Abstract：
:Kynuramine increased heart rate and blood pressure in pithed rats. Heart rate responses were blocked by beta-adrenoceptor antagonists and reserpine pretreatment. Both of these treatments reduced the pressor responses to kynuramine. Remaining pressor activity was inhibited by phentolamine. The pressor responses to kynuramine were reversed to depressor responses during infusion of norepinephrine but not vasopressin. It is concluded that kynuramine releases cardiac catecholamines and acts as a partial agonist on vascular alpha-adrenoceptors.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Johnson TD,Clarke DEdoi
10.1016/0014-2999(83)90346-1subject
Has Abstractpub_date
1983-02-18 00:00:00pages
323-6issue
2-3eissn
0014-2999issn
1879-0712pii
0014-2999(83)90346-1journal_volume
87pub_type
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journal_title：European journal of pharmacology
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