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Effects of FK409, a nitric oxide donor, on renal responses to renal nerve stimulation in anesthetized dogs.

Abstract：

:We examined the effects of (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK409), a nitric oxide (NO) donor, on renal actions and norepinephrine overflow induced by renal nerve stimulation in anesthetized dogs, with or without N(G)-nitro-L-arginine (NOARG), a NO synthase inhibitor. Renal nerve stimulation at a low frequency (0.5-2.0 Hz) produced significant decreases in urine flow and urinary excretion of Na+ and increases in norepinephrine secretion rate. Renal nerve stimulation at a high frequency (2.5-5.0 Hz) which diminishes renal hemodynamics, elicited more marked decreases in urine formation and increases in norepinephrine secretion rate. Intrarenal arterial infusion of FK409 (0.25 microg/kg/min) failed to alter renal actions and increases in norepinephrine secretion rate in response to both low- and high frequency renal nerve stimulation. When NOARG (40 microg/kg/min) was administrated intrarenally, low-frequency renal nerve stimulation caused a potent antidiuresis and renal vasoconstriction. The renal nerve stimulation-induced increase in norepinephrine secretion rate was markedly enhanced by NOARG infusion. Simultaneous infusion of FK409 markedly attenuated the NOARG-induced enhancement of renal actions and increases in norepinephrine secretion rate, in response to low-frequency renal nerve stimulation. These results suggest that exogenous NO suppresses the renal nerve stimulation-induced norepinephrine overflow and renal actions in NO-depleted conditions. We also propose that endogenous NO functions tonically as an inhibitory modulator of renal noradrenergic neurotransmission.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Tadano K,Matsuo G,Hashimoto T,Matsumura Y

doi

10.1016/s0014-2999(97)01424-6

subject

Has Abstract

pub_date

1998-01-12 00:00:00

pages

191-9

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(97)01424-6

journal_volume

341

pub_type

杂志文章

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