Characterization of atypical beta-adrenoceptors in the guinea pig duodenum.

abstract：:The authors investigated the effects of spinal and supraspinal administration of the benzodiazepine receptor agonist midazolam alone and with opioids on tests of nociception (tail-flick and hot-plate tests) and motor function (catalepsy) in rats. At the spinal level, the dose-response curves for peak effect and area u...

journal_title：European journal of pharmacology

authors： Luger TJ,Hayashi T,Weiss CG,Hill HF

更新日期：1995-03-06 00:00:00

abstract：:The patch-clamp technique (single-channel recordings) was used to study the effects of glibenclamide and some channel openers on the KATP channel in mouse skeletal muscle. In outside/out membrane patches, glibenclamide reversibly inhibited KATP channel activity in a dose-dependent manner with an apparent Ki of 190 nM....

journal_title：European journal of pharmacology

authors： Allard B,Lazdunski M

更新日期：1993-06-04 00:00:00

abstract：:Maternal undernutrition is associated with programming of obesity in offspring. While previous evidence has linked programming to the hypothalamic, pituitary, and adrenal (HPA) axis it could also affect the hypothalamic neuropeptides which regulate food intake and energy balance. Alpha melanocyte stimulating hormone (...

journal_title：European journal of pharmacology

authors： Stevens A,Begum G,White A

更新日期：2011-06-11 00:00:00

abstract：:The density of dopamine D3 receptors was determined in young (4-month-old) and aged (37-month-old) Fischer-344 x Brown-Norway (F1) male rats using the putative D3 receptor-preferring agonist, [3H](+)-7.hydroxy-2-(N,N-di-n-propylamino)tetralin ([3H](+)-7-OH-DPAT). In the presence of the non-hydrolyzable GTP analog, 5'-...

journal_title：European journal of pharmacology

authors： Wallace DR,Booze RM

更新日期：1996-07-25 00:00:00

abstract：:The aim of our review is to summarize common genetic variations of some receptors associated with clinical consequences, which were not outlined in the previous special issue of this journal. Because of the multiple pathomechanisms of diseases, a set of genetic variation can play a role in the development of pathologi...

journal_title：European journal of pharmacology

authors： Császár A,Abel T

更新日期：2001-02-23 00:00:00

abstract：:We have investigated the cardiac and pressor responses to (±)-ephedrine and (-)-ephedrine in pentobarbitone anaesthetized male wistar rats. The tachycardiac responses to (±)- and (-)-ephedrine were similar, but pressor responses to (-)-ephedrine (10 mg/kg) were significantly greater than those to (±)-ephedrine, and fo...

journal_title：European journal of pharmacology

authors： Alsufyani HA,Docherty JR

更新日期：2018-04-15 00:00:00

abstract：:Chronic restraint stress (CRS) is known to cause metabolic and neurological complications in a number of ways. Prolonged exposure to stress evident by increased corticosterone level led to impaired altered insulin signaling and oxidative stress in mice, in the present study. Impaired insulin signaling or insulin resis...

journal_title：European journal of pharmacology

authors： Mourya A,Akhtar A,Ahuja S,Sah SP,Kumar A

更新日期：2018-09-15 00:00:00

abstract：:A series of 26 drugs was tested for in vitro binding to opiate receptors in the presence and absence of 0.1 M NaCl. The results were correlated with assays for in vivo pharmacological potency. Highly significant correlation was found between binding in the presence and absence of sodium ions and analgesic potency. For...

journal_title：European journal of pharmacology

authors： Stahl KD,van Bever W,Janssen P,Simon EJ

更新日期：1977-12-01 00:00:00

abstract：:Ellagic acid, a natural phenol compound found in numerous fruits and vegetables, causes various physiological effects in different cell models. However, the effect of this compound on Ca(2+) homeostasis in liver cells is unknown. This study examined the effect of ellagic acid on intracellular Ca(2+) concentration ([Ca...

journal_title：European journal of pharmacology

authors： Liang WZ,Chou CT,Cheng JS,Wang JL,Chang HT,Chen IS,Lu T,Yeh JH,Kuo DH,Shieh P,Chen FA,Kuo CC,Jan CR

更新日期：2016-06-05 00:00:00

abstract：:Carbamazepine moderately depressed the input fiber volley resulting in attenuation of the dendritic epsp and the population spike in CA1 of rat hippocampal slices with a threshold concentration of 20 microM. The depressant effect on the population spike was not antagonized by the adenosine receptor blocker caffeine. P...

journal_title：European journal of pharmacology

authors： Olpe HR,Baudry M,Jones RS

更新日期：1985-03-26 00:00:00

abstract：:The aim was to determine whether blockade of store-operated Ca(2+) entry, or inhibition of Ca(2+) sensitisation, is the predominant mechanism by which neuronally released nitric oxide mediates relaxation of the mouse anococcygeus. Nitrergic relaxations to field stimulation (10 Hz, 10 s trains) were unaffected by the s...

journal_title：European journal of pharmacology

authors： Gibson A,Wallace P,McFadzean I

更新日期：2003-06-27 00:00:00

abstract：:The differentiation-inducing factor-1 (DIF-1) is a signal molecule that induces stalk cell differentiation in the cellular slime mold Dictyostelium discoideum. In addition, DIF-1 is a potent antileukemic agent that induces growth arrest in K562 cells. In this study, we investigated the mechanism of action of DIF-1 in ...

journal_title：European journal of pharmacology

authors： Akaishi E,Narita T,Kawai S,Miwa Y,Sasaguri T,Hosaka K,Kubohara Y

更新日期：2004-02-06 00:00:00

abstract：:Effects of the alpha2-adrenoceptor antagonist yohimbine on the antinociception produced by a low dose of naloxone were examined in a rat model of carrageenan-induced inflammation. In rats receiving saline prior to naloxone injection, the low dose of naloxone (5 microg/kg, i.p.) significantly prolonged paw withdrawal l...

journal_title：European journal of pharmacology

authors： Tsuruoka M,Hiruma Y,Matsutani K,Matsui Y

更新日期：1998-05-08 00:00:00

abstract：:The muscarinic agonist McN-A-343 did not affect the tone or nitroprusside-induced relaxations of the rat anococcygeus, but inhibited non-adrenergic non-cholinergic (NANC) relaxations. Atropine, pirenzepine and gallamine blocked the McN-A-343 inhibition of NANC relaxations. Agonists of alpha 1-(methoxamine) or alpha 2-...

journal_title：European journal of pharmacology

authors： Li CG,Rand MJ

更新日期：1989-09-01 00:00:00

abstract：:The effects of capsaicin on the ability of platelets to aggregate in response to thrombin, platelet-activating factor or calcium ionophore (A23187) were examined. At concentrations previously shown to activate sensory afferent neurons, capsaicin markedly inhibited the responsiveness of platelets to the three agonists....

journal_title：European journal of pharmacology

authors： Hogaboam CM,Wallace JL

更新日期：1991-09-04 00:00:00

abstract：:The effects of some alpha 1-adrenoceptor antagonists (prazosin, nonselective for the alpha 1A- and alpha 1B-adrenoceptor subtypes; 5-methyl-urapidil, selective for the alpha 1A-adrenoceptor subtype; chloroethylclonidine, selective for the alpha 1B-adrenoceptor subtype) and nifedipine were compared on contractile respo...

journal_title：European journal of pharmacology

authors： Teng CM,Guh JH,Ko FN

更新日期：1994-11-14 00:00:00

abstract：:Using a batch method for incubation of hippocampal slices, we have examined the effects of 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (RU24969) and (m-trifluoromethylphenyl)piperazine (TFMPP) on release of endogenous 5-hydroxytryotamine (5-HT). Release of 5-HT from slices was enhanced by RU24969 and TFMPP ...

journal_title：European journal of pharmacology

authors： Auerbach SB,Kamalakannan N,Rutter JJ

更新日期：1990-11-06 00:00:00

abstract：:Previous results provided evidence for an inhibitory GABAergic influence on the dopamine neurons of the rat retina, without proving that endogenous GABA physiologically regulates the activity of these cells. We injected picrotoxinin intraocularly to dark-adapted rats and measured retinal dopamine turnover. Dopamine wa...

journal_title：European journal of pharmacology

authors： Kamp CW,Morgan WW

更新日期：1981-01-29 00:00:00

abstract：:Selegiline, a therapeutic agent of Parkinson's disease, and its metabolite, desmethylselegiline, were explored for their neuroprotective effects against N-methyl-D-aspartate (NMDA)-induced cell death in rat retina. Morphometric analysis of the retina revealed that an intravitreal injection of NMDA induced a significan...

journal_title：European journal of pharmacology

authors： Takahata K,Katsuki H,Kobayashi Y,Muraoka S,Yoneda F,Kume T,Kashii S,Honda Y,Akaike A

更新日期：2003-01-01 00:00:00

abstract：:The overactivation of glutamate receptors is a major cause of Ca(2+) overload in cells, potentially leading to cell damage and death. There is an abundance of agents and mechanisms by which glutamate receptor activation can be prevented or modulated in order to control these effects. They include the well-established,...

journal_title：European journal of pharmacology

authors： Stone TW,Addae JI

更新日期：2002-07-05 00:00:00

abstract：:The response of lymph vessels, arterioles and venules in the exteriorized rat mesentery to endothelin-1, vasopressin and norepinephrine was examined with the aid of high-resolution television microscopy. On a molar basis, endothelin-1 was more potent than vasopressin to contract the three types of vessels. Norepinephr...

journal_title：European journal of pharmacology

authors： Fortes ZB,Scivoletto R,Garcia-Leme J

更新日期：1989-10-24 00:00:00

abstract：:Helicobacter pylori (H. pylori) and nonsteroidal anti-inflammatory drugs (NSAID) are the most common pathogens in the gastroduodenal mucosa in animals and humans, but their relationship in ulcerogenesis has been little studied. According to some authors, H. pylori infection in humans does not act synergistically with ...

journal_title：European journal of pharmacology

authors： Pawlik T,Konturek PC,Konturek JW,Konturek SJ,Brzozowski T,Cześnikiewicz M,Plonka M,Bielanski W,Areny H

更新日期：2002-08-02 00:00:00

abstract：:Pancreatic adenocarcinoma is a leading cause of cancer death in the United States and represents a challenging chemotherapeutic problem. The pharmacological control of angiogenesis might represent a novel approach to the management of pancreas cancer, since the pathological development of vascular supply is a critical...

journal_title：European journal of pharmacology

authors： Bocci G,Danesi R,Marangoni G,Fioravanti A,Boggi U,Esposito I,Fasciani A,Boschi E,Campani D,Bevilacqua G,Mosca F,Del Tacca M

更新日期：2004-09-13 00:00:00

abstract：:Unlike classical antipsychotic drugs, clozapine activates the hypothalamo-pituitary-adrenal axis and induces a specific regional pattern of Fos-protein expression in the rat forebrain. Whether corticosterone plays a role in the clozapine-induced Fos response is the subject of this study. Some rats were adrenalectomize...

journal_title：European journal of pharmacology

authors： Sebens JB,Middelveld RJ,Koch T,Ter Horst GJ,Korf J

更新日期：2001-04-06 00:00:00

abstract：:Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and in the induction of corticosteroid (CS) insensitivity. Chronic ozone exposure leads to a model of COPD with lung inflammation and emphysema. Mitogen-activated protein kinase phosphatase-1 (MKP-1) may underl...

journal_title：European journal of pharmacology

authors： Pinart M,Hussain F,Shirali S,Li F,Zhu J,Clark AR,Ammit AJ,Chung KF

更新日期：2014-12-05 00:00:00

abstract：:Three apparently distinct pertussis toxin (PTX)-sensitive substrates, with Mrs of 39, 40 and 41 kDa, were identified in membranes prepared from the sino-atrial (SA) node and right atrium of bovine heart. Based on their biochemical characterization, the effects of guanine nucleotides/MgCl2 on their PTX-catalyzed [32P]A...

journal_title：European journal of pharmacology

authors： Braun AP,Gupta RC,Sulakhe PV

更新日期：1990-07-31 00:00:00

abstract：:In isolated rat aorta, endothelin-1 induced contractions at lower concentrations than endothelin-3. The contractile effects were augmented by removing the endothelium. In contrast, endothelium-1 and endothelin-3 at similar concentrations induced endothelium-dependent relaxation in norepinephrine-stimulated aorta. IRL ...

journal_title：European journal of pharmacology

authors： Karaki H,Sudjarwo SA,Hori M,Sakata K,Urade Y,Takai M,Okada T

更新日期：1993-02-16 00:00:00

abstract：:The effect of aclarubicin on vasocontractility was investigated using aortic strips isolated from rats. The aortic strips from rats injected i.p. with aclarubicin (4 mg/kg body weight per day for 5 consecutive days) showed diminished contractile responses to KCl and phenylephrine in comparison with the controls inject...

journal_title：European journal of pharmacology

authors： Wakabayashi I,Hatake K,Kakishita E

更新日期：1989-08-11 00:00:00

abstract：:Endogenous opioid and nociceptin systems are widely distributed in the gastrointestinal tract where they seem to play a crucial role in maintaining the intestinal homeostasis. The aim of our study was to assess whether activation of nociceptin (NOP) and µ-opioid (MOP) receptors by a mixed NOP/MOP receptor agonist, BU0...

journal_title：European journal of pharmacology

authors： Zielińska M,Ben Haddou T,Cami-Kobeci G,Sałaga M,Jarmuż A,Padysz M,Kordek R,Spetea M,Husbands SM,Fichna J

更新日期：2015-10-15 00:00:00

abstract：:We have shown that the major active agent of Cannabis sativa, Delta(9)-tetrahydrocannabinol, activates peroxisome proliferator-activated receptor gamma [PPARgamma, O'Sullivan, S.E., Tarling, E.J., Bennett, A.J., Kendall, D.A., Randall, M.D., 2005c. Novel time-dependent vascular actions of delta9-tetrahydrocannabinol m...

journal_title：European journal of pharmacology

authors： O'Sullivan SE,Sun Y,Bennett AJ,Randall MD,Kendall DA

更新日期：2009-06-10 00:00:00