Endothelin ET(A) receptor antagonist reverses the inhibitory effect of platelet-derived growth factor on cytokine-induced nitric oxide production.

abstract：:ATP and other extracellular nucleotides have diverse and potent effects in different organs. Evidence indicates that extracellular nucleotides and nucleosides deliver crucial signals by acting upon a wide variety of purinergic receptors, which include 19 members separated in three families. Purinergic receptors encomp...

journal_title：European journal of pharmacology

authors： Mathieu P

更新日期：2012-12-05 00:00:00

abstract：:The endogenous release of adenosine 5'-triphosphate (ATP) from strips of guinea-pig gallbladder during transmural stimulation (TS) was measured with a firefly luciferine-luciferase reaction. TS (15V, 1 ms, 0.5-5 Hz, for 1 min) caused a rapid and marked increase of ATP release in a frequency-dependent manner. Both ATP ...

journal_title：European journal of pharmacology

authors： Takahashi T,Kusunoki M,Ishikawa Y,Kantoh M,Yamamura T,Utsunomiya J

更新日期：1987-01-28 00:00:00

abstract：:The effects of endothelin, a potent endogenous vasoconstrictor peptide, were examined in a range of vascular and non-vascular tissues. At concentrations that cause vasoconstriction in portal vein and aorta, the peptide strongly contracted rat uterus, trachea and vas deferens, but not guinea pig ileum. Nifedipine, a di...

journal_title：European journal of pharmacology

authors： Borges R,Von Grafenstein H,Knight DE

更新日期：1989-06-20 00:00:00

abstract：:The inhibitory actions of the Ca2+ antagonist Cd2+, morphine and noradrenaline (exogenously added + endogenously released) on electrically evoked release of [3H]noradrenaline from superfused rat neocortical slices were strongly reduced when release was enhanced by 4-aminopyridine. In the presence of 4-aminopyridine th...

journal_title：European journal of pharmacology

authors： Schoffelmeer AN,Mulder AH

更新日期：1983-03-04 00:00:00

abstract：:We designed a randomized controlled study to identify and compare the liver tissue responses in systemic hypoxia and resuscitation with 21% and 100% oxygen using an animal model of neonatal hypoxia and reoxygenation. Twenty-seven piglets (1-3 days old, weight 1.5-2.0 kg) were acutely instrumented and mechanically vent...

journal_title：European journal of pharmacology

authors： Stevens JP,Churchill T,Fokkelman K,Haase E,Idikio H,Korbutt G,Bigam DL,Cheung PY

更新日期：2008-02-12 00:00:00

abstract：:The effect of apomorphine (ap) was investigated in rats kept in a familiar cage; 0.25-5 mg/kg s.c. produced a short-lasting, abnormal hypermotility consisting mainly of locomotion and sniffing without grooming. Ap was administered to rate pretreated s.c. with various drugs. Ap hypermotility was antagonized by 12 neuro...

journal_title：European journal of pharmacology

authors： Lassen JB

更新日期：1976-04-01 00:00:00

abstract：:Inactivation of gamma-aminobutric acid (GABA) as a neurotransmitter is mediated by diffusion in the synaptic cleft followed by binding to transporter sites and translocation into the intracellular compartment. The GABA transporters of which four subtypes have been cloned (GAT1-4) are distributed at presynaptic nerve e...

journal_title：European journal of pharmacology

authors： Schousboe A,Larsson OM,Sarup A,White HS

更新日期：2004-10-01 00:00:00

abstract：:Isolated porcine myocardial trabeculae from right atria and left ventricles were paced at 1.5 Hz in tissue baths, and changes in isometric contractile force upon exposure to agonist were studied. Alpha calcitonin gene-related peptide (alpha-CGRP) increased contractile force in nearly half of the trabeculae, whereas th...

journal_title：European journal of pharmacology

authors： Saetrum Opgaard O,de Vries R,Tom B,Edvinsson L,Saxena PR

更新日期：1999-12-03 00:00:00

abstract：:Four analogues of Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2, a mammalian FMRFamide-like peptide with antiopiate properties, were synthesized with N-terminus modifications and were shown to have high affinity for F8Famide binding sites. The degradation rate of these analogues in mouse brain slices was 3 times lower than that...

journal_title：European journal of pharmacology

authors： Gicquel S,Mazarguil H,Allard M,Simonnet G,Zajac JM

更新日期：1992-11-03 00:00:00

abstract：:There is experimental evidence indicating that chronic moderate ethanol consumption delays the age-dependent increase in blood pressure. Since the brain natriuretic peptide (BNP) is a potent hypotensive hormone, the effect of chronic ethanol treatment on the heart BNP system was investigated, using spontaneously hyper...

journal_title：European journal of pharmacology

authors： Guillaume P,Jankowski M,Gutkowska J,Gianoulakis C

更新日期：1996-11-28 00:00:00

abstract：:Chronic restraint stress (CRS) is known to cause metabolic and neurological complications in a number of ways. Prolonged exposure to stress evident by increased corticosterone level led to impaired altered insulin signaling and oxidative stress in mice, in the present study. Impaired insulin signaling or insulin resis...

journal_title：European journal of pharmacology

authors： Mourya A,Akhtar A,Ahuja S,Sah SP,Kumar A

更新日期：2018-09-15 00:00:00

abstract：:The effects of continuous subcutaneous infusions of rats for 336 h with vehicle, SKF 38393 (a dopamine D1 receptor agonist), (+)-4-propyl-9-hydroxynaphthoxazine (PHNO, a dopamine D2 receptor agonist) or both D1 and D2 receptor agonists, on locomotor activity were investigated. Rats were maintained under constant light...

journal_title：European journal of pharmacology

authors： Martin-Iverson MT,Yamada N

更新日期：1992-04-29 00:00:00

abstract：:The goal of our study was to determine whether GPR55 agonists, O-1602, could reverse the cyclophosphamide (CYP)-induced changes in cystometric and inflammatory parameters, indicative of the development of bladder inflammation and overactivity. If confirmed, the stimulation of novel cannabinoid receptor - GPR55, could ...

journal_title：European journal of pharmacology

authors： Wróbel A,Zapała Ł,Zapała P,Piecha T,Radziszewski P

更新日期：2020-09-05 00:00:00

abstract：:Dapagliflozin (DAPA) or canagliflozin (CANA), Na+-dependent glucose co-transporter type 2 (SGLT2) inhibitors, were used for treatment of type II diabetes mellitus. Addition of DAPA or CANA suppressed M-type K+ current (IK(M)) in pituitary tumor (GH3) and pheochromocytoma PC12 cells. The IC50 value for DAPA- or CANA-me...

journal_title：European journal of pharmacology

authors： So EC,Liu PY,Wu SN

更新日期：2020-07-15 00:00:00

abstract：:3H-Mepyramine (3H-MEP) binds to slide-mounted tissue sections with characteristics indicating the labelling of a H1-histamine receptor. It is saturable (Bmax 12 pg/g tissue), of a high affinity (KD 0.5 mM) and possesses a drug specificity similar to that observed for H1 receptors in a variety of systems. In agreement ...

journal_title：European journal of pharmacology

authors： Palacios JM,Young WS 3rd,Kuhar MJ

更新日期：1979-10-01 00:00:00

abstract：:Substance P causes histamine release from rat peritoneal mast cells probably through direct activation of a specific G protein at micromolar concentrations. We found that peritoneal mast cells of a substrain of Wistar rats (Std:Wistar) responds to nanomolar concentrations of substance P by releasing histamine in a con...

journal_title：European journal of pharmacology

authors： Ogawa K,Nabe T,Yamamura H,Kohno S

更新日期：1999-06-18 00:00:00

abstract：:Recent evidence suggests that polydatin (PD), a resveratrol glucoside, may have beneficial actions on the cardiac hypertrophy. Therefore, the current study focused on the underlying mechanism of the PD anti-hypertrophic effect in cultured cardiomyocytes and in progression from cardiac hypertrophy to heart failure in v...

journal_title：European journal of pharmacology

authors： Dong M,Ding W,Liao Y,Liu Y,Yan D,Zhang Y,Wang R,Zheng N,Liu S,Liu J

更新日期：2015-01-05 00:00:00

abstract：:The binding properties of a new 1,5-benzothiazepine, clentiazem (TA-3090), were investigated in rat cerebral cortex and skeletal muscle membranes with [3H]diltiazem and [3H]nitrendipine as radioligands. Clentiazem inhibited [3H]diltiazem binding to cerebral cortex membranes at the same concentrations as diltiazem at 2...

journal_title：European journal of pharmacology

authors： Suzuki T,Kurosawa H,Naito K,Otsuka M,Ohashi M,Takaiti O

更新日期：1991-03-05 00:00:00

abstract：:Interleukin-6 (IL-6) is a key proinflammatory cytokine which plays a central role in the pathogenesis of periodontal disease. Host modulatory agents targeting at inhibiting IL-6, therefore, appear to be beneficial in slowing the progression of periodontal disease and potentially reducing destructive aspects of the hos...

journal_title：European journal of pharmacology

authors： Choi EY,Jin JY,Choi JI,Choi IS,Kim SJ

更新日期：2014-04-15 00:00:00

abstract：:Tricyclic antidepressants not only inhibit monoamine reuptake but also modulate Cys-loop receptors. However, it is not understood how this modulation is involved in their therapeutic effects. We analyzed the mechanisms of inhibition of homomeric 5-HT(3A) and alpha7-5HT(3A) receptors by tricyclic antidepressants at the...

journal_title：European journal of pharmacology

authors： Gumilar F,Bouzat C

更新日期：2008-04-14 00:00:00

abstract：:We assessed the roles of brain monoaminergic systems in the analgesic action of spiradoline, a novel kappa-opioid agonist, behaviorally and biochemically by using noradrenaline (NE) and serotonin (5-HT) uptake inhibitors. Analgesic activity was evaluated by measuring latency time in the mouse tail-pinch test. Spiradol...

journal_title：European journal of pharmacology

authors： Kunihara M,Ohyama M,Nakano M

更新日期：1992-04-22 00:00:00

abstract：:Local anesthetics bind to dopamine transporters and inhibit dopamine uptake in rodent brain. Additionally, local anesthetics are self-administered in rhesus monkeys. The present study determined binding affinities of cocaine and five local anesthetics at dopamine transporters in rhesus monkey brain, and compared bindi...

journal_title：European journal of pharmacology

authors： Wilcox KM,Paul IA,Woolverton WL

更新日期：1999-02-19 00:00:00

abstract：:Several lines of evidence suggest that acetylcholinesterase inhibitors (AChE) have their cognitive enhancing effects by stimulating cholinergic receptors within the medial septum. However, intraseptal administration of cholinergic enhancing drugs produce mixed results that appear to depend on both the integrity of the...

journal_title：European journal of pharmacology

authors： Roland JJ,Levinson M,Vetreno RP,Savage LM

更新日期：2010-03-10 00:00:00

abstract：:Dexmedetomidine is a highly specific alpha2-adrenoreceptor agonist, which is now clinically used to induce sedation in patients in the intensive care units. Behavioural effects of dexmedetomidine have been little studied so far. The drug was reported to reduce behaviour such as locomotion or measures of anxiety or agg...

journal_title：European journal of pharmacology

authors： Votava M,Hess L,Slíva J,Krsiak M,Agová V

更新日期：2005-10-31 00:00:00

abstract：:Citrus flavonoids are acknowledged for numerous pharmacological activities, including the myorelaxant effect on various smooth muscles. However, there is no data on their effect on jejunum contractility. Therefore, the aim of the study at hand was to evaluate the impact of hesperetin and diosmetin along with their gly...

journal_title：European journal of pharmacology

authors： Mendel M,Chłopecka M,Dziekan N,Karlik W

更新日期：2016-11-15 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is one of the most common liver diseases involving chronic accumulation of fat and inflammation, often leading to advanced fibrosis, cirrhosis and carcinoma. However, the pathological mechanism for this is unknown. GPR120/FFAR4 has been recognized as a functional fatty acid receptor...

journal_title：European journal of pharmacology

authors： Nakamoto K,Shimada K,Harada S,Morimoto Y,Hirasawa A,Tokuyama S

更新日期：2018-02-05 00:00:00

abstract：:Gerbils trained to respond differentially to the presence or absence of diazepam (8.0 mg/kg) in a T-maze showed a dose-related antagonism when challenged with bemegride (5.0-40.0 mg/kg). Gerbils trained with a mixture of diazepam (8.0 mg/kg) and bemegride (20.0 mg/kg) evidenced response control more slowly than the gr...

journal_title：European journal of pharmacology

authors： Johansson JO,Järbe TU

更新日期：1975-02-01 00:00:00

abstract：:The effects of the benzodiazepine receptor antagonist Ro 15-1788, an imidazobenzodiazepine derivative, were studied with respect to three pharmacological activities exerted by diazepam in rats. Two of these, release of shock-induced suppression of drinking and attenuation of non-reward-induced cessation of responding ...

journal_title：European journal of pharmacology

authors： Thiébot MH,Childs M,Soubrié P,Simon P

更新日期：1983-03-18 00:00:00

abstract：:Di-isobutyryl apomorphine (5 mg/kg i.p.) and lergotrile (5 mg/kg i.p.) produce long lasting turning behaviour in rats with 6-hydroxydopamine lesions at the level of the substantia nigra. Haloperidol (1.5 and 3.0 mg/kg p.o.) blocks the rotational behaviour due to the apomorphine ester but has no effect on lergotrile tu...

journal_title：European journal of pharmacology

authors： Tye NC,Horsman L,Wright FC,Large BT,Pullar IA

更新日期：1977-09-01 00:00:00

abstract：:The effects of veratrine and veratridine on the release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) from incubations of pituitary alone, hypothalamus alone, and coincubations of hypothalamus and pituitary were examined. Veratrine produced only small increases in LH secretion from pituitaries ...

journal_title：European journal of pharmacology

authors： Powers CA,Johnson DC

更新日期：1980-08-29 00:00:00