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Pertussis toxin-sensitive G-proteins in the sino-atrial node and right atrium of bovine heart.

Abstract：

:Three apparently distinct pertussis toxin (PTX)-sensitive substrates, with Mrs of 39, 40 and 41 kDa, were identified in membranes prepared from the sino-atrial (SA) node and right atrium of bovine heart. Based on their biochemical characterization, the effects of guanine nucleotides/MgCl2 on their PTX-catalyzed [32P]ADP ribosylation, and the PTX-induced decrease in radiolabelled agonist high-affinity binding to muscarinic acetylcholine receptors present in these membranes, we tentatively identify these proteins as the alpha-subunits of the G0 and Gi subtypes of G-proteins. These results indicate that PTX alters the G-protein modulation of SA nodal and atrial muscarinic acetylcholine receptors by disrupting at least one of a group of PTX-sensitive G-proteins present in these tissues.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Braun AP,Gupta RC,Sulakhe PV

doi

10.1016/0922-4106(90)90236-q

subject

Has Abstract

pub_date

1990-07-31 00:00:00

pages

105-9

issue

1

eissn

0014-2999

issn

1879-0712

journal_volume

189

pub_type

杂志文章

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