Co-administration of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid and arachidonic acid potentiates synaptic transmission in rat hippocampal slices.

abstract：:This study investigated the effect of the platelet-activating factor (PAF) receptor antagonist, PCA 4248, on the rat pleurisy caused by PAF, serotonin, bradykinin, histamine or allergen. The pleurisy was assessed by measuring liquid extravasation and leucocyte infiltration. Oral pretreatment with PCA 4248 (2.5-20 mg/k...

journal_title：European journal of pharmacology

authors： Martins MA,Lima MC,Bozza PT,Faria Neto HC,Silva PM,Sunkel CE,Cordeiro RS

更新日期：1993-06-11 00:00:00

abstract：:A substantial proportion of depressed patients do not respond to current antidepressant drug therapies. So far, antidepressant drugs have been developed based on the "monoaminergic hypothesis" of depression, which considers a synaptic deficiency in 5-hydroxytryptamine (5-HT; serotonin) or noradrenaline as main cause. ...

journal_title：European journal of pharmacology

authors： Leggio GM,Salomone S,Bucolo C,Platania C,Micale V,Caraci F,Drago F

更新日期：2013-11-05 00:00:00

abstract：:The administration to mice of 1-methyl-4-(2'-methylphenyl)-1,2,3, 6-tetrahydropyridine (2'-CH3-MPTP), a substituted analog of the dopaminergic neurotoxin MPTP caused even more dopaminergic toxicity than MPTP itself. Under conditions in which MPTP was relatively ineffective (i.e. two injections per day of 0.113 mmol/kg...

journal_title：European journal of pharmacology

authors： Youngster SK,Duvoisin RC,Hess A,Sonsalla PK,Kindt MV,Heikkila RE

更新日期：1986-03-18 00:00:00

abstract：:Induction of anaphylactic shock in mice by i.v. antigen challenge (bovine serum albumin, 100 micrograms) or i.v. treatment with the mast cell degranulator compound 48/80 resulted in 80 and 90% mortality rate, respectively. Inhibition of nitric oxide (NO) synthesis from L-arginine by co-injection of the L-arginine anal...

journal_title：European journal of pharmacology

authors： Amir S,English AM

更新日期：1991-10-02 00:00:00

abstract：:The ability of the novel non-glucocorticoid 21-aminosteroid U74006F to protect against the development of hemorrhagic shock was examined in pentobarbital-anesthetized cats. The animals were hemorrhaged to a mean arterial blood pressure (MAP) of 45-50 mm Hg where they were held for 2 h. At the end of the hemorrhage per...

journal_title：European journal of pharmacology

authors： Hall ED,Yonkers PA,McCall JM

更新日期：1988-03-01 00:00:00

abstract：:The extracts of Phellodendron amurense (P. amurense) have been shown to contain many active ingredients e.g. flavone glycosides and to exert a wide range of physiological activities including anti-tumor activity. However, the effects of phellamurin (Phe), a plant flavonone glycoside from the leaves of P. amurense, on ...

journal_title：European journal of pharmacology

authors： Zhang H,Jiang H,Zhang H,Liu J,Hu X,Chen L

更新日期：2019-09-05 00:00:00

abstract：:Although hypoxia induces adrenomedullin gene expression in cultured rat cardiac myocytes, it is still unknown whether oxidative stress is involved in the hypoxia-induced adrenomedullin production. We investigated whether oxidative stress might participate in hypoxia-induced adrenomedullin secretion and whether adrenom...

journal_title：European journal of pharmacology

authors： Yoshihara F,Horio T,Nishikimi T,Matsuo H,Kangawa K

更新日期：2002-02-01 00:00:00

abstract：:Adenosine 5'-triphosphate (ATP), beta, gamma-methylene ATP and alpha, beta-methylene ATP produced relaxation of carbachol-precontracted isolated trachealis muscle from the guinea-pig in the presence of indomethacin (2.8 microM) and the adenosine uptake inhibitor S-(4-nitrobenzyl)-6-thioinosine (NBTI; 300 nM). The pote...

journal_title：European journal of pharmacology

authors： Piper AS,Hollingsworth M

更新日期：1996-06-27 00:00:00

abstract：:The thromboxane mimetic U46619 (11 alpha,9 alpha-epoxymethano PGH2) increased 45Ca2+ uptake in sheep coronary artery rings. A larger increase occurred in endothelium-denuded than in endothelium-inact rings (increase in 45Ca2+ uptake: endothelium intact = 9.6 +/- 3.8, endothelium-denuded = 33.2 +/- 8.1 nmol g-1), in ag...

journal_title：European journal of pharmacology

authors： Dalen T,Vestereng M,Wadsworth R,Kane K

更新日期：1994-08-03 00:00:00

abstract：:We have examined the effect of various chemokines on neuronal toxicity in culture. In mixed cortical cultures, challenged with a brief pulse of N-methyl-D-aspartate (NMDA, 60 microM, 10 min), chemokines were either present for 2 h preceding the pulse or they were co-applied with NMDA and then kept in the medium for th...

journal_title：European journal of pharmacology

authors： Bruno V,Copani A,Besong G,Scoto G,Nicoletti F

更新日期：2000-07-07 00:00:00

abstract：:Diadenosine tetraphosphate (AP4A) is a vasoactive mediator that may be released from platelet granules and that may reach higher plasma concentrations during coronary ischemia-reperfusion. The objective of this study was to analyze its coronary effects in such conditions. To this, rat hearts were perfused in a Langend...

journal_title：European journal of pharmacology

authors： García-Villalón AL,Fernández N,Monge L,Diéguez G

更新日期：2011-06-25 00:00:00

abstract：:Increased motor activity and poor performance in the active avoidance test were observed in the offspring of rats treated with dl-propranolol or sotalol during pregnancy, but not with atenolol and d-propranolol. All substances were administered in drinking water from days 8-22 of gestation. A significant increase in t...

journal_title：European journal of pharmacology

authors： Speiser Z,Gordon I,Rehavi M,Gitter S

更新日期：1991-03-19 00:00:00

abstract：:As part of a program aimed at designing irreversible antagonists of the stimulant and reinforcing properties of cocaine, derivatives of GBR-12783 containing electrophilic substituents were synthesized. GBR-12783, a potent and selective inhibitor of both stimulant binding and dopamine transport, was modified to incorpo...

journal_title：European journal of pharmacology

authors： Deutsch HM,Schweri MM,Culbertson CT,Zalkow LH

更新日期：1992-09-22 00:00:00

abstract：:The constitutive androstane receptor (CAR, NR1I3) has a central role in detoxification processes, regulating the expression of a set of genes involved in metabolism. The dual role of NR1I3 as both a xenosensor and as a regulator of endogenous energy metabolism has recently been accepted. Here, we investigated the mech...

journal_title：European journal of pharmacology

authors： Kachaylo EM,Yarushkin AA,Pustylnyak VO

更新日期：2012-03-15 00:00:00

abstract：:Rats were treated with ethanol for 11-15 days, after which the brain neurotransmitter receptors for dopamine, acetylcholine, serotonin and noradrenaline were measured. The rats were intubated at 12 h intervals with 4 g/kg ethanol, and sacrificed 10 h after the last intubation. After ethanol treatment, the specific bin...

journal_title：European journal of pharmacology

authors： Muller P,Britton RS,Seeman P

更新日期：1980-07-11 00:00:00

abstract：:Pharmacological experiments have implicated a role for serotonin (5-HT)(1A) receptors in the modulation of anxiety. More recent is the interest in corticotropin-releasing hormone (CRH) system as a potential target for the treatment of anxiety disorders. However, selective pharmacological tools for the CRH system are l...

journal_title：European journal of pharmacology

authors： Groenink L,Pattij T,De Jongh R,Van der Gugten J,Oosting RS,Dirks A,Olivier B

更新日期：2003-02-28 00:00:00

abstract：:We investigated sex differences in the motor responses to the full and selective dopamine D1-like receptor agonist, (+/-)-6-chloro-7,8-dihydroxyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (SKF-81297; 0.3, 3, and 10 mg/kg, s.c.), in non-habituated adult rats. In general, SKF-81297 produced a biphasic ef...

journal_title：European journal of pharmacology

authors： Heijtz RD,Beraki S,Scott L,Aperia A,Forssberg H

更新日期：2002-06-07 00:00:00

abstract：:Cervical cancer is the third most prevalent cancer among women worldwide. Theanine from tea and its derivatives show some anticancer activities. However, the role of theanine and its derivatives against human cervical cancer and the molecular mechanisms of action remain unclear. Thus, in this study, we aim to investig...

journal_title：European journal of pharmacology

authors： Liu J,Sun Y,Zhang H,Ji D,Wu F,Tian H,Liu K,Zhang Y,Wu B,Zhang G

更新日期：2016-11-15 00:00:00

abstract：:Diazepam (10(-5)-3 X 10(-4) M) selectively enhanced the negative inotropic responses of guinea-pig atria and the relaxation of guinea-pig taenia coli caused by adenosine and ATP. In the atria, the effect of 2-chloroadenosine, a stable analog of adenosine, was not affected by diazepam. Segments of guinea-pig atria or t...

journal_title：European journal of pharmacology

authors： Moritoki H,Fukuda H,Kotani M,Ueyama T,Ishida Y,Takei M

更新日期：1985-07-11 00:00:00

abstract：:The tension in isolated ring preparations of the thoracic aorta from Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) was measured isometrically to study if there are any differences in the mechanisms of 17beta-estradiol- or progesterone-induced relaxation between WKY and SHR aortic rings. 17beta-Estr...

journal_title：European journal of pharmacology

authors： Unemoto T,Honda H,Kogo H

更新日期：2003-07-04 00:00:00

abstract：:The anti-migraine drug, eletriptan [(R)-3-(1-methyl-2-pyrrolidinylmethyl)-5-[2-(phenylsulphonyl )ethyl]-1 H-indole; UK-116,044], is a novel 5-HT(1B/1D) receptor agonist. In this paper, the regional vasoconstrictor profile of eletriptan, in comparison with sumatriptan, was examined in the anaesthetised dog. The inhibit...

journal_title：European journal of pharmacology

authors： Gupta P,Butler P,Shepperson NB,McHarg A

更新日期：2000-06-09 00:00:00

abstract：:The effects of omega-conotoxin GVIA (omega-CgTx), a peptide isolated from the venom of a marine mollusc, were studied in rat hippocampal neurons. Intracellular recordings from the CA1 area were made for the purpose in in vitro slice preparations. Omega-CgTx (0.1-1 microM) rapidly and irreversibly blocked the EPSP and ...

journal_title：European journal of pharmacology

authors： Dutar P,Rascol O,Lamour Y

更新日期：1989-12-19 00:00:00

abstract：:Kynuramine increased heart rate and blood pressure in pithed rats. Heart rate responses were blocked by beta-adrenoceptor antagonists and reserpine pretreatment. Both of these treatments reduced the pressor responses to kynuramine. Remaining pressor activity was inhibited by phentolamine. The pressor responses to kynu...

journal_title：European journal of pharmacology

authors： Johnson TD,Clarke DE

更新日期：1983-02-18 00:00:00

abstract：:Observations of sigma (sigma) receptor heterogeneity have prompted interest in identifying ligands for sigma receptor subtypes. Selective ligands for the sigma-2 are unavailable, but [3H]ifenprodil labels sigma-2 sites. Therefore, isomers and analogues of ifenprodil were compared as potential sigma-2 ligands. Threo-if...

journal_title：European journal of pharmacology

authors： Hashimoto K,London ED

更新日期：1995-02-06 00:00:00

abstract：:Radioligand receptor binding techniques were used to characterize the effects of different structural types of antidepressant drugs on neurotransmitter receptors. The tricyclic antidepressants more or less potently inhibited the binding to rat brain preparations of several different radiolabelled ligands [3H]WB4101, [...

journal_title：European journal of pharmacology

authors： Hall H,Ogren SO

更新日期：1981-03-26 00:00:00

abstract：:Small-conductance calcium-activated potassium channels (K(Ca)2) generating the medium afterhyperpolarization seen after an action potential modulate the neuronal integration signal. The effects of two K(Ca)2 channel blockers, apamin, specific to K(Ca)2.2 and K(Ca)2.3 channels, and lei-Dab7, which binds to K(Ca)2.2 cha...

journal_title：European journal of pharmacology

authors： Mpari B,Sreng L,Regaya I,Mourre C

更新日期：2008-07-28 00:00:00

abstract：:The effect of intrathecal clonidine on thermal nociception and hindlimb flexion was assessed in acute and chronic spinally transected rats. After an acute, 1-day spinalization, there was no change in the antinociceptive dose-response function to clonidine, relative to intact rats. However, there was a significant incr...

journal_title：European journal of pharmacology

authors： Advokat C

更新日期：2002-02-15 00:00:00

abstract：:Cytokines and cytokine-induced nitric oxide (NO) play important roles in inflammatory glomerular diseases, and both platelet-derived growth factor and transforming growth factor-beta inhibit cytokine-induced NO production. In this study, we demonstrated that a selective endothelin ET(A) receptor antagonist, BQ-485 (He...

journal_title：European journal of pharmacology

authors： Hirahashi J,Nakaki T,Hishikawa K,Marumo T,Hayashi M,Saruta T

更新日期：1999-01-15 00:00:00

abstract：:Levodopa is the standard-of-care for Parkinson's disease, but continued loss of dopamine neurons with disease progression decreases its bioconversion to dopamine, leading to increased side effects and decreased efficacy. In theory, dopamine agonists could equal levodopa, but no approved oral "dopamine agonist" matches...

journal_title：European journal of pharmacology

authors： Mailman RB,Yang Y,Huang X

更新日期：2021-02-05 00:00:00

abstract：:In order to investigate the possible role of the N-methyl-D-aspartate (NMDA) receptor in the development of the behavioural recovery which occurs following unilateral labyrinthectomy (vestibular compensation) in the guinea pig, we administered systemically the specific NMDA receptor/channel antagonists MK801 and CPP (...

journal_title：European journal of pharmacology

authors： Darlington CL,Smith PF

更新日期：1989-12-19 00:00:00