Abstract:
:The effect of resveratrol, an aryl hydrocarbon receptor antagonist, on the teratogenicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated. Pregnant C57BL/6J mice were orally administered resveratrol (50 mg/kg) for 6 consecutive days, from gestational day (GD) 8 to GD13, followed by an oral challenge with TCDD (14 mug/kg) on GD12. TCDD caused severe fetal malformations including cleft palate (40.7%), renal pelvic dilatation (100%, mean score 3.060), and ureteric dilatation (100%, mean score 3.210) and tortuosity (95.1%). Resveratrol significantly reduced both the incidence of TCDD-induced cleft palate to 18.4% and the degrees of renal pelvic and ureteric dilatations caused by TCDD. The results suggest that pretreatment with resveratrol might bring a beneficial outcome for reducing the incidence and severity of fetal malformations caused by TCDD exposure in utero.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Jang JY,Park D,Shin S,Jeon JH,Choi BI,Joo SS,Hwang SY,Nahm SS,Kim YBdoi
10.1016/j.ejphar.2008.05.033subject
Has Abstractpub_date
2008-09-04 00:00:00pages
280-3issue
1-3eissn
0014-2999issn
1879-0712pii
S0014-2999(08)00582-7journal_volume
591pub_type
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