Abstract:
:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) destroys dopamine-containing nigrostriatal neurons and increases the apparent Bmax of both D1 and D2 binding sites in the striatum. However, the changes of Bmax occur at different intervals after the lesion. Up-regulation of D2 sites becomes evident about 3 weeks after the lesion and lasts for about 3 months. In contrast, about 3 months are required for the up-regulation of D1 sites and increased binding is still evident after 5 months.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Weihmuller FB,Bruno JP,Neff NH,Hadjiconstantinou Mdoi
10.1016/0014-2999(90)90324-ysubject
Has Abstractpub_date
1990-05-16 00:00:00pages
369-72issue
2-3eissn
0014-2999issn
1879-0712pii
0014-2999(90)90324-Yjournal_volume
180pub_type
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