Substance P suppresses stress-induced eating.

abstract：:The present study examined the adverse effects of delta-9-tetrahydrocannabinol (i.p injection in albino mice) on free radical damage of testicular lipids (lipid peroxidation) at low doses and the role of antioxidant enzymes defense system at high dose and particularly at the withdrawal of the drug after applying highe...

journal_title：European journal of pharmacology

authors： Mandal TK,Das NS

更新日期：2009-04-01 00:00:00

abstract：:The impacts of prenatal propofol on cognition and emotion of offspring remain elusive. In the present study, pregnant rats in the second trimester were anesthetized with propofol. Neuronal apoptosis and proliferation was determined in fetuses and postnatal rats by detecting caspase-3 and BrdU expression. The offspring...

journal_title：European journal of pharmacology

authors： Chen D,Qi X,Zhuang R,Cao J,Xu Y,Huang X,Li Y

更新日期：2019-01-15 00:00:00

abstract：:According to the American Society of Clinical Oncology or ASCO's clinical practice guidelines, administration of Tamoxifen for hormone receptor positive patients improved outcomes. However, many studies have been conducted in this issue, with the rise of Tamoxifen resistance in recent decades. There are many alternati...

journal_title：European journal of pharmacology

authors： Mansouri S,Naghavi-Al-Hosseini F,Farahmand L,Majidzadeh-A K

更新日期：2017-06-05 00:00:00

abstract：:We investigated the in vitro effects of therapeutical concentrations of S 21403 (a succinic acid derivative also known as KAD 1229 and mitiglinide) on insulin and glucagon secretion during a metabolic stimulus (glucose rising from 5 to 8.33 mM) or at a stable 2.22 mM glucose using the isolated perfused rat pancreas mo...

journal_title：European journal of pharmacology

authors： Gregorio F,Ambrosi F,Boemi M,Carle F,Filipponi P

更新日期：2002-12-05 00:00:00

abstract：:The effects of two predominant dopamine D2-like receptor agonists, talipexole (6-allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo [4,5-d]-azepine dihydrochloride, B-HT 920 CL2) and pramipexole (S(-)2-amino-4,5,6,7-tetrahydro-6-propyl-aminobenzothiazole dihydrochloride, SND 919 CL2Y), were studied alone and in combination ...

journal_title：European journal of pharmacology

authors： Domino EF,Ni L,Zhang H,Kohno Y,Sasa M

更新日期：1997-05-01 00:00:00

abstract：:The effects of the dopamine D2 receptor agonist quinpirole (LY 171555) on locomotor activity and margin time (thigmotaxis or wall-hugging) were measured for 2 h in rats injected either s.c. (vehicle, 0.02, 2.0 mg/kg) or directly into either the dorsal striatum or nucleus accumbens (vehicle, 0.1, 1.0, 10, 20 or 40 micr...

journal_title：European journal of pharmacology

authors： Van Hartesveldt C,Cottrell GA,Potter T,Meyer ME

更新日期：1992-04-07 00:00:00

abstract：:GABAA and GABAB receptor agonists and antagonists were administered locally in the striatum of intact and kainic acid lesioned rats. (+/-)-Baclofen, a GABAB receptor agonist, significantly decreased the level of extracellular dopamine in the striatum of intact rats. (+/-)-Phaclofen, a GABAB receptor antagonist, increa...

journal_title：European journal of pharmacology

authors： Smolders I,De Klippel N,Sarre S,Ebinger G,Michotte Y

更新日期：1995-09-15 00:00:00

abstract：:The effects of endothelin, a potent endogenous vasoconstrictor peptide, were examined in a range of vascular and non-vascular tissues. At concentrations that cause vasoconstriction in portal vein and aorta, the peptide strongly contracted rat uterus, trachea and vas deferens, but not guinea pig ileum. Nifedipine, a di...

journal_title：European journal of pharmacology

authors： Borges R,Von Grafenstein H,Knight DE

更新日期：1989-06-20 00:00:00

abstract：:Transgenic rabbits expressing loss-of-function pore mutants of the human gene KCNQ1 (K(v)LQT1-Y315S) have a Long QT-Syndrome 1 (LQT1) phenotype. We evaluated for the first time the effect of nicorandil, an opener of ATP-sensitive potassium channels, and of isoproterenol on cardiac action potential duration and heart r...

journal_title：European journal of pharmacology

authors： Biermann J,Wu K,Odening KE,Asbach S,Koren G,Peng X,Zehender M,Bode C,Brunner M

更新日期：2011-01-10 00:00:00

abstract：:In the past decade, a growing bulk of evidence has accumulated to suggest that patients suffering from major depression (MD) present some cognitive disturbances, such as impairment in attention, working memory, and executive function, including cognitive inhibition, problem- and task-planning. If the results of short-...

journal_title：European journal of pharmacology

authors： Marazziti D,Consoli G,Picchetti M,Carlini M,Faravelli L

更新日期：2010-01-10 00:00:00

abstract：:Thaliporphine (0.1-100 microM) produced sustained, concentration-dependent contraction in isolated rings of rat aorta. Thaliporphine (ED50 = 1.5 +/- 0.5 microM) was less potent than endothelin (ED50 = 3.9 +/- 0.4 nM), but was more potent than Bay K 8644 (ED50 = 5.5 +/- 0.6 microM). Thaliporphine also contracted guinea...

journal_title：European journal of pharmacology

authors： Teng CM,Yu SM,Lee SS,Ko FN,Su MJ,Huang TF

更新日期：1993-03-16 00:00:00

abstract：:Most virus infections induce cycloxygenase-2 (COX-2) expression and subsequent prostaglandin E(2) (PGE(2)) production in cells, an inflammatory response that might be detrimental to virus replication and pathogenesis. This response in dengue virus infection remains to be elucidated. Triptolide and tetrandrine, compoun...

journal_title：European journal of pharmacology

authors： Liou JT,Chen ZY,Ho LJ,Yang SP,Chang DM,Liang CC,Lai JH

更新日期：2008-07-28 00:00:00

abstract：:The effects of gentamicin, an aminoglycoside antibiotic, on changes in the catecholamine levels in the rat striatum, hypothalamus, adrenal medulla and vas deferens were studied. When rats were i.v. injected with gentamicin (1.0 mg/kg), the catecholamine content of all tissues increased 2-4 h after injection. The incre...

journal_title：European journal of pharmacology

authors： Mikami M,Tachikawa E,Kashimoto T

更新日期：1992-01-07 00:00:00

abstract：:The identity of the muscarinic receptor subtype in the chick ileum was investigated in functional and binding studies. Preliminary studies [Choo, L.-K., Mitchelson, F., Napier, P. 1988. J. Auton. Pharmacol. 8, 259-266] suggested apparent avian and mammalian family differences in the muscarinic receptor profile of ilea...

journal_title：European journal of pharmacology

authors： Darroch S,Irving HR,Mitchelson FJ

更新日期：2000-08-18 00:00:00

abstract：:5-(2'-[18F]Fluoroethyl)flumazenil ([18F]FEF), a fluorine-18-labeled analogue of the benzodiazepine antagonist flumazenil, was evaluated for use with positron emission tomography (PET). PET imaging of a baboon after i.v. injection of [18F]FEF showed that the radiofluorinated ligand rapidly localized in vivo within benz...

journal_title：European journal of pharmacology

authors： Moerlein SM,Perlmutter JS

更新日期：1992-07-21 00:00:00

abstract：:We determined the role of high-grade inflammation on endothelial function and its association with biomarkers of endothelial dysfunction in collagen-induced arthritis. Sprague-Dawley rats were divided into a control (n = 12) or collagen-induced arthritis (CIA; n = 21) group. To induce arthritis, Bovine-type-II collage...

journal_title：European journal of pharmacology

authors： Mokotedi L,Millen AME,Mogane C,Gomes M,Woodiwiss AJ,Norton GR,Michel FS

更新日期：2019-12-15 00:00:00

abstract：:The inward chloride current induced by angiotensin II (AII) in Xenopus oocytes shows strong and homologous desensitization, and was suggested to be mediated by phosphatidylinositol (PI) hydrolysis (Sakuta et al., 1991, Eur. J. Pharmacol. Mol. Pharmacol. 208, 31). As a model of agonist-induced desensitization of recept...

journal_title：European journal of pharmacology

authors： Sakuta H,Sekiguchi M,Okamoto K,Sakai Y

更新日期：1991-09-12 00:00:00

abstract：:Several contractile responses of longitudinal muscles of the guinea-pig digestive tract to exogenously applied ATP (10-300 micrometer), including "rebound" contractions, were inhibited by indomethacin (3-20 micrometer) or polyphloretin phosphate (10-100 microgram/ml). Relaxations to ATP in stomach and large intestina...

journal_title：European journal of pharmacology

authors： Kamikawa Y,Serizawa K,Shimo Y

更新日期：1977-09-15 00:00:00

abstract：:Many atypical antipsychotic drugs, such as olanzapine, induce significant weight gain. However, ziprasidone produces minimal weight gain, the mechanism of which remains unclear. The aim of the present study was to investigate whether ziprasidone would reduce the acute effect of olanzapine on feeding behaviour. The res...

journal_title：European journal of pharmacology

authors： Kirk SL,Neill JC,Jones DN,Reynolds GP

更新日期：2004-11-28 00:00:00

abstract：:The muscarinic agonist McN-A-343 did not affect the tone or nitroprusside-induced relaxations of the rat anococcygeus, but inhibited non-adrenergic non-cholinergic (NANC) relaxations. Atropine, pirenzepine and gallamine blocked the McN-A-343 inhibition of NANC relaxations. Agonists of alpha 1-(methoxamine) or alpha 2-...

journal_title：European journal of pharmacology

authors： Li CG,Rand MJ

更新日期：1989-09-01 00:00:00

abstract：:Two novel 8 alpha-amino ergolines (CH 29-717 and CU 32-085) have been shown to inhibit secretion of prolactin in rats in vivo. However, when tested for dopaminomimetic potency on pituitary cell culture preparations in vitro, CH 29-717 inhibited prolactin release with an IC50 = 4 X 10(-9) M. In the same model the 1-met...

journal_title：European journal of pharmacology

authors： Markó M

更新日期：1984-06-01 00:00:00

abstract：:The role of tuberoinfundibular and periventricular-hypophysial dopaminergic neurons in mediating rimcazole-induced decreases in plasma concentrations of prolactin and alpha-melanocyte stimulating hormone was assessed. Dopaminergic neuronal activity was estimated by measuring concentrations of 3,4-dihydroxyphenylacetic...

journal_title：European journal of pharmacology

authors： Eaton MJ,Lookingland KJ,Moore KE

更新日期：1996-03-28 00:00:00

abstract：:Inhibition of local cortisol regeneration from circulating cortisone by blocking 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been shown to ameliorate the risk factors associated with the metabolic syndrome. Chronic modulation of glucocorticoid homeostasis may result in hypothalamic-pituitary-adrenal (HPA) axis s...

journal_title：European journal of pharmacology

authors： Hamilton BS,Schoelch C,Schuler-Metz A,Krosky P,Lala DS,Claremon DA,McGeehan GM

更新日期：2016-10-15 00:00:00

abstract：:Local infusions of PYY (3-100 pmol.min-1) caused a slowly developing vasoconstriction of a long duration in the cat submandibular salivary gland. The vasoconstrictor action of PYY was also present after alpha-adrenoceptor blockade and in sympathectomized animals. Local APP infusions caused only weak vasoconstriction. ...

journal_title：European journal of pharmacology

authors： Lundberg JM,Tatemoto K

更新日期：1982-09-10 00:00:00

abstract：:Diabetes mellitus is associated with an increased risk of cardiovascular disease. Endothelial dysfunction (i.e. decreased endothelium-dependent vasorelaxation) plays a key role in the pathogenesis of diabetic vascular disease. The present study was undertaken to determine whether diabetes induced by streptozotocin alt...

journal_title：European journal of pharmacology

authors： Fatehi-Hassanabad Z,Imen-Shahidi M,Fatehi M,Farrokhfall K,Parsaeei H

更新日期：2006-03-27 00:00:00

abstract：:It has been shown that analgesics such as morphine, lidocaine and clonidine increase the release of spinal acetylcholine. Acetylcholine may therefore play an important role in the regulation of spinal pain threshold. Since behavioral as well as in vitro studies have shown a clear involvement of GABA (gamma-amino butyr...

journal_title：European journal of pharmacology

authors： Kommalage M,Höglund AU

更新日期：2005-11-21 00:00:00

abstract：:To study the role of K(+) channels in the coronary and renal vascular response to vasopressin during diabetes mellitus, and whether there are gender differences in this role, we have examined the isometric response to this peptide of 2-mm-long arterial segments from male and female, normoglycemic and streptozotocin-in...

journal_title：European journal of pharmacology

authors： Sanz E,Fernández N,Monge L,Climent B,Diéguez G,García-Villalón AL

更新日期：2003-06-13 00:00:00

abstract：:The present investigation was designed to identify potential biomarker(s) and assess the involvement of inflammatory pathway in dimethylnitrosamine (DMN)-induced liver fibrosis in rats. Following DMN-treatment (10 mg/ml/kg, i.p., given three consecutive days each week for 4 weeks) body and liver weights were significa...

journal_title：European journal of pharmacology

authors： Saha JK,Xia J,Sandusky GE,Chen YF,Gerlitz B,Grinnell B,Jakubowski JA

更新日期：2007-12-01 00:00:00

abstract：:In the rat distal colon, 5-hydroxytryptamine (5-HT)-induced Cl- secretion is seen as a rise in short circuit current (Isc). We investigated the 5-HT receptor mediating 5-HT-induced Cl- secretion in the rat distal colon. Rat distal colon was prepared either by stripping away the muscularis propria with the neural gangl...

journal_title：European journal of pharmacology

authors： Budhoo MR,Harris RP,Kellum JM

更新日期：1996-03-07 00:00:00

abstract：:The effect of an antisense oligonucleotide to the K+ channel coding mKv1.1 mRNA on antinociception induced by the tricyclic antidepressants, clomipramine (20-35 mg kg(-1) s.c.) and amitriptyline (10-25 mg kg(-1) s.c.), was investigated in the mouse hot-plate test. Antisense oligonucleotide (0.5-1.0-2.0-3.0 nmol per i....

journal_title：European journal of pharmacology

authors： Galeotti N,Ghelardini C,Capaccioli S,Quattrone A,Nicolin A,Bartolini A

更新日期：1997-07-02 00:00:00