Abstract:
:Di-isobutyryl apomorphine (5 mg/kg i.p.) and lergotrile (5 mg/kg i.p.) produce long lasting turning behaviour in rats with 6-hydroxydopamine lesions at the level of the substantia nigra. Haloperidol (1.5 and 3.0 mg/kg p.o.) blocks the rotational behaviour due to the apomorphine ester but has no effect on lergotrile turning. Clozapine (10 and 20 mg/kg p.o.) blocks the lergotrile turning but stimulates the rotational behaviour produced by the apomorphine ester. The results support the concept of two anatomically separate dopamine receptors and their relevance to the study of antipsychotic activity is discussed.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Tye NC,Horsman L,Wright FC,Large BT,Pullar IAdoi
10.1016/0014-2999(77)90063-2subject
Has Abstractpub_date
1977-09-01 00:00:00pages
87-90issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(77)90063-2journal_volume
45pub_type
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