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Pharmacological characterization of alpha1-adrenoceptors in mouse isolated femoral small arteries.

Abstract：

:Arteries were isolated from male DBA/2 mice and mounted on a small vessel wire myograph for isometric recording. Responses to exogenous noradrenaline were inhibited with high affinity by prazosin (pKB, 9.3) and 5-methyl-urapidil (pKB, 9.2) and with low affinity by 8-[2-[4-(2-methoxyphenyl)-1 piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione (BMY 7378) (pA(2), 6.7). Chloroethylclonidine (10 microM) produced only a small reduction in the maximum response to noradrenaline. Responses to electrical field stimulation were also inhibited with high affinity by prazosin (pIC50, 9.3-9.5) and 5-methyl-urapidil (pIC50, 8.0-8.3). Responses were sensitive to BMY 7378 at low frequencies of stimulation (pIC50 at 2 Hz, 8.2) but not at high frequencies (pIC50 at 20 Hz, 6.5). In conclusion, contractions to exogenous and endogenous noradrenaline in mouse femoral small arteries are mediated mainly by alpha1A-adrenoceptors. alpha1D-adrenoceptors are not involved in responses to exogenous noradrenaline but appear to be activated by neurally released noradrenaline at a low frequency of stimulation.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Zacharia J,Hillier C,Macdonald A

doi

10.1016/j.ejphar.2004.09.046

keywords:

subject

Has Abstract

pub_date

2004-10-25 00:00:00

pages

155-63

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(04)01083-0

journal_volume

503

pub_type

杂志文章

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