromolar concentration of Ca2+ caused phasic contraction followed by relaxation while a submicromolar concentration caused rela...

journal_title：European journal of pharmacology

authors： Matsuo K,Uchida MK

更新日期：1987-08-21 00:00:00

abstract：:Neurotensin induced the release of histamine from both purified and non-purified rat peritoneal mast cells by a non-cytotoxic mechanism. It was effective at a concentration as low as 10(-8) M. The dose-response curve for the neurotensin effect was triphasic: and initial gentle rise, a plateau (2.5 X 10(-7) -2.5 X 10(-...

journal_title：European journal of pharmacology

authors： Kurose M,Saeki K

更新日期：1981-12-03 00:00:00

abstract：:Transient ischemia was produced for 15 min by occlusion of the middle cerebral artery in halothane-anesthetized rats, and changes in the extracellular concentrations of neurotransmitter monoamines and amino acids were examined in the striatum. The occlusion produced marked increases in the extracellular concentrations...

journal_title：European journal of pharmacology

authors： Hamami G,Adachi N,Liu K,Arai T

更新日期：2004-01-26 00:00:00

abstract：:SB203580 is the prototypical p38 MAPK inhibitor; however it cannot be used clinically due to liver toxicity. We developed a structural analogue of SB203580 - ML3403 - with equal in vitro and ex vivo p38alpha MAPK inhibition as SB203580, but with reduced activity towards liver cytochrome P450 enzymes. In addition, we d...

journal_title：European journal of pharmacology

authors： Munoz L,Ramsay EE,Manetsch M,Ge Q,Peifer C,Laufer S,Ammit AJ

更新日期：2010-06-10 00:00:00

abstract：:Prostaglandin D2 (PGD2) and the selective DP receptor agonist BW 245C have been previously shown to lower intraocular pressure in rabbits, while PGD2, but not BW 245C, caused plasma extravasation, eosinophil infiltration, and goblet cell depletion. In these present studies definition of the ocular pharmacology of pros...

journal_title：European journal of pharmacology

authors： Woodward DF,Spada CS,Hawley SB,Williams LS,Protzman CE,Nieves AL

更新日期：1993-01-19 00:00:00

abstract：:Alcuronium is known to stabilize allosterically the binding of the muscarinic antagonist N-methylscopolamine to muscarinic M2 receptors and thus to elevate the equilibrium binding of N-methylscopolamine in homogenized cardiac tissue. In order to check for a functional consequence of this effect, the action of alcuroni...

journal_title：European journal of pharmacology

authors： Maass A,Kostenis E,Mohr K

更新日期：1995-01-05 00:00:00

abstract：:Bradykinin (BK; 10(-10)-10(-7) M) relaxes phenylephrine-contracted rabbit isolated pulmonary arterial rings. The mechanical destruction of the endothelial layer obliterates acetylcholine (ACh) and A23187-induced relaxation without influencing BK-, isoproterenol-, sodium nitroprusside- and papaverine-induced relaxation...

journal_title：European journal of pharmacology

authors： Chand N,Mahoney TP Jr,Diamantis W,Sofia RD

更新日期：1987-06-04 00:00:00

abstract：:The endogenous release of adenosine 5'-triphosphate (ATP) from strips of guinea-pig gallbladder during transmural stimulation (TS) was measured with a firefly luciferine-luciferase reaction. TS (15V, 1 ms, 0.5-5 Hz, for 1 min) caused a rapid and marked increase of ATP release in a frequency-dependent manner. Both ATP ...

journal_title：European journal of pharmacology

authors： Takahashi T,Kusunoki M,Ishikawa Y,Kantoh M,Yamamura T,Utsunomiya J

更新日期：1987-01-28 00:00:00

abstract：:Glucagon release upon hypoglycemia is an important homeostatic mechanism utilized by vertebrates to restore blood glucose to normal. Glucagon secretion itself is triggered by Ca2+ influx through voltage-gated ion channels, and the gene inactivation of R-type Ca2+ channels, with Ca(v)2.3 as the ion conducting subunit, ...

journal_title：European journal of pharmacology

authors： Pereverzev A,Salehi A,Mikhna M,Renström E,Hescheler J,Weiergräber M,Smyth N,Schneider T

更新日期：2005-03-21 00:00:00

abstract：:The functions of the 5-HT(4) receptor in the gastrointestinal tract are complex, depending on the species and anatomical regions, and localization of the receptor was not clear. The present study attempted to examine the localization of the 5-HT(4) receptor in the colon of human for comparison with that in guinea pig ...

journal_title：European journal of pharmacology

authors： Sakurai-Yamashita Y,Yamashita K,Kanematsu T,Taniyama K

更新日期：1999-11-03 00:00:00

abstract：:Melanocortin peptides have been shown to produce neuroprotection in experimental ischemic stroke. The aim of the present investigation was to identify the therapeutic treatment window of melanocortins, and to determine whether these neuropeptides chronically protect against damage consequent to brain ischemia. A 10-mi...

journal_title：European journal of pharmacology

authors： Giuliani D,Leone S,Mioni C,Bazzani C,Zaffe D,Botticelli AR,Altavilla D,Galantucci M,Minutoli L,Bitto A,Squadrito F,Guarini S

更新日期：2006-05-24 00:00:00

abstract：:Novel insulinotropic agent nateglinide stimulates insulin via binding to sulfonylurea receptor and closing the ATP-dependent K+ (K(ATP)) channels in pancreatic beta-cells, leading to an increase in [Ca(2+)](i) for exocytosis. The voltage-dependent Ca(2+) channel and the delayed rectifier K+ (Kv) channels are also pres...

journal_title：European journal of pharmacology

authors： Hu S,Wang S

更新日期：2001-09-14 00:00:00

abstract：:In the present study, we investigated the vasculoprotective effect of sigma-1 receptor stimulation with fluvoxamine on pressure overload hypertrophy-induced vascular injury in the thoracic aorta and defined mechanisms underlying that activity. Wistar rats underwent bilateral ovariectomy, and two weeks later were furth...

journal_title：European journal of pharmacology

authors： Bhuiyan MS,Tagashira H,Fukunaga K

更新日期：2011-01-15 00:00:00

abstract：:Administration of the 5-HT1C/5-HT2 receptor agonist 1-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane (DOI, 0.125-2.0 mg/kg i.v.) triggered dose-dependent increases in plasma glucose; plasma insulin levels remained unchanged. Pretreatment with the 5-HT1C/5-HT2 receptor antagonists LY 53857, ritanserin, or the mixed 5-HT2...

journal_title：European journal of pharmacology

authors： Chaouloff F,Laude D,Baudrie V

更新日期：1990-10-23 00:00:00

abstract：:A substantial barrier to the treatment of Opioid Use Disorder (OUD) is the elevated relapse rates in affected patients, and a significant contributor to these events of relapse is exposure to cues and contexts that are intensely associated with prior drug abuse. The neurotransmitter dopamine plays a key role in reward...

journal_title：European journal of pharmacology

authors： McKendrick G,Sharma S,Sun D,Randall PA,Graziane NM

更新日期：2020-12-15 00:00:00