Diversion of prostaglandin endoperoxide metabolism by selective inhibition of thromboxane A2 biosynthesis in lung, spleen or platelets.

abstract：:Dextrans of molecular weight 10(4) to 2 x 10(6) induced histamine release from rat peritoneal mast cells in the presence of calcium (1 mM) and phosphatidyl serine (10 micrograms/ml). Glucose and low molecular weight dextrans inhibited the histamine release induced by high molecular weight dextrans but the inhibition c...

journal_title：European journal of pharmacology

authors： Moodley I,Mongar JL,Foreman JC

更新日期：1982-09-10 00:00:00

abstract：:In rats, a selective inhibition for 3 weeks of monoamineoxydase (MAO) type B elicited by daily doses of pargyline (2.5 mumol/kg) or (-)-deprenyl (1 mumol/kg) attenuated the NE dependent stimulation of cortical adenylate cyclase and reduced the number of brain recognition sites for beta-adrenergic receptor ligands. Sim...

journal_title：European journal of pharmacology

authors： Zsilla G,Barbaccia ML,Gandolfi O,Knoll J,Costa E

更新日期：1983-04-22 00:00:00

abstract：:Protective effect of quercetin and alpha-tocopherol on experimental reflux oesophagitis in rats was investigated. Rats received quercetin, (100 mg/kg), alpha-tocopherol (16 mg/kg), omeprazole (30 mg/kg) given at 1 h prior to surgery. Quercetin and alpha-tocopherol significantly inhibited the oesophagitis index to 1.33...

journal_title：European journal of pharmacology

authors： Rao CV,Vijayakumar M

更新日期：2008-07-28 00:00:00

abstract：:CPP, administered systemically, elicited four distinct responses characteristic of serotonin-receptor activation in the central nervous system. The crossed extensor reflex in the acutely spinalized rat was enhanced by treatment with CPP, 1-16 mg/kg. CPP, 1.11-10 mg/kg, elicited a dose-related increase in head twitches...

journal_title：European journal of pharmacology

authors： Clineschmidt BV,Mcguffin JC,Pflueger AB

更新日期：1977-07-01 00:00:00

abstract：:We have tested for anti-nociceptive effects of the anticonvulsant KCNQ channel opener, N-(2-amino-4-(4-fluorobenzylamino)-phenyl)carbamic acid ethyl ester (retigabine), in rat models of experimental pain. In the chronic constriction injury and spared nerve models of neuropathic pain, injection of retigabine (5 and 20 ...

journal_title：European journal of pharmacology

authors： Blackburn-Munro G,Jensen BS

更新日期：2003-01-24 00:00:00

abstract：:Epristeride, a 5alpha-reductase inhibitor, decreases prostate size and improves symptoms in men with benign prostatic hyperplasia. However, little is known about the histopathology of the prostate after treatment with epristeride. To study the relationship between apoptosis and the mechanism of epristeride in the trea...

journal_title：European journal of pharmacology

authors： Sun ZY,Wu HY,Wang MY,Tu ZH

更新日期：1999-04-29 00:00:00

abstract：:Cholinergic system stimulation in some parts of the brain may affect anxiety-related behaviors. This system has many interactions with dopaminergic neurotransmission in the brain. We have studied the effect of cholinergic system activation in the basolateral amygdala on anxiety-related behaviors in adult male wistar r...

journal_title：European journal of pharmacology

authors： Zarrindast MR,Sroushi A,Bananej M,Vousooghi N,Hamidkhaniha S

更新日期：2011-12-15 00:00:00

abstract：:The aim of this study was to investigate the contribution of the Na(+)/H(+) exchanger to cerebral ischemia using SM-20220 (N-(aminoiminomethyl)-1-methyl-1H-indole-2-carboxamide methanesulfonate), a newly synthesized compound. In in vitro experiments, we evaluated the inhibitory effect of SM-20220 on the Na(+)/H(+) exc...

journal_title：European journal of pharmacology

authors： Kuribayashi Y,Itoh N,Kitano M,Ohashi N

更新日期：1999-10-27 00:00:00

abstract：:The calcium currents (ICa) of isolated smooth muscle cells (urinary bladder of the guinea-pig) were analyzed at 35 degrees C and 3.6 mM [Ca]0. The whole cells were voltage-clamped with a single patch electrode which was filled with 150 mM CsCl in order to block potassium outward currents. Tiapamil reduced ICa at conce...

journal_title：European journal of pharmacology

authors： Klöckner U,Isenberg G

更新日期：1986-08-15 00:00:00

abstract：:The effect of regression of left ventricular hypertrophy was studied in deoxycorticosterone-acetate-salt hypertensive rats (DOCA-salt hypertensive rats) treated with tetrandrine. Treatment with tetrandrine (by gastric intubation, 50 mg/kg per day for 9 weeks) lowered systolic blood pressure, left ventricular weight, C...

journal_title：European journal of pharmacology

authors： Xu Y,Rao MR

更新日期：1995-05-04 00:00:00

abstract：:We investigated whether tolerance develops to the vasorelaxant effects of a new vasodilator, (+-)-(E)-4-ethyl-2-[(E)-hydroxy-imino]-5-nitro-3-hexenamide (FK409), in isolated canine coronary artery strips and to its hypotensive effect in rats, and whether FK409 activates soluble guanylate cyclase isolated from vascular...

journal_title：European journal of pharmacology

authors： Isono T,Sato N,Yamamoto T,Sawada T,Yamazaki S,Miura S,Furuichi A,Ozaki R,Koibuchi Y,Ohtsuka M

更新日期：1994-08-01 00:00:00

abstract：:Cannabinoids have been widely reported to produce antinociception in models such as tail flick and hot plate. However, their role in modulating thermal hyperalgesia is unknown. The potency of some drugs, such as the opioids, increases during hyperalgesia. Thus, we evaluated whether there is a change in the effectivene...

journal_title：European journal of pharmacology

authors： Richardson JD,Aanonsen L,Hargreaves KM

更新日期：1998-03-19 00:00:00

abstract：:Nerisopam, an anxiolytic and antipsychotic homophthalazine induces rapid, intense expression of Fos-like immunoreactivity in the rostral, dorsomedial and lateral parts of the striatum in the rat. Fos-positive cells also occurred in the globus pallidus, the olfactory tubercle and in the accumbens nucleus (in the cone a...

journal_title：European journal of pharmacology

authors： Palkovits M,Baffi JS,Berzsenyi P,Horváth EJ

更新日期：1997-07-16 00:00:00

abstract：:Canine femoral arteries responded to acetylcholine with relaxations; these were abolished in potassium free solution, restored by potassium or rubidium but not by cesium or amonium. Potassium and rubidium were equipotent in inducing ouabain-sensitive relaxation, while amonium and cesium were less potent. The results (...

journal_title：European journal of pharmacology

authors： De Mey J,Vanhoutte PM

更新日期：1980-10-03 00:00:00

abstract：:Acute kidney injury (AKI) is defined as a rapid loss of kidney function characterised by inflammation and cell death, ultimately leading to further functional and structural renal alterations. Based on experimental and epidemiological pieces of evidence, AKI may progress to chronic kidney disease (CKD) even after a re...

journal_title：European journal of pharmacology

authors： Ogbadu J,Singh G,Aggarwal D

更新日期：2019-12-15 00:00:00

abstract：:The thromboxane mimetic U46619 (11 alpha,9 alpha-epoxymethano PGH2) increased 45Ca2+ uptake in sheep coronary artery rings. A larger increase occurred in endothelium-denuded than in endothelium-inact rings (increase in 45Ca2+ uptake: endothelium intact = 9.6 +/- 3.8, endothelium-denuded = 33.2 +/- 8.1 nmol g-1), in ag...

journal_title：European journal of pharmacology

authors： Dalen T,Vestereng M,Wadsworth R,Kane K

更新日期：1994-08-03 00:00:00

abstract：:Peptides based in the stabilised tetrapeptide HTyr-D-Ala-Gly-MePheOH have been synthesised and shown to have substantial opioid activity both in vitro and in vivo. The selectivity of these compounds of different receptor populations has been investigated using both isolated tissue assays and binding studies. Results s...

journal_title：European journal of pharmacology

authors： Handa BK,Land AC,Lord JA,Morgan BA,Rance MJ,Smith CF

更新日期：1981-04-09 00:00:00

abstract：:The protective potency of ischemic preconditioning decreases with increasing age. A key step in ischemic preconditioning is the opening of mitochondrial Ca(2+) sensitive K(+) (mK(Ca)) channels, which causes mild uncoupling of mitochondrial respiration. We hypothesized that aging reduces the effects of mK(Ca) channel o...

journal_title：European journal of pharmacology

authors： Heinen A,Winning A,Schlack W,Hollmann MW,Preckel B,Frässdorf J,Weber NC

更新日期：2008-01-14 00:00:00

abstract：:The efficacy of SR 47436 (BMS-186295), 2-n-butyl-3-[(2'-(1H-tetrazol-5-yl)- biphenyl-4-yl)methyl]-1,3-diaza-spiro[4,4]non-1-en-4-one, a non-peptide angiotensin AT1 receptor antagonist, was characterized in various conscious hypertensive rat models. In spontaneously hypertensive rats, single intravenous or oral doses o...

journal_title：European journal of pharmacology

authors： Lacour C,Canals F,Galindo G,Cazaubon C,Segondy D,Nisato D

更新日期：1994-11-03 00:00:00

abstract：:Resveratrol pretreatment can protect the heart by inducing pharmacological preconditioning. Whether resveratrol protects the heart when applied at reperfusion remains unknown. We examined the effect of resveratrol on myocardial infarct size when given at reperfusion and investigated the mechanism underlying the effect...

journal_title：European journal of pharmacology

authors： Xi J,Wang H,Mueller RA,Norfleet EA,Xu Z

更新日期：2009-02-14 00:00:00

abstract：:We have investigated the effect of 2(4-((2-carboxymethyl)phenyl)ethylamino)-5'-N-ethylcarboxamidoadenosine (CGS 21680), a potent and selective agonist at adenosine A2A receptors, on pulmonary inflammation induced by allergen challenge in the ovalbumin-sensitised, Brown Norway rat. Aerosol administration of ovalbumin (...

journal_title：European journal of pharmacology

authors： Fozard JR,Ellis KM,Villela Dantas MF,Tigani B,Mazzoni L

更新日期：2002-03-08 00:00:00

abstract：:Statins are some of the most widely used drugs worldwide, but one of their major side effects is myotoxicity. Using mouse myoblast (C2C12) and human alveolar rhabdomyosarcoma cell lines (RH30) in both 2-dimensional (2D) and 3-dimensional (3D) cell culture, we investigated the mechanisms of simvastatin's myotoxicity. W...

journal_title：European journal of pharmacology

authors： Emami A,Shojaei S,da Silva Rosa SC,Aghaei M,Samiei E,Vosoughi AR,Kalantari F,Kawalec P,Thliveris J,Sharma P,Zeki AA,Akbari M,Gordon JW,Ghavami S

更新日期：2019-11-05 00:00:00

abstract：:Dopamine (DA) was injected in the third brain ventricle of goats and the thermoregulatory effects were studied under different ambient conditions. The effects depended on dose, ambient conditions and cannula used. In the cold, there was a drop in body temperature, sometimes accompanied by suppression of shivering and ...

journal_title：European journal of pharmacology

authors： De Roij TA,Frens J,Bakker J,Németh F

更新日期：1977-05-01 00:00:00

abstract：:The antihypertensive drug doxazosin has been associated with an increased risk for congestive heart failure and cardiomyocyte apoptosis. Human ether-a-go-go-related gene (hERG) K(+) channels, previously shown to be blocked by doxazosin at therapeutically relevant concentrations, represent plasma membrane receptors for...

journal_title：European journal of pharmacology

authors： Thomas D,Bloehs R,Koschny R,Ficker E,Sykora J,Kiehn J,Schlömer K,Gierten J,Kathöfer S,Zitron E,Scholz EP,Kiesecker C,Katus HA,Karle CA

更新日期：2008-01-28 00:00:00

abstract：:The pharmacology of neurogenic trigeminovascular vasodilator responses in the dura mater is of interest for understanding the pathophysiology of migraine and to develop new therapies for this disabling common condition. Aminergic mechanisms have been implicated in migraine through direct study of amines in patients, a...

journal_title：European journal of pharmacology

authors： Akerman S,Williamson DJ,Hill RG,Goadsby PJ

更新日期：2001-07-13 00:00:00

abstract：:The ability of isoproterenol to relax guinea-pig trachea was examined in tissues precontracted with three concentrations of methacholine or three corresponding equieffective concentrations of leukotriene D4. Although increasing the concentration of either contractile agent progressively shifted isoproterenol concentra...

journal_title：European journal of pharmacology

authors： Torphy TJ

更新日期：1984-07-20 00:00:00

abstract：:The effect of the pro-inflammatory cytokine, interleukin-1beta on an NMDA receptor-independent form of synaptic plasticity brought about by the application of the K+ channel blocker tetraethylammonium, was examined in the rat dentate gyrus in vitro. Field excitatory postsynaptic potentials (EPSPs) were recorded from t...

journal_title：European journal of pharmacology

authors： Coogan AN,O'Connor JJ

更新日期：1999-06-18 00:00:00

abstract：:The G protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor and is associated with angiotensin-(1-7) signaling. We investigated the effect of Mas-deficiency on blood pressure regulation under physiological conditions and salt load using radiotelemetry. Mas-knockout mice and t...

journal_title：European journal of pharmacology

authors： Heringer-Walther S,Gembardt F,Perschel FH,Katz N,Schultheiss HP,Walther T

更新日期：2012-08-15 00:00:00

abstract：:We have investigated, by using the whole-cell patch-clamp technique, the Ca2+ channel antagonist properties of eliprodil in cultured cerebellar granule cells which are known to express L-, N-, P- as well as Q- and R-type Ca2+ channels. Eliprodil maximally antagonized 50% of the voltage-dependent Ba2+ current with an I...

journal_title：European journal of pharmacology

authors： Biton B,Godet D,Granger P,Avenet P

更新日期：1997-04-04 00:00:00

abstract：:Angiotensin AT1 receptor antagonists represent a novel class of cardiovascular drugs. In conscious, normotensive rats, irbesartan ((2-n-butyl-3-[(2'-(1H-tetrazol-5-yl)-biphenyl-4-yl) methyl]-1,3-diaza-spiro[4,4]non) and losartan ((2 n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl -4-yl) methyl] imid...

journal_title：European journal of pharmacology

authors： Culman J,von Heyer C,Piepenburg B,Rascher W,Unger T

更新日期：1999-02-19 00:00:00