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Caffeine inhibits depolarization-activated outward currents in rat ventricular myocytes.

Abstract：

:The effects of caffeine (10 mM) on depolarization-activated, calcium-independent outward K+ currents were investigated in isolated rat ventricular myocytes, using whole-cell clamping. The external solution contained CoCl2 2 mM and the internal solution contained ethylene glycol-bis(-aminoethyl ether) N,N,N',N'-tetraacetic acid 10 mM. Caffeine decreased the peak amplitude of the total current and the sustained plateau current. Caffeine did not modify the steady state inactivation curve, which was fitted by two Boltzmann functions. Caffeine blocked the tetraethylammonium-sensitive slowly activating and inactivating outward current by 32% and the 4-aminopyridine-sensitive rapidly activating and inactivating transient outward current by 19%. Caffeine did not modify the inactivation rate or the time course of the recovery from inactivation of the transient current. Ryanodine 10 microM did not modify any of the current components and the effect of caffeine was not modified by ryanodine pretreatment. The phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine 100 microM, did not modify the depolarization-activated calcium-independent outward currents.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Sanchez-Chapula J

doi

10.1016/0014-2999(92)90551-e

keywords:

subject

Has Abstract

pub_date

1992-12-15 00:00:00

pages

163-9

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(92)90551-E

journal_volume

229

pub_type

杂志文章

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