Dopamine D3 receptor density elevation in aged Fischer-344 x Brown-Norway (F1) rats.

abstract：:We have developed a model of ischaemia-reperfusion injury in C57BL/6 mice involving ischaemia for 0.5 to 2.5 h with an elastic tourniquet on one hind limb and reperfusion for 24 h, analogous to a well-established model of ischaemia-reperfusion injury in the rat. Viability was assessed in tissue homogenates of the gast...

journal_title：European journal of pharmacology

authors： Knight KR,Zhang B,Morrison WA,Stewart AG

更新日期：1997-08-13 00:00:00

abstract：:We directly compared the effects of YM337, the Fab fragment of the humanized monoclonal antibody C4G1, on platelet aggregation and template bleeding time with those of abciximab, the Fab fragment of the human/murine chimeric monoclonal antibody 7E3, in rhesus monkeys. The duration of inhibition of platelet aggregation...

journal_title：European journal of pharmacology

authors： Suzuki K,Sakai Y,Hisamichi N,Taniuchi Y,Sato K,Terazaki C,Kaku S,Kawasaki T,Yano S,Inagaki O,Masuho Y

更新日期：1997-10-08 00:00:00

abstract：:The pharmacological properties of two angiotensin II analogues containing carboranylalanine (Car) are reported. Sar-Arg-Val-Tyr-Val-His-Pro-Car is a weak partial agonist showing 15% intrinsic activity and a very long lasting action, specific for the angiotensin II receptor of the rabbit aorta. Sar-Arg-Val-Car-Val-His-...

journal_title：European journal of pharmacology

authors： Escher E,Guillemette G,Leukart O,Regoli D

更新日期：1980-09-05 00:00:00

abstract：:The study concerned the effect of arachidonic acid metabolites on the inflammatory reaction in granulation tissue of open wounds in rats. Metabolites or inhibitors were applied in a wound chamber attached to circular, open, full-thickness skin wounds 5 days post-wounding. The adjacent wound served as control. Blood fl...

journal_title：European journal of pharmacology

authors： Lundberg C,Gerdin B

更新日期：1984-01-27 00:00:00

abstract：:This study uses immediate early transcription factor gene expression to map neuronal activation after a single exposure to the elevated X-maze. Exposure to this novel environment leads to widespread upregulation in the gene expression of c-fos, NGFI-A and NGFI-B (the nerve growth factor induced genes), but not c-jun n...

journal_title：European journal of pharmacology

authors： Hinks GL,Brown P,Field M,Poat JA,Hughes J

更新日期：1996-09-26 00:00:00

abstract：:It was previously shown that haloperidol, but not clozapine, induced intense rat catalepsy when co-administered with delta-9-tetrahydrocannabinol. The present study investigated whether similar alterations could be observed on striatal c-Fos immunoreactivity after administration of the same drug combinations. Western ...

journal_title：European journal of pharmacology

authors： Marchese G,Sanna A,Casu G,Casti P,Spada GP,Ruiu S,Pani L

更新日期：2008-11-19 00:00:00

abstract：:This study examined the mechanism of action of neurotensin on intraluminal pressure in rat proximal colon. The direct and indirect contractile response to neurotensin (100 nM) was abolished in Ca(2+)-free solution, and was antagonized by nifedipine (1-5-10 nM) and potentiated by Bay K 8644 (methyl 1,4-dihydro-2,6-dime...

journal_title：European journal of pharmacology

authors： Mulè F,Serio R

更新日期：1997-01-29 00:00:00

abstract：:A specific protein kinase C inhibitor, calphostin C, which injected alone had no effect on the antinociception induced by intrathecal (i.t.) administration of a selective mu-opioid receptor agonist, [D-Ala2,NMePhe4,Gly(ol)5]enkephalin (DAMGO), dose-dependently attenuated the development of acute tolerance to the i.t. ...

journal_title：European journal of pharmacology

authors： Narita M,Narita M,Mizoguchi H,Tseng LF

更新日期：1995-07-04 00:00:00

abstract：:In formyl-Met-Leu-Phe (fMLP)-stimulated rat neutrophils, 2-benzyl-3-(4-hydroxymethylphenyl)indazole (CHS-111) inhibited superoxide anion (O(2)(-)) generation, which was not mediated by scavenging the generated O(2)(-) or by a cytotoxic effect, and attenuated migration. CHS-111 had no effect on the arachidonic acid-ind...

journal_title：European journal of pharmacology

authors： Chang LC,Lin RH,Huang LJ,Chang CS,Kuo SC,Wang JP

更新日期：2009-08-01 00:00:00

abstract：:MK-801 (a potent non-competitive antagonist of N-methyl-D-aspartic acid-mediated events) in subcutaneous doses of 0.1 and 0.2 mg/kg increased the threshold for electroconvulsions and in doses of 0.0031 and 0.0125 mg/kg enhanced the protective activity of valproate against maximal electroshock-induced convulsions in mi...

journal_title：European journal of pharmacology

authors： Urbańska E,Dziki M,Kleinrok Z,Czuczwar SJ,Turski WA

更新日期：1991-08-06 00:00:00

abstract：:Various in vitro models have been developed to study ischemia and/or hypoxia. In the present experiment, we examined whether hypoxia/hypoglycemia (ischemia) in rat hippocampal slices reduced the 2-deoxyglucose (2-DG) uptake and CA1 field potentials evoked by stimulation of Schaffer collaterals. Autoradiograms revealed...

journal_title：European journal of pharmacology

authors： Shibata S,Kagami-Ishi Y,Tominaga K,Kodama K,Ueki S,Watanabe S

更新日期：1992-12-08 00:00:00

abstract：:Effects of the 5-HT3 receptor agonist, m-chlorophenylbiguanide (10.0-40.0 microg), on sleep and waking were studied in control, vehicle-treated and 6-hydroxydopamine-injected rats. Bilateral injections of m-chlorophenylbiguanide into the nucleus accumbens of the control and the vehicle-infused animals significantly in...

journal_title：European journal of pharmacology

authors： Monti JM,Ponzoni A,Jantos H,Lagos P,Silveira R,Banchero P

更新日期：1999-01-08 00:00:00

abstract：:Racemic baclofen, (-)-baclofen and muscimol depressed all spontaneously firing locus coeruleus neurons tested in a slice preparation. Racemic phaclofen (100 microM; 1 mM) moderately antagonized the effects of racemic baclofen without antagonizing those of muscimol. Bicuculline (10, 30, 100 microM) potently antagonized...

journal_title：European journal of pharmacology

authors： Olpe HR,Steinmann MW,Hall RG,Brugger F,Pozza MF

更新日期：1988-04-27 00:00:00

abstract：:Pteropodine and isopteropodine are heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd.) DC, a Peruvian medicinal plant known as cat's claw. In this study, the effects of these alkaloids on the function of Ca(2+)-activated Cl(-) currents evoked by stimulation of G protein-coupled muscarinic M...

journal_title：European journal of pharmacology

authors： Kang TH,Matsumoto K,Tohda M,Murakami Y,Takayama H,Kitajima M,Aimi N,Watanabe H

更新日期：2002-05-24 00:00:00

abstract：:Mizoribine is a disease-modifying anti-rheumatic drug (DMARD) that is used in the treatment of rheumatoid arthritis. However, clinical use of the drug is restricted to a few Asian countries due to a lack of comprehensive evidence on its effectiveness. The inhibitory effect of the drug on human osteoclastogenesis was i...

journal_title：European journal of pharmacology

authors： Lee YA,Yang HI,Park EK,Bang JS,Choi HM,Oh DH,Lee SH,Hong SJ,Jo YJ,Yoo MC,Kim KS

更新日期：2009-03-01 00:00:00

abstract：:The direct effects or right atrial pacing and nitroglycerin on myocardial oxygen balance were studied in isolated canine hearts. Whereas atrial pacing produced an increase in myocardial oxygen consumption (MVO2) and no change in the affinity of hemoglobin for oxygen (P-50), an intracoronary infusion of nitroglycerin d...

journal_title：European journal of pharmacology

authors： Warltier DC,Gross GJ,Hardman HF

更新日期：1975-11-01 00:00:00

abstract：:The effects of the two prandial glucose regulators, repaglinide and nateglinide, on ATP-sensitive K(+) (K(ATP)) channel activity, membrane potential and exocytosis in single rat pancreatic A-cells were investigated using the patch-clamp technique. K(ATP) channel activity was reversibly blocked by repaglinide (K(d)=22 ...

journal_title：European journal of pharmacology

authors： Bokvist K,Hoy M,Buschard K,Holst JJ,Thomsen MK,Gromada J

更新日期：1999-12-10 00:00:00

abstract：:Oxygen free radicals have been involved in the pathophysiology of cerebral ischemia, especially after spontaneous or thrombolytic reperfusion. In this study with rats, we have combined a severe focal ischemic insult (2 h) and a prolonged reperfusion time (7 days) to assess the possible sustained neuroprotective effect...

journal_title：European journal of pharmacology

authors： Salom JB,Pérez-Asensio FJ,Burguete MC,Marín N,Pitarch C,Torregrosa G,Romero FJ,Alborch E

更新日期：2004-07-08 00:00:00

abstract：:A series of neurochemical studies evaluated the selectivity of the depletions of norepinephrine produced by intraventricular injections of xylamine. Brain monoamines were assayed by liquid chromatography with electrochemical detection. With ether anesthesia, bilateral injections of 50 or 100 micrograms xylamine reduce...

journal_title：European journal of pharmacology

authors： Geyer MA,Gordon J,Adams LM

更新日期：1984-04-20 00:00:00

abstract：:The cyclic peptide urotensin II has recently been cloned from human and reported to potently constrict primate blood vessels. To elucidate the cellular signalling mechanisms of this peptide, we investigated a possible relationship of vasomotor effects of human urotensin II and phosphoinositide turnover in isolated rab...

journal_title：European journal of pharmacology

authors： Saetrum Opgaard O,Nothacker H,Ehlert FJ,Krause DN

更新日期：2000-10-13 00:00:00

abstract：:The coronary vasoconstrictor effect of endothelin-1 was characterized in the isolated rat heart by using the endothelin ETA receptor antagonist D-Asp-L-Pro-D-Val-L-Leu-D-Trp (BQ-123) and the endothelin ETB receptor antagonist [Cys11-Cys15]endothelin-1-(11-21) (IRL 1038). In addition, the involvement of nitric oxide an...

journal_title：European journal of pharmacology

authors： Wang QD,Li XS,Pernow J

更新日期：1994-12-12 00:00:00

abstract：:Carbamazepine, a drug effective in pain, seizure, and affective disorders, was screened for its ability to interact with a variety of neurotransmitter and neuromodulator binding sites on brain membranes. The most potent effect was observed on adenosine antagonist ( [3H]DPX) binding to the adenosine receptor (KI = 3.5 ...

journal_title：European journal of pharmacology

authors： Marangos PJ,Post RM,Patel J,Zander K,Parma A,Weiss S

更新日期：1983-09-30 00:00:00

abstract：:Recently, it has been revealed that angiotensin II type 1 receptor (AT(1)) antagonists act as antiarrhythmic agents and that the T-type Ca2+ channel plays an important role in arrhythmia. However, it remains unclear how the T-type Ca2+ channel expression system is involved in angiotensin II-mediated arrhythmogenesis i...

journal_title：European journal of pharmacology

authors： Morishima M,Wang Y,Akiyoshi Y,Miyamoto S,Ono K

更新日期：2009-05-01 00:00:00

abstract：:The involvement of delta opioid receptors in supraspinal analgesia was investigated. With this aim, opioids that produced analgesia in the tail immersion test were administered i.c.v. to mice a few minutes before the irreversible antagonist, beta-funaltrexamine (beta-FNA). Protection of the respective analgesic effect...

journal_title：European journal of pharmacology

authors： Sánchez-Blázquez P,Garzón J

更新日期：1989-01-02 00:00:00

abstract：:For the development of efficient pulmonary delivery systems for protein and peptide drugs, it is important to understand their transport mechanisms in alveolar epithelial cells. In this study, the uptake mechanism for FITC-insulin in cultured alveolar epithelial cell line RLE-6TN was elucidated. FITC-insulin uptake by...

journal_title：European journal of pharmacology

authors： Oda K,Yumoto R,Nagai J,Katayama H,Takano M

更新日期：2011-12-15 00:00:00

abstract：:The effects on rat serum prolactin level of the two isomers constituting the racemic form of amisulpride were compared. (S-)-amisulpride induced hyperprolactinemia at lower doses (ED(50) = 0.09 +/- 0.01 mg/kg) than racemic- (ED(50) = 0.24 +/- 0.03 mg/kg) and (R+)-amisulpride (ED(50) = 4.13 +/- 0.05 mg/kg), in accord w...

journal_title：European journal of pharmacology

authors： Marchese G,Ruiu S,Casti P,Saba P,Gessa GL,Pani L

更新日期：2002-07-19 00:00:00

abstract：:Ovarian cancer (OC) is a major cause of cancer-related deaths in women all over the world. The easy metastasis of OC and the problem of radioresistance are serious issues remaining to be overcome. Thus, research on molecular mechanisms underlying is in urgent demand. Long non-coding RNAs (lncRNAs) are a class of RNAs ...

journal_title：European journal of pharmacology

authors： Dou Q,Xu Y,Zhu Y,Hu Y,Yan Y,Yan H

更新日期：2019-06-05 00:00:00

abstract：:Diabetic osteopenia can result in an increased incidence of bone fracture and a delay in fracture healing. Quercetin, one of the most widely distributed flavonoids in plants, possesses antioxidant property and beneficial effect on osteoporosis in ovariectomized mice. All these properties make quercetin a potential can...

journal_title：European journal of pharmacology

authors： Liang W,Luo Z,Ge S,Li M,Du J,Yang M,Yan M,Ye Z,Luo Z

更新日期：2011-11-16 00:00:00

abstract：:Although a number of studies have shown that perivascular adipose tissue (PVAT) attenuates arterial contraction through the release of perivascular-derived relaxation factors (PVRF), the role of PVAT in modulating venous function and its mechanism(s) remained unknown. Here we examined the role of PVAT in the modulatio...

journal_title：European journal of pharmacology

authors： Lu C,Zhao AX,Gao YJ,Lee RM

更新日期：2011-04-25 00:00:00

abstract：:Inhibitory effects of the saponin fraction and its principal constituents, escins Ia, Ib, IIa, and IIb, from horse chestnuts on gastric emptying were investigated in mice loaded with a non-nutrient or nutrient meal. The saponin fraction and escins Ia-IIb inhibited gastric emptying of a 1.5% carboxymethyl cellulose sod...

journal_title：European journal of pharmacology

authors： Matsuda H,Li Y,Murakami T,Yamahara J,Yoshikawa M

更新日期：1999-03-05 00:00:00